{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:39:43Z","timestamp":1792532383305,"version":"4.5.0"},"reference-count":256,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K0019494\/1"],"award-info":[{"award-number":["MR\/K0019494\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R023026\/1"],"award-info":[{"award-number":["MR\/R023026\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jhep.2022.01.029","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T02:20:29Z","timestamp":1644632429000},"page":"219-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Metabolic dysfunction and cancer in HCV: Shared pathways and mutual interactions"],"prefix":"10.1016","volume":"77","author":[{"given":"Jack","family":"Leslie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-7469","authenticated-orcid":false,"given":"Daniel","family":"Geh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-3734","authenticated-orcid":false,"given":"Ahmed M.","family":"Elsharkawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-224X","authenticated-orcid":false,"given":"Michele","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2022.01.029_bib1","series-title":"Global Hepatitis Report, 2017","year":"2017"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.gtc.2020.01.001","article-title":"Global epidemiology of viral hepatitis","volume":"49","author":"Razavi","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib3","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJMra2033539","article-title":"Extrahepatic manifestations of chronic HCV infection","volume":"384","author":"Cacoub","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib4","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/gut.2009.192732","article-title":"Abnormalities of lipid metabolism in hepatitis C virus infection","volume":"59","author":"Negro","year":"2010","journal-title":"Gut"},{"issue":"24","key":"10.1016\/j.jhep.2022.01.029_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246333","article-title":"Altered metabolic profile and adipocyte insulin resistance mark severe liver fibrosis in patients with chronic liver disease","volume":"20","author":"Gaggini","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejim.2014.12.001","article-title":"Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease","volume":"26","author":"Pais","year":"2015","journal-title":"Eur J Intern Med"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/00042737-199602000-00006","article-title":"Liver steatosis and chronic hepatitis C","volume":"8","author":"Fiore","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jhep.2016.04.008","article-title":"Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy","volume":"65","author":"Reig","year":"2016","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-pathol-012615-044224","article-title":"Nonalcoholic fatty liver disease: pathogenesis and disease spectrum","volume":"11","author":"Hardy","year":"2016","journal-title":"Annu Rev Pathol Mech Dis"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A\u00a0new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J\u00a0Hepatol"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib11","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1053\/j.gastro.2019.12.054","article-title":"Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease","volume":"158","author":"Azzu","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.01.029_bib12","article-title":"Increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis with concurrent fatty liver","author":"Kim","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib13","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s10620-005-2788-1","article-title":"Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver","volume":"50","author":"Yamaguchi","year":"2005","journal-title":"Dig Dis Sci"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib14","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1053\/j.gastro.2010.03.008","article-title":"Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner","volume":"138","author":"Lin","year":"2010","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-230X-13-112","article-title":"Impaired mitochondrial \u03b2-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance","volume":"13","author":"Sato","year":"2013","journal-title":"BMC Gastroenterol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib18","first-page":"683","article-title":"PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice","volume":"118","author":"Tanaka","year":"2008","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib19","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/hep.22508","article-title":"Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production","volume":"48","author":"Yang","year":"2008","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib20","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0168-8278(00)00036-2","article-title":"Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C","volume":"34","author":"Serfaty","year":"2001","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib21","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1053\/jhep.2002.32470","article-title":"Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity","volume":"35","author":"Tsutsumi","year":"2002","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib22","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jhep.2004.12.034","article-title":"An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation","volume":"42","author":"Abid","year":"2005","journal-title":"J\u00a0Hepatol"},{"issue":"12","key":"10.1016\/j.jhep.2022.01.029_bib23","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/nchembio.2193","article-title":"Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection","volume":"12","author":"Levy","year":"2016","journal-title":"Nat Chem Biol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1053\/j.gastro.2004.11.016","article-title":"Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection","volume":"128","author":"Dharancy","year":"2005","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2036.2006.02729.x","article-title":"Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection","volume":"23","author":"de Gottardi","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/hep.21751","article-title":"Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction","volume":"46","author":"Diamond","year":"2007","journal-title":"Hepatology"},{"issue":"14","key":"10.1016\/j.jhep.2022.01.029_bib27","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1073\/pnas.0700760104","article-title":"Hepatitis C virus\u00a0production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins","volume":"104","author":"Huang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib28","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1128\/JVI.02053-07","article-title":"Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion","volume":"82","author":"Gastaminza","year":"2008","journal-title":"J\u00a0Virol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib29","doi-asserted-by":"crossref","DOI":"10.1096\/fj.01-0396com","article-title":"Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis","volume":"16","author":"Perlemuter","year":"2002","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000719","article-title":"Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics","volume":"6","author":"Diamond","year":"2010","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1053\/j.gastro.2007.11.010","article-title":"Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis","volume":"134","author":"Moucari","year":"2008","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib32","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0168-8278(05)80631-2","article-title":"Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population","volume":"21","author":"Allison","year":"1994","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/cen.13924","article-title":"Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure","volume":"90","author":"Lim","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib34","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/hep.23031","article-title":"Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C","volume":"50","author":"Vanni","year":"2009","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib35","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1053\/j.gastro.2009.11.050","article-title":"Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance","volume":"138","author":"Milner","year":"2010","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217751","article-title":"Treatment with direct-acting antivirals improves peripheral insulin sensitivity