{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:32:51Z","timestamp":1793406771146,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"am","delay-in-days":348,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK084567"],"award-info":[{"award-number":["P30DK084567"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2ZHP3_168561"],"award-info":[{"award-number":["P2ZHP3_168561"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA021171"],"award-info":[{"award-number":["AA021171"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK59615"],"award-info":[{"award-number":["DK59615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jhep.2022.03.029","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T21:08:57Z","timestamp":1649711337000},"page":"723-734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in\u00a0vitro and in\u00a0vivo"],"prefix":"10.1016","volume":"77","author":[{"given":"Thomas","family":"Greuter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Yaqoob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-0121","authenticated-orcid":false,"given":"Nidhi","family":"Jalan-Sakrikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7138-5580","authenticated-orcid":false,"given":"Enis","family":"Kostallari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liankang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejasav S.","family":"Sehrawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-8337","authenticated-orcid":false,"given":"Samar H.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-5929","authenticated-orcid":false,"given":"Kunimaro","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Nozickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing Q.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-7734","authenticated-orcid":false,"given":"Michael","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-3966","authenticated-orcid":false,"given":"Sheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-573X","authenticated-orcid":false,"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jhep.2022.03.029_bib1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00535-016-1190-4","article-title":"Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights","volume":"51","author":"Greuter","year":"2016","journal-title":"J\u00a0Gastroenterol"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/labinvest.3700366","article-title":"Lipopolysaccharide signaling in endothelial cells","volume":"86","author":"Dauphinee","year":"2006","journal-title":"Lab Invest"},{"issue":"4","key":"10.1016\/j.jhep.2022.03.029_bib3","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/hep.22443","article-title":"Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines","volume":"48","author":"Schrage","year":"2008","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jhep.2022.03.029_bib4","doi-asserted-by":"crossref","first-page":"G246","DOI":"10.1152\/ajpgi.00118.2016","article-title":"Angiocrine signaling in the hepatic sinusoids in health and disease","volume":"311","author":"Kostallari","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1053\/j.gastro.2019.03.013","article-title":"Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal hypertension","volume":"157","author":"Hilscher","year":"2019","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.jhep.2022.03.029_bib6","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.bbadis.2013.02.007","article-title":"Tissue mechanics and fibrosis","volume":"1832","author":"Wells","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"10.1016\/j.jhep.2022.03.029_bib7","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.jbiomech.2014.03.031","article-title":"Mechanotransduction and fibrosis","volume":"47","author":"Duscher","year":"2014","journal-title":"J\u00a0Biomech"},{"issue":"12","key":"10.1016\/j.jhep.2022.03.029_bib8","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"10.1016\/j.jhep.2022.03.029_bib9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ceb.2013.05.006","article-title":"Integrins in mechanotransduction","volume":"25","author":"Ross","year":"2013","journal-title":"Curr Opin Cell Biol"},{"issue":"5914","key":"10.1016\/j.jhep.2022.03.029_bib10","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1126\/science.1162912","article-title":"Stretching single talin rod molecules activates vinculin binding","volume":"323","author":"del Rio","year":"2009","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.jhep.2022.03.029_bib11","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1093\/nar\/gkv1348","article-title":"Integrin \u03b14\u03b21 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration","volume":"44","author":"Zhang","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.yexcr.2015.11.017","article-title":"Mechanosensitive components of integrin adhesions: role of vinculin","volume":"343","author":"Atherton","year":"2016","journal-title":"Exp Cell Res"},{"issue":"3","key":"10.1016\/j.jhep.2022.03.029_bib13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","article-title":"Role of PFKFB3-driven glycolysis in vessel sprouting","volume":"154","author":"De Bock","year":"2013","journal-title":"Cell"},{"issue":"7653","key":"10.1016\/j.jhep.2022.03.029_bib14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature22322","article-title":"FGF-dependent metabolic control of vascular development","volume":"545","author":"Yu","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.jhep.2022.03.029_bib15","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","article-title":"Force triggers YAP nuclear entry by regulating transport across nuclear pores","volume":"171","author":"Elosegui-Artola","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2022.03.029_bib16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-kappa B and I kappa B proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bone.2010.03.014","article-title":"Activation of NF-kappaB by fluid shear stress, but not TNF-alpha, requires focal adhesion kinase in