{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:28:57Z","timestamp":1792549737509,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TR285\/10-2"],"award-info":[{"award-number":["TR285\/10-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR57"],"award-info":[{"award-number":["SFB\/TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["120\/17"],"award-info":[{"award-number":["120\/17"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["031\\u2009L0049"],"award-info":[{"award-number":["031\\u2009L0049"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["L0049"],"award-info":[{"award-number":["L0049"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009398","name":"Medizinische Fakult\u00e4t, RWTH Aachen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jhep.2020.09.037","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T21:43:46Z","timestamp":1603489426000},"page":"638-648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":134,"title":["Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-0696","authenticated-orcid":false,"given":"Antje","family":"Mohs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-3055","authenticated-orcid":false,"given":"Tobias","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-3794","authenticated-orcid":false,"given":"Kai Markus","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-031X","authenticated-orcid":false,"given":"Mona","family":"Peltzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2139-0795","authenticated-orcid":false,"given":"Mark","family":"Boekschoten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-5786","authenticated-orcid":false,"given":"Christian H.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-0838","authenticated-orcid":false,"given":"Christian A.","family":"Hudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kalveram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Wiegand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Saez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Longerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Hengstler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-8247","authenticated-orcid":false,"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2020.09.037_bib1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","article-title":"The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the Global Burden of Disease Study 2015","volume":"3","author":"Akinyemiju","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jhep.2020.09.037_bib2","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular carcinoma: epidemiology and molecular carcinogenesis","volume":"132","author":"El-Serag","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2020.09.037_bib3","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cichoz-Lach","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2020.09.037_bib4","doi-asserted-by":"crossref","first-page":"1245049","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jhep.2020.09.037_bib5","first-page":"240","article-title":"New insights on oxidative stress in cancer","volume":"12","author":"Visconti","year":"2009","journal-title":"Curr Opin Drug Discov Devel"},{"key":"10.1016\/j.jhep.2020.09.037_bib6","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.3390\/ijms15046002","article-title":"Oxidative stress in cardiovascular disease","volume":"15","author":"Csanyi","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2020.09.037_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.jhep.2020.09.037_bib8","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0891-5849(00)00158-1","article-title":"How important is oxidative damage? Lessons from Alzheimer's disease","volume":"28","author":"Perry","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2020.09.037_bib9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2020.09.037_bib10","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1073\/pnas.081082098","article-title":"An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen","volume":"98","author":"Chan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2020.09.037_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/toxsci\/kfn267","article-title":"Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species","volume":"108","author":"Reisman","year":"2009","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2020.09.037_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.taap.2012.05.010","article-title":"Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation","volume":"262","author":"Wu","year":"2012","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jhep.2020.09.037_bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.fct.2018.09.042","article-title":"NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice","volume":"121","author":"Sun","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jhep.2020.09.037_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.freeradbiomed.2009.11.007","article-title":"Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis","volume":"48","author":"Chowdhry","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2020.09.037_bib15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1124\/jpet.107.135822","article-title":"NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet","volume":"325","author":"Tanaka","year":"2008","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jhep.2020.09.037_bib16","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/carcin\/bgr045","article-title":"Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms","volume":"32","author":"Bishayee","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jhep.2020.09.037_bib17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1349-7006.2006.00352.x","article-title":"Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline","volume":"98","author":"Kitamura","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jhep.2020.09.037_bib18","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1158\/0008-5472.CAN-16-3538","article-title":"Nrf2 Mutagenic activation drives hepatocarcinogenesis","volume":"77","author":"Ngo","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2020.09.037_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fonc.2017.00085","article-title":"The KEAP1-NRF2 system in cancer","volume":"7","author":"Taguchi","year":"2017","journal-title":"Front Oncol"},{"key":"10.1016\/j.jhep.2020.09.037_bib20","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s001120170107","article-title":"Perzentile f\u00fcr den body-mass-index f\u00fcr das Kindes-und Jugendalter unter Heranziehung verschiedener deutscher Stichproben","volume":"149","author":"Kromeyer-Hauschild","year":"2001","journal-title":"Monatsschrift Kinderheilkunde"},{"key":"10.1016\/j.jhep.2020.09.037_bib21","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<151::AID-GENE17>3.0.CO;2-E","article-title":"Hepatocyte-specific expression of Cre recombinase","volume":"26","author":"Kellendonk","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.jhep.2020.09.037_bib22","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1084\/jem.20082152","article-title":"Hepatocyte-specific NEMO deletion promotes NK\/NKT cell- and TRAIL-dependent liver damage","volume":"206","author":"Beraza","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2020.09.037_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbrc.2005.10.185","article-title":"Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity","volume":"339","author":"Okawa","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2020.09.037_bib24","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1101\/gr.240663.118","article-title":"Benchmark and integration of resources for the estimation of human transcription factor activities","volume":"29","author":"Garcia-Alonso","year":"2019","journal-title":"Genome