in non-diabetic, lean chronic hepatitis C patients","volume":"14","author":"Gastaldi","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib37","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2003.11.056","article-title":"Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance","volume":"126","author":"Shintani","year":"2004","journal-title":"Gastroenterology"},{"issue":"31","key":"10.1016\/j.jhep.2022.01.029_bib38","doi-asserted-by":"crossref","first-page":"12860","DOI":"10.1074\/jbc.M117.785030","article-title":"Hepatitis C virus induces a prediabetic state by directly impairing hepatic glucose metabolism in mice","volume":"292","author":"Lerat","year":"2017","journal-title":"J\u00a0Biol Chem"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib39","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/hep.27047","article-title":"Relationship of hepatitis C virus infection with diabetes in the U.S. population","volume":"60","author":"Ruhl","year":"2014","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.jhep.2022.01.029_bib40","doi-asserted-by":"crossref","first-page":"592","DOI":"10.7326\/0003-4819-133-8-200010170-00009","article-title":"Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States","volume":"133","author":"Mehta","year":"2000","journal-title":"Ann Intern Med"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib41","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s11606-020-05782-6","article-title":"Excess weight gain after cure of hepatitis C infection with direct-acting antivirals","volume":"35","author":"Do","year":"2020","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.jhep.2022.01.029_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-48382-5_1","article-title":"The definition and prevalence of obesity and metabolic syndrome","volume":"960","author":"Engin","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib43","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib44","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","article-title":"Adipose tissue expandability, lipotoxicity and the\u00a0Metabolic Syndrome--an allostatic perspective","volume":"1801","author":"Virtue","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib45","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/hep.25539","article-title":"Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease","volume":"55","author":"Lomonaco","year":"2012","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MD.0b013e3182779d49","article-title":"Nonalcoholic fatty liver disease in lean individuals in the United States","volume":"91","author":"Younossi","year":"2012","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib47","doi-asserted-by":"crossref","DOI":"10.1111\/obr.12358","article-title":"Why are there race\/ethnic differences in adult body mass index-adiposity relationships? A quantitative critical review","volume":"17","author":"Heymsfield","year":"2016","journal-title":"Obes Rev"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib48","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jhepr.2019.08.002","article-title":"Non-alcoholic fatty liver disease in lean individuals","volume":"1","author":"Albhaisi","year":"2019","journal-title":"JHEP Reports Innov Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib49","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0038-1677517","article-title":"NASH in lean individuals","volume":"39","author":"Younes","year":"2019","journal-title":"Semin Liver Dis"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib50","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1210\/jc.2013-3253","article-title":"Association of adipose tissue and liver fibrosis with tissue stiffness in morbid obesity: links with diabetes and BMI loss after gastric bypass","volume":"99","author":"Abdennour","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib51","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrendo.2017.90","article-title":"Adapting to obesity with adipose tissue inflammation","volume":"13","author":"Reilly","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib52","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.jhep.2011.12.015","article-title":"Structural and inflammatory heterogeneity in subcutaneous adipose\u00a0tissue: relation with liver histopathology in morbid obesity","volume":"56","author":"Tordjman","year":"2012","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib53","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2009.02.031","article-title":"Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status","volume":"51","author":"Tordjman","year":"2009","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib54","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cmet.2013.06.016","article-title":"Fibrosis and adipose tissue dysfunction","volume":"18","author":"Sun","year":"2013","journal-title":"Cell Metab"},{"issue":"6 Pt 2","key":"10.1016\/j.jhep.2022.01.029_bib55","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S1262-3636(08)74601-9","article-title":"Adipose tissue inflammation and liver pathology in human obesity","volume":"34","author":"Tordjman","year":"2008","journal-title":"Diabetes Metab"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib56","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1365-2796.2007.01851.x","article-title":"Regulation of inflammation-related genes in human adipose tissue","volume":"262","author":"Clement","year":"2007","journal-title":"J\u00a0Intern Med"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib57","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/jhep.2003.50267","article-title":"Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C","volume":"38","author":"Poynard","year":"2003","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib58","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jhep.2020.11.021","article-title":"Clinical outcomes following DAA therapy in patients with HCV-related cirrhosis depend on disease severity","volume":"74","author":"Krassenburg","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"10","key":"10.1016\/j.jhep.2022.01.029_bib59","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1007\/s11606-020-06004-9","article-title":"Hepatitis C virus cure and obesity: watch the weight","volume":"35","author":"Mukhtar","year":"2020","journal-title":"J\u00a0Gen Intern Med"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib60","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000513705","article-title":"Impact of obesity and heavy alcohol consumption on hepatocellular carcinoma development after HCV eradication with antivirals","volume":"10","author":"Minami","year":"2021","journal-title":"Liver cancer"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib61","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1053\/j.gastro.2017.06.012","article-title":"Risk of hepatocellular cancer in HCV patients treated with direct-acting antiviral agents","volume":"153","author":"Kanwal","year":"2017","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib62","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jhep.2016.06.015","article-title":"Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals","volume":"65","author":"Conti","year":"2016","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib63","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000503074","article-title":"Long-term follow-up of advanced liver disease after sustained virological response to treatment of hepatitis C with direct-acting antivirals: outcomes from a real-world Portuguese cohort","volume":"27","author":"Pereira Guedes","year":"2020","journal-title":"GE Port J Gastroenterol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib64","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jhep.2020.03.031","article-title":"DAA therapy and long-term hepatic function in advanced\/decompensated cirrhosis: real-world experience from HCV-TARGET cohort","volume":"73","author":"Verna","year":"2020","journal-title":"J\u00a0Hepatol"},{"issue":"8","key":"10.1016\/j.jhep.2022.01.029_bib65","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.2337\/dc18-0071","article-title":"Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars","volume":"41","author":"Luukkonen","year":"2018","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib66","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13059-018-1439-8","article-title":"Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption","volume":"19","author":"Sanders","year":"2018","journal-title":"Genome Biol"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib67","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/hep.23229","article-title":"The plasma lipidomic signature of nonalcoholic