{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:01:33Z","timestamp":1793109693187,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jhep.2020.05.053","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T20:53:28Z","timestamp":1594155208000},"page":"1379-1390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis"],"prefix":"10.1016","volume":"73","author":[{"given":"Am\u00e9d\u00e9e","family":"Renand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Cervera-Marzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurine","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Kervagoret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Aubl\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Habes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-2020","authenticated-orcid":false,"given":"Caroline","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-4354","authenticated-orcid":false,"given":"Fabienne","family":"Vavasseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Cl\u00e9menceau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-6632","authenticated-orcid":false,"given":"Ana\u00efs","family":"Cardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Judor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Mosnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tann\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David-Axel","family":"Laplaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Brouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Gournay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Milpied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2602-3385","authenticated-orcid":false,"given":"Sophie","family":"Conchon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2020.05.053_bib1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.immuni.2009.03.003","article-title":"Follicular helper T cells: lineage and location","volume":"30","author":"Fazilleau","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2020.05.053_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.it.2010.07.001","article-title":"The elusive identity of T follicular helper cells","volume":"31","author":"Yu","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hep.27306","article-title":"CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis","volume":"61","author":"Wang","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.05.053_bib4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jgh.13844","article-title":"Possible involvement of CCR7(\u2013) PD-1(+) follicular helper T cell subset in the pathogenesis of autoimmune hepatitis","volume":"33","author":"Kimura","year":"2017","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2020.05.053_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2012.01122.x","article-title":"T\u00a0cells that promote B-cell maturation in systemic autoimmunity","volume":"247","author":"Weinstein","year":"2012","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jhep.2020.05.053_bib6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fimmu.2018.00609","article-title":"Autoantibodies in autoimmune liver disease\u2014clinical and diagnostic relevance","volume":"9","author":"Sebode","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaut.2018.10.022","article-title":"Novel therapeutic targets in autoimmune hepatitis","volume":"95","author":"Taubert","year":"2018","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jhep.2020.05.053_bib8","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/hep.26583","article-title":"Dysfunctional CD39(POS) regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis","volume":"59","author":"Grant","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.05.053_bib9","doi-asserted-by":"crossref","first-page":"e18909","DOI":"10.1371\/journal.pone.0018909","article-title":"Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2020.05.053_bib10","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.4049\/jimmunol.1900124","article-title":"TNF-producing Th1 cells are selectively expanded in liver infiltrates of patients with autoimmune hepatitis","volume":"203","author":"Bovensiepen","year":"2019","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib11","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1053\/j.gastro.2008.07.029","article-title":"Identification of CD4 T-cell epitopes in soluble liver antigen\/liver pancreas autoantigen in autoimmune hepatitis","volume":"135","author":"Mix","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2020.05.053_bib12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature20810","article-title":"Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis","volume":"542","author":"Rao","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2020.05.053_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41591-018-0254-9","article-title":"A\u00a0CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate","volume":"25","author":"Caielli","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2020.05.053_bib14","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib15","doi-asserted-by":"crossref","first-page":"e130062","DOI":"10.1172\/jci.insight.130062","article-title":"PD-1hiCXCR5-T peripheral helper cells promote B cell responses in lupus via MAF and IL-21","volume":"4","author":"Bocharnikov","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jhep.2020.05.053_bib16","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0140-6736(12)62163-1","article-title":"Autoimmune hepatitis","volume":"382","author":"Heneghan","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2020.05.053_bib17","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep4.1202","article-title":"Immune alterations in patients with type 1 autoimmune hepatitis persist upon standard immunosuppressive treatment","volume":"2","author":"Renand","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2020.05.053_bib18","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/hep.27983","article-title":"Prediction of short- and long-term outcome in patients with autoimmune hepatitis","volume":"62","author":"Kirstein","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.05.053_bib19","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.jaci.2015.07.031","article-title":"Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization","volume":"136","author":"Renand","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib20","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3389\/fimmu.2018.01408","article-title":"Heterogeneity