{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:11:32Z","timestamp":1791922292434,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671195"],"award-info":[{"award-number":["31671195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871381"],"award-info":[{"award-number":["31871381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971066"],"award-info":[{"award-number":["31971066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871411"],"award-info":[{"award-number":["31871411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91957114"],"award-info":[{"award-number":["91957114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0802701"],"award-info":[{"award-number":["2019YFA0802701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0800700"],"award-info":[{"award-number":["2018YFA0800700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jhep.2020.03.050","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T13:04:44Z","timestamp":1593090284000},"page":"603-615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"title":["Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p"],"prefix":"10.1016","volume":"73","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiu","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2020.03.050_bib1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc1408","article-title":"Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms","volume":"4","author":"Calle","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jhep.2020.03.050_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cld.2007.02.006","article-title":"Non-alcoholic steatohepatitis and cancer","volume":"11","author":"Bugianesi","year":"2007","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhep.2020.03.050_bib3","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2020.03.050_bib4","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1002\/cncr.24687","article-title":"Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link","volume":"115","author":"Siegel","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.jhep.2020.03.050_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/cen.12055","article-title":"The risk of maternal obesity to the long-term health of the offspring","volume":"78","author":"O'Reilly","year":"2013","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jhep.2020.03.050_bib6","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1471-0528.2006.00989.x","article-title":"The short- and long-term implications of maternal obesity on the mother and her offspring","volume":"113","author":"Catalano","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.jhep.2020.03.050_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mad.2011.01.003","article-title":"Transgenerational endocrine pancreatic adaptation in mice from maternal protein restriction in utero","volume":"132","author":"Frantz","year":"2011","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.jhep.2020.03.050_bib8","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jhep.2011.10.018","article-title":"Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets","volume":"56","author":"Li","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.03.050_bib9","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1017\/S0029665112000055","article-title":"Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes","volume":"71","author":"Martinez","year":"2012","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.jhep.2020.03.050_bib10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2217\/epi.10.57","article-title":"Transgenerational genetic effects","volume":"2","author":"Nelson","year":"2010","journal-title":"Epigenomics"},{"key":"10.1016\/j.jhep.2020.03.050_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13238-015-0156-2","article-title":"Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression","volume":"6","author":"Li","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.jhep.2020.03.050_bib12","doi-asserted-by":"crossref","first-page":"E1994","DOI":"10.3390\/ijms17121994","article-title":"Roles of microRNA across prenatal and postnatal periods","volume":"17","author":"Floris","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2020.03.050_bib13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ijo.2013.98","article-title":"DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding","volume":"38","author":"Ding","year":"2014","journal-title":"Int J Obes"},{"key":"10.1016\/j.jhep.2020.03.050_bib14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/hep.29202","article-title":"Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase","volume":"66","author":"Liu","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.03.050_bib15","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1113\/JP277367","article-title":"Histone demethylase UTX is a therapeutic target for diabetic kidney disease","volume":"597","author":"Chen","year":"2019","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.jhep.2020.03.050_bib16","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/s41418-019-0412-8","article-title":"Histone methyltransferase G9a protects against acute liver injury through GSTP1","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhep.2020.03.050_bib17","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41419-018-0555-4","article-title":"Reducing protein regulator of cytokinesis 1 as a prospective therapy for hepatocellular carcinoma","volume":"9","author":"Liu","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2020.03.050_bib18","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/15548627.2017.1293768","article-title":"Histone HIST1H1C\/H1.2 regulates autophagy in the development of diabetic retinopathy","volume":"13","author":"Wang","year":"2017","journal-title":"Autophagy"},{"key":"10.1016\/j.jhep.2020.03.050_bib19","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1038\/s41467-017-02355-w","article-title":"ANGPTL8 negatively regulates NF-kappaB activation by facilitating selective autophagic degradation of IKKgamma","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2020.03.050_bib20","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1158\/0008-5472.CAN-14-1279","article-title":"MPHOSPH1: a potential therapeutic target for hepatocellular