steatohepatitis","volume":"50","author":"Puri","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.01.029_bib68","doi-asserted-by":"crossref","first-page":"101210","DOI":"10.1016\/j.molmet.2021.101210","article-title":"Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression","volume":"48","author":"Azzu","year":"2021","journal-title":"Mol Metab"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib69","doi-asserted-by":"crossref","first-page":"10596","DOI":"10.1038\/s41598-019-46664-0","article-title":"Virus genotype-dependent transcriptional alterations in lipid metabolism and inflammation pathways in the hepatitis C virus-infected liver","volume":"9","author":"d\u2019Avigdor","year":"2019","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib70","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1477-2574.2010.00207.x","article-title":"Evidence of aberrant lipid metabolism in hepatitis C and hepatocellular carcinoma","volume":"12","author":"Wu","year":"2010","journal-title":"HPB (Oxford)"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib71","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1053\/j.gastro.2006.02.035","article-title":"Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis","volume":"130","author":"Mirandola","year":"2006","journal-title":"Gastroenterology"},{"issue":"48","key":"10.1016\/j.jhep.2022.01.029_bib72","doi-asserted-by":"crossref","first-page":"33466","DOI":"10.1074\/jbc.M109.019810","article-title":"Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice","volume":"284","author":"Lerat","year":"2009","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib73","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-0035-1562945","article-title":"Fatty acid and glucose sensors in hepatic lipid metabolism: implications in NAFLD","volume":"35","author":"Vacca","year":"2015","journal-title":"Semin Liver Dis"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031812","article-title":"Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass","volume":"7","author":"Knebel","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib75","first-page":"956","article-title":"ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver","volume":"118","author":"Denechaud","year":"2008","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib76","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1172\/JCI41636","article-title":"The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans","volume":"122","author":"Benhamed","year":"2012","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib77","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0002-9440(10)63408-6","article-title":"Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3","volume":"165","author":"Kawaguchi","year":"2004","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib78","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1128\/JVI.01683-06","article-title":"Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein","volume":"81","author":"Miyamoto","year":"2007","journal-title":"J\u00a0Virol"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib79","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/gut.2006.108647","article-title":"The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model","volume":"56","author":"Hourioux","year":"2007","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib80","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2007.08.006","article-title":"Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver","volume":"6","author":"Matsumoto","year":"2007","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib81","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2008.06.006","article-title":"Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation","volume":"8","author":"Dong","year":"2008","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib82","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1210\/en.2004-0921","article-title":"Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance","volume":"146","author":"Khamzina","year":"2005","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.jhep.2022.01.029_bib83","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1210\/en.2006-0541","article-title":"Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism","volume":"147","author":"Qu","year":"2006","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib84","first-page":"986","article-title":"Increased insulin receptor substrate 2 expression is associated with\u00a0steatohepatitis and altered lipid metabolism in obese subjects","volume":"37","author":"Rametta","year":"2013","journal-title":"Int\u00a0J\u00a0Obes (Lond)"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib85","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2337\/db07-0714","article-title":"Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis","volume":"57","author":"Valenti","year":"2008","journal-title":"Diabetes"},{"issue":"29","key":"10.1016\/j.jhep.2022.01.029_bib86","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1038\/onc.2013.347","article-title":"Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor","volume":"33","author":"Liu","year":"2014","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib87","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1053\/j.gastro.2007.10.010","article-title":"PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65\/mTOR-dependent mechanism","volume":"134","author":"Vinciguerra","year":"2008","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib88","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/hep.22737","article-title":"Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes","volume":"49","author":"Vinciguerra","year":"2009","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib89","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/hep.24340","article-title":"Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets","volume":"54","author":"Cl\u00e9ment","year":"2011","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib90","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jhep.2013.04.012","article-title":"PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism","volume":"59","author":"Peyrou","year":"2013","journal-title":"J\u00a0Hepatol"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib91","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/liv.14112","article-title":"Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein","volume":"39","author":"Cl\u00e9ment","year":"2019","journal-title":"Liver Int"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib92","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41580-018-0015-0","article-title":"The functions and regulation of the\u00a0PTEN\u00a0tumour suppressor: new modes and prospects","volume":"19","author":"Lee","year":"2018","journal-title":"Nat Rev Mol\u00a0Cell\u00a0Biol"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib93","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1073\/pnas.0308617100","article-title":"Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]","volume":"101","author":"Stiles","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.jhep.2022.01.029_bib94","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1172\/JCI20513","article-title":"Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas","volume":"113","author":"Horie","year":"2004","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib95","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ijc.10458","article-title":"Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthase","volume":"100","author":"Rahman","year":"2002","journal-title":"Int J Cancer"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib96","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1053\/j.gastro.2003.08.032","article-title":"Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]","volume":"125","author":"Hui","year":"2003","journal-title":"Gastroenterology"},{"issue":"18","key":"10.1016\/j.jhep.2022.01.029_bib97","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3748\/wjg.v16.i18.2265","article-title":"Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection","volume":"16","author":"Hung","year":"2010","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib98","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1053\/j.gastro.2006.03.014","article-title":"Relationship between steatosis, inflammation, and fibrosis in chronic\u00a0hepatitis C: a meta-analysis of individual patient data","volume":"130","author":"Leandro","year":"2006","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib99","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/hep.1840150403","article-title":"The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis","volume":"15","author":"Bach","year":"1992","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4254\/wjh.v11.i1.1","article-title":"Hepatocellular