Res"},{"key":"10.1016\/j.jhep.2020.09.037_bib25","doi-asserted-by":"crossref","first-page":"12541","DOI":"10.1038\/s41598-019-48746-5","article-title":"Gene expression predicts histological severity and reveals distinct molecular profiles of nonalcoholic fatty liver disease","volume":"9","author":"Hoang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2020.09.037_bib26","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/oxfordjournals.bmb.a011637","article-title":"The importance of oxidative stress in apoptosis","volume":"53","author":"Clutton","year":"1997","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jhep.2020.09.037_bib27","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.molcel.2010.01.021","article-title":"Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair","volume":"37","author":"Petermann","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2020.09.037_bib28","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/nsmb.1927","article-title":"Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis","volume":"17","author":"Hashimoto","year":"2010","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jhep.2020.09.037_bib29","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1053\/j.gastro.2007.03.045","article-title":"Hepatocyte-specific IKK gamma\/NEMO expression determines the degree of liver injury","volume":"132","author":"Beraza","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2020.09.037_bib30","first-page":"361","article-title":"Molecular pathogenesis of liver fibrosis","volume":"120","author":"Brenner","year":"2009","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"10.1016\/j.jhep.2020.09.037_bib31","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.freeradbiomed.2015.10.420","article-title":"Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis","volume":"89","author":"Shearn","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2020.09.037_bib32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1478-3231.2005.01213.x","article-title":"Expression of oxidative stress-related molecules in circulating leukocytes and urine in patients with chronic viral hepatitis","volume":"26","author":"Saeki","year":"2006","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2020.09.037_bib33","first-page":"1262","article-title":"Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis?","volume":"19","author":"Bedossa","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2020.09.037_bib34","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2015.12.014","article-title":"Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development","volume":"91","author":"Ramadori","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2020.09.037_bib35","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1128\/MCB.01384-13","article-title":"Nrf2 enhances cholangiocyte expansion in Pten-deficient livers","volume":"34","author":"Taguchi","year":"2014","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2020.09.037_bib36","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2020.09.037_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ccr.2006.12.016","article-title":"Deletion of NEMO\/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma","volume":"11","author":"Luedde","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2020.09.037_bib38","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.2353\/ajpath.2006.051365","article-title":"Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice","volume":"169","author":"Was","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2020.09.037_bib39","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00280-011-1722-9","article-title":"Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer","volume":"69","author":"Ma","year":"2012","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jhep.2020.09.037_bib40","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1158\/1078-0432.CCR-08-2822","article-title":"Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer","volume":"15","author":"Homma","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhep.2020.09.037_bib41","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1179\/1743132813Y.0000000251","article-title":"Correlation of Nrf2 and HIF-1alpha in glioblastoma and their relationships to clinicopathologic features and survival","volume":"35","author":"Ji","year":"2013","journal-title":"Neurol Res"},{"key":"10.1016\/j.jhep.2020.09.037_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-4598-10-37","article-title":"Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy","volume":"10","author":"Lister","year":"2011","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jhep.2020.09.037_bib43","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.cellsig.2010.06.004","article-title":"Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation","volume":"22","author":"Kim","year":"2010","journal-title":"Cell Signal"},{"key":"10.1016\/j.jhep.2020.09.037_bib44","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/JTO.0b013e3182289479","article-title":"Genetic disruption of KEAP1\/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer","volume":"6","author":"Thu","year":"2011","journal-title":"J\u00a0Thorac Oncol"},{"key":"10.1016\/j.jhep.2020.09.037_bib45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.molcel.2009.07.025","article-title":"KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta","volume":"36","author":"Lee","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2020.09.037_bib46","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.2337\/db11-0807","article-title":"Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy","volume":"60","author":"Zheng","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2020.09.037_bib47","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jcmgh.2017.11.016","article-title":"Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 (NF-E2 p45-related factor 2)","volume":"5","author":"Sharma","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2020.09.037_bib48","doi-asserted-by":"crossref","first-page":"e0201044","DOI":"10.1371\/journal.pone.0201044","article-title":"Nrf2 protects stellate cells from Smad-dependent cell activation","volume":"13","author":"Prestigiacomo","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2020.09.037_bib49","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.225680.113","article-title":"The emerging role of the Nrf2-Keap1 signaling pathway in cancer","volume":"27","author":"Jaramillo","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhep.2020.09.037_bib50","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ng.3252","article-title":"Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets","volume":"47","author":"Schulze","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2020.09.037_bib51","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ccr.2012.05.016","article-title":"Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming","volume":"22","author":"Mitsuishi","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2020.09.037_bib52","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1158\/1535-7163.MCT-10-0108","article-title":"Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype","volume":"9","author":"Singh","year":"2010","journal-title":"Mol Cancer Ther"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820336953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827820336953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:55:23Z","timestamp":1777510523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827820336953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0168827820336953"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2020.09.037","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2020.09.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}