{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:02:44Z","timestamp":1792839764940,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Nuovo Soldati Foundation - Liechtenstein"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jhep.2020.02.030","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T11:38:56Z","timestamp":1583494736000},"page":"533-539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":185,"title":["Chronic hepatitis D and hepatocellular carcinoma: A systematic review and meta-analysis of observational studies"],"prefix":"10.1016","volume":"73","author":[{"given":"Dulce","family":"Alfaiate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Cl\u00e9ment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Negro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2020.02.030_bib1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jhep.2020.02.030_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.chom.2014.02.011","article-title":"Human viral oncogenesis: a cancer hallmarks analysis","volume":"15","author":"Mesri","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jhep.2020.02.030_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/gutjnl-2018-316601","article-title":"Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis","volume":"68","author":"Chen","year":"2019","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.jhep.2020.02.030_bib4","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/infdis\/jiz633","article-title":"Estimating the global prevalence, disease progression and clinical outcome of hepatitis delta virus infection","volume":"221","author":"Miao","year":"2020","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jhep.2020.02.030_bib5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/gutjnl-2018-317874","article-title":"Hepatitis D prevalence: problems with extrapolation to global population estimates","volume":"69","author":"Stockdale","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2020.02.030_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/cid\/ciz001","article-title":"Prevalence of hepatitis B and hepatitis D virus infections in the United States, 2011-2016","volume":"69","author":"Patel","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jhep.2020.02.030_bib7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.antiviral.2015.08.009","article-title":"Hepatitis delta virus: from biological and medical aspects to current and investigational therapeutic options","volume":"122","author":"Alfaiate","year":"2015","journal-title":"Antivir Res"},{"key":"10.1016\/j.jhep.2020.02.030_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hep.27102","article-title":"Late HDV RNA relapse after peginterferon alpha-based therapy of chronic hepatitis delta","volume":"60","author":"Heidrich","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.02.030_bib9","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/j.jhep.2016.02.013","article-title":"The hepatitis delta virus: replication and pathogenesis","volume":"64","author":"Sureau","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.02.030_bib10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1365-2893.2010.01324.x","article-title":"Clinical outcome of acute and chronic hepatitis delta over time: a long-term follow-up study","volume":"18","author":"Buti","year":"2011","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1016\/j.jhep.2020.02.030_bib11","first-page":"77","article-title":"Occurrence of hepatocellular carcinoma and decompensation in western European patients with cirrhosis type B. The EUROHEP Study Group on Hepatitis B Virus and Cirrhosis","volume":"21","author":"Fattovich","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.02.030_bib12","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jhep.2010.06.008","article-title":"Outcome of chronic delta hepatitis in Italy: a long-term cohort study","volume":"53","author":"Niro","year":"2010","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.02.030_bib13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/hep.1840130305","article-title":"Hepatitis B virus replication modulates pathogenesis of hepatitis D virus in chronic hepatitis D","volume":"13","author":"Smedile","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.02.030_bib14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/gut.46.3.420","article-title":"Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B. The European Concerted Action on Viral Hepatitis (Eurohep)","volume":"46","author":"Fattovich","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2020.02.030_bib15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jhep.2016.10.007","article-title":"Hepatitis delta-associated mortality in HIV\/HBV-coinfected patients","volume":"66","author":"B\u00e9guelin","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.02.030_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/apt.15188","article-title":"Clinical outcomes in patients with hepatitis D, cirrhosis and persistent hepatitis B virus replication, and receiving long-term tenofovir or entecavir","volume":"49","author":"Brancaccio","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2020.02.030_bib17","doi-asserted-by":"crossref","first-page":"e92062","DOI":"10.1371\/journal.pone.0092062","article-title":"High serum levels of HDV RNA are predictors of cirrhosis and liver cancer in patients with chronic hepatitis delta","volume":"9","author":"Romeo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2020.02.030_bib18","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1001\/jama.280.19.1690","article-title":"What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes","volume":"280","author":"Zhang","year":"1998","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jhep.2020.02.030_bib19","first-page":"1","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.jhep.2020.02.030_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jhep.2020.02.030_bib21","article-title":"9.5. 