carcinoma in non-cirrhotic liver: a comprehensive review","volume":"11","author":"Desai","year":"2019","journal-title":"World J Hepatol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib101","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.pharmthera.2013.12.004","article-title":"Molecular targets for cancer therapy in the PI3K\/AKT\/mTOR pathway","volume":"142","author":"Polivka","year":"2014","journal-title":"Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib102","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/hep.21651","article-title":"WNT\/beta-catenin signaling in liver health and disease","volume":"45","author":"Thompson","year":"2007","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib103","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2022.01.029_bib104","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fendo.2018.00338","article-title":"PTEN: tumor suppressor and metabolic regulator","volume":"9","author":"Chen","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"10.1016\/j.jhep.2022.01.029_bib105","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","article-title":"Akt signalling in health and disease","volume":"23","author":"Hers","year":"2011","journal-title":"Cell Signal"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008181","article-title":"Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals","volume":"15","author":"Perez","year":"2019","journal-title":"PLoS Genet"},{"issue":"8","key":"10.1016\/j.jhep.2022.01.029_bib107","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1053\/j.gastro.2019.02.038","article-title":"HCV-induced epigenetic changes associated with liver\u00a0cancer\u00a0risk\u00a0persist after sustained virologic response","volume":"156","author":"Hamdane","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.01.029_bib108","doi-asserted-by":"crossref","first-page":"8341937","DOI":"10.1155\/2016\/8341937","article-title":"Hepatitis C virus NS5A protein triggers oxidative stress by inducing NADPH oxidases 1 and 4 and cytochrome P450 2E1","volume":"2016","author":"Smirnova","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib109","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1053\/gast.2002.30983","article-title":"Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein","volume":"122","author":"Okuda","year":"2002","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib110","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3390\/v5020439","article-title":"HCV and oxidative stress in the liver","volume":"5","author":"Ivanov","year":"2013","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib111","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/hep.23671","article-title":"Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection","volume":"52","author":"de Mochel","year":"2010","journal-title":"Hepatology"},{"issue":"17","key":"10.1016\/j.jhep.2022.01.029_bib112","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1073\/pnas.1321114111","article-title":"Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence","volume":"111","author":"Kim","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib113","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1128\/JVI.00769-09","article-title":"Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1\u03b1-mediated glycolytic adaptation","volume":"84","author":"Ripoli","year":"2010","journal-title":"J\u00a0Virol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003285","article-title":"Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy","volume":"9","author":"Kim","year":"2013","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib115","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/path.2703","article-title":"In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C","volume":"221","author":"Asselah","year":"2010","journal-title":"J\u00a0Pathol"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib116","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024660","article-title":"HCV causes chronic endoplasmic reticulum stress leading to adaptation\u00a0and interference with the unfolded protein response","volume":"6","author":"Merquiol","year":"2011","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.jhep.2022.01.029_bib117","doi-asserted-by":"crossref","first-page":"7453","DOI":"10.1128\/JVI.76.15.7453-7459.2002","article-title":"Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway","volume":"76","author":"Tardif","year":"2002","journal-title":"J\u00a0Virol"},{"issue":"10","key":"10.1016\/j.jhep.2022.01.029_bib118","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/j.1572-0241.2002.06041.x","article-title":"Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C","volume":"97","author":"Yadav","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib120","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/jmv.21661","article-title":"Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells","volume":"82","author":"Moriya","year":"2010","journal-title":"J\u00a0Med Virol"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib121","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jhep.2005.03.004","article-title":"NASH: a mitochondrial disease","volume":"42","author":"Pessayre","year":"2005","journal-title":"J\u00a0Hepatol"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib122","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/gast.2001.23256","article-title":"Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities","volume":"120","author":"Sanyal","year":"2001","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111410","article-title":"Hepatitis C virus downregulates core subunits of oxidative phosphorylation, reminiscent of the warburg effect in cancer cells","volume":"8","author":"Gerresheim","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib124","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1038\/s41598-019-40028-4","article-title":"The metabolic fingerprints of HCV and HBV infections studied by Nuclear Magnetic Resonance Spectroscopy","volume":"9","author":"Meoni","year":"2019","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib125","doi-asserted-by":"crossref","first-page":"826","DOI":"10.2174\/1389450116666150825110532","article-title":"Innate and adaptive immune responses in chronic HCV infection","volume":"18","author":"Dustin","year":"2017","journal-title":"Curr Drug Targets"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib126","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni1102-991","article-title":"Cancer immunoediting: from immunosurveillance to tumor escape","volume":"3","author":"Dunn","year":"2002","journal-title":"Nat Immunol"},{"issue":"12","key":"10.1016\/j.jhep.2022.01.029_bib127","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1093\/infdis\/jiw457","article-title":"Direct-acting antiviral-induced hepatitis C virus clearance does not completely restore the altered cytokine and chemokine milieu in patients with chronic hepatitis C","volume":"214","author":"Hengst","year":"2016","journal-title":"J\u00a0Infect Dis"},{"issue":"7854","key":"10.1016\/j.jhep.2022.01.029_bib128","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41586-021-03362-0","article-title":"NASH limits anti-tumour surveillance in immunotherapy-treated HCC","volume":"592","author":"Pfister","year":"2021","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2020.11.040","article-title":"Residual risk of liver disease after hepatitis C virus eradication","volume":"74","author":"Negro","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"8","key":"10.1016\/j.jhep.2022.01.029_bib130","doi-asserted-by":"crossref","DOI":"10.3390\/v12080799","article-title":"Reversal of T Cell exhaustion in chronic HCV infection","volume":"12","author":"Osuch","year":"2020","journal-title":"Viruses"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib131","doi-asserted-by":"crossref","DOI":"10.3390\/v10110645","article-title":"HCV-specific T cell responses during and after chronic HCV infection","volume":"10","author":"Luxenburger","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.jhep.2022.01.029_bib132","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.3389\/fimmu.2019.01926","article-title":"Direct-acting antiviral treatment of HCV infection does not resolve the dysfunction of circulating CD8+ T-cells in advanced liver disease","volume":"10","author":"Vranjkovic","year":"2019","journal-title":"Front Immunol"},{"issue":"7374","key":"10.1016\/j.jhep.2022.01.029_bib133","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10599","article-title":"Senescence surveillance of pre-malignant hepatocytes limits liver cancer