{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:46:16Z","timestamp":1792799176799,"version":"4.5.0"},"reference-count":165,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jhep.2022.09.001","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:55:51Z","timestamp":1663210551000},"page":"401-414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Loss of liver function in chronic liver disease: An\u00a0identity crisis"],"prefix":"10.1016","volume":"78","author":[{"given":"Carmen","family":"Berasain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-1924","authenticated-orcid":false,"given":"Maria","family":"Arechederra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josepmaria","family":"Argem\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite G.","family":"Fern\u00e1ndez-Barrena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-3557","authenticated-orcid":false,"given":"Mat\u00edas A.","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2022.09.001_bib1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00204-013-1078-5","article-title":"Recent advances in 2D and 3D in\u00a0vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME","volume":"87","author":"Godoy","year":"2013","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2022.09.001_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.ctdb.2018.12.003","article-title":"Molecular regulation of mammalian hepatic architecture","volume":"132","author":"Huppert","year":"2019","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41575-019-0134-x","article-title":"Spatial heterogeneity in the mammalian liver","volume":"16","author":"Ben-Moshe","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jhep.2021.10.015","article-title":"Hallmarks of the human intestinal microbiome on liver maturation and function","volume":"76","author":"Almeida","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/hep.32408","article-title":"Liver zonation, revisited","author":"Paris","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082026","article-title":"Transcription control of liver development","volume":"10","author":"Tachmatzidi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2022.09.001_bib7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature21065","article-title":"Single-cell spatial reconstruction reveals global division of labour in the mammalian liver","volume":"542","author":"Halpern","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2022.09.001_bib8","doi-asserted-by":"crossref","DOI":"10.1242\/dev.199814","article-title":"Signalling pathways and transcriptional regulators orchestrating liver development and cancer","volume":"148","author":"Campbell","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.jhep.2022.09.001_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.tig.2020.05.002","article-title":"Unraveling the epigenetic basis of liver development, regeneration and disease","author":"Macchi","year":"2020","journal-title":"Trends Genet"},{"key":"10.1016\/j.jhep.2022.09.001_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14092048","article-title":"DNA methylation regulates a set of long non-coding RNAs compromising hepatic identity during hepatocarcinogenesis","volume":"14","author":"Recalde","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jhep.2022.09.001_bib11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1101\/gad.337691.120","article-title":"Collapse of the hepatic gene regulatory network in the absence of FoxA factors","volume":"34","author":"Reizel","year":"2020","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhep.2022.09.001_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib13","article-title":"Clinical presentation of alcoholic liver disease and non-alcoholic fatty liver disease: spectrum and diagnosis","volume":"5","author":"Sharma","year":"2020","journal-title":"Transl Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib14","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gin\u00e8s","year":"2021","journal-title":"Lancet (London, England)"},{"issue":"Suppl 1","key":"10.1016\/j.jhep.2022.09.001_bib15","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.jhep.2021.01.002","article-title":"Pathophysiology of decompensated cirrhosis: portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction","volume":"75","author":"Engelmann","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib16","article-title":"Natural recovery by the liver and other organs after chronic alcohol use","volume":"41","author":"Thomes","year":"2021","journal-title":"Alcohol Res"},{"key":"10.1016\/j.jhep.2022.09.001_bib17","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story","volume":"64","author":"Lee","year":"2015","journal-title":"Gut"},{"issue":"Suppl 1","key":"10.1016\/j.jhep.2022.09.001_bib18","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.jhep.2021.01.018","article-title":"New clinical and pathophysiological perspectives defining the trajectory of cirrhosis","volume":"75","author":"Jalan","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1155\/1997\/34842","article-title":"Significance of liver size in hepatic surgery","volume":"10","author":"Yanaga","year":"1997","journal-title":"HPB Surg"},{"key":"10.1016\/j.jhep.2022.09.001_bib20","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1007\/s00018-015-1970-7","article-title":"Regulation of hepatocyte identity and quiescence","volume":"72","author":"Berasain","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jhep.2022.09.001_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0041-1725023","article-title":"The inside-out of end-stage liver disease: hepatocytes are the keystone","volume":"41","author":"Haep","year":"2021","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib22","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1242\/dev.114215","article-title":"Orchestrating liver development","volume":"142","author":"Gordillo","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.jhep.2022.09.001_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/cas.15352","article-title":"Physiological and pathological roles of the Hippo-YAP\/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis","author":"Nishina","year":"2022","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jhep.2022.09.001_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-021-00571-w","article-title":"Hippo signalling in the liver: role in development, regeneration and disease","volume":"19","author":"Russell","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib25","doi-asserted-by":"crossref","first-page":"13795","DOI":"10.1074\/jbc.R117.001232","article-title":"Pioneer