{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:23:30Z","timestamp":1793899410534,"version":"4.8.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["634413"],"award-info":[{"award-number":["634413"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["777377"],"award-info":[{"award-number":["777377"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1292"],"award-info":[{"award-number":["CRC 1292"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1066"],"award-info":[{"award-number":["SFB 1066"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jhep.2021.12.004","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T11:03:08Z","timestamp":1639393388000},"page":"800-811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-4351","authenticated-orcid":false,"given":"David A.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8519-8276","authenticated-orcid":false,"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nata\u0161a","family":"Nikoli\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Iruarrizaga-Lejarreta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-2694","authenticated-orcid":false,"given":"Tore","family":"Skjaeret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2019-678X","authenticated-orcid":false,"given":"Cristina","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.P.","family":"Kastelein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arild C.","family":"Rustan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-2028","authenticated-orcid":false,"given":"Yong Ook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Schuppan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.gastro.2018.06.031","article-title":"Bioactive lipid species and metabolic pathways in progression and resolution of nonalcoholic steatohepatitis","volume":"155","author":"Musso","year":"2018","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jhep.2021.12.004_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jhep.2017.11.012","article-title":"Determinants of fibrosis progression and regression in NASH","volume":"68","author":"Schuppan","year":"2018","journal-title":"J\u00a0Hepatol"},{"issue":"1\u20132","key":"10.1016\/j.jhep.2021.12.004_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0049-3848(79)90281-0","article-title":"Evidence for the mechanism by which eicosapentaenoic acid inhibits human platelet aggregation and secretion - implications for the prevention of vascular disease","volume":"16","author":"Jakubowski","year":"1979","journal-title":"Thromb Res"},{"key":"10.1016\/j.jhep.2021.12.004_bib5","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1172\/JCI124219","article-title":"A\u00a0maresin 1\/RORalpha\/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis","volume":"130","author":"Han","year":"2019","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.jhep.2021.12.004_bib6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1194\/jlr.P055640","article-title":"Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis","volume":"56","author":"Loomba","year":"2015","journal-title":"J\u00a0Lipid Res"},{"issue":"4","key":"10.1016\/j.jhep.2021.12.004_bib8","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/hep.28953","article-title":"Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease","volume":"65","author":"Hall","year":"2017","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/j.gastro.2014.04.046","article-title":"No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial","volume":"147","author":"Sanyal","year":"2014","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jhep.2021.12.004_bib10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jhep.2020.09.037","article-title":"Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis","volume":"74","author":"Mohs","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.12.004_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.atherosclerosis.2017.06.916","article-title":"Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia","volume":"264","author":"Berbee","year":"2017","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.jhep.2021.12.004_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0009-8981(90)90246-O","article-title":"Effect of fish-oil and vitamin E supplementation on lipid peroxidation and whole-blood aggregation in man","volume":"193","author":"Brown","year":"1990","journal-title":"Clin Chim Acta"},{"issue":"11","key":"10.1016\/j.jhep.2021.12.004_bib13","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1161\/01.ATV.17.11.2576","article-title":"Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants","volume":"17","author":"Brude","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.jhep.2021.12.004_bib14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbalip.2014.09.013","article-title":"Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis","volume":"1851","author":"Guichardant","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"10.1016\/j.jhep.2021.12.004_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083756","article-title":"A\u00a0metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-\/- mice","volume":"8","author":"Depner","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jhep.2021.12.004_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204119","article-title":"Ethanol and unsaturated dietary fat induce unique patterns of hepatic omega-6 and omega-3 PUFA oxylipins in a mouse model of alcoholic liver disease","volume":"13","author":"Warner","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0021-9150(00)00523-2","article-title":"Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil","volume":"155","author":"Song","year":"2001","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plefa.2013.03.010","article-title":"Bioavailability of long-chain omega-3 fatty acids","volume":"89","author":"Schuchardt","year":"2013","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/hep4.1453","article-title":"Icosabutate exerts beneficial effects upon insulin sensitivity, hepatic inflammation, lipotoxicity, and fibrosis in mice","volume":"4","author":"van den Hoek","year":"2020","journal-title":"Hepatol Commun"},{"issue":"11","key":"10.1016\/j.jhep.2021.12.004_bib20","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1111\/liv.14643","article-title":"Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative","volume":"40","author":"Stokman","year":"2020","journal-title":"Liver Int"},{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12008","article-title":"An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis","volume":"94","author":"Matsumoto","year":"2013","journal-title":"Int J Exp