development","volume":"479","author":"Kang","year":"2011","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jhep.2022.01.029_bib134","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib135","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.cell.2020.11.009","article-title":"Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity","volume":"183","author":"Ringel","year":"2020","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib136","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0016-5085(99)70353-7","article-title":"Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C","volume":"117","author":"Gerlach","year":"1999","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.jhep.2022.01.029_bib137","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1172\/JCI43127","article-title":"Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity","volume":"120","author":"McMahan","year":"2010","journal-title":"J\u00a0Clin Invest"},{"issue":"7593","key":"10.1016\/j.jhep.2022.01.029_bib138","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature16969","article-title":"NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis","volume":"531","author":"Ma","year":"2016","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib139","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jhep.2016.12.019","article-title":"Increased peripheral CD4+ regulatory T cells persist after successful\u00a0direct-acting antiviral treatment of chronic hepatitis C","volume":"66","author":"Langhans","year":"2017","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib140","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhep.2014.08.038","article-title":"Regulatory CD4+ T cells modulate the interaction between\u00a0NK\u00a0cells\u00a0and\u00a0hepatic stellate cells by acting on either cell type","volume":"62","author":"Langhans","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib141","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jhep.2021.07.032","article-title":"Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis","volume":"75","author":"Wang","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.01.029_bib142","article-title":"The detrimental role of regulatory T cells in nonalcoholic steatohepatitis","author":"Dywicki","year":"2021","journal-title":"Hepatol Commun"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib143","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a037101","article-title":"Control of HCV infection by natural killer cells and macrophages","volume":"10","author":"Rosen","year":"2020","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib144","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep4.1166","article-title":"Early and late changes in natural killer cells in response to ledipasvir\/sofosbuvir treatment","volume":"2","author":"Golden-Mason","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2022.01.029_bib145","doi-asserted-by":"crossref","first-page":"640869","DOI":"10.3389\/fimmu.2021.640869","article-title":"Revisiting the role of natural killer cells in non-alcoholic fatty liver disease","volume":"12","author":"Mart\u00ednez-Chantar","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib146","doi-asserted-by":"crossref","DOI":"10.1111\/j.1440-1746.2006.04454.x","article-title":"Role of cell-cycle turnover and oxidative stress in telomere shortening and cellular senescence in patients with chronic hepatitis C","volume":"22","author":"Sekoguchi","year":"2007","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib147","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/apt.14802","article-title":"Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection","volume":"48","author":"Wandrer","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib148","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/hep.29604","article-title":"Telomere length and reactive oxygen species levels are positively associated with a high risk of mortality and recurrence in hepatocellular carcinoma","volume":"67","author":"Ko","year":"2018","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib149","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/hep.510300211","article-title":"Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: convenient evaluation by slot-blot analysis","volume":"30","author":"Isokawa","year":"1999","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib150","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1053\/gast.1997.v112.pm9024303","article-title":"Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease","volume":"112","author":"Kojima","year":"1997","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib151","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/hupa.2001.22747","article-title":"Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas","volume":"32","author":"Paradis","year":"2001","journal-title":"Hum Pathol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib152","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1440-1827.2009.02504.x","article-title":"Nuclear size measurement is a simple method for the assessment of hepatocellular aging in non-alcoholic fatty liver disease: comparison with telomere-specific quantitative FISH and p21 immunohistochemistry","volume":"60","author":"Nakajima","year":"2010","journal-title":"Pathol Int"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib153","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/jdi.12555","article-title":"Deoxyribonucleic acid telomere length shortening can predict the incidence of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus","volume":"8","author":"Ping","year":"2017","journal-title":"J\u00a0Diabetes Investig"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib154","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1158\/2159-8290.CD-16-0932","article-title":"Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity","volume":"7","author":"Loo","year":"2017","journal-title":"Cancer Discov"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib155","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jhep.2020.11.052","article-title":"Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target","volume":"74","author":"Ningarhari","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib156","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jhep.2016.05.030","article-title":"Senescence in chronic liver disease: is the future in aging?","volume":"65","author":"Aravinthan","year":"2016","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib157","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2016.171","article-title":"Telomeres in cancer: tumour suppression and genome instability","volume":"18","author":"Maciejowski","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"10.1016\/j.jhep.2022.01.029_bib158","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A\u00a0complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat Cell Biol"},{"issue":"7372","key":"10.1016\/j.jhep.2022.01.029_bib159","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2022.01.029_bib160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu Rev Pathol"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib161","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106048","article-title":"Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner","volume":"40","author":"Lagnado","year":"2021","journal-title":"EMBO J"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib162","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41574-020-0335-y","article-title":"The role of cellular senescence in ageing and endocrine disease","volume":"16","author":"Khosla","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib163","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib164","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1038\/s41467-019-12664-x","article-title":"Mice with hyper-long telomeres show less metabolic aging and longer lifespans","volume":"10","author":"Mu\u00f1oz-Lorente","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib165","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2013.08.011","article-title":"Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team","volume":"60","author":"Dyson","year":"2014","journal-title":"J\u00a0Hepatol"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib166","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20071723","article-title":"The role of fibrosis and liver-associated fibroblasts in the pathogenesis of hepatocellular carcinoma","volume":"20","author":"Baglieri","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2022.01.029_bib167","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathol-052016-100322","article-title":"The role of cancer-associated fibroblasts and fibrosis in liver