{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:50:05Z","timestamp":1793116205333,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007055","name":"Third Military Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jhep.2020.07.036","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T11:31:57Z","timestamp":1596022317000},"page":"96-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma"],"prefix":"10.1016","volume":"74","author":[{"given":"Yuan-Deng","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Qiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Tong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Da","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Bie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-6612","authenticated-orcid":false,"given":"Chuan-Ming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2020.07.036_bib1","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/hep.26323","article-title":"The mTOR pathway in hepatic malignancies","volume":"58","author":"Bhat","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.07.036_bib2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2020.07.036_bib3","doi-asserted-by":"crossref","first-page":"e81081","DOI":"10.1371\/journal.pone.0081081","article-title":"Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2020.07.036_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.molcel.2011.03.017","article-title":"Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size","volume":"42","author":"Saci","year":"2011","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2020.07.036_bib5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jhep.2013.11.031","article-title":"Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends","volume":"60","author":"Matter","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.07.036_bib6","doi-asserted-by":"crossref","first-page":"13571","DOI":"10.1073\/pnas.202476899","article-title":"Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling","volume":"99","author":"Tee","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2020.07.036_bib7","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1136\/gutjnl-2016-312734","article-title":"TSC1\/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication","volume":"66","author":"Ho","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2020.07.036_bib8","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrclinonc.2014.136","article-title":"Liver cancer: time to evolve trial design after everolimus failure","volume":"11","author":"Llovet","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jhep.2020.07.036_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrc.2017.109","article-title":"Targeting mutant p53 for efficient cancer therapy","volume":"18","author":"Bykov","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jhep.2020.07.036_bib10","doi-asserted-by":"crossref","first-page":"143944","DOI":"10.1016\/j.gene.2019.143944","article-title":"LncRNA PLAC2 upregulates p53 to induce hepatocellular carcinoma cell apoptosis","volume":"712","author":"Zheng","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.jhep.2020.07.036_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/cancers10050135","article-title":"The guardian of the genome revisited: p53 downregulates genes required for telomere maintenance, DNA repair, and centromere structure","volume":"10","author":"Toufektchan","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jhep.2020.07.036_bib12","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.bbrc.2005.03.190","article-title":"p53 mutation heterogeneity in cancer","volume":"331","author":"Soussi","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2020.07.036_bib13","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2012.04.026","article-title":"Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence","volume":"149","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2020.07.036_bib14","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1093\/hmg\/ddx345","article-title":"Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming","volume":"26","author":"Armstrong","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jhep.2020.07.036_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gutjnl-2014-307616","article-title":"A\u00a0subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras\/Mek\/Erk-induced hyperactive mTOR signalling","volume":"65","author":"Kong","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2020.07.036_bib16","first-page":"2531493","article-title":"p53-mediated PI3K\/AKT\/mTOR pathway played a role in Ptox(Dpt)-induced EMT inhibition in liver cancer cell lines","volume":"2019","author":"Li","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jhep.2020.07.036_bib17","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1038\/s41598-017-03070-8","article-title":"CRISPR\/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2020.07.036_bib18","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","article-title":"Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4","volume":"21","author":"Dapito","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2020.07.036_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/jfb.12423","article-title":"Comparative studies of zebrafish Danio rerio lipoprotein lipase (lpl) and hepatic lipase (lipc) genes belonging to the lipase gene family: evolution and expression pattern","volume":"85","author":"Feng","year":"2014","journal-title":"J\u00a0Fish Biol"},{"key":"10.1016\/j.jhep.2020.07.036_bib20","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2020.07.036_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41467-017-02583-0","article-title":"Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer","volume":"9","author":"Fang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2020.07.036_bib22","first-page":"4691","article-title":"Expression of p53 gene in 184 unifocal hepatocellular carcinomas: association with tumor growth and invasiveness","volume":"53","author":"Hsu","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2020.07.036_bib23","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0002-9440(10)61129-7","article-title":"Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation","volume":"160","author":"Liu","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2020.07.036_bib24","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/s41467-018-03716-9","article-title":"TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-\u03baB signaling","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2020.07.036_bib25","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1073\/pnas.1417549111","article-title":"Loss of p53 induces cell proliferation via Ras-independent activation of the Raf\/Mek\/Erk signaling pathway","volume":"111","author":"Drosten","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2020.07.036_bib26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-biochem-060815-014710","article-title":"The p53 pathway: origins, inactivation in cancer, and emerging therapeutic approaches","volume":"85","author":"Joerger","year":"2016","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jhep.2020.07.036_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1097-2765(01)00323-9","article-title":"Regulation of PTEN transcription by p53","volume":"8","author":"Stambolic","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2020.07.036_bib28","doi-asserted-by":"crossref","first-page":"e000291","DOI":"10.1136\/esmoopen-2017-000291","article-title":"Phase I study of the