{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:34:05Z","timestamp":1783830845933,"version":"3.55.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jhep.2022.03.005","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T11:59:09Z","timestamp":1652702349000},"page":"1306-1317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Long-term albumin treatment in patients with cirrhosis and ascites"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-056X","authenticated-orcid":false,"given":"Paolo","family":"Caraceni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9168-7009","authenticated-orcid":false,"given":"Alastair","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Gines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2022.03.005_bib1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gin\u00e8s","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2022.03.005_bib2","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1073\/pnas.74.4.1358","article-title":"Rat liver preproalbumin: in\u00a0vitro synthesis and partial amino acid sequence","volume":"74","author":"Strauss","year":"1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2022.03.005_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.mam.2011.12.002","article-title":"Human serum albumin: from bench to bedside","volume":"33","author":"Fanali","year":"2012","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.jhep.2022.03.005_bib4","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/gutjnl-2019-318843","article-title":"Albumin in decompensated cirrhosis: new concepts and perspectives","volume":"69","author":"Bernardi","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2022.03.005_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000413159","article-title":"Physiology and pathophysiology of colloid osmotic pressure and albumin metabolism","volume":"53","author":"Lundsgaard-Hansen","year":"1986","journal-title":"Curr Stud Hematol Blood Transfus"},{"key":"10.1016\/j.jhep.2022.03.005_bib6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0016-5085(88)90441-6","article-title":"Prognostic value of arterial pressure, endogenous vasoactive systems, and renal function in cirrhotic patients admitted to the hospital for the treatment of ascites","volume":"94","author":"Llach","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.03.005_bib7","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.jhep.2021.07.018","article-title":"Performance of the model for end-stage liver disease score for mortality prediction and the potential role of etiology","volume":"75","author":"D'Amico","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"6","key":"10.1016\/j.jhep.2022.03.005_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cardfail.2011.02.010","article-title":"Human serum albumin in the clinical syndrome of heart failure","volume":"17","author":"Arques","year":"2011","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jhep.2022.03.005_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jpba.2017.04.023","article-title":"Structural and functional integrity of human serum albumin: analytical approaches and clinical relevance in patients with liver cirrhosis","volume":"144","author":"Naldi","year":"2017","journal-title":"J\u00a0Pharm Biomed Anal"},{"key":"10.1016\/j.jhep.2022.03.005_bib10","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/hep.28740","article-title":"Systemic inflammation in decompensated cirrhosis. Characterization and role in acute-on-chronic liver failure","volume":"64","author":"Cl\u00e0ria","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib11","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.27322","article-title":"Posttranscriptional changes of serum albumin: clinical and prognostic significance in hospitalized patients with cirrhosis","volume":"60","author":"Domenicali","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib12","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/hep.31798","article-title":"Determination of effective albumin in patients with decompensated cirrhosis: clinical and prognostic implications","volume":"74","author":"Baldassarre","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hep.22913","article-title":"Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality","volume":"50","author":"Jalan","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/hep.28897","article-title":"Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis","volume":"65","author":"Das","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib15","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1002\/hep.30135","article-title":"Oxidized albumin triggers a cytokine storm in leukocytes through p38 mitogen-activated protein kinase: role in systemic inflammation in decompensated cirrhosis","volume":"68","author":"Alcaraz-Quiles","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib16","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.26338","article-title":"Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complications","volume":"58","author":"Garcia-Martinez","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1172\/JCI101959","article-title":"The use of concentrated human serum albumin in the treatment of cirrhosis of the liver","volume":"27","author":"Kunkel","year":"1948","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2022.03.005_bib18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL clinical practice guidelines for the management of patients wit decompensated cirrhosis","volume":"69","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib19","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/hep.31884","article-title":"Diagnosis, evaluation, and management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases","volume":"74","author":"Biggins","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib20","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0016-5085(96)70068-9","article-title":"Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis","volume":"111","author":"Gin\u00e8s","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.03.005_bib21","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/0016-5085(88)90691-9","article-title":"Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis","volume":"94","author":"Gin\u00e8s","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.03.005_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41572-018-0022-7","article-title":"Hepatorenal