cancer","volume":"12","author":"Affo","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jhep.2022.01.029_bib168","doi-asserted-by":"crossref","first-page":"22487","DOI":"10.1038\/srep22487","article-title":"HCV induces transforming growth factor \u03b21 through activation of endoplasmic reticulum stress and the unfolded protein response","volume":"6","author":"Chusri","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib169","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1124\/pr.108.00001","article-title":"Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis","volume":"60","author":"Anderson","year":"2008","journal-title":"Pharmacol Rev"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib170","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1053\/j.gastro.2021.04.064","article-title":"TGF-\u03b2 signaling in liver, pancreas, and gastrointestinal diseases and cancer","volume":"161","author":"Gough","year":"2021","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib171","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112456","article-title":"Simultaneous induction of glycolysis and oxidative phosphorylation during activation of hepatic stellate cells reveals novel mitochondrial targets to treat liver fibrosis","volume":"9","author":"Smith-Cortinez","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib172","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/j.gastro.2020.03.008","article-title":"CPEB4 increases expression of PFKFB3 to induce glycolysis and activate mouse and human hepatic stellate cells, promoting liver fibrosis","volume":"159","author":"Mejias","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib173","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2020.04.037","article-title":"Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation","volume":"73","author":"Bates","year":"2020","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib174","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s10620-017-4470-9","article-title":"Activation of insulin-PI3K\/Akt-p70S6K pathway in hepatic stellate cells contributes to fibrosis in nonalcoholic steatohepatitis","volume":"62","author":"Cai","year":"2017","journal-title":"Dig Dis Sci"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib175","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/hep.510290632","article-title":"Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways","volume":"29","author":"Svegliati-Baroni","year":"1999","journal-title":"Hepatology"},{"issue":"4 Pt 1","key":"10.1016\/j.jhep.2022.01.029_bib176","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.28055","article-title":"High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis","volume":"34","author":"Paradis","year":"2001","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib177","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.tem.2010.08.002","article-title":"Obesity and leptin resistance: distinguishing cause from effect","volume":"21","author":"Myers","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhep.2022.01.029_bib178","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-230X-7-17","article-title":"An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study","volume":"7","author":"Manolakopoulos","year":"2007","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib179","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jhep.2006.10.002","article-title":"Leptin and liver tissue repair: do rodent models provide the answers?","volume":"46","author":"Marra","year":"2007","journal-title":"J\u00a0Hepatol"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib180","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41568-020-0295-5","article-title":"Hyperinsulinaemia in cancer","volume":"20","author":"Gallagher","year":"2020","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib181","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/gut.2004.052167","article-title":"Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study","volume":"54","author":"Davila","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2022.01.029_bib182","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.metabol.2018.11.001","article-title":"Obesity and cancer risk: emerging biological mechanisms and perspectives","volume":"92","author":"Avgerinos","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.jhep.2022.01.029_bib183","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ebiom.2018.02.022","article-title":"Obesity and cancer: existing and new hypotheses for a causal connection","volume":"30","author":"Stone","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jhep.2022.01.029_bib184","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-pathol-012615-044359","article-title":"Obesity, inflammation, and cancer","volume":"11","author":"Deng","year":"2016","journal-title":"Annu Rev Pathol"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib185","first-page":"1384","article-title":"Impaired IRS-1\/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes","volume":"38","author":"Aytug","year":"2003","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib186","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib187","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1038\/s41598-017-03299-3","article-title":"Role of insulin receptor substrates in the progression of hepatocellular carcinoma","volume":"7","author":"Sakurai","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib188","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/hep.31391","article-title":"Lipid remodeling in hepatocyte proliferation and hepatocellular carcinoma","volume":"73","author":"Hall","year":"2021","journal-title":"Hepatology"},{"issue":"13","key":"10.1016\/j.jhep.2022.01.029_bib189","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1158\/0008-5472.CAN-12-3824","article-title":"Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors","volume":"73","author":"Chettouh","year":"2013","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib190","first-page":"1880","article-title":"The insulin\/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents","volume":"119","author":"Celton-Morizur","year":"2009","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib191","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/hep4.1181","article-title":"Inhibition of insulin-like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival","volume":"2","author":"Wang","year":"2018","journal-title":"Hepatol Commun"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib192","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jhep.2010.01.015","article-title":"IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage","volume":"52","author":"Tovar","year":"2010","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib193","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cmet.2018.08.020","article-title":"Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma","volume":"29","author":"Lally","year":"2019","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib194","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1053\/j.gastro.2019.04.003","article-title":"Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development","volume":"157","author":"Lupberger","year":"2019","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib195","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1053\/j.gastro.2010.12.006","article-title":"Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma","volume":"140","author":"Calvisi","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.01.029_bib196","doi-asserted-by":"crossref","first-page":"581863","DOI":"10.3389\/fcell.2020.581863","article-title":"Transcriptomic data analyses reveal a reprogramed lipid metabolism in HCV-derived hepatocellular cancer","volume":"8","author":"Liu","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jhep.2022.01.029_bib197","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-021-04049-2","article-title":"Low glycaemic diets alter lipid metabolism to influence tumour growth","author":"Lien","year":"2021","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jhep.2022.01.029_bib198","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.celrep.2015.10.045","article-title":"Stratification of hepatocellular carcinoma patients based on acetate utilization","volume":"13","author":"Bj\u00f6rnson","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2022.01.029_bib199","doi-asserted-by":"crossref","first-page":"20484","DOI":"10.1038\/srep20484","article-title":"Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1\/FASN pathway in mice","volume":"6","author":"Hu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2022.01.029_bib200","doi-asserted-by":"crossref","first-page":"109336","DOI":"10.1016\/j.cellsig.2019.06.001","article-title":"Role