{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:45:09Z","timestamp":1792460709604,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jhep.2020.09.019","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T17:16:53Z","timestamp":1601054213000},"page":"522-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"title":["Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx"],"prefix":"10.1016","volume":"74","author":[{"given":"Sheng-Tao","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Li","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Kam","family":"Wai Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty Yuen","family":"Kwan Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Fei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Xin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Long","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2020.09.019_bib1","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/S0140-6736(14)60220-8","article-title":"Hepatitis B virus infection","volume":"384","author":"Trepo","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2020.09.019_bib2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.idc.2019.08.004","article-title":"Viral hepatitis: etiology, epidemiology, transmission, diagnostics, treatment, and prevention","volume":"33","author":"Lanini","year":"2019","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.jhep.2020.09.019_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.antiviral.2015.06.008","article-title":"Chronic hepatitis B: virology, natural history, current management and a glimpse at future opportunities","volume":"121","author":"Gish","year":"2015","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jhep.2020.09.019_bib4","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/hep.29479","article-title":"Epigenetic regulation of hepatitis B virus covalently closed circular DNA: implications for epigenetic therapy against chronic hepatitis B","volume":"66","author":"Hong","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.09.019_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10620-017-4842-1","article-title":"Advanced strategies for eliminating the cccDNA of HBV","volume":"63","author":"Dong","year":"2018","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2020.09.019_bib6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12072-017-9829-7","article-title":"Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread","volume":"11","author":"Karayiannis","year":"2017","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2020.09.019_bib7","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1128\/JVI.02020-06","article-title":"Enhancement of hepatitis B virus replication by the regulatory X protein in\u00a0vitro and in\u00a0vivo","volume":"81","author":"Keasler","year":"2007","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2020.09.019_bib8","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/JVI.79.7.4238-4245.2005","article-title":"Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death","volume":"79","author":"Leupin","year":"2005","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2020.09.019_bib9","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1128\/JVI.79.9.5548-5556.2005","article-title":"The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication","volume":"79","author":"Tang","year":"2005","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2020.09.019_bib10","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jhep.2011.02.015","article-title":"Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection","volume":"55","author":"Lucifora","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.09.019_bib11","doi-asserted-by":"crossref","first-page":"19975","DOI":"10.1073\/pnas.0908365106","article-title":"Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function","volume":"106","author":"Belloni","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2020.09.019_bib12","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jhep.2015.06.023","article-title":"HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase","volume":"63","author":"Riviere","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.09.019_bib13","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/hep.29133","article-title":"PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation","volume":"66","author":"Zhang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.09.019_bib14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nature17170","article-title":"Hepatitis B virus X protein identifies the Smc5\/6 complex as a host restriction factor","volume":"531","author":"Decorsiere","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2020.09.019_bib15","doi-asserted-by":"crossref","first-page":"104618","DOI":"10.1016\/j.antiviral.2019.104618","article-title":"Hepatitis B virus replicating in hepatocellular carcinoma encodes HBx variants with preserved ability to antagonize restriction by Smc5\/6","volume":"172","author":"Riviere","year":"2019","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jhep.2020.09.019_bib16","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41573-019-0037-0","article-title":"Therapeutic strategies for hepatitis B virus infection: towards a cure","volume":"18","author":"Fanning","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhep.2020.09.019_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.antiviral.2017.12.006","article-title":"Research priorities for the discovery of a cure for chronic hepatitis B: report of a workshop","volume":"150","author":"Block","year":"2018","journal-title":"Antiviral Res"},{"key":"10.1016\/j.jhep.2020.09.019_bib18","doi-asserted-by":"crossref","first-page":"13593","DOI":"10.1038\/ncomms13593","article-title":"NQO1 inhibits proteasome-mediated degradation of