osteoblasts","volume":"47","author":"Young","year":"2010","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.jhep.2022.03.029_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005465","article-title":"YAP1 exerts its transcriptional control via TEAD-mediated activation of enhancers","volume":"11","author":"Stein","year":"2015","journal-title":"Plos Genet"},{"issue":"8","key":"10.1016\/j.jhep.2022.03.029_bib20","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1053\/j.gastro.2018.02.015","article-title":"P300 acetyltransferase mediates stiffness-induced activation of hepatic stellate cells into tumor-promoting myofibroblasts","volume":"154","author":"Dou","year":"2018","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.jhep.2022.03.029_bib21","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng1891","article-title":"Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions","volume":"38","author":"Zhao","year":"2006","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ng.3167","article-title":"What are super-enhancers?","volume":"47","author":"Pott","year":"2015","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.jhep.2022.03.029_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jhep.2022.03.029_bib24","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jhep.2022.03.029_bib25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/hep.27387","article-title":"Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces","volume":"61","author":"Simonetto","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib26","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1038\/s41467-021-24843-w","article-title":"Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0003-9861(89)90110-0","article-title":"Properties of the interaction between phosphofructokinase and actin","volume":"269","author":"Roberts","year":"1989","journal-title":"Arch Biochem Biophys"},{"issue":"10","key":"10.1016\/j.jhep.2022.03.029_bib28","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41419-019-1968-4","article-title":"Targeting a moonlighting function of aldolase induces apoptosis in cancer cells","volume":"10","author":"Gizak","year":"2019","journal-title":"Cell Death Dis"},{"issue":"12","key":"10.1016\/j.jhep.2022.03.029_bib29","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1074\/jbc.M115.708313","article-title":"YAP nuclear localization in the absence of cell-cell contact is mediated by a filamentous actin-dependent, myosin II- and phospho-YAP-independent pathway during extracellular matrix mechanosensing","volume":"291","author":"Das","year":"2016","journal-title":"J\u00a0Biol Chem"},{"issue":"5","key":"10.1016\/j.jhep.2022.03.029_bib30","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A\u00a0mechanical checkpoint controls multicellular growth through YAP\/TAZ regulation by actin-processing factors","volume":"154","author":"Aragona","year":"2013","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jhep.2022.03.029_bib31","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/ncb3336","article-title":"Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity","volume":"18","author":"Elosegui-Artola","year":"2016","journal-title":"Nat Cell Biol"},{"issue":"5","key":"10.1016\/j.jhep.2022.03.029_bib32","doi-asserted-by":"crossref","first-page":"100145","DOI":"10.1016\/j.jhepr.2020.100145","article-title":"Nuclear deformation mediates liver cell mechanosensing in cirrhosis","volume":"2","author":"Guix\u00e9-Muntet","year":"2020","journal-title":"JHEP Rep"},{"issue":"12","key":"10.1016\/j.jhep.2022.03.029_bib33","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1164\/rccm.201504-0780OC","article-title":"Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis","volume":"192","author":"Xie","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.jhep.2022.03.029_bib34","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/nmat5024","article-title":"Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis","volume":"16","author":"Liu","year":"2017","journal-title":"Nat Mater"},{"issue":"7","key":"10.1016\/j.jhep.2022.03.029_bib35","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1136\/gutjnl-2015-311157","article-title":"Role and therapeutic potential of vascular stem\/progenitor cells in pathological neovascularisation during chronic portal hypertension","volume":"66","author":"Garcia-Pras","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jhep.2022.03.029_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gutjnl-2015-309600","article-title":"Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis","volume":"66","author":"Klein","year":"2017","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.jhep.2022.03.029_bib37","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143690","article-title":"Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis","volume":"131","author":"Furuta","year":"2021","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.jhep.2022.03.029_bib38","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1053\/j.gastro.2009.07.051","article-title":"Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response","volume":"137","author":"Tang","year":"2009","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jhep.2022.03.029_bib39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/hep.21016","article-title":"Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes","volume":"43","author":"Nahmias","year":"2006","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822002057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822002057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:47:51Z","timestamp":1759175271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827822002057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0168827822002057"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2022.03.029","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in\u00a0vitro and in\u00a0vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2022.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}