of fatty acid binding proteins (FABPs) in cancer development and progression","volume":"62","author":"McKillop","year":"2019","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib201","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1158\/1940-6207.CAPR-11-0228","article-title":"Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis","volume":"5","author":"Bhalla","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib202","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jhep.2018.12.014","article-title":"Association between physical activity and risk of hepatobiliary cancers: a multinational cohort study","volume":"70","author":"Baumeister","year":"2019","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib203","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jhep.2013.10.034","article-title":"Mediterranean diet and hepatocellular carcinoma","volume":"60","author":"Turati","year":"2014","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib204","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"issue":"14","key":"10.1016\/j.jhep.2022.01.029_bib205","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143424","article-title":"Association of physical activity with the risk of hepatocellular carcinoma in patients with chronic hepatitis B","volume":"13","author":"Chun","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.jhep.2022.01.029_bib206","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1158\/1940-6207.CAPR-19-0447","article-title":"Physical activity and risk of hepatocellular carcinoma among U.S. Men and women","volume":"13","author":"Luo","year":"2020","journal-title":"Cancer Prev Res (Phila)"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib207","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.jhep.2015.01.017","article-title":"Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis","volume":"62","author":"Piguet","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib208","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jhep.2020.02.006","article-title":"Exercise retards hepatocarcinogenesis in obese mice independently of weight control","volume":"73","author":"Arfianti","year":"2020","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib209","doi-asserted-by":"crossref","first-page":"904","DOI":"10.4049\/jimmunol.2001022","article-title":"Moderate exercise inhibits age-related inflammation, liver steatosis, senescence, and tumorigenesis","volume":"206","author":"Bianchi","year":"2021","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib210","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/hep4.1159","article-title":"Anti-tumoral effects of exercise on hepatocellular carcinoma growth","volume":"2","author":"Saran","year":"2018","journal-title":"Hepatol Commun"},{"issue":"10","key":"10.1016\/j.jhep.2022.01.029_bib211","first-page":"582","article-title":"Pharmacologic management of nonalcoholic steatohepatitis","volume":"14","author":"Neuschwander-Tetri","year":"2018","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib212","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tem.2015.11.008","article-title":"The role of cholesterol in the pathogenesis of NASH","volume":"27","author":"Ioannou","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhep.2022.01.029_bib213","doi-asserted-by":"crossref","first-page":"925807","DOI":"10.1155\/2012\/925807","article-title":"Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol","volume":"2012","author":"Enjoji","year":"2012","journal-title":"Int J Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib214","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/gutjnl-2011-301708","article-title":"Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies","volume":"62","author":"Chen","year":"2013","journal-title":"Gut"},{"issue":"19","key":"10.1016\/j.jhep.2022.01.029_bib215","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006888","article-title":"Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patients","volume":"96","author":"Ma","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib216","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa1912035","article-title":"Association of aspirin with hepatocellular carcinoma and liver-related mortality","volume":"382","author":"Simon","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib217","doi-asserted-by":"crossref","first-page":"318","DOI":"10.7326\/M18-2753","article-title":"Lipophilic statins and risk for hepatocellular carcinoma and death in patients with chronic viral hepatitis: results from a nationwide Swedish population","volume":"171","author":"Simon","year":"2019","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib219","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jhep.2014.08.013","article-title":"Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C","volume":"62","author":"Simon","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.01.029_bib220","doi-asserted-by":"crossref","first-page":"33743","DOI":"10.1038\/srep33743","article-title":"Systematic review with network meta-analysis: antidiabetic medication and risk of hepatocellular carcinoma","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.jhep.2022.01.029_bib221","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1177\/1060028013503108","article-title":"Safety and efficacy of metformin in patients with type 2 diabetes mellitus and chronic hepatitis C","volume":"47","author":"Harris","year":"2013","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jhep.2022.01.029_bib222","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1196\/annals.1322.052","article-title":"Induction of apoptosis and inhibition of cell growth\u00a0in\u00a0human hepatocellular carcinoma cells by COX-2 inhibitors","volume":"1028","author":"Foder\u00e0","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib223","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41591-019-0379-5","article-title":"Platelet GPIb\u03b1 is a mediator and potential interventional target for NASH and subsequent liver cancer","volume":"25","author":"Malehmir","year":"2019","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib224","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1053\/j.gastro.2015.09.007","article-title":"Hepatitis C virus infection is associated with increased cardiovascular mortality: a meta-analysis of observational studies","volume":"150","author":"Petta","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.01.029_bib225","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13098-015-0096-2","article-title":"Metabolic syndrome related to cardiovascular events in a 10-year prospective study","volume":"7","author":"Kazlauskien\u0117","year":"2015","journal-title":"Diabetol Metab Syndr"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib226","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11020073","article-title":"Glucagon-like peptide-1 receptor agonists for treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an updated meta-analysis of randomized controlled trials","volume":"11","author":"Mantovani","year":"2021","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib227","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2015.08.038","article-title":"Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis","volume":"64","author":"Armstrong","year":"2016","journal-title":"J\u00a0Hepatol"},{"issue":"12","key":"10.1016\/j.jhep.2022.01.029_bib228","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1056\/NEJMoa2028395","article-title":"A\u00a0placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis","volume":"384","author":"Newsome","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"16","key":"10.1016\/j.jhep.2022.01.029_bib229","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165722","article-title":"Glucagon-like peptide-1 receptor agonist prevented the progression\u00a0of\u00a0hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis","volume":"21","author":"Kojima","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"29","key":"10.1016\/j.jhep.2022.01.029_bib230","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1038\/onc.2017.38","article-title":"The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis","volume":"36","author":"Zhou","year":"2017","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib231","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s42255-020-0209-6","article-title":"Resolution of NASH and hepatic fibrosis by the GLP-1R\/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis","volume":"2","author":"Boland","year":"2020","journal-title":"Nat Metab"},{"issue":"1-2","key":"10.1016\/j.jhep.2022.01.029_bib233","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mce.2012.06.025","article-title":"Nuclear