2 Identifying and measuring heterogeneity","volume":"5","author":"Deeks","year":"2011","journal-title":"Cochrane Handb Syst Rev Interv Version"},{"key":"10.1016\/j.jhep.2020.02.030_bib22","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/jmv.20755","article-title":"High frequency of hepatocellular carcinoma in Mongolia; association with mono-, or co-infection with hepatitis C, B, and delta viruses","volume":"78","author":"Oyunsuren","year":"2006","journal-title":"J\u00a0Med Virol"},{"issue":"6","key":"10.1016\/j.jhep.2020.02.030_bib23","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2011.12.061","article-title":"Epidemiology of viral hepatitis and hepatocellular carcinoma","volume":"142","author":"El-Serag","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2020.02.030_bib24","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/j.jhep.2005.11.023","article-title":"Multiple viral infections","volume":"44","author":"Gaeta","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.02.030_bib25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/QAD.0000000000001422","article-title":"Hepatocellular carcinoma: an evolving challenge in viral hepatitis and HIV coinfection","volume":"31","author":"Pinato","year":"2017","journal-title":"AIDS Lond Engl"},{"key":"10.1016\/j.jhep.2020.02.030_bib26","first-page":"719","article-title":"Hepatitis B virus markers, hepatitis D virus antigen and hepatitis C virus antibodies in Nigerian patients with chronic liver disease","volume":"72","author":"Ojo","year":"1995","journal-title":"East Afr Med J"},{"key":"10.1016\/j.jhep.2020.02.030_bib27","first-page":"221","article-title":"General evaluation of hepatectomy and hepatocellular carcinoma cases","volume":"27","author":"Ba\u015fs\u00fcll\u00fc","year":"2011","journal-title":"Turk Patoloji Derg"},{"key":"10.1016\/j.jhep.2020.02.030_bib28","first-page":"898A","article-title":"Epidemiological, clinical, biological and virological factors influencing the occurrence of hepatocellular carcinoma and validation of predictive scores in 317 HBV-related cirrhotic patients. Prospective study Cir-B nested in the ANRS CO12 CirVir cohort","volume":"63","author":"Brichler","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.02.030_bib29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1056\/NEJM199109053251002","article-title":"Hepatocellular carcinoma in Italian patients with cirrhosis","volume":"325","author":"Colombo","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2020.02.030_bib30","doi-asserted-by":"crossref","first-page":"S687","DOI":"10.1016\/S0168-8278(17)31848-2","article-title":"In patients under treatment, chronic hepatitis D is a greater risk factor for hepatocellular carcinoma development than chronic hepatitis B","volume":"66","author":"Keskin","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.02.030_bib31","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1017\/S0950268818001942","article-title":"Hepatitis delta virus and hepatocellular carcinoma: an update","volume":"146","author":"Romeo","year":"2018","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jhep.2020.02.030_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis","volume":"12","author":"Mokdad","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.jhep.2020.02.030_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0016-5085(99)70563-9","article-title":"Changing pattern of chronic hepatitis D in Southern Europe","volume":"117","author":"Rosina","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2020.02.030_bib34","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.jhep.2016.02.021","article-title":"Mechanisms of HBV-induced hepatocellular carcinoma","volume":"64","author":"Levrero","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.02.030_bib35","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1158\/1541-7786.MCR-18-0012","article-title":"Molecular signature and mechanisms of hepatitis D virus-associated hepatocellular carcinoma","volume":"16","author":"Diaz","year":"2018","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jhep.2020.02.030_bib36","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.febslet.2013.03.021","article-title":"Hepatitis delta virus induces specific DNA methylation processes in Huh-7 liver cancer cells","volume":"587","author":"Benegiamo","year":"2013","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jhep.2020.02.030_bib37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nrgastro.2016.176","article-title":"Global epidemiology and burden of HCV infection and HCV-related disease","volume":"14","author":"Thrift","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"Suppl 13","key":"10.1016\/j.jhep.2020.02.030_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02990102","article-title":"Hepatitis C virus superinfection in patients with chronic hepatitis B virus infection","volume":"37","author":"Liaw","year":"2002","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jhep.2020.02.030_bib39","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1053\/jhep.2001.26511","article-title":"Role of hepatitis B, C, and D viruses in dual and triple infection: influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral replicative interference","volume":"34","author":"Jardi","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.02.030_bib40","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ijc.25321","article-title":"Coinfection of hepatitis B and C viruses and risk of hepatocellular carcinoma: systematic review and meta-analysis","volume":"128","author":"Cho","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jhep.2020.02.030_bib41","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/jmv.10361","article-title":"Molecular epidemiological and clinical aspects of hepatitis D virus in a unique triple hepatitis viruses (B, C, D) endemic community in Taiwan","volume":"70","author":"Lu","year":"2003","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.jhep.2020.02.030_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2893.2000.00195.x","article-title":"Replication status and histological features of patients with triple (B, C, D) and dual (B, C) hepatic infections","volume":"7","author":"Mathurin","year":"2000","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1016\/j.jhep.2020.02.030_bib43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/hep.20944","article-title":"Longitudinal evaluation reveals a complex spectrum of virological profiles in hepatitis B virus\/hepatitis C virus-coinfected patients","volume":"43","author":"Raimondo","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.02.030_bib44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.02.030_bib45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep.29913","article-title":"Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American association for the study of liver diseases","volume":"68","author":"Marrero","year":"2018","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782030129X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782030129X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:40:36Z","timestamp":1759174836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882782030129X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S016882782030129X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2020.02.030","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic hepatitis D and hepatocellular carcinoma: A systematic review and meta-analysis of observational studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2020.02.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}