{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:53:59Z","timestamp":1792194839198,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T00:00:00Z","timestamp":1618617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"FRS-FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"FWO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003134","name":"FRIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003134","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jhep.2021.02.037","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:35:32Z","timestamp":1618533332000},"page":"292-301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Muscle fat content is strongly associated with NASH: A longitudinal study in patients with morbid obesity"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-9213","authenticated-orcid":false,"given":"Maxime","family":"Nachit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9474-6695","authenticated-orcid":false,"given":"Wilhelmus J.","family":"Kwanten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Thissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Op De Beeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Gaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-9259","authenticated-orcid":false,"given":"Luisa","family":"Vonghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-8837","authenticated-orcid":false,"given":"An","family":"Verrijken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-610X","authenticated-orcid":false,"given":"Ann","family":"Driessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Horsmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Francque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-6693","authenticated-orcid":false,"given":"Isabelle A.","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jhep.2021.02.037_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41575-019-0144-8","article-title":"Past, present and future perspectives in nonalcoholic fatty liver disease","volume":"16","author":"Sanyal","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib2","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2018.12.036","article-title":"Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease","volume":"156","author":"Castera","year":"2019","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jhep.2021.02.037_bib3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jhep.2016.04.005","article-title":"Non-alcoholic fatty liver disease and cardiovascular risk: pathophysiological mechanisms and implications","volume":"65","author":"Francque","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.02.037_bib4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2015.09.001","article-title":"Computed tomography-defined muscle and fat wasting are associated with cancer clinical outcomes","volume":"54","author":"Kazemi-Bajestani","year":"2016","journal-title":"Semin Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.jhep.2021.02.037_bib5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/jcsm.12039","article-title":"Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis","volume":"7","author":"Montano-Loza","year":"2016","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"May","key":"10.1016\/j.jhep.2021.02.037_bib6","first-page":"1","article-title":"Extracellular vesicles: delivery vehicles of myokines","volume":"10","author":"Trovato","year":"2019","journal-title":"Front Physiol"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib7","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/hep.26716","article-title":"Relationship between sarcopenia and nonalcoholic fatty liver disease: the Korean Sarcopenic Obesity Study","volume":"59","author":"Hong","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2021.02.037_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jhep.2016.08.019","article-title":"Sarcopenia is an independent risk factor for non-alcoholic steatohepatitis and significant fibrosis","volume":"66","author":"Koo","year":"2017","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2021.02.037_bib9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/apt.13889","article-title":"Sarcopenia is associated with severe liver fibrosis in patients with non-alcoholic fatty liver disease","volume":"45","author":"Petta","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.jhep.2021.02.037_bib10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.clnu.2019.04.023","article-title":"Low muscle mass and low muscle strength associate with nonalcoholic fatty liver disease","volume":"39","author":"Gan","year":"2020","journal-title":"Clin Nutr"},{"issue":"9","key":"10.1016\/j.jhep.2021.02.037_bib11","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/jgh.12227","article-title":"Severity of non-alcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle","volume":"28","author":"Kitajima","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2021.02.037_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/CS20180421","article-title":"Emerging awareness on the importance of skeletal muscle in liver diseases: time to dig deeper into mechanisms!","volume":"133","author":"Nachit","year":"2019","journal-title":"Clin Sci"},{"issue":"1","key":"10.1016\/j.jhep.2021.02.037_bib13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/liv.14253","article-title":"Relationship between nonalcoholic fatty liver disease and muscle quality as well as quantity evaluated by computed tomography","volume":"40","author":"Tanaka","year":"2020","journal-title":"Liver Int"},{"issue":"2","key":"10.1016\/j.jhep.2021.02.037_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/obr.12776","article-title":"Sarcopenia in patients with non-alcoholic fatty liver disease: is it a clinically significant entity?","volume":"20","author":"De Fr\u00e9","year":"2019","journal-title":"Obes Rev"},{"issue":"4","key":"10.1016\/j.jhep.2021.02.037_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14218\/JCTH.2020.00065","article-title":"Skeletal muscle dysfunction in the development and progression of nonalcoholic fatty liver disease","volume":"8","author":"Altajar","year":"2020","journal-title":"J\u00a0Clin Transl Hepatol"},{"issue":"December","key":"10.1016\/j.jhep.2021.02.037_bib16","first-page":"1","article-title":"Harnessing muscle\u2013liver crosstalk to treat nonalcoholic steatohepatitis","volume":"11","author":"Chakravarthy","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10191","key":"10.1016\/j.jhep.2021.02.037_bib17","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jhep.2021.02.037_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/glu010","article-title":"The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates","volume":"69","author":"Studenski","year":"2014","journal-title":"J\u00a0Gerontol Ser A"},{"issue":"4","key":"10.1016\/j.jhep.2021.02.037_bib20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4161\/adip.28546","article-title":"Intermuscular and intramuscular adipose tissues: bad vs.. good adipose tissues","volume":"3","author":"Hausman","year":"2014","journal-title":"Adipocyte"},{"issue":"August","key":"10.1016\/j.jhep.2021.02.037_bib21","article-title":"Myosteatosis in the context of skeletal muscle function deficit: an interdisciplinary workshop at the national Institute on aging","volume":"11","author":"Correa-de-Araujo","year":"2020","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.jhep.2021.02.037_bib22","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/JOE-15-0533","article-title":"Insulin