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Its role in the development of spontaneous bacterial peritonitis","volume":"35","author":"Llovet","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2019.10.003_b0630","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jhep.2013.01.038","article-title":"Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function","volume":"58","author":"Du Plessis","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2019.10.003_b0635","doi-asserted-by":"crossref","first-page":"40516","DOI":"10.1038\/srep40516","article-title":"Bacterial translocation aggravates CCl4-induced liver cirrhosis by regulating CD4(+) T cells in rats","volume":"7","author":"Shi","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2019.10.003_b0640","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/hep.1840050325","article-title":"Biliary and urinary excretion of sulfated, glucuronidated and 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