{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:12:01Z","timestamp":1793772721109,"version":"4.6.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"am","delay-in-days":344,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"European Genomic Institute for Diabetes","award":["ANR-10-LABX-46"],"award-info":[{"award-number":["ANR-10-LABX-46"]}]},{"name":"Conseil r\u00e9gional Nord Pas-de-Calais"},{"name":"Fonds europ\u00e9ens de d\u00e9veloppement r\u00e9gional"},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Long-Term Fellowship"},{"name":"Nouvelle Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Ath\u00e9roscl\u00e9rose"},{"DOI":"10.13039\/501100011738","name":"Lee Kong Chian School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nanyang Technological University Singapore Start-Up"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jhep.2018.12.037","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T01:35:51Z","timestamp":1548034551000},"page":"963-973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Hepatic PPAR\u03b1 is critical in the metabolic adaptation to sepsis"],"prefix":"10.1016","volume":"70","author":[{"given":"R\u00e9jane","family":"Paumelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel T.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Hennuyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Baug\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Deleye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Mesotten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lies","family":"Langouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Vanhoutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cudejko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiaan","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Anissa","family":"Hannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Legry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Lancel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lalloyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Polizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarra","family":"Smati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gourdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Vallez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bouchaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Derudas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Dehondt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Gheeraert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Fleury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tailleux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Montagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Wahli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greet","family":"Van Den Berghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-9081","authenticated-orcid":false,"given":"Herv\u00e9","family":"Guillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dombrowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Staels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2018.12.037_b0005","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0010","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJMoa1705835","article-title":"Adjunctive glucocorticoid therapy in patients with septic shock","volume":"378","author":"Venkatesh","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0015","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1056\/NEJMoa011300","article-title":"Intensive insulin therapy in critically ill patients","volume":"345","author":"van den Berghe","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0020","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJMoa1102662","article-title":"Early versus late parenteral nutrition in critically ill adults","volume":"365","author":"Casaer","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0025","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1189\/jlb.0212078","article-title":"Fueling the flame: bioenergy couples metabolism and inflammation","volume":"92","author":"Liu","year":"2012","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2018.12.037_b0030","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1210\/endo-128-2-645","article-title":"Gram-negative infection increases noninsulin-mediated glucose disposal","volume":"128","author":"Lang","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhep.2018.12.037_b0035","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1136\/jcp.40.9.1108","article-title":"Interpretation of the metabolic effects of trauma and sepsis","volume":"40","author":"Stoner","year":"1987","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jhep.2018.12.037_b0040","doi-asserted-by":"crossref","first-page":"S476","DOI":"10.1097\/01.CCM.0000278066.05354.53","article-title":"Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance","volume":"35","author":"Cree","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(04)16815-3","article-title":"Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation","volume":"364","author":"Singer","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2018.12.037_b0050","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI88894","article-title":"Distinct but complementary contributions of PPAR isotypes to energy homeostasis","volume":"127","author":"Dubois","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2018.12.037_b0055","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/01.RES.0000127122.22685.0A","article-title":"Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells","volume":"94","author":"Marx","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jhep.2018.12.037_b0060","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","article-title":"A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders","volume":"96","author":"Leone","year":"1999","journal-title":"PNAS"},{"key":"10.1016\/j.jhep.2018.12.037_b0065","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI6223","article-title":"Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting","volume":"103","author":"Kersten","year":"1999","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jhep.2018.12.037_b0070","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/384039a0","article-title":"The PPARalpha-leukotriene B4 pathway to inflammation control","volume":"384","author":"Devchand","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2018.12.037_b0075","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/SHK.0b013e31823f1a00","article-title":"Reduced peroxisome proliferator-activated receptor \u03b1 expression is associated with decreased survival and increased tissue bacterial load in sepsis","volume":"37","author":"Standage","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.jhep.2018.12.037_b0080","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1097\/CCM.0000000000001585","article-title":"Nonhematopoietic peroxisome proliferator-activated receptor-\u03b1 protects against cardiac injury and enhances survival in experimental polymicrobial sepsis","volume":"44","author":"Standage","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0085","doi-asserted-by":"crossref","first-page":"H239","DOI":"10.1152\/ajpheart.00457.2016","article-title":"PPAR\u03b1 augments heart