{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:27:20Z","timestamp":1780406840161,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","award":["2016191"],"award-info":[{"award-number":["2016191"]}],"id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010890","name":"Central People&apos;s Government of the People&apos;s Republic of China Scholarship Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR36"],"award-info":[{"award-number":["TRR36"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["272983813\/TP14"],"award-info":[{"award-number":["272983813\/TP14"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR179"],"award-info":[{"award-number":["TRR179"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"German Centre for Infection Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009318","name":"Helmholtz Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jhep.2021.06.022","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T04:15:58Z","timestamp":1624421758000},"page":"1058-1071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice"],"prefix":"10.1016","volume":"75","author":[{"given":"Oliver","family":"Quitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0961-4215","authenticated-orcid":false,"given":"Shanshan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-9591","authenticated-orcid":false,"given":"Marten","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Golsaz-Shirazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Loffredo-Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Festag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hendrik","family":"Bockmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Min","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raindy","family":"Tedjokusumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen Martin","family":"Wettengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-1602","authenticated-orcid":false,"given":"Chunkyu","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfriede","family":"Noe\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Bulbuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazel","family":"Shokri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"L\u00fcttgau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Heikenw\u00e4lder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bohne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Moldenhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Momburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-1911","authenticated-orcid":false,"given":"Ulrike","family":"Protzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2021.06.022_bib1","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1056\/NEJMra1810477","article-title":"Global elimination of chronic hepatitis","volume":"380","author":"Thomas","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2021.06.022_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri3169","article-title":"Living in the liver: hepatic infections","volume":"12","author":"Protzer","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2021.06.022_bib3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41573-019-0037-0","article-title":"Therapeutic strategies for hepatitis B virus infection: towards a cure","volume":"18","author":"Fanning","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhep.2021.06.022_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A\u00a0global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2021.06.022_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1053\/j.gastro.2018.10.032","article-title":"Targeting innate and adaptive immune responses to cure chronic HBV infection","volume":"156","author":"Gehring","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.06.022_bib6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jhep.2014.10.001","article-title":"Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient","volume":"62","author":"Qasim","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.06.022_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.gastro.2007.11.002","article-title":"T\u00a0cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes","volume":"134","author":"Bohne","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.06.022_bib8","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1172\/JCI120228","article-title":"T\u00a0cell receptor grafting allows virological control of hepatitis B virus infection","volume":"129","author":"Wisskirchen","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2021.06.022_bib9","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1158545","article-title":"Tumor regression in cancer patients by very low doses of a T cell-engaging antibody","volume":"321","author":"Bargou","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jhep.2021.06.022_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fonc.2014.00063","article-title":"Blinatumomab, a Bi-specific anti-CD19\/CD3 BiTE((R)) antibody for the treatment of acute lymphoblastic leukemia: perspectives and current pediatric applications","volume":"4","author":"Hoffman","year":"2014","journal-title":"Front Oncol"},{"key":"10.1016\/j.jhep.2021.06.022_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005233","article-title":"Targeting HIV reservoir in infected CD4 T cells by dual-affinity Re-targeting molecules (DARTs) that bind HIV envelope and recruit cytotoxic T cells","volume":"11","author":"Sloan","year":"2015","journal-title":"Plos Pathog"},{"key":"10.1016\/j.jhep.2021.06.022_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.omtm.2017.08.006","article-title":"In situ liver expression of HBsAg\/CD3-bispecific antibodies for HBV immunotherapy","volume":"7","author":"Kruse","year":"2017","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jhep.2021.06.022_bib13","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s00705-016-2980-y","article-title":"Localization of immunodominant epitopes within the \"a\" determinant of hepatitis B surface antigen using monoclonal antibodies","volume":"161","author":"Golsaz-Shirazi","year":"2016","journal-title":"Arch Virol"},{"key":"10.1016\/j.jhep.2021.06.022_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.314668","article-title":"Monoclonal antibodies defining distinctive human T cell surface antigens","volume":"206","author":"Kung","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jhep.2021.06.022_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0008-8749(89)90188-3","article-title":"The anti-T cell monoclonal antibody 9.3 (anti-CD28) provides a helper signal and bypasses the need for accessory cells in T cell activation with immobilized anti-CD3 and mitogens","volume":"120","author":"Baroja","year":"1989","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jhep.2021.06.022_bib16","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jhep.2018.08.012","article-title":"Hepatitis B virus genome recycling and de novo secondary infection\u00a0events maintain stable cccDNA levels","volume":"69","author":"Ko","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.06.022_bib17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2015.09.026","article-title":"Interferon-gamma and tumor necrosis factor-alpha produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis","volume":"150","author":"Xia","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.06.022_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01440-19","article-title":"A\u00a0New role for capsid assembly modulators to target mature hepatitis B virus capsids and prevent virus infection","volume":"64","author":"Ko","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jhep.2021.06.022_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/35005534","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"402","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2021.06.022_bib20","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.1243462","article-title":"Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA","volume":"343","author":"Lucifora","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jhep.2021.06.022_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan0241","article-title":"RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg","volume":"9","author":"Wooddell","year":"2017","journal-title":"Sci translational Med"},{"key":"10.1016\/j.jhep.2021.06.022_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/genes9100495","article-title":"The global hepatitis B virus genotype distribution approximated from available genotyping data","volume":"9","author":"Velkov","year":"2018","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jhep.2021.06.022_bib23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1158\/0008-5472.CAN-07-2182","article-title":"Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3","volume":"68","author":"Amann","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2021.06.022_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s43018-019-0004-z","article-title":"Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation","volume":"1","author":"Wu","year":"2020","journal-title":"Nat Cancer"},{"key":"10.1016\/j.jhep.2021.06.022_bib25","first-page":"418","article-title":"Combination of a bispecific antibody and costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy","volume":"35","author":"Hornig","year":"2012","journal-title":"J\u00a0Immunother"},{"key":"10.1016\/j.jhep.2021.06.022_bib26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF01534426","article-title":"Unprimed CD4+ and CD8+ T cells can be rapidly activated by a CD3\u00d7CD19 bispecific antibody to proliferate and become cytotoxic","volume":"39","author":"Haagen","year":"1994","journal-title":"Cancer Immunol Immunother"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821004438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821004438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:55:29Z","timestamp":1777510529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827821004438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0168827821004438"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2021.06.022","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2021.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}