{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:50:34Z","timestamp":1794358234620,"version":"4.9.0"},"reference-count":138,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jhep.2021.11.004","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T11:58:09Z","timestamp":1652702289000},"page":"1291-1305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":132,"title":["Haemostatic alterations and management of haemostasis in patients with cirrhosis"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-7140","authenticated-orcid":false,"given":"Ton","family":"Lisman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M.","family":"Intagliata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2021.11.004_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2021.11.004_bib2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1182\/blood-2010-02-261891","article-title":"Rebalanced haemostasis in patients with liver disease: evidence and clinical consequences","volume":"116","author":"Lisman","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2021.11.004_bib3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/hep.31646","article-title":"Vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver disease: 2020 practice guidance by the American association for the study of liver diseases","volume":"73","author":"Northup","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/jth.15239","article-title":"The concept of rebalanced haemostasis in patients with liver disease: communication from the ISTH SSC working group on haemostatic management of patients with liver disease","volume":"19","author":"Lisman","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1053\/j.gastro.2019.03.070","article-title":"AGA clinical practice update: coagulation in cirrhosis","volume":"157","author":"O\u2019Leary","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.14309\/ajg.0000000000000486","article-title":"ACG clinical guideline: disorders of the hepatic and mesenteric circulation","volume":"115","author":"Simonetto","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2021.11.004_bib7","article-title":"Periprocedural management of abnormal coagulation parameters and thrombocytopenia in patients with cirrhosis: guidance from the SSC of the ISTH","author":"Roberts","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/rth2.12028","article-title":"Pathogenesis, prevention, and management of bleeding and thrombosis in patients with liver diseases","volume":"1","author":"Lisman","year":"2017","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib9","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1055\/s-0040-1715102","article-title":"Thrombin generation and cirrhosis: state of the art and perspectives","volume":"46","author":"Lebreton","year":"2020","journal-title":"Semin Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib10","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1053\/j.gastro.2019.01.265","article-title":"Diagnosis, development, and treatment of portal vein thrombosis in patients with and without cirrhosis","volume":"156","author":"Intagliata","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib11","first-page":"716","article-title":"The spectrum of disease severity\u00a0in\u00a0cirrhosis and its implications for haemostasis","volume":"46","author":"Stotts","year":"2020","journal-title":"Semin Thromb\u00a0Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-0038-1660523","article-title":"Prevention and management of bleeding risk related to invasive procedures in cirrhosis","volume":"38","author":"Schepis","year":"2018","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2021.11.004_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jhepr.2019.02.006","article-title":"Anticoagulation in the cirrhotic patient","volume":"1","author":"Turco","year":"2019","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2021.11.004_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/hep.27783","article-title":"Impact of anticoagulation on upper-gastrointestinal bleeding in cirrhosis. A retrospective multicenter study","volume":"62","author":"Cerini","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib15","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/hep.22216","article-title":"Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: a randomfd, controlled trial","volume":"47","author":"Bosch","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib16","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0140-6736(20)30848-5","article-title":"Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial","volume":"395","author":"Roberts","year":"2020","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.jhep.2021.11.004_bib17","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1111\/jth.15364","article-title":"Treatment of bleeding in patients with liver disease","volume":"19","author":"Northup","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1046\/j.1537-2995.1987.27387235624.x","article-title":"Blood use in liver transplantation","volume":"27","author":"Lewis","year":"1987","journal-title":"Transfusion"},{"key":"10.1016\/j.jhep.2021.11.004_bib19","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1055\/s-0035-1550428","article-title":"Classical notions of coagulation revisited in relation with blood losses, transfusion rate for 700 consecutive liver transplantations","volume":"41","author":"Massicotte","year":"2015","journal-title":"Semin Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hep.21231","article-title":"Elevated levels of von Willebrand factor in cirrhosis support platelet adhesion despite reduced functional capacity","volume":"44","author":"Lisman","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/gast.2001.25481","article-title":"Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis","volume":"121","author":"Lisman","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib22","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1053\/j.gastro.2009.08.045","article-title":"An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis","volume":"137","author":"Tripodi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib23","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/hep.20569","article-title":"Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests","volume":"41","author":"Tripodi","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcrc.2017.07.053","article-title":"Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure","volume":"43","author":"Fisher","year":"2018","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.jhep.2021.11.004_bib25","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1111\/liv.13882","article-title":"In\u00a0vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis","volume":"38","author":"Lisman","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib26","article-title":"Global