transcription factors shape the epigenetic landscape","volume":"293","author":"Mayran","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2022.09.001_bib26","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jhep.2017.11.026","article-title":"The molecular functions of hepatocyte nuclear factors - in and beyond the liver","volume":"68","author":"Lau","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib27","first-page":"43","article-title":"Onecut transcription factors in development and disease","volume":"9","author":"Kropp","year":"2016","journal-title":"Trends Dev Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4161\/cc.5.2.2341","article-title":"Control of hepatic differentiation by activin\/TGFbeta signaling","volume":"5","author":"Clotman","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jhep.2022.09.001_bib29","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1101\/gad.4.12b.2353","article-title":"Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily","volume":"4","author":"Sladek","year":"1990","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhep.2022.09.001_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102185","article-title":"Control of cell identity by the nuclear receptor HNF4 in organ pathophysiology","volume":"9","author":"Dubois","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2022.09.001_bib31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3727\/105221610X12717040569901","article-title":"Developmental and tissue-specific regulation of hepatocyte nuclear factor 4-alpha (HNF4-alpha) isoforms in rodents","volume":"14","author":"Dean","year":"2010","journal-title":"Gene Expr"},{"key":"10.1016\/j.jhep.2022.09.001_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.apsb.2016.07.003","article-title":"Crosstalk of HNF4 \u03b1 with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids","volume":"6","author":"Lu","year":"2016","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jhep.2022.09.001_bib33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1101\/gad.14.4.464","article-title":"Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha","volume":"14","author":"Li","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhep.2022.09.001_bib34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ng1175","article-title":"Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis","volume":"34","author":"Parviz","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2022.09.001_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1387\/ijdb.062146aw","article-title":"C\/EBPalpha and C\/EBPbeta are markers of early liver development","volume":"50","author":"Westmacott","year":"2006","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-pathmechdis-012418-013013","article-title":"Development of the intrahepatic and extrahepatic biliary tract: a framework for understanding congenital diseases","volume":"15","author":"Lemaigre","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jhep.2022.09.001_bib37","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1128\/MCB.21.21.7320-7330.2001","article-title":"Regulatory mechanisms controlling human hepatocyte nuclear factor 4alpha gene expression","volume":"21","author":"Hatzis","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib38","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1242\/dev.126.21.4795","article-title":"Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification","volume":"126","author":"Barbacci","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.jhep.2022.09.001_bib39","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1101\/gad.390906","article-title":"Plasticity and expanding complexity of the hepatic transcription factor network during liver development","volume":"20","author":"Kyrmizi","year":"2006","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhep.2022.09.001_bib40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.celrep.2014.08.046","article-title":"Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation","volume":"9","author":"Alder","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2022.09.001_bib41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.devcel.2010.01.011","article-title":"Organogenesis and development of the liver","volume":"18","author":"Si-Tayeb","year":"2010","journal-title":"Dev Cell"},{"key":"10.1016\/j.jhep.2022.09.001_bib42","doi-asserted-by":"crossref","first-page":"33398","DOI":"10.1074\/jbc.M405312200","article-title":"Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6\/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver","volume":"279","author":"Brian\u00e7on","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2022.09.001_bib43","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4161\/nucl.19321","article-title":"Chromatin \u201cpre-pattern\u201d and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm","volume":"3","author":"Xu","year":"2012","journal-title":"Nucleus"},{"key":"10.1016\/j.jhep.2022.09.001_bib44","doi-asserted-by":"crossref","first-page":"e1427","DOI":"10.1002\/wsbm.1427","article-title":"The mechanistic basis for chromatin regulation by pioneer transcription factors","volume":"11","author":"Iwafuchi-Doi","year":"2019","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"10.1016\/j.jhep.2022.09.001_bib45","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ceb.2020.12.014","article-title":"Epigenetic memory of cell fate commitment","volume":"69","author":"Elsherbiny","year":"2021","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib46","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.celrep.2020.01.006","article-title":"Bookmarking by non-pioneer transcription factors during liver development establishes competence for future gene activation","volume":"30","author":"Karagianni","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2022.09.001_bib47","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/hep.30631","article-title":"Hepatocyte nuclear factor 4-alpha is essential for the active epigenetic state at enhancers in mouse liver","volume":"70","author":"Thakur","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib48","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nm.1853","article-title":"Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress","volume":"14","author":"Bochkis","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2022.09.001_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/hep.32414","article-title":"A\u00a0hierarchical regulatory network ensures stable albumin transcription under various pathophysiological