{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:47Z","timestamp":1793060027954,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100011500","name":"Abigail Wexner Research Institute at Nationwide Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI139511"],"award-info":[{"award-number":["R01AI139511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI137912"],"award-info":[{"award-number":["R21AI137912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jhep.2021.04.036","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T15:46:16Z","timestamp":1620143176000},"page":"557-564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Resolution of hepatitis E virus infection in CD8+ T cell-depleted rhesus macaques"],"prefix":"10.1016","volume":"75","author":[{"given":"William","family":"Bremer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-3591","authenticated-orcid":false,"given":"Heather","family":"Blasczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-6718","authenticated-orcid":false,"given":"Xin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4490-9289","authenticated-orcid":false,"given":"Eduardo","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Grakoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7913-1027","authenticated-orcid":false,"given":"Zongdi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6456-5834","authenticated-orcid":false,"given":"Christopher","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2021.04.036_bib1","article-title":"Clinical manifestations, pathogenesis and treatment of hepatitis E virus infections","volume":"9","author":"Lhomme","year":"2020","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jhep.2021.04.036_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/v11070617","article-title":"The clinical perspective on hepatitis E","volume":"11","author":"Horvatits","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jhep.2021.04.036_bib3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031872","article-title":"Acute and persistent hepatitis E virus genotype 3 and 4 infection: clinical features, pathogenesis, and treatment","volume":"9","author":"Kamar","year":"2019","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jhep.2021.04.036_bib4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1099\/vir.0.81545-0","article-title":"Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay","volume":"87","author":"Emerson","year":"2006","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.jhep.2021.04.036_bib5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1099\/vir.0.82535-0","article-title":"Development and evaluation of an efficient cell-culture system for Hepatitis E virus","volume":"88","author":"Tanaka","year":"2007","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.jhep.2021.04.036_bib6","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00705-008-0179-6","article-title":"Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces","volume":"153","author":"Takahashi","year":"2008","journal-title":"Arch Virol"},{"key":"10.1016\/j.jhep.2021.04.036_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033472","article-title":"Adaptive immune responses in hepatitis A virus and hepatitis E virus infections","volume":"9","author":"Walker","year":"2019","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jhep.2021.04.036_bib8","article-title":"Transmission of rat hepatitis E virus infection to humans in Hong Kong: a clinical and epidemiological analysis","author":"Sridhar","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.04.036_bib9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/hep.24738","article-title":"Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection","volume":"55","author":"Suneetha","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.04.036_bib10","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/hep.28819","article-title":"Characterization of the specificity, functionality, and durability of host T-cell responses against the full-length hepatitis E virus","volume":"64","author":"Brown","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.04.036_bib11","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/liv.13521","article-title":"Hepatitis\u00a0E virus ORF 1 induces proliferative and functional T-cell responses\u00a0in\u00a0patients with ongoing and resolved hepatitis E","volume":"38","author":"Al-Ayoubi","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.04.036_bib12","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/jmv.25548","article-title":"CD8(+) lymphocytes but not B lymphocytes are required for protection against chronic hepatitis E virus infection in chickens","volume":"91","author":"Rogers","year":"2019","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.jhep.2021.04.036_bib13","first-page":"11","article-title":"Animal models for hepatitis E virus","author":"Corneillie","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jhep.2021.04.036_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174070","article-title":"Cynomolgus monkeys are successfully and persistently infected with hepatitis E virus genotype 3 (HEV-3) after long-term immunosuppressive therapy","volume":"12","author":"Gardinali","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.jhep.2021.04.036_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1034\/j.1399-0039.1999.540306.x","article-title":"Identification of DRB alleles in rhesus monkeys using polymerase chain reaction-sequence-specific primers (PCR-SSP) amplification","volume":"54","author":"Lobashevsky","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jhep.2021.04.036_bib16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00251-007-0233-7","article-title":"Molecular typing of major histocompatibility complex class I alleles in the Indian rhesus macaque which restrict SIV CD8+ T cell epitopes","volume":"59","author":"Kaizu","year":"2007","journal-title":"Immunogenetics"},{"key":"10.1016\/j.jhep.2021.04.036_bib17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1056\/NEJMc0903778","article-title":"Persistent carriage of hepatitis E virus in patients with HIV infection","volume":"361","author":"Dalton","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2021.04.036_bib18","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0002-9440(10)65450-8","article-title":"A\u00a0nonhuman primate model for the selective elimination of CD8+ lymphocytes using a mouse-human chimeric monoclonal antibody","volume":"154","author":"Schmitz","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2021.04.036_bib19","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.1128\/JVI.73.10.8035-8039.1999","article-title":"The simian immunodeficiency virus envelope glycoprotein contains two epitopes presented by the Mamu-A\u221701 class I molecule","volume":"73","author":"Furchner","year":"1999","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2021.04.036_bib20","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.20111906","article-title":"Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection","volume":"209","author":"Zhou","year":"2012","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2021.04.036_bib21","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1073\/pnas.1721345115","article-title":"Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection","volume":"115","author":"Yin","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2021.04.036_bib22","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1136\/jcp.31.12.1152","article-title":"Evaluation of dithiothreitol (DTT) for inactivation of IgM antibodies","volume":"31","author":"Okuno","year":"1978","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jhep.2021.04.036_bib23","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1084\/jem.20090356","article-title":"Profound CD4+\/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis","volume":"206","author":"Okoye","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2021.04.036_bib24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature10624","article-title":"Natural killer cells act as rheostats modulating antiviral T cells","volume":"481","author":"Waggoner","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2021.04.036_bib25","first-page":"217","article-title":"Regulation of the germinal center and humoral immunity by interleukin-21","author":"Tangye","year":"2020","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2021.04.036_bib26","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1128\/AAC.02427-15","article-title":"Antiviral activities of different interferon types and subtypes against hepatitis E virus replication","volume":"60","author":"Todt","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jhep.2021.04.036_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jbspin.2016.09.017","article-title":"Exacerbation of hepatitis E virus infection during anti-TNF\u03b1 treatment","volume":"84","author":"Behrendt","year":"2017","journal-title":"Jt Bone Spine"},{"key":"10.1016\/j.jhep.2021.04.036_bib28","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1128\/JVI.02804-15","article-title":"Distinct entry mechanisms for nonenveloped and quasi-enveloped hepatitis E viruses","volume":"90","author":"Yin","year":"2016","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2021.04.036_bib29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature12029","article-title":"A\u00a0pathogenic picornavirus acquires an envelope by hijacking cellular membranes","volume":"496","author":"Feng","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2021.04.036_bib30","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jhep.2019.04.008","article-title":"Convalescent plasma therapy for persistent hepatitis E virus infection","volume":"71","author":"Ankcorn","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.04.036_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/infdis\/jiw161","article-title":"Hepatitis E virus (HEV) ORF2 antigen levels differentiate between acute and chronic HEV infection","volume":"214","author":"Behrendt","year":"2016","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jhep.2021.04.036_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jhep.2019.06.005","article-title":"Defining virus-specific CD8+ TCR repertoires for therapeutic regeneration of T cells against chronic hepatitis E","volume":"71","author":"Soon","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.04.036_bib33","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/s41591-020-1039-5","article-title":"Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in\u00a0vivo","volume":"26","author":"Maldini","year":"2020","journal-title":"Nat Med"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821003019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821003019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T08:55:42Z","timestamp":1736585742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827821003019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0168827821003019"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2021.04.036","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resolution of hepatitis E virus infection in CD8+ T cell-depleted rhesus macaques","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2021.04.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}