haemostatic status in patients with acute-on-chronic liver failure and septics without underlying liver disease","author":"Lisman","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib27","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/hep.30915","article-title":"Mixed fibrinolytic phenotypes in decompensated cirrhosis and acute-on-chronic liver failure with hypofibrinolysis in those with complications and poor survival","volume":"71","author":"Blasi","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib28","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/jth.15185","article-title":"Prophylactic fresh frozen plasma and platelet transfusion have a prothrombotic effect in patients with liver disease","volume":"19","author":"von Meijenfeldt","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib29","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/hep.26372","article-title":"An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: implications for haemostasis and clinical outcome","volume":"58","author":"Hugenholtz","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/liv.15001","article-title":"Coagulopathy is not predictive of bleeding in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure","author":"Campello","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib31","article-title":"Intraperitoneal activation of coagulation and fibrinolysis in patients with cirrhosis and ascites","author":"Thaler","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1055\/s-0035-1556730","article-title":"Coagulopathy of acute sepsis","volume":"41","author":"Semeraro","year":"2015","journal-title":"Semin Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib33","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1002\/hep.30103","article-title":"Coagulation failure in patients with acute-on-chronic liver failure and decompensated cirrhosis: beyond the international normalized ratio","volume":"68","author":"Blasi","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib34","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/liv.14034","article-title":"Coagulation failure is associated with bleeding events and clinical outcome during systemic inflammatory response and sepsis in acute-on-chronic liver failure: an observational cohort study","volume":"39","author":"Premkumar","year":"2019","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12072-020-10036-y","article-title":"Viscoelastic test-based bleeding risk score reliably predicts coagulopathic bleeding in decompensated cirrhosis and ACLF patients","volume":"14","author":"Bihari","year":"2020","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/MCG.0000000000001327","article-title":"Interpreting haemostatic profiles assessed with viscoelastic tests in patients with cirrhosis","volume":"54","author":"Lisman","year":"2020","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2021.11.004_bib37","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/hep.31443","article-title":"Acute kidney injury in decompensated cirrhosis is associated with both hypo-coagulable and hyper-coagulable features","volume":"72","author":"Zanetto","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib38","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.dld.2019.03.011","article-title":"Acute kidney injury is associated with low factor XIII in decompensated cirrhosis","volume":"51","author":"Intagliata","year":"2019","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jhep.2021.11.004_bib39","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/hep.28628","article-title":"Coagulation parameters and major bleeding in critically ill patients with cirrhosis","volume":"64","author":"Drolz","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib40","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/hep.28148","article-title":"Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: a randomized, controlled trial","volume":"63","author":"De Pietri","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/MCG.0000000000001214","article-title":"Thromboelastography-guided blood product transfusion in cirrhosis patients with variceal bleeding: a randomized controlled trial","volume":"54","author":"Rout","year":"2020","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2021.11.004_bib42","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.28426","article-title":"Prediction of bleeding in cirrhosis patients: is the forecast any clearer?","volume":"64","author":"Intagliata","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/gut.36.3.437","article-title":"Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British society of Gastroenterology and the royal college of physicians of london","volume":"36","author":"Gilmore","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2021.11.004_bib44","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ejrad.2007.04.002","article-title":"US-guided placement of central vein catheters in patients with disorders of haemostasis","volume":"65","author":"Tercan","year":"2008","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jhep.2021.11.004_bib45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jhep.2019.09.024","article-title":"Nails in the coffin of fresh frozen plasma to prevent or treat bleeding in cirrhosis?","volume":"72","author":"Bernal","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib46","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/apt.16078","article-title":"Systematic review with meta-analysis: abnormalities in the international normalised ratio do not correlate with periprocedural bleeding events among patients with cirrhosis","volume":"52","author":"Kovalic","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2021.11.004_bib47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11739-011-0528-4","article-title":"Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh-frozen plasma","volume":"7","author":"Tripodi","year":"2012","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jhep.2021.11.004_bib48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jhep.2019.09.008","article-title":"Fresh frozen plasma transfusion in patients with cirrhosis and coagulopathy: effect on conventional coagulation tests and thrombomodulin-modified thrombin generation","volume":"72","author":"Rassi","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/hep.27029","article-title":"Correction