{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:30:18Z","timestamp":1777552218654,"version":"3.51.4"},"reference-count":5,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jhep.2021.05.030","type":"journal-article","created":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T19:19:21Z","timestamp":1623007161000},"page":"1241-1242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["First things first! Can bacterial infections be considered as decompensating events per se?"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-0575","authenticated-orcid":false,"given":"Matthias Christian","family":"Reichert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ripoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2021.05.030_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2021.04.022","article-title":"Bacterial infections adversely influence the risk of decompensation and survival in compensated cirrhosis","volume":"75","author":"Villanueva","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.05.030_bib2","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(18)31875-0","article-title":"\u03b2 blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled multicentre trial","volume":"393","author":"Villanueva","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2021.05.030_bib3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/ajg.2017.19","article-title":"Bacterial infections change natural history of cirrhosis irrespective of liver disease severity","volume":"112","author":"Dionigi","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2021.05.030_bib4","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1053\/j.gastro.2010.06.019","article-title":"Infections in patients with cirrhosis increase mortality four-fold and\u00a0should be used in determining prognosis","volume":"139","author":"Arvaniti","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.05.030_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/liv.14842","article-title":"Isolated bacterial infection without decompensation has no impact on survival of compensated patients with cirrhosis","author":"Reichert","year":"2021","journal-title":"Liver Int"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821004037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821004037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:43:53Z","timestamp":1759175033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827821004037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0168827821004037"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2021.05.030","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First things first! Can bacterial infections be considered as decompensating events per se?","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2021.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2021.04.022","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}