Pathol"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib22","doi-asserted-by":"crossref","first-page":"G174","DOI":"10.1152\/ajpgi.00041.2019","article-title":"Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer","volume":"318","author":"Wei","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000445047","article-title":"Icosabutate, a structurally engineered fatty acid, improves the cardiovascular risk profile in statin-treated patients with residual hypertriglyceridemia","volume":"135","author":"Kastelein","year":"2016","journal-title":"Cardiology"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jacl.2015.10.012","article-title":"Icosabutate for the treatment of very high triglycerides: a placebo-controlled, randomized, double-blind, 12-week clinical trial","volume":"10","author":"Bays","year":"2016","journal-title":"J\u00a0Clin Lipidol"},{"issue":"suppl_2","key":"10.1016\/j.jhep.2021.12.004_bib25","doi-asserted-by":"crossref","DOI":"10.1161\/circ.130.suppl_2.11889","article-title":"Abstract 11889: phase Ib study of icosabutate, a novel structurally enhanced fatty acid, in subjects with hypercholesterolemia","volume":"130","author":"Qin","year":"2014","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jhep.2021.12.004_bib26","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2337\/diabetes.53.3.542","article-title":"Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes","volume":"53","author":"Gaster","year":"2004","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.jhep.2021.12.004_bib27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1194\/jlr.D600047-JLR200","article-title":"Cell-based multiwell assays for the detection of substrate accumulation and oxidation","volume":"48","author":"Wensaas","year":"2007","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jhep.2021.12.004_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.21006","article-title":"Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob\/ob mice","volume":"43","author":"Ding","year":"2006","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/ars.2016.6953","article-title":"Gliptins suppress inflammatory macrophage activation to mitigate inflammation, fibrosis, oxidative stress, and vascular dysfunction in models of nonalcoholic steatohepatitis and liver fibrosis","volume":"28","author":"Wang","year":"2018","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"10.1016\/j.jhep.2021.12.004_bib31","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/gutjnl-2016-312473","article-title":"Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal","volume":"66","author":"Ikenaga","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib32","doi-asserted-by":"crossref","first-page":"17463","DOI":"10.1038\/s41598-019-53323-x","article-title":"Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease","volume":"9","author":"Ashfaq-Khan","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2021.12.004_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ebiom.2018.01.028","article-title":"IL-4 receptor alpha signaling through macrophages differentially regulates liver fibrosis progression and reversal","volume":"29","author":"Weng","year":"2018","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.jhep.2021.12.004_bib34","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jhep.2020.06.007","article-title":"Repeated FIB-4 measurements can help identify individuals at risk of severe liver disease","volume":"73","author":"Hagstrom","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2021.12.004_bib35","article-title":"A\u00a0placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis","author":"Newsome","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2021.12.004_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"10.1016\/j.jhep.2021.12.004_bib37","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1194\/jlr.M007096","article-title":"Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"51","author":"Feldstein","year":"2010","journal-title":"J\u00a0Lipid Res"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/hep.30969","article-title":"Is\u00a0the\u00a0total amount as important as localization and type of collagen in\u00a0liver\u00a0fibrosis attributable to steatohepatitis?","volume":"71","author":"Karsdal","year":"2020","journal-title":"Hepatology"},{"issue":"396","key":"10.1016\/j.jhep.2021.12.004_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal3694","article-title":"Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-beta","volume":"9","author":"Hart","year":"2017","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.jhep.2021.12.004_bib40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.jhep.2021.12.004_bib41","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/hep.30333","article-title":"Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis","volume":"69","author":"Farrell","year":"2019","journal-title":"Hepatology"},{"issue":"24","key":"10.1016\/j.jhep.2021.12.004_bib42","doi-asserted-by":"crossref","first-page":"18528","DOI":"10.1074\/jbc.M109.099333","article-title":"Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione","volume":"285","author":"Caballero","year":"2010","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020532","article-title":"The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiometabolic risk factors: a systematic review","volume":"19","author":"Innes","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"41","key":"10.1016\/j.jhep.2021.12.004_bib44","doi-asserted-by":"crossref","first-page":"32357","DOI":"10.1074\/jbc.M005638200","article-title":"Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic\u00a0phospholipase A2-linked cascade","volume":"275","author":"Woo","year":"2000","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.jhep.2021.12.004_bib45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.gastro.2018.09.021","article-title":"Factors associated with histologic response in adult patients with nonalcoholic steatohepatitis","volume":"156","author":"Loomba","year":"2019","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jhep.2021.12.004_bib46","first-page":"27","article-title":"A\u00a0simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J\u00a0Basic Clin Pharm"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821022443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827821022443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:45:12Z","timestamp":1759175112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827821022443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0168827821022443"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2021.12.004","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2021.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}