of haemostatic abnormalities and portal pressure variations in patients with cirrhosis","volume":"60","author":"Giannini","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/j.1537-2995.2012.03663.x","article-title":"Adverse effects of plasma transfusion","volume":"52","author":"Pandey","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.jhep.2021.11.004_bib51","article-title":"The efficacy and safety of thrombopoietin receptor agonists in patients with chronic liver disease undergoing elective procedures: a systematic review and meta-analysis","author":"Lindquist","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.jhep.2021.11.004_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta24510","article-title":"Avatrombopag and lusutrombopag for thrombocytopenia in people with chronic liver disease needing an elective procedure: a systematic review and cost-effectiveness analysis","volume":"24","author":"Armstrong","year":"2020","journal-title":"Health Technol Assess (Rockv)"},{"key":"10.1016\/j.jhep.2021.11.004_bib53","article-title":"Transfusion with cryoprecipitate for very low fibrinogen levels does not affect bleeding or survival in critically ill cirrhosis patients","author":"Budnick","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib54","article-title":"Concepts and controversies in haemostasis and thrombosis associated with liver disease: proceedings of the 7th international coagulation in liver disease conference","volume":"118","author":"Intagliata","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib55","article-title":"Clinical cirrhosis dilemmas: survey of practice from the 7th international coagulation in liver disease conference","author":"Stine","year":"2019","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2021.11.004_bib56","doi-asserted-by":"crossref","DOI":"10.5604\/16652681.1226811","article-title":"A\u00a0summary of the 6th international conference on coagulation in liver disease: discussion, debate, deliberations","volume":"16","author":"Caldwell","year":"2017","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib57","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2010.01.042","article-title":"Haemostasis and thrombosis in patients with liver disease: the ups and downs","volume":"53","author":"Lisman","year":"2010","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib58","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/hep.28906","article-title":"Portal hypertensive bleeding in cirrhosis: risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases","volume":"65","author":"Garcia-Tsao","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1211801","article-title":"Transfusion strategies for acute upper gastrointestinal bleeding","volume":"368","author":"Villanueva","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.jhep.2021.11.004_bib60","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/liv.14936","article-title":"Fresh frozen plasma transfusion in acute variceal haemorrhage: results from a multicenter cohort study","volume":"41","author":"Mohanty","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib61","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1111\/liv.14988","article-title":"Fresh frozen plasma in treating acute variceal bleeding: not effective and likely harmful","volume":"41","author":"Lisman","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib62","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial","volume":"389","author":"Shakur","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2021.11.004_bib63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events,\u00a0and\u00a0blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","author":"Olldashi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2021.11.004_bib64","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/hep.27363","article-title":"Activated recombinant factor VIIa should not\u00a0be\u00a0used in patients with refractory variceal bleeding: it is mostly\u00a0ineffective, is expensive, and may rarely cause serious adverse events","volume":"60","author":"Sozio","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib65","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib66","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","author":"Angeli","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib67","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cgh.2009.04.019","article-title":"A\u00a0prospective study of conventional and expanded coagulation indices in predicting ulcer bleeding after variceal band ligation","volume":"7","author":"Vieira da Rocha","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib68","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2036.2010.04331.x","article-title":"Predictive factors of bleeding related to post-banding ulcer following endoscopic variceal ligation in cirrhotic patients: a case-control study","volume":"32","author":"Vanbiervliet","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2021.11.004_bib69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.dld.2019.06.019","article-title":"Ulcer bleeding after band ligation of esophageal varices: risk factors and prognosis","volume":"52","author":"Due\u00f1as","year":"2020","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jhep.2021.11.004_bib70","doi-asserted-by":"crossref","first-page":"100363","DOI":"10.1016\/j.jhepr.2021.100363","article-title":"A\u00a0multicenter analysis of the role of prophylactic transfusion of blood products in patients with cirrhosis and esophageal varices undergoing endoscopic band ligation","volume":"0","author":"Blasi","year":"2021","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2021.11.004_bib71","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1160\/TH08-01-0006","article-title":"Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis","volume":"99","author":"Uemura","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib72","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.atherosclerosis.2009.04.013","article-title":"Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients","volume":"207","author":"Bongers","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jhep.2021.11.004_bib73","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/jth.15191","article-title":"The ADAMTS13-von Willebrand factor axis in COVID-19 patients","volume":"19","author":"Mancini","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib74","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.thromres.2021.03.028","article-title":"Thrombin