HIF-1alpha","volume":"7","author":"Oh","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2020.09.019_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/embor.2008.48","article-title":"NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)","volume":"9","author":"Garate","year":"2008","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jhep.2020.09.019_bib20","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1128\/JVI.01024-14","article-title":"Recombinant covalently closed circular hepatitis B virus DNA induces prolonged viral persistence in immunocompetent mice","volume":"88","author":"Qi","year":"2014","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2020.09.019_bib21","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.3390\/ijerph16183307","article-title":"A\u00a0global view to HBV chronic infection: evolving strategies for diagnosis, treatment and prevention in immunocompetent individuals","volume":"16","author":"Nicolini","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jhep.2020.09.019_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01032-19","article-title":"Revisiting hepatitis B virus: challenges of curative therapies","volume":"93","author":"Hu","year":"2019","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2020.09.019_bib23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S2468-1253(19)30119-0","article-title":"A\u00a0global scientific strategy to cure hepatitis B","volume":"4","author":"Revill","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2020.09.019_bib24","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.jhep.2016.02.009","article-title":"Attacking hepatitis B virus cccDNA--the holy grail to hepatitis B cure","volume":"64","author":"Lucifora","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2020.09.019_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.chroma.2018.01.043","article-title":"Determination of dicoumarol in Melilotus officinalis L. by using molecularly imprinted polymer solid-phase extraction coupled with high performance liquid chromatography","volume":"1539","author":"Hrobonova","year":"2018","journal-title":"J\u00a0Chromatogr A"},{"key":"10.1016\/j.jhep.2020.09.019_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/toxics6010013","article-title":"Hematological abnormality, oxidative stress, and genotoxicity induction in the greenhouse pesticide sprayers; investigating the role of NQO1 gene polymorphism","volume":"6","author":"Ahmadi","year":"2018","journal-title":"Toxics"},{"key":"10.1016\/j.jhep.2020.09.019_bib27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.5483\/BMBRep.2016.49.11.117","article-title":"Protective effects of Tat-NQO1 against oxidative stress-induced HT-22 cell damage, and ischemic injury in animals","volume":"49","author":"Jo","year":"2016","journal-title":"BMB Rep"},{"key":"10.1016\/j.jhep.2020.09.019_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.5483\/BMBRep.2015.48.11.190","article-title":"Implications of NQO1 in cancer therapy","volume":"48","author":"Oh","year":"2015","journal-title":"BMB Rep"},{"key":"10.1016\/j.jhep.2020.09.019_bib29","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbapap.2019.05.002","article-title":"NQO1: a target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms","volume":"1867","author":"Beaver","year":"2019","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"10.1016\/j.jhep.2020.09.019_bib30","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180459","article-title":"NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places","volume":"39","author":"Pey","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jhep.2020.09.019_bib31","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1021\/acs.jmedchem.8b00124","article-title":"NAD(P)H:quinone oxidoreductase 1 (NQO1) as a therapeutic and diagnostic target in cancer","volume":"61","author":"Zhang","year":"2018","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jhep.2020.09.019_bib32","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1073\/pnas.052706799","article-title":"NQO1 stabilizes p53 through a distinct pathway","volume":"99","author":"Asher","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2020.09.019_bib33","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.1038\/ncomms8244","article-title":"HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD(P)H:quinine oxidoreductase 1 (NQO1)","volume":"6","author":"Lata","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2020.09.019_bib34","doi-asserted-by":"crossref","first-page":"37416","DOI":"10.1074\/jbc.M605063200","article-title":"Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells","volume":"281","author":"Du","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2020.09.019_bib35","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1038\/sj.onc.1209162","article-title":"Dicoumarol potentiates cisplatin-induced apoptosis mediated by c-Jun N-terminal kinase in p53 wild-type urogenital cancer cell lines","volume":"25","author":"Watanabe","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2020.09.019_bib36","doi-asserted-by":"crossref","first-page":"104355","DOI":"10.1016\/j.micpath.2020.104355","article-title":"The assessment of selected MiRNAs profile in HIV, HBV, HCV, HIV\/HCV, HIV\/HBV Co-infection and elite controllers for determination of biomarker","volume":"147","author":"Yousefpouran","year":"2020","journal-title":"Microb Pathog"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820336618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820336618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:41:40Z","timestamp":1759174900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827820336618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0168827820336618"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2020.09.019","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2020.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Association for the Study of the Liver. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}