{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:12:45Z","timestamp":1794107565551,"version":"4.8.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003030","name":"AGAUR","doi-asserted-by":"publisher","award":["AGAUR-SGR2017-517"],"award-info":[{"award-number":["AGAUR-SGR2017-517"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","award":["BEX 5960\/13-4"],"award-info":[{"award-number":["BEX 5960\/13-4"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"UEFISCDI","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-PD-2016-0689"],"award-info":[{"award-number":["PN-III-P1-1.1-PD-2016-0689"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00131"],"award-info":[{"award-number":["PI21\/00131"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["SAF PID2019-105\/48RB-100"],"award-info":[{"award-number":["SAF PID2019-105\/48RB-100"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00569"],"award-info":[{"award-number":["PI20\/00569"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008318","name":"Asociaci\u00f3n Espa\u00f1ola para el Estudio del H\u00edgado","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006366","name":"Minist\u00e9rio da Educa\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jhep.2022.08.023","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T03:16:29Z","timestamp":1662088589000},"page":"114-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Incidence and factors predictive of recurrent thrombosis in people with non-cirrhotic portal vein thrombosis"],"prefix":"10.1016","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-9203","authenticated-orcid":false,"given":"Anna","family":"Baiges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-1760","authenticated-orcid":false,"given":"Bogdan","family":"Procopet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Silva-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Llop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Tellez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Darnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Garcia-Criado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Turon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Nicoara-Farcau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonz\u00e1lez-Alay\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Larrue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-1739","authenticated-orcid":false,"given":"Marta","family":"Magaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-0284","authenticated-orcid":false,"given":"Pol","family":"Olivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-9511","authenticated-orcid":false,"given":"Valeria","family":"Perez-Campuzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-6591","authenticated-orcid":false,"given":"Jose Luis","family":"Calleja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Albillos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1274-4782","authenticated-orcid":false,"given":"Juan Carlos","family":"Reverter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-0055","authenticated-orcid":false,"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Hern\u00e1ndez-Gea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-4954","authenticated-orcid":false,"given":"Juan Carlos","family":"Garcia-Pag\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2022.08.023_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1055\/s-0028-1085096","article-title":"Extrahepatic portal vein thrombosis","volume":"1","author":"Garcia-Pag\u00e1n","year":"2008","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2022.08.023_bib2","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/liv.14342","article-title":"Congenital antithrombin deficiency in patients with splanchnic vein thrombosis","volume":"40","author":"Baiges","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2022.08.023_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhep.2014.08.032","article-title":"Role of calreticulin mutations in the aetiological diagnosis of splanchnic vein thrombosis","volume":"62","author":"Turon","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jhep.2020.06.045","article-title":"Next-generation sequencing in the diagnosis of non-cirrhotic splanchnic vein thrombosis","volume":"74","author":"Magaz","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib5","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1111\/j.1572-0241.2007.01477.x","article-title":"Prognostic factors in noncirrhotic patients with splanchnic vein thromboses","volume":"102","author":"Amitrano","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2022.08.023_bib6","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1053\/gast.2001.21209","article-title":"Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy","volume":"120","author":"Condat","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.08.023_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jth.12121","article-title":"Anticoagulant therapy in patients with non-cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding","volume":"11","author":"Spaander","year":"2013","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2022.08.023_bib8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhep.2015.07.040","article-title":"EASL Clinical Practice Guidelines: vascular diseases of the liver","volume":"64","author":"Garcia-Pag\u00e1n","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib9","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension. Report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","author":"de Franchis","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII \u2013 renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cgh.2011.09.010","article-title":"Hypercoagulability in patients with chronic noncirrhotic portal vein thrombosis","volume":"10","author":"Raffa","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.thromres.2017.05.002","article-title":"Thrombin generation in patients with non-cirrhotic vascular liver diseases treated or not treated with vitamin K antagonist","volume":"155","author":"de Raucourt","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.jhep.2022.08.023_bib13","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jhep.2008.12.020","article-title":"High levels of factor VIII and risk of extra-hepatic portal vein obstruction","volume":"50","author":"Martinelli","year":"2009","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJM200008173430702","article-title":"High plasma levels of factor VIII and the risk of recurrent venous thromboembolism","volume":"343","author":"Kyrle","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2022.08.023_bib15","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1111\/jth.13113","article-title":"Predictive value of factor VIII levels for recurrent venous thrombosis: results from the MEGA follow-up study","volume":"13","author":"Timp","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jhep.2022.08.023_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/j.seminhematol.2004.09.009","article-title":"von Willebrand factor and factor VIII as risk factors for arterial and venous thrombosis","volume":"42","author":"Martinelli","year":"2005","journal-title":"Semin Hematol"},{"key":"10.1016\/j.jhep.2022.08.023_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0140-6736(95)90166-3","article-title":"Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis","volume":"345","author":"Koster","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2022.08.023_bib18","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1038\/leu.2016.85","article-title":"High rate of recurrent venous thromboembolism in patients with myeloproliferative neoplasms and effect of prophylaxis with vitamin K antagonists","volume":"30","author":"De Stefano","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.jhep.2022.08.023_bib19","first-page":"S191","article-title":"Prophylaxis of recurrent thrombosis by rivaroxaban in patients with non-cirrhotic portal vein thrombosis a multicentre randomized controlled study testing rivaroxaban vs no anticoagulation","volume":"75","author":"Plessier","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.08.023_bib20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0037-1613747","article-title":"High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism","volume":"83","author":"Kraaijenhagen","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2022.08.023_bib21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.thromres.2007.12.024","article-title":"D-dimer and factor VIII\u00a0are independent risk factors for recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis","volume":"122","author":"Cosmi","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.jhep.2022.08.023_bib22","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1046\/j.1365-2141.2003.04795.x","article-title":"High plasma levels of factor VIII and risk of recurrence of venous thromboembolism","volume":"124","author":"Cristina","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jhep.2022.08.023_bib23","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1111\/j.1538-7836.2011.04484.x","article-title":"Long-term follow-up of patients with portal vein thrombosis and myeloproliferative neoplasms","volume":"9","author":"Hoekstra","year":"2011","journal-title":"J\u00a0Thromb Haemost"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822030549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822030549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:21:07Z","timestamp":1778512867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827822030549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0168827822030549"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2022.08.023","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incidence and factors predictive of recurrent thrombosis in people with non-cirrhotic portal vein thrombosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2022.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}