generation is associated with ischemic stroke at a young age","volume":"202","author":"Donkel","year":"2021","journal-title":"Thromb Res"},{"key":"10.1016\/j.jhep.2021.11.004_bib75","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/jth.13043","article-title":"The risk of a first and a recurrent venous thrombosis associated with an elevated D-dimer level and an elevated thrombin potential: results of the THE-VTE study","volume":"13","author":"van Hylckama Vlieg","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib76","article-title":"Decreased plasma fibrinolytic potential as a risk for venous and arterial thrombosis","volume":"43","author":"Lisman","year":"2017","journal-title":"Semin Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox9080737","article-title":"Super-resolution microscopy reveals an altered fibrin network in cirrhosis: the key role of oxidative stress in fibrinogen structural modifications","volume":"9","author":"Becatti","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jhep.2021.11.004_bib78","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/jth.13278","article-title":"Procoagulant changes in fibrin clot structure in patients with cirrhosis are associated with oxidative modifications of fibrinogen","volume":"14","author":"Hugenholtz","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib79","article-title":"Biomarkers of liver dysfunction correlate with a prothrombotic and not with a prohaemorrhagic profile in patients with cirrhosis","volume":"2","author":"Zermatten","year":"2020","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2021.11.004_bib80","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1111\/jth.14963","article-title":"Hypercoagulability (thrombin generation) in patients with cirrhosis is detected with ST-Genesia","volume":"18","author":"Talon","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib81","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1053\/j.gastro.2019.03.013","article-title":"Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal hypertension","volume":"157","author":"Hilscher","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib82","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1055\/s-0040-1715474","article-title":"Netting liver disease: neutrophil extracellular traps in the initiation and exacerbation of liver pathology","volume":"46","author":"Meijenfeldt","year":"2020","journal-title":"Semin Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib83","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhepr.2019.06.002","article-title":"Plasma levels of circulating DNA are associated with outcome, but not with activation of coagulation in decompensated cirrhosis and ACLF","volume":"1","author":"Blasi","year":"2019","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2021.11.004_bib84","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jhep.2021.04.029","article-title":"Current knowledge and management of portal vein thrombosis in cirrhosis","volume":"75","author":"Senzolo","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib85","series-title":"Portal Hypertens. Clin. Physiol. Asp.","first-page":"3","article-title":"Anatomy of the portal vein system and hepatic vasculature","author":"Okudaira","year":"1991"},{"key":"10.1016\/j.jhep.2021.11.004_bib86","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0049-3848(84)90224-X","article-title":"Flow through a venous valve and its implication for thrombus formation","volume":"36","author":"Karino","year":"1984","journal-title":"Thromb Res"},{"key":"10.1016\/j.jhep.2021.11.004_bib87","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/rth2.12253","article-title":"Inherited thrombophilia and portal vein thrombosis in cirrhosis: a systematic review and meta-analysis","volume":"3","author":"Ma","year":"2019","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib88","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.jhep.2021.07.020","article-title":"Predicting portal thrombosis in cirrhosis: a prospective study of clinical, ultrasonographic and haemostatic factors","volume":"75","author":"Turon","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib89","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/liv.13500","article-title":"Decreased portal vein velocity is predictive of the development of portal vein thrombosis: a matched case-control study","volume":"38","author":"Stine","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib90","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.27546","article-title":"Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study","volume":"61","author":"Nery","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib91","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.32169","article-title":"Non-malignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin-rich thrombus","volume":"75","author":"Driever","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib92","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/j.1572-0241.2006.00588.x","article-title":"Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism","volume":"101","author":"Northup","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2021.11.004_bib93","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1160\/TH16-06-0450","article-title":"The risk of venous thromboembolism in patients with cirrhosis: a systematic review and meta-analysis","volume":"117","author":"Ambrosino","year":"2017","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/hep.32019","article-title":"Risk and outcome of venous and arterial thrombosis in patients with cirrhosis: a Danish nationwide cohort study","author":"Jepsen","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2015.27","article-title":"Cirrhosis is associated with an increased 30-day mortality after venous thromboembolism","volume":"6","author":"S\u00f8gaard","year":"2015","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.jhep.2021.11.004_bib96","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.07.018","article-title":"Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis","volume":"143","author":"Villa","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib97","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1053\/j.gastro.2017.04.042","article-title":"Effects of anticoagulants in patients with cirrhosis and portal vein thrombosis: a systematic review and meta-analysis","volume":"153","author":"Loffredo","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib98","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/hep4.1513","article-title":"Direct oral anticoagulants in patients with atrial fibrillation and advanced liver disease: an exploratory meta-analysis","volume":"4","author":"Violi","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2021.11.004_bib99","doi-asserted-by":"crossref","first-page":"e195S","DOI":"10.1378\/chest.11-2296","article-title":"Prevention of VTE in nonsurgical patients. Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Kahn","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jhep.2021.11.004_bib100","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/imj.13766","article-title":"Suboptimal use of pharmacological venous thromboembolism prophylaxis in cirrhotic patients","volume":"48","author":"Yang","year":"2018","journal-title":"Intern Med J"},{"key":"10.1016\/j.jhep.2021.11.004_bib101","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/liv.12211","article-title":"Prophylactic anticoagulation for venous thromboembolism in hospitalized cirrhosis patients is not associated with high rates of gastrointestinal bleeding","volume":"34","author":"Intagliata","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib102","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/jth.13000","article-title":"Safety and efficacy of pharmacological thromboprophylaxis for hospitalized patients with cirrhosis: a single-center retrospective cohort study","volume":"13","author":"Shatzel","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2021.11.004_bib103","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1053\/j.gastro.2021.09.004","article-title":"AGA technical review on coagulation in cirrhosis","volume":"161","author":"Intagliata","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib104","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1053\/j.gastro.2021.08.015","article-title":"AGA clinical practice guideline on the management of coagulation disorders in patients with cirrhosis","volume":"161","author":"O\u2019Shea","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2021.11.004_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104825","article-title":"What intervention regimen is most effective prevention for Portal venous system thrombosis after splenectomy in cirrhotics patients with Portal hypertension? Systematic review and network meta-analysis","volume":"157","author":"Ding","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jhep.2021.11.004_bib106","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.chest.2018.07.040","article-title":"Antithrombotic therapy for atrial fibrillation: CHEST guideline and expert panel report","volume":"154","author":"Lip","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.jhep.2021.11.004_bib107","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/ejh.13045","article-title":"Safety of direct oral anticoagulants vs warfarin in patients with chronic liver disease and atrial fibrillation","volume":"100","author":"Goriacko","year":"2018","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jhep.2021.11.004_bib108","article-title":"The safety and efficacy of Vitamin K antagonist in atrial fibrillation patients with previous ulcer bleeding Long-term results from a multicenter study","volume":"95","author":"Lee","year":"2016","journal-title":"Med\u00a0(United States)"},{"key":"10.1016\/j.jhep.2021.11.004_bib109","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1016\/j.jacc.2019.04.052","article-title":"Direct oral anticoagulants in patients with atrial fibrillation and liver disease","volume":"73","author":"Lee","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jhep.2021.11.004_bib110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijcard.2018.01.097","article-title":"Incidence of bleeding in patients with atrial fibrillation and advanced liver fibrosis on treatment with vitamin K or non-vitamin K antagonist oral anticoagulants","volume":"264","author":"Pastori","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jhep.2021.11.004_bib111","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.31264","article-title":"Mortality and hepatic decompensation in patients with cirrhosis and atrial fibrillation treated with anticoagulation","volume":"73","author":"Serper","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib112","article-title":"Efficacy and safety of non\u2013vitamin K antagonist oral anticoagulants in atrial fibrillation patients with impaired liver function: a retrospective cohort study","volume":"7","author":"Wang","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jhep.2021.11.004_bib113","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.thromres.2016.12.008","article-title":"Changes of in\u00a0vitro potency of anticoagulant drugs are similar between patients with cirrhosis due to alcohol or non-alcoholic fatty liver disease","volume":"150","author":"Bos","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.jhep.2021.11.004_bib114","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/bjh.12593","article-title":"Routine coagulation assays underestimate levels of antithrombin-dependent drugs but not of direct anticoagulant drugs in plasma from patients with cirrhosis","volume":"163","author":"Potze","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jhep.2021.11.004_bib115","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/hep.27350","article-title":"Decreased in\u00a0vitro anticoagulant potency of Rivaroxaban and Apixaban in plasma from patients with cirrhosis","volume":"61","author":"Potze","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib116","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088390","article-title":"Differential in\u00a0vitro inhibition of thrombin generation by anticoagulant drugs in plasma from patients with cirrhosis","volume":"9","author":"Potze","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2021.11.004_bib117","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood.2020005319","article-title":"Anticoagulant activity of edoxaban in patients with cirrhosis","volume":"136","author":"Bos","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2021.11.004_bib118","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/gut.2004.042796","article-title":"Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation","volume":"54","author":"Francoz","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2021.11.004_bib119","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/MCG.0b013e3181b3ab44","article-title":"Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis","volume":"44","author":"Amitrano","year":"2010","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2021.11.004_bib120","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.cgh.2012.01.012","article-title":"Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis","volume":"10","author":"Delgado","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib121","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1007\/s10620-012-2548-y","article-title":"Portal