of Ara h component-specific CD4 T cell responses in peanut-allergic subjects","volume":"9","author":"Renand","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib21","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.4049\/jimmunol.1202221","article-title":"Antigen-reactive T cell enrichment for direct, high-resolution analysis of the human naive and memory Th cell repertoire","volume":"190","author":"Bacher","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib22","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/eji.201970107","article-title":"Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)","volume":"49","author":"Cossarizza","year":"2019","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations (\u2217)","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib24","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41591-019-0403-9","article-title":"Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions","volume":"25","author":"Christophersen","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2020.05.053_bib25","doi-asserted-by":"crossref","first-page":"780","DOI":"10.4049\/jimmunol.1500909","article-title":"IL-17-mediated immunity to the opportunistic fungal pathogen Candida albicans","volume":"195","author":"Conti","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fimmu.2020.00216","article-title":"FB5P-seq: FACS-based 5-prime end single-cell RNA-seq for integrative analysis of transcriptome and antigen receptor repertoire in B and T cells","volume":"11","author":"Attaf","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib27","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2013.08.031","article-title":"Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses","volume":"39","author":"Locci","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2020.05.053_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib29","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1136\/annrheumdis-2019-215473","article-title":"CD109 regulates the inflammatory response and is required for the pathogenesis of rheumatoid arthritis","volume":"78","author":"Song","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jhep.2020.05.053_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.imlet.2016.07.007","article-title":"Multi-functional lectin-like transcript-1: a new player in human immune regulation","volume":"177","author":"Llibre","year":"2016","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jhep.2020.05.053_bib31","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/eji.1830191214","article-title":"Derivation of a T cell hybridoma variant deprived of functional T cell receptor alpha and beta chain transcripts reveals a nonfunctional alpha-mRNA of BW5147 origin","volume":"19","author":"Letourneur","year":"1989","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib32","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1002\/eji.1830231203","article-title":"Analysis of tetanus toxin peptide\/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma","volume":"23","author":"Blank","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib33","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1186\/s40064-016-2512-y","article-title":"Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis","volume":"5","author":"Abe","year":"2016","journal-title":"Springerplus"},{"key":"10.1016\/j.jhep.2020.05.053_bib34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/liv.12245","article-title":"Tfh and plasma cells are correlated with hypergammaglobulinaemia in patients with autoimmune hepatitis","volume":"34","author":"Ma","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2020.05.053_bib35","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1111\/jcmm.14997","article-title":"Dysregulated TFR and TFH cells correlate with B-cell differentiation and antibody production in autoimmune hepatitis","volume":"24","author":"Liang","year":"2020","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.jhep.2020.05.053_bib36","doi-asserted-by":"crossref","first-page":"eaaf8848","DOI":"10.1126\/scitranslmed.aaf8848","article-title":"A\u00a0divergent population of autoantigen-responsive CD4+ T cells in infants prior to \u03b2 cell autoimmunity","volume":"9","author":"Heninger","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhep.2020.05.053_bib37","doi-asserted-by":"crossref","first-page":"eaaq0305","DOI":"10.1126\/scitranslmed.aaq0305","article-title":"Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis","volume":"10","author":"Fonseka","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhep.2020.05.053_bib38","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1172\/JCI76238","article-title":"Follicular helper T cell signature in type 1 diabetes","volume":"125","author":"Kenefeck","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2020.05.053_bib39","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2889","article-title":"Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases","volume":"10","author":"Buckner","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2020.05.053_bib40","doi-asserted-by":"crossref","first-page":"287ra74","DOI":"10.1126\/scitranslmed.aaa8038","article-title":"Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis","volume":"7","author":"Cao","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhep.2020.05.053_bib41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver\u2014from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2020.05.053_bib42","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1038\/s41467-019-10018-1","article-title":"Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells","volume":"10","author":"Truong","year":"2019","journal-title":"Nat Commun"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820304530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820304530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:40:53Z","timestamp":1759174853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827820304530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0168827820304530"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2020.05.053","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.06.895938","asserted-by":"object"}]},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2020.05.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}