{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:42Z","timestamp":1793060022654,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009033","name":"NHS Blood and Transplant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journal-of-hepatology.eu","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.jhep.2019.04.008","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:27:43Z","timestamp":1557268063000},"page":"434-438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Convalescent plasma therapy for persistent hepatitis E virus infection"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-620X","authenticated-orcid":false,"given":"Michael","family":"Ankcorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gallacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samreen","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusri","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli","family":"Harvala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Maclennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-0889","authenticated-orcid":false,"given":"Emma C.","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"da Silva Filipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Smollett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Niebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm G.","family":"Semple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Tedder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2019.04.008_b0005","doi-asserted-by":"crossref","first-page":"17086","DOI":"10.1038\/nrdp.2017.86","article-title":"Hepatitis E virus infection","volume":"3","author":"Kamar","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jhep.2019.04.008_b0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/TP.0000000000001908","article-title":"Summary of the British Transplantation Society UK guidelines for hepatitis E and solid organ transplantation","volume":"102","author":"McPherson","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2019.04.008_b0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.coviro.2018.10.001","article-title":"Hepatitis E virus treatment and ribavirin therapy: viral mechanisms of nonresponse","volume":"32","author":"Todt","year":"2018","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.jhep.2019.04.008_b0020","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (EASL) Clinical Practice Guidelines on hepatitis E virus infection. J Hepatol 2018;68:1256\u20131271.","DOI":"10.1016\/j.jhep.2018.03.005"},{"key":"10.1016\/j.jhep.2019.04.008_b0025","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/JCM.00330-16","article-title":"Comparison of next-generation sequencing technologies for comprehensive assessment of full-length hepatitis C viral genomes","volume":"54","author":"Thomson","year":"2016","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jhep.2019.04.008_b0030","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s12859-018-2459-9","article-title":"GLUE: a flexible software system for virus sequence data","volume":"19","author":"Singer","year":"2018","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.jhep.2019.04.008_b0035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jviromet.2017.11.007","article-title":"Confirmation of specificity of reactivity in a solid phase ELISA for the detection of hepatitis E viral antigen improves utility of the assay","volume":"252","author":"Ankcorn","year":"2018","journal-title":"J Virol Methods"},{"key":"10.1016\/j.jhep.2019.04.008_b0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jviromet.2012.07.027","article-title":"Minor groove binder modification of widely used TaqMan probe for hepatitis E virus reduces risk of false negative real-time PCR results","volume":"186","author":"Garson","year":"2012","journal-title":"J Virol Methods"},{"key":"10.1016\/j.jhep.2019.04.008_b0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1511812","article-title":"Evaluation of convalescent plasma for Ebola virus disease in guinea","volume":"374","author":"van Griensven","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2019.04.008_b0050","unstructured":"Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee. Guidelines for the Blood Transfusion Services in the UK. Available from: https:\/\/www.transfusionguidelines.org\/red-book. 2013 [cited 2019 March 3]."},{"key":"10.1016\/j.jhep.2019.04.008_b0055","article-title":"Absence of persistent Hepatitis E virus infection in antibody-deficient patients is associated with the transfer of antigen neutralising antibodies from immunoglobulin products","author":"Ankcorn","year":"2018","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2019.04.008_b0060","doi-asserted-by":"crossref","first-page":"10198","DOI":"10.1073\/pnas.91.21.10198","article-title":"Successful passive and active immunization of cynomolgus monkeys against hepatitis E","volume":"91","author":"Tsarev","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2019.04.008_b0065","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.molmed.2017.07.002","article-title":"Clinical evaluation of Ebola virus disease therapeutics","volume":"23","author":"Liu","year":"2017","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jhep.2019.04.008_b0070","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/infdis\/jiu396","article-title":"The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis","volume":"211","author":"Mair-Jenkins","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2019.04.008_b0075","article-title":"Characterization of the quasi-enveloped hepatitis E virus particles released by the cellular exosomal","volume":"91","author":"Nagashima","year":"2017","journal-title":"Pathway. J Virol"},{"key":"10.1016\/j.jhep.2019.04.008_b0080","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa070546","article-title":"Hepatitis A vaccine versus immune globulin for postexposure prophylaxis","volume":"357","author":"Victor","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2019.04.008_b0085","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature12029","article-title":"A pathogenic picornavirus acquires an envelope by hijacking cellular membranes","volume":"496","author":"Feng","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2019.04.008_b0090","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiy199","article-title":"Anti-Ebola virus antibody levels in convalescent plasma and viral load after plasma infusion in patients with Ebola virus disease","author":"Brown","year":"2018","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2019.04.008_b0095","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2017.09.020","article-title":"Hepatitis E virus lifecycle and identification of 3 forms of the ORF2 capsid protein","volume":"154","author":"Montpellier","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2019.04.008_b0100","article-title":"Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection","author":"Yin","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2019.04.008_b0105","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/hep.24738","article-title":"Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection","volume":"55","author":"Suneetha","year":"2012","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827819302697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827819302697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T21:46:33Z","timestamp":1568929593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827819302697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0168827819302697"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2019.04.008","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Convalescent plasma therapy for persistent hepatitis E virus infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2019.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}