investigational oral mTORC1\/2 inhibitor sapanisertib (TAK-228): tolerability and food effects of a milled formulation in patients with advanced solid tumours","volume":"3","author":"Moore","year":"2018","journal-title":"ESMO Open"},{"key":"10.1016\/j.jhep.2020.07.036_bib29","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10555-017-9688-7","article-title":"mTOR co-targeting strategies for head and neck cancer therapy","volume":"36","author":"Wang","year":"2017","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.jhep.2020.07.036_bib30","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.15252\/embj.201489920","article-title":"Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy","volume":"34","author":"Desantis","year":"2015","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2020.07.036_bib31","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cell.2008.06.028","article-title":"p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling","volume":"134","author":"Budanov","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2020.07.036_bib32","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1073\/pnas.0502857102","article-title":"The coordinate regulation of the p53 and mTOR pathways in cells","volume":"102","author":"Feng","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2020.07.036_bib33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/aps.2012.143","article-title":"Negative regulation of mTOR activity by LKB1-AMPK signaling in non-small cell lung cancer cells","volume":"34","author":"Dong","year":"2013","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jhep.2020.07.036_bib34","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/gutjnl-2013-306202","article-title":"Targeting mTOR dependency in pancreatic cancer","volume":"63","author":"Morran","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2020.07.036_bib35","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jhep.2018.05.034","article-title":"Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib","volume":"69","author":"Tong","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.07.036_bib36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jhep.2019.08.035","article-title":"Targeting Jak\/Stat pathway as a therapeutic strategy against SP\/CD44+ tumorigenic cells in Akt\/\u03b2-catenin-driven hepatocellular carcinoma","volume":"72","author":"Toh","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.07.036_bib37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41571-018-0073-4","article-title":"Molecular therapies and precision medicine for hepatocellular carcinoma","volume":"15","author":"Llovet","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jhep.2020.07.036_bib38","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/hep.29715","article-title":"Significance and mechanism of androgen receptor overexpression and androgen receptor\/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma","volume":"67","author":"Zhang","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.07.036_bib39","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1038\/nrdp.2017.9","article-title":"Renal cell carcinoma","volume":"3","author":"Hsieh","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jhep.2020.07.036_bib40","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/annonc\/mdu273","article-title":"Phase I trial of rituximab, cladribine, and temsirolimus (RCT) for initial therapy of mantle cell lymphoma","volume":"25","author":"Inwards","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jhep.2020.07.036_bib41","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.oooo.2014.08.023","article-title":"mTOR inhibitor-associated stomatitis (mIAS) in three patients with cancer treated with everolimus","volume":"119","author":"Kalogirou","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"10.1016\/j.jhep.2020.07.036_bib42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jama.2014.7189","article-title":"Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial","volume":"312","author":"Zhu","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2020.07.036_bib43","first-page":"2376","article-title":"A\u00a0preclinical study on the combination therapy of everolimus and transarterial chemoembolization in hepatocellular carcinoma","volume":"5","author":"Chow","year":"2015","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.jhep.2020.07.036_bib44","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.trre.2015.12.003","article-title":"Use of everolimus in liver transplantation: the French experience","volume":"30","author":"Dumortier","year":"2016","journal-title":"Transpl Rev (Orlando)"},{"key":"10.1016\/j.jhep.2020.07.036_bib45","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gr.184901","article-title":"The human ATP-binding cassette (ABC) transporter superfamily","volume":"11","author":"Dean","year":"2001","journal-title":"Genome Res"},{"key":"10.1016\/j.jhep.2020.07.036_bib46","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1177\/2472555219867070","article-title":"Functional expression of multidrug resistance protein 4 MRP4\/ABCC4","volume":"24","author":"Hardy","year":"2019","journal-title":"SLAS Discov"},{"key":"10.1016\/j.jhep.2020.07.036_bib47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1124\/mol.118.115444","article-title":"Identification of MRP4\/ABCC4 as a target for reducing the proliferation of pancreatic ductal adenocarcinoma cells by modulating the cAMP efflux","volume":"96","author":"Carozzo","year":"2019","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jhep.2020.07.036_bib48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/0973-1482.143334","article-title":"The overexpression of MRP4 is related to multidrug resistance in osteosarcoma cells","volume":"11","author":"He","year":"2015","journal-title":"J\u00a0Cancer Res Ther"},{"key":"10.1016\/j.jhep.2020.07.036_bib49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1089\/gtmb.2018.0259","article-title":"Dual-targeting of miR-124-3p and ABCC4 promotes sensitivity to adriamycin in breast cancer cells","volume":"23","author":"Hu","year":"2019","journal-title":"Genet Test Mol Biomarkers"},{"key":"10.1016\/j.jhep.2020.07.036_bib50","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejca.2017.06.024","article-title":"Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in\u00a0vivo","volume":"83","author":"Murray","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jhep.2020.07.036_bib51","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1038\/ctg.2016.47","article-title":"Influence of genetic polymorphisms in prostaglandin E2 pathway (COX-2\/HPGD\/SLCO2A1\/ABCC4) on the risk for colorectal adenoma development and recurrence after polypectomy","volume":"7","author":"Pereira","year":"2016","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.jhep.2020.07.036_bib52","first-page":"950","volume":"58","author":"Tanaka","year":"2017","journal-title":"Rinsho Ketsueki"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782030489X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782030489X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:42:34Z","timestamp":1759174954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882782030489X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S016882782030489X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2020.07.036","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2020.07.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Association for the Study of the Liver. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}