receptors in regenerating liver and hepatocellular carcinoma","volume":"368","author":"Vacca","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib234","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1053\/j.gastro.2015.07.029","article-title":"The FXR-FGF19 gut-liver Axis as a novel \"hepatostat\"","volume":"149","author":"Avila","year":"2015","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib235","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.jhep.2021.07.029","article-title":"Dark and bright side of targeting fibroblast growth factor receptor 4 in the liver","volume":"75","author":"Gadaleta","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"10215","key":"10.1016\/j.jhep.2022.01.029_bib236","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib237","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/hep.27274","article-title":"Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation","volume":"61","author":"Degirolamo","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib238","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13287-021-02298-6","article-title":"Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model","volume":"12","author":"Chen","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jhep.2022.01.029_bib239","doi-asserted-by":"crossref","first-page":"114497","DOI":"10.1016\/j.bcp.2021.114497","article-title":"Activation of FXR modulates SOCS3\/Jak2\/STAT3 signaling axis in a NASH-dependent hepatocellular carcinoma animal model","volume":"186","author":"Attia","year":"2021","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib240","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1038\/s41598-017-12629-4","article-title":"The FXR agonist, obeticholic acid, suppresses HCC proliferation & metastasis: role of IL-6\/STAT3 signalling pathway","volume":"7","author":"Attia","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib241","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1053\/j.gastro.2018.07.027","article-title":"GS-0976 Reduces hepatic steatosis and fibrosis markers in patients with nonalcoholic fatty liver disease","volume":"155","author":"Loomba","year":"2018","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.jhep.2022.01.029_bib242","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/s41591-021-01489-1","article-title":"ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials","volume":"27","author":"Calle","year":"2021","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib243","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jcmgh.2020.06.001","article-title":"Acetyl-CoA carboxylase inhibition improves multiple dimensions of NASH pathogenesis in model systems","volume":"10","author":"Ross","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib244","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J\u00a0Hepatol"},{"issue":"Suppl 4","key":"10.1016\/j.jhep.2022.01.029_bib245","doi-asserted-by":"crossref","first-page":"iv238","DOI":"10.1093\/annonc\/mdy308","article-title":"Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis,\u00a0treatment and follow-up","volume":"29","author":"Vogel","year":"2018","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib246","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/hep.31060","article-title":"Hepatitis C guidance 2019 update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America recommendations for testing, managing, and treating hepatitis C virus infection","volume":"71","author":"Ghany","year":"2020","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib247","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jhepr.2019.11.001","article-title":"Management of patients with pre-therapeutic advanced liver fibrosis following HCV eradication","volume":"1","author":"Nahon","year":"2019","journal-title":"JHEP Rep Innov Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib248","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2020.11.040","article-title":"Residual risk of liver disease after hepatitis C virus eradication","volume":"74","author":"Negro","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"11","key":"10.1016\/j.jhep.2022.01.029_bib249","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/jvh.13167","article-title":"Liver steatosis is a major predictor of poor outcomes in chronic hepatitis C patients with sustained virological response","volume":"26","author":"Peleg","year":"2019","journal-title":"J\u00a0Viral Hepat"},{"issue":"7","key":"10.1016\/j.jhep.2022.01.029_bib250","first-page":"2394","article-title":"Nonalcoholic fatty liver disease risk factors affect liver-related outcomes\u00a0after direct-acting antiviral treatment for hepatitis C","volume":"66","author":"Benhammou","year":"2021","journal-title":"Dig Dis\u00a0Sci"},{"issue":"6","key":"10.1016\/j.jhep.2022.01.029_bib251","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.cgh.2018.10.038","article-title":"Factors associated with increased risk of de novo or\u00a0recurrent hepatocellular carcinoma in patients with cirrhosis treated\u00a0with direct-acting antivirals for HCV infection","volume":"17","author":"Degasperi","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib252","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jhep.2016.10.017","article-title":"Risk of cirrhosis-related complications in patients with advanced fibrosis following hepatitis C virus eradication","volume":"66","author":"van der Meer","year":"2017","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib253","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hep.26644","article-title":"Evaluation of liver disease progression in the German hepatitis\u00a0C\u00a0virus (1b)-contaminated anti-D cohort at 35 years after infection","volume":"59","author":"Wiese","year":"2014","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib254","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jhep.2006.02.014","article-title":"Cancer incidence in people with hepatitis B or C infection: a large community-based linkage study","volume":"45","author":"Amin","year":"2006","journal-title":"J\u00a0Hepatol"},{"issue":"20","key":"10.1016\/j.jhep.2022.01.029_bib255","first-page":"1894","article-title":"Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N\u00a0Engl\u00a0J\u00a0Med"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib256","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12967-020-02404-x","article-title":"Association between body mass index and survival outcomes for cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis","volume":"18","author":"An","year":"2020","journal-title":"J\u00a0Transl Med"},{"issue":"1","key":"10.1016\/j.jhep.2022.01.029_bib257","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41591-018-0221-5","article-title":"Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade","volume":"25","author":"Wang","year":"2019","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.jhep.2022.01.029_bib258","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1470-2045(18)30078-0","article-title":"Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis","volume":"19","author":"McQuade","year":"2018","journal-title":"Lancet Oncol"},{"issue":"4","key":"10.1016\/j.jhep.2022.01.029_bib259","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jamaoncol.2019.5241","article-title":"Association between body mass index and overall survival with immune checkpoint inhibitor therapy for advanced non-small cell lung cancer","volume":"6","author":"Kichenadasse","year":"2020","journal-title":"JAMA Oncol"},{"issue":"2","key":"10.1016\/j.jhep.2022.01.029_bib260","article-title":"Obesity diminishes response to PD-1-based immunotherapies in renal cancer","volume":"8","author":"Boi","year":"2020","journal-title":"J\u00a0Immunother Cancer"},{"issue":"5","key":"10.1016\/j.jhep.2022.01.029_bib261","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12051230","article-title":"The effects of obesity on anti-cancer immunity and cancer immunotherapy","volume":"12","author":"Woodall","year":"2020","journal-title":"Cancers (Basel)"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822000769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822000769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:45:06Z","timestamp":1759175106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827822000769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":256,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0168827822000769"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2022.01.029","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic dysfunction and cancer in HCV: Shared pathways and mutual interactions","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2022.01.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}