vein thrombosis in patients with end stage liver disease\u00a0awaiting\u00a0liver transplantation: outcome of anticoagulation","volume":"58","author":"Werner","year":"2013","journal-title":"Dig\u00a0Dis Sci"},{"key":"10.1016\/j.jhep.2021.11.004_bib122","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3350\/cmh.2014.20.4.384","article-title":"Safety, efficacy, and response predictors of anticoagulation for the treatment of nonmalignant portal-vein thrombosis in patients with cirrhosis: a propensity score matching analysis","volume":"20","author":"Chung","year":"2014","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib123","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/lt.24387","article-title":"Nontumoral portal vein thrombosis in patients awaiting liver transplantation","volume":"22","author":"Chen","year":"2016","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhep.2021.11.004_bib124","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/hep.28466","article-title":"Natural history and management of esophagogastric varices in chronic noncirrhotic, nontumoral portal vein thrombosis","volume":"63","author":"Noronha Ferreira","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2021.11.004_bib125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/MEG.0000000000001237","article-title":"A\u00a0prediction model for successful anticoagulation in cirrhotic portal vein thrombosis","volume":"31","author":"Rodriguez-Castro","year":"2019","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib126","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00508-018-1351-y","article-title":"Anticoagulation in non-malignant portal vein thrombosis is safe and improves hepatic function","volume":"130","author":"Scheiner","year":"2018","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jhep.2021.11.004_bib127","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41395-018-0421-0","article-title":"Clinical impact and safety of anticoagulants for portal vein thrombosis in cirrhosis","volume":"114","author":"Pettinari","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2021.11.004_bib128","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1478-3231.2012.02785.x","article-title":"Prospective evaluation of anticoagulation and transjugular intrahepatic portosistemic shunt for the management of portal vein thrombosis in cirrhosis","volume":"32","author":"Senzolo","year":"2012","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib129","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.jvir.2017.08.005","article-title":"Pretransplantation portal vein recanalization and transjugular intrahepatic portosystemic shunt creation for chronic portal vein thrombosis: final analysis of a 61-patient cohort","volume":"28","author":"Thornburg","year":"2017","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jhep.2021.11.004_bib130","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1097\/TP.0000000000000729","article-title":"Pretransplant portal vein recanalization-transjugular intrahepatic portosystemic shunt in patients with complete obliterative portal vein thrombosis","volume":"99","author":"Salem","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2021.11.004_bib131","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1136\/gut.2010.228023","article-title":"Short- and long-term effects of the transjugular intrahepatic portosystemic shunt on portal vein thrombosis in patients with cirrhosis","volume":"60","author":"Luca","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2021.11.004_bib132","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s10620-015-4012-2","article-title":"Direct oral anticoagulants in cirrhosis patients pose similar risks of bleeding when compared to traditional anticoagulation","volume":"61","author":"Intagliata","year":"2016","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2021.11.004_bib133","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/ejh.12844","article-title":"The efficacy and safety of direct oral anticoagulants vs traditional anticoagulants in cirrhosis","volume":"98","author":"Hum","year":"2017","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jhep.2021.11.004_bib134","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/liv.13285","article-title":"Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis","volume":"37","author":"De Gottardi","year":"2017","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib135","doi-asserted-by":"crossref","DOI":"10.1007\/s11239-021-02424-4","article-title":"Safety of direct oral anticoagulants in patients with mild to moderate cirrhosis: a systematic review and meta-analysis","author":"Nisly","year":"2021","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.jhep.2021.11.004_bib136","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.cgh.2020.08.007","article-title":"Rates of bleeding and discontinuation of direct oral anticoagulants in patients with decompensated cirrhosis","volume":"19","author":"Mort","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2021.11.004_bib137","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1111\/liv.14992","article-title":"Safety of direct oral anticoagulants in patients with advanced liver disease","volume":"41","author":"Semmler","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2021.11.004_bib138","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/MOT.0b013e3282fce79d","article-title":"The two tales of coagulation in liver transplantation","volume":"13","author":"Warnaar","year":"2008","journal-title":"Curr Opin Organ Transpl"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821021723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821021723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:45:32Z","timestamp":1759175132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827821021723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":138,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0168827821021723"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2021.11.004","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haemostatic alterations and management of haemostasis in patients with cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2021.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}