carcinoma","volume":"74","author":"Liu","year":"2014","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2020.03.050_bib21","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1681\/ASN.2016111210","article-title":"ELABELA and an ELABELA fragment protect against AKI","volume":"28","author":"Chen","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jhep.2020.03.050_bib22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbadis.2017.10.037","article-title":"Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1","volume":"1864","author":"Xue","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jhep.2020.03.050_bib23","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/s41388-019-1026-9","article-title":"Comprehensive characterization of the rRNA metabolism-related genes in human cancer","volume":"39","author":"Cui","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2020.03.050_bib24","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1158\/0008-5472.CAN-15-2601","article-title":"Decreased expression of fructose-1,6-bisphosphatase associates with glucose metabolism and tumor progression in hepatocellular carcinoma","volume":"76","author":"Hirata","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2020.03.050_bib25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cmet.2014.06.011","article-title":"A\u00a0switch from white to brown fat increases energy expenditure in cancer-associated cachexia","volume":"20","author":"Petruzzelli","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2020.03.050_bib26","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular carcinoma","volume":"365","author":"El-Serag","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2020.03.050_bib27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3748\/wjg.v22.i1.262","article-title":"Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma","volume":"22","author":"Song","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2020.03.050_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2020.03.050_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12539-015-0117-8","article-title":"miRNA-mRNA interaction network in non-small cell lung cancer","volume":"8","author":"Ma","year":"2016","journal-title":"Interdiscip Sci Comput Life Sci"},{"key":"10.1016\/j.jhep.2020.03.050_bib30","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3724\/SP.J.1005.2012.00651","volume":"34","author":"Yang","year":"2012","journal-title":"Yi Chuan"},{"key":"10.1016\/j.jhep.2020.03.050_bib31","doi-asserted-by":"crossref","first-page":"924206","DOI":"10.1155\/2013\/924206","article-title":"MicroRNAs in hepatocellular carcinoma: regulation, function, and clinical implications","volume":"2013","author":"Sun","year":"2013","journal-title":"Scientific World J"},{"key":"10.1016\/j.jhep.2020.03.050_bib32","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2020.03.050_bib33","doi-asserted-by":"crossref","first-page":"51943","DOI":"10.18632\/oncotarget.10460","article-title":"MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jhep.2020.03.050_bib34","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1186\/1471-2407-14-678","article-title":"MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2 in laryngeal carcinoma","volume":"14","author":"Tian","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jhep.2020.03.050_bib35","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.3892\/or.2017.5544","article-title":"Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10","volume":"37","author":"Li","year":"2017","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jhep.2020.03.050_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2010.06.010","article-title":"Secreted monocytic miR-150 enhances targeted endothelial cell migration","volume":"39","author":"Zhang","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2020.03.050_bib37","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1080\/15592294.2017.1358345","article-title":"Second trimester extracellular microRNAs in maternal blood and fetal growth: an exploratory study","volume":"12","author":"Rodosthenous","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.jhep.2020.03.050_bib38","doi-asserted-by":"crossref","first-page":"27816","DOI":"10.1074\/jbc.M109.022467","article-title":"Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition","volume":"284","author":"Li","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2020.03.050_bib39","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.freeradbiomed.2011.11.033","article-title":"Aldehyde dehydrogenases and cell proliferation","volume":"52","author":"Muzio","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2020.03.050_bib40","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/hep.29006","article-title":"Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice","volume":"65","author":"Hou","year":"2017","journal-title":"Hepatology"},{"issue":"Suppl 7","key":"10.1016\/j.jhep.2020.03.050_bib41","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2164-16-S7-S7","article-title":"Network-based stratification analysis of 13 major cancer types using mutations in panels of cancer genes","volume":"16","author":"Zhong","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jhep.2020.03.050_bib42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1389450114666140106095151","article-title":"Targeting tumor suppressor networks for cancer therapeutics","volume":"15","author":"Guo","year":"2014","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.jhep.2020.03.050_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/B978-0-12-416618-9.00003-0","article-title":"Regulation of cancer metabolism by oncogenes and tumor suppressors","volume":"542","author":"Iurlaro","year":"2014","journal-title":"Methods Enzymol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820302166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820302166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:21:06Z","timestamp":1778534466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827820302166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0168827820302166"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2020.03.050","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2020.03.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}