{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:42:35Z","timestamp":1778884955392,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011029","name":"Helmholtz-Alberta Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011029","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hannover School for Biomolecular Drug Research"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.jhep.2019.01.033","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T03:52:31Z","timestamp":1550029951000},"page":"1082-1092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors"],"prefix":"10.1016","volume":"70","author":[{"given":"Dominic H.","family":"Banda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula M.","family":"Perin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-6671","authenticated-orcid":false,"given":"Richard J.P.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-1014","authenticated-orcid":false,"given":"Daniel","family":"Todt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wladimir","family":"Solodenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Hoffmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamlesh","family":"Kumar Sahu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Meuleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kirschning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-4422","authenticated-orcid":false,"given":"Thomas","family":"Pietschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2019.01.033_b0005","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/hep.26744","article-title":"Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource","volume":"59","author":"Smith","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2019.01.033_b0010","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jhep.2018.07.002","article-title":"Challenges and perspectives of direct antivirals for the treatment of hepatitis C virus infection","volume":"69","author":"Vermehren","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2019.01.033_b0015","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/hep4.1050","article-title":"Sequencing of hepatitis C virus for detection of resistance to direct-acting antiviral therapy: a systematic review","volume":"1","author":"Bartlett","year":"2017","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2019.01.033_b0020","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2017.11.007","article-title":"Patterns of resistance-associated substitutions in patients with chronic HCV infection following treatment with direct-acting antivirals","volume":"154","author":"Dietz","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2019.01.033_b0025","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(18)31311-4","article-title":"Hiv","volume":"392","author":"Ghosn","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2019.01.033_b0030","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jhep.2016.04.016","article-title":"Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib\/IIa study","volume":"65","author":"Bogomolov","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2019.01.033_b0035","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1021\/acsinfecdis.7b00091","article-title":"Entry inhibitors: a perspective for prevention of hepatitis C virus infection in organ transplantation","volume":"3","author":"Colpitts","year":"2017","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.jhep.2019.01.033_b0040","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1136\/gutjnl-2014-309045","article-title":"Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice","volume":"65","author":"Vercauteren","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2019.01.033_b0045","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01914-16","article-title":"Clinically approved ion channel inhibitors close gates for hepatitis C virus and open doors for drug repurposing in infectious viral diseases","volume":"91","author":"Pietschmann","year":"2017","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2019.01.033_b0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hep.28111","article-title":"Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1","volume":"63","author":"Perin","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2019.01.033_b0055","doi-asserted-by":"crossref","first-page":"282ra249","DOI":"10.1126\/scitranslmed.3010286","article-title":"Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection","volume":"7","author":"He","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhep.2019.01.033_b0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.chom.2010.12.002","article-title":"Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment","volume":"9","author":"Reiss","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jhep.2019.01.033_b0065","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/gutjnl-2012-304299","article-title":"Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells","volume":"63","author":"Anggakusuma","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2019.01.033_b0070","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1128\/JVI.02460-05","article-title":"Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses","volume":"80","author":"Koutsoudakis","year":"2006","journal-title":"JVirol"},{"key":"10.1016\/j.jhep.2019.01.033_b0075","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1128\/JVI.80.4.1734-1741.2006","article-title":"Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry","volume":"80","author":"Tscherne","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2019.01.033_b0080","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.03.036","article-title":"A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes","volume":"143","author":"Haid","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2019.01.033_b0085","series-title":"Synthese von Flunarizin-Derivaten mit \u201cPhotoaffinit\u00e4ts-label\u201d","author":"Hoffmeyer","year":"2015"},{"key":"10.1016\/j.jhep.2019.01.033_b0090","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.bmcl.2011.09.047","article-title":"Development of small-molecule probes that selectively kill cells induced to express mutant RAS","volume":"22","author":"Weiwer","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jhep.2019.01.033_b0095","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1128\/JVI.02642-06","article-title":"Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus","volume":"81","author":"Lavillette","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2019.01.033_b0100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0042-6822(02)00065-X","article-title":"Proteomics computational analyses suggest that hepatitis C virus E1 and pestivirus E2 envelope glycoproteins are truncated class II fusion proteins","volume":"307","author":"Garry","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.jhep.2019.01.033_b0105","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1128\/JVI.73.8.6782-6790.1999","article-title":"Functional analysis of cell surface-expressed hepatitis C virus E2 glycoprotein","volume":"73","author":"Flint","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2019.01.033_b0110","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.virol.2015.03.043","article-title":"Viral membrane fusion","volume":"479\u2013480","author":"Harrison","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.jhep.2019.01.033_b0115","article-title":"Low pH-dependent hepatitis C virus membrane fusion depends on E2 integrity, target lipid composition and density of virus particles","author":"Haid","year":"2009","journal-title":"JBiolChem"},{"key":"10.1016\/j.jhep.2019.01.033_b0120","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1128\/JVI.80.4.1817-1825.2006","article-title":"Functional analysis of hepatitis C virus envelope proteins, using a cell-cell fusion assay","volume":"80","author":"Kobayashi","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2019.01.033_b0125","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1074\/jbc.M509747200","article-title":"Hepatitis C virus glycoproteins mediate low pH-dependent membrane fusion with liposomes","volume":"281","author":"Lavillette","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2019.01.033_b0130","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nsb1096-842","article-title":"Experimentally determined hydrophobicity scale for proteins at membrane interfaces","volume":"3","author":"Wimley","year":"1996","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.jhep.2019.01.033_b0135","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.str.2006.07.011","article-title":"The Role of histidine residues in low-pH-mediated viral membrane fusion","volume":"14","author":"Kampmann","year":"2006","journal-title":"Structure"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827819301102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827819301102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T13:05:56Z","timestamp":1738501556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827819301102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0168827819301102"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2019.01.033","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2019.01.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}