syndrome","volume":"4","author":"Gin\u00e8s","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jhep.2022.03.005_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1053\/jhep.2002.35819","article-title":"Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: results of a prospective, nonrandomized study","volume":"36","author":"Ortega","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jhep.2014.04.012","article-title":"Human serum albumin, systemic inflammation, and cirrhosis","volume":"6","author":"Arroyo","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/j.gastro.2019.03.021","article-title":"Effects of albumin treatment on systemic and portal hemodynamics and systemic inflammation in patients with decompensated cirrhosis","volume":"157","author":"Fern\u00e1ndez","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.03.005_bib26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hep.20829","article-title":"A\u00a0randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis","volume":"42","author":"Fern\u00e1ndez","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/hep.26021","article-title":"Positive cardiac inotropic effect of albumin infusion in rodents with cirrhosis and ascites: molecular mechanisms","volume":"57","author":"Bortoluzzi","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib28","first-page":"1","article-title":"Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2","volume":"20","author":"O\u2019Brien","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2022.03.005_bib29","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cgh.2017.08.027","article-title":"Albumin counteracts immune-suppressive effects of lipid mediators in patients with advanced liver disease","volume":"16","author":"China","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.cgh.2019.07.055","article-title":"Efficacy of albumin treatment for patients with cirrhosis and infections unrelated to spontaneous bacterial peritonitis","volume":"18","author":"Fern\u00e1ndez","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"566","key":"10.1016\/j.jhep.2022.03.005_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax5135","article-title":"Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis","volume":"12","author":"Casulleras","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhep.2022.03.005_bib32","first-page":"1","article-title":"Hemodynamic and systemic effects of albumin in patients with advanced liver disease","author":"Tufoni","year":"2020","journal-title":"Curr Hepatol Rep"},{"key":"10.1016\/j.jhep.2022.03.005_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hep.1840070124","article-title":"Compensated cirrhosis: natural history and prognostic factors","volume":"7","author":"Gin\u00e9s","year":"1987","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D\u2019Amico","year":"2006","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib35","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2021.04.022","article-title":"Bacterial infections adversely influence the risk of decompensation and survival in compensated cirrhosis","volume":"75","author":"Villanueva","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib36","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.jhep.2012.07.020","article-title":"Factors related to quality of life in patients with cirrhosis and ascites: relevance of serum sodium concentration and leg edema","volume":"57","author":"Sol\u00e0","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib37","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.14309\/ajg.0000000000001292","article-title":"Trends\u00a0in the economic burden of chronic liver diseases and cirrhosis\u00a0in\u00a0the United States: 1996-2016","volume":"116","author":"Ma","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2022.03.005_bib38","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0140-6736(62)90895-4","article-title":"The effect of repeated albumin infusions in patients with cirrhosis","volume":"2","author":"Wilkinson","year":"1962","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2022.03.005_bib39","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0140-6736(61)92479-5","article-title":"Intravenous albumin in the treatment of diuretic-resistant ascites in portal cirrhosis","volume":"2","author":"Losowsky","year":"1961","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2022.03.005_bib40","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0168-8278(99)80194-9","article-title":"Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trial","volume":"30","author":"Gentilini","year":"1999","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib41","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3748\/wjg.v12.i9.1403","article-title":"Long-term albumin infusion improves survival in patients with cirrhosis and ascites: an unblinded randomized trial","volume":"12","author":"Romanelli","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2022.03.005_bib42","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/S0140-6736(18)30840-7","article-title":"Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial","volume":"391","author":"Caraceni","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2022.03.005_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/liv.13968","article-title":"Long-term administration of human albumin improves survival in patients with cirrhosis and refractory ascites","volume":"39","author":"Di Pascoli","year":"2019","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2022.03.005_bib44","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jhep.2018.08.006","article-title":"Midodrine and albumin for prevention of complications in patients with cirrhosis awaiting liver transplantation. A randomized placebo-controlled