resistance and sarcopenia: mechanistic links between common co-morbidities","volume":"229","author":"Cleasby","year":"2016","journal-title":"J\u00a0Endocrinol"},{"issue":"9","key":"10.1016\/j.jhep.2021.02.037_bib23","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/gerona\/glv027","article-title":"Greater skeletal muscle fat infiltration is associated with higher all-cause and cardiovascular mortality in older men","volume":"70","author":"Miljkovic","year":"2015","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/ijo.2010.4","article-title":"Visceral adipose tissue and inflammation correlate with elevated liver tests in a cohort of overweight and obese patients","volume":"34","author":"Verrijken","year":"2010","journal-title":"Int J Obes"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib25","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s12325-019-00898-6","article-title":"Pharmacological treatment for non-alcoholic fatty liver disease","volume":"36","author":"Francque","year":"2019","journal-title":"Adv Ther"},{"issue":"6","key":"10.1016\/j.jhep.2021.02.037_bib26","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1053\/j.gastro.2015.09.015","article-title":"Liver histology and clinical trials for nonalcoholic steatohepatitis-perspectives from 2 pathologists","volume":"149","author":"Kleiner","year":"2015","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jhep.2021.02.037_bib27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jhep.2019.04.019","article-title":"Report on the AASLD\/EASL joint workshop on clinical trial endpoints in NAFLD","volume":"71","author":"Rinella","year":"2019","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2021.02.037_bib28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev.nutr.17.1.527","article-title":"Human body composition: advances in models and methods","volume":"17","author":"Heymsfield S","year":"1997","journal-title":"Annu Rev Nutr"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/lt.24750","article-title":"A\u00a0multicenter study to define sarcopenia in patients with end-stage liver disease","volume":"23","author":"Carey","year":"2017","journal-title":"Liver Transpl"},{"issue":"1","key":"10.1016\/j.jhep.2021.02.037_bib30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1152\/jappl.2000.89.1.104","article-title":"Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content","volume":"89","author":"Goodpaster","year":"2000","journal-title":"J\u00a0Appl Physiol"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib31","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1210\/jc.2014-4318","article-title":"Role of Activin A and myostatin in human cancer cachexia","volume":"100","author":"Loumaye","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.jhep.2021.02.037_bib32","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/jcsm.12209","article-title":"Circulating Activin A predicts survival in cancer patients","volume":"8","author":"Loumaye","year":"2017","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.jhep.2021.02.037_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcsm.12159","article-title":"Bioelectrical impedance analysis for diagnosing sarcopenia and cachexia: what are we really estimating?","volume":"8","author":"Gonzalez","year":"2017","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.jhep.2021.02.037_bib34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.24.3.539","article-title":"A\u00a0model-based method for assessing insulin sensitivity from the oral glucose tolerance test","volume":"24","author":"Mari","year":"2001","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1016\/j.jhep.2021.02.037_bib35","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/hep4.1391","article-title":"Body composition and genetic lipodystrophy risk score associate with nonalcoholic fatty liver disease and liver fibrosis","volume":"3","author":"Chen","year":"2019","journal-title":"Hepatol Commun"},{"issue":"8","key":"10.1016\/j.jhep.2021.02.037_bib36","doi-asserted-by":"crossref","first-page":"E1056","DOI":"10.1210\/jc.2014-4032","article-title":"The association between subcutaneous fat density and the propensity to store fat viscerally","volume":"100","author":"Yeoh","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.jhep.2021.02.037_bib37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41574-018-0062-9","article-title":"Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies","volume":"14","author":"Batsis","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.jhep.2021.02.037_bib38","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.clnu.2017.11.021","article-title":"Nonalcoholic fatty liver disease and sarcopenia in a Western population (NHANES III): the importance of sarcopenia definition","volume":"38","author":"Peng","year":"2019","journal-title":"Clin Nutr"},{"issue":"6","key":"10.1016\/j.jhep.2021.02.037_bib39","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jhep.2016.07.040","article-title":"Sarcopenia from mechanism to diagnosis and treatment in liver disease","volume":"65","author":"Dasarathy","year":"2016","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2021.02.037_bib40","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jhep.2019.10.024","article-title":"Predicting NASH response with liver fat: are we back to square one?","volume":"72","author":"Wong","year":"2020","journal-title":"J\u00a0Hepatol"},{"issue":"9","key":"10.1016\/j.jhep.2021.02.037_bib41","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00125-019-4927-9","article-title":"Myokines in metabolic homeostasis and diabetes","volume":"62","author":"Eckel","year":"2019","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.jhep.2021.02.037_bib42","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1111\/apha.13367","article-title":"Myokines in skeletal muscle physiology and metabolism: recent advances and future perspectives","volume":"228","author":"Das","year":"2020","journal-title":"Acta Physiol"},{"issue":"September","key":"10.1016\/j.jhep.2021.02.037_bib43","first-page":"1","article-title":"Myosteatosis rather than sarcopenia associates with non-alcoholic steatohepatitis in non-alcoholic fatty liver disease preclinical models","volume":"32","author":"Nachit","year":"2020","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.jhep.2021.02.037_bib44","doi-asserted-by":"crossref","first-page":"11369","DOI":"10.1038\/s41598-018-29825-5","article-title":"Skeletal muscle cutoff values for sarcopenia diagnosis using T10 to L5 measurements in a healthy US population","volume":"8","author":"Derstine","year":"2018","journal-title":"Sci Rep"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821002348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821002348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:42:01Z","timestamp":1759174921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827821002348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0168827821002348"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2021.02.037","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Muscle fat content is strongly associated with NASH: A longitudinal study in patients with morbid obesity","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2021.02.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}