function and cardiac fatty acid oxidation in early experimental polymicrobial sepsis","volume":"312","author":"Standage","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jhep.2018.12.037_b0090","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/MCB.15.6.3012","article-title":"Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators","volume":"15","author":"Lee","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2018.12.037_b0095","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2018.12.037_b0100","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1182\/blood.V60.3.618.618","article-title":"Cellular and extracellular myeloperoxidase in pyogenic inflammation","volume":"60","author":"Bradley","year":"1982","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2018.12.037_b0105","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1172\/JCI25385","article-title":"Intensive insulin therapy protects the endothelium of critically ill patients","volume":"115","author":"Langouche","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2018.12.037_b0110","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhep.2018.12.037_b0115","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1214\/16-AOAS920","article-title":"Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression","volume":"10","author":"Phipson","year":"2016","journal-title":"Ann Appl Stat"},{"key":"10.1016\/j.jhep.2018.12.037_b0120","doi-asserted-by":"crossref","first-page":"Article14","DOI":"10.2202\/1544-6115.1041","article-title":"Multiple testing. Part II. Step-down procedures for control of the family-wise error rate","volume":"3","author":"van der Laan","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"10.1016\/j.jhep.2018.12.037_b0125","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/bioinformatics\/btl140","article-title":"Improved scoring of functional groups from gene expression data by decorrelating GO graph structure","volume":"22","author":"Alexa","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhep.2018.12.037_b0130","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.jhep.2018.12.037_b0135","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1161\/ATVBAHA.110.220525","article-title":"Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice","volume":"31","author":"Lalloyer","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jhep.2018.12.037_b0140","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1186\/cc12839","article-title":"Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis","volume":"17","author":"Takahashi","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.jhep.2018.12.037_b0145","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature13961","article-title":"Nutrient-sensing nuclear receptors coordinate autophagy","volume":"516","author":"Lee","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2018.12.037_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrneph.2016.186","article-title":"Metabolic reprogramming and tolerance during sepsis-induced AKI","volume":"13","author":"G\u00f3mez","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jhep.2018.12.037_b0155","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1189\/jlb.0912437","article-title":"Current trends in inflammatory and immunomodulatory mediators in sepsis","volume":"93","author":"Aziz","year":"2013","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jhep.2018.12.037_b0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.it.2012.09.004","article-title":"The inflammatory response in sepsis","volume":"34","author":"Bosmann","year":"2013","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jhep.2018.12.037_b0165","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1677\/joe.0.1690453","article-title":"Peroxisome proliferator-activated receptors in inflammation control","volume":"169","author":"Delerive","year":"2001","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jhep.2018.12.037_b0170","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1002\/hep.22284","article-title":"Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl-CoA dehydrogenase (MCAD)-deficient mice","volume":"47","author":"Herrema","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2018.12.037_b0175","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10545-010-9121-7","article-title":"Mitochondrial fatty acid oxidation disorders: pathophysiological studies in mouse models","volume":"33","author":"Spiekerkoetter","year":"2010","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jhep.2018.12.037_b0180","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1097\/CCM.0b013e3181f85b2a","article-title":"Thioredoxin binding protein-2 mediates metabolic adaptation in response to lipopolysaccharide in vivo","volume":"38","author":"Oka","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0185","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/572405","article-title":"Role of PPARalpha in hepatic carbohydrate metabolism","author":"Peeters","year":"2010","journal-title":"PPAR Res"},{"key":"10.1016\/j.jhep.2018.12.037_b0190","first-page":"E311","article-title":"Increased muscle glucose uptake and lactate release after endotoxin administration","volume":"239","author":"Romanosky","year":"1980","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jhep.2018.12.037_b0195","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1210\/en.2005-1536","article-title":"Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain","volume":"147","author":"Knauf","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhep.2018.12.037_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.07.026","article-title":"Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation","volume":"166","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2018.12.037_b0205","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1210\/me.2014-1383","article-title":"Ketone body therapy protects from lipotoxicity and acute liver failure upon Ppar\u03b1 deficiency","volume":"29","author":"Pawlak","year":"2015","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jhep.2018.12.037_b0210","doi-asserted-by":"crossref","first-page":"195ra95","DOI":"10.1126\/scitranslmed.3005893","article-title":"An integrated clinico-metabolomic model improves prediction of death in sepsis","volume":"5","author":"Langley","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhep.2018.12.037_b0215","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1164\/rccm.201404-0624OC","article-title":"Integrative \u201comic\u201d analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes","volume":"190","author":"Langley","year":"2014","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827819300273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827819300273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:35:48Z","timestamp":1759174548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827819300273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0168827819300273"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2018.12.037","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic PPAR\u03b1 is critical in the metabolic adaptation to sepsis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2018.12.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}