trial","volume":"69","author":"Sol\u00e0","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib45","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jhep.2020.08.021","article-title":"On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites","volume":"74","author":"Caraceni","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib46","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jhep.2020.08.009","article-title":"Endpoints and design of clinical trials in patients with decompensated cirrhosis: position paper of the LiverHope Consortium","volume":"74","author":"Sol\u00e0","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib47","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMra0809139","article-title":"Renal failure in cirrhosis","volume":"361","author":"Gin\u00e8s","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2022.03.005_bib48","doi-asserted-by":"crossref","first-page":"m2687","DOI":"10.1136\/bmj.m2687","article-title":"Hepatorenal syndrome: pathophysiology, diagnosis, and management","volume":"370","author":"Simonetto","year":"2020","journal-title":"Brit Med J"},{"key":"10.1016\/j.jhep.2022.03.005_bib49","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.510290629","article-title":"Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide","volume":"29","author":"Angeli","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib50","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/hep.27709","article-title":"Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: a randomized trial","volume":"62","author":"Cavallin","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib51","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jhep.2014.12.029","article-title":"Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites","volume":"62","author":"Angeli","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib52","article-title":"Baveno VII Renewing consensus in portal hypertension","author":"De Franchis","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib53","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jhep.2012.06.013","article-title":"Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study","volume":"57","author":"Guevara","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib54","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.jhep.2014.11.017","article-title":"Effect of albumin in cirrhotic patients with infection other than spontaneous bacterial peritonitis. A randomized trial","volume":"62","author":"Th\u00e9venot","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib55","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jhep.2012.06.013","article-title":"Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study","volume":"57","author":"Guevara","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib56","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1056\/NEJMoa2022166","article-title":"A\u00a0randomized trial of albumin infusions in hospitalized patients with cirrhosis","volume":"384","author":"China","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2022.03.005_bib57","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.dld.2021.06.021","article-title":"Portal hypertension and ascites: patient-and population-centered clinical practice guidelines by the Italian Association for the Study of the Liver (AISF)","volume":"53","year":"2021","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jhep.2022.03.005_bib58","first-page":"M18","article-title":"The effect of age on serum albumin leveld in healthy males: report from the normative aging study","volume":"43","author":"Campion","year":"1988","journal-title":"Gerontol"},{"key":"10.1016\/j.jhep.2022.03.005_bib59","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa2008290","article-title":"Terlipressin plus albumin for the treatment of type 1 hepatorenal syndrome","volume":"384","author":"Wong","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2022.03.005_bib60","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.cgh.2017.09.012","article-title":"Administration of albumin solution increases serum levels of albumin in patients with chronic liver failure in a single-arm feasibility trial","volume":"16","author":"China","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib61","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/hep.31908","article-title":"The \"Alter Ego\" of albumin in cirrhosis","volume":"74","author":"Mehta","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib62","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/hep.31838","article-title":"The addition of C-reactive protein and Von Willebrand factor to model for end-stage liver disease-sodium improves prediction of waitlist mortality","volume":"74","author":"Starlinger","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.03.005_bib63","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jhep.2021.08.031","article-title":"Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in\u00a0patients with decompensated cirrhosis","volume":"76","author":"Juanola","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib64","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jhep.2016.07.003","article-title":"Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis","volume":"65","author":"Sol\u00e0","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.03.005_bib65","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.29581","article-title":"Cell death markers in patients with cirrhosis and acute decompensation","volume":"67","author":"Macdonald","year":"2018","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822001738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822001738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:44:19Z","timestamp":1759175059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827822001738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0168827822001738"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2022.03.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742171766.793593872","asserted-by":"object"}]},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term albumin treatment in patients with cirrhosis and ascites","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2022.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}