conditions","author":"Feng","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.02626","article-title":"Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways","volume":"3","author":"Ballester","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jhep.2022.09.001_bib51","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1101\/gr.217075.116","article-title":"The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions","volume":"27","author":"Dubois-Chevalier","year":"2017","journal-title":"Genome Res"},{"key":"10.1016\/j.jhep.2022.09.001_bib52","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2217\/epi-2019-0290","article-title":"Perspectives on the use of super-enhancers as a defining feature of cell\/tissue-identity genes","volume":"12","author":"Dubois-Chevalier","year":"2020","journal-title":"Epigenomics"},{"key":"10.1016\/j.jhep.2022.09.001_bib53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcdb.2016.12.003","article-title":"Gene regulatory networks in differentiation and direct reprogramming of hepatic cells","volume":"66","author":"G\u00e9rard","year":"2017","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib54","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ebiom.2018.12.056","article-title":"LRH1-driven transcription factor circuitry for hepatocyte identity: super-enhancer cistromic analysis","volume":"40","author":"Joo","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jhep.2022.09.001_bib55","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1128\/MCB.21.4.1393-1403.2001","article-title":"Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis","volume":"21","author":"Hayhurst","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib56","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1128\/MCB.00927-09","article-title":"Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism","volume":"30","author":"Martinez-Jimenez","year":"2010","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib57","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/hep.24280","article-title":"The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4\u03b1","volume":"53","author":"Santangelo","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib58","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1074\/jbc.M111.334599","article-title":"Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4\u03b1 in adult mice","volume":"287","author":"Bonzo","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2022.09.001_bib59","doi-asserted-by":"crossref","first-page":"17177","DOI":"10.1073\/pnas.2002898117","article-title":"A\u00a0negative reciprocal regulatory axis between cyclin D1 and HNF4\u03b1 modulates cell cycle progression and metabolism in the liver","volume":"117","author":"Wu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2022.09.001_bib60","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1126\/science.1089769","article-title":"Control of pancreas and liver gene expression by HNF transcription factors","volume":"303","author":"Odom","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jhep.2022.09.001_bib61","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1210\/me.2015-1311","article-title":"Changes in gene expression and estrogen receptor cistrome in mouse liver upon acute E2 treatment","volume":"30","author":"Palierne","year":"2016","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jhep.2022.09.001_bib62","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000450905","article-title":"Fibroblast growth factor 15\/19 in hepatocarcinogenesis","volume":"35","author":"Alvarez-Sola","year":"2017","journal-title":"Dig Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib63","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20199156","article-title":"Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver","volume":"16","author":"Dubois","year":"2020","journal-title":"Mol Syst Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib64","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep.30405","article-title":"Hepatocyte nuclear factor 4 alpha activation is essential for termination of liver regeneration in mice","volume":"70","author":"Huck","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib65","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.cell.2011.10.043","article-title":"An HNF4\u03b1-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis","volume":"147","author":"Hatziapostolou","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2022.09.001_bib66","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/hep.27177","article-title":"Hepatocyte nuclear factor 4\u03b1-nuclear factor-\u03baB feedback circuit modulates liver cancer progression","volume":"60","author":"Ning","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib67","doi-asserted-by":"crossref","first-page":"10574","DOI":"10.1074\/jbc.M117.785592","article-title":"An HNF4\u03b1-microRNA-194\/192 signaling axis maintains hepatic cell function","volume":"292","author":"Morimoto","year":"2017","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2022.09.001_bib68","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2022.09.001_bib69","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41575-020-00365-6","article-title":"Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis","volume":"18","author":"Zhu","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib70","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2022.05.007","article-title":"NOTCH-YAP1\/TEAD-DNMT1 Axis drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma","volume":"163","author":"Hu","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.09.001_bib71","article-title":"Alternative RNA splicing in the pathogenesis of liver disease","volume":"8","author":"Navi","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jhep.2022.09.001_bib72","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.3748\/wjg.v16.i25.3091","article-title":"Impairment of pre-mRNA splicing in liver disease: mechanisms and consequences","volume":"16","author":"Berasain","year":"2010","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2022.09.001_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9768","article-title":"ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation","volume":"6","author":"Bhate","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib74","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1128\/MCB.01071-15","article-title":"Liver-specific deletion of SRSF2 caused acute liver failure and early death in mice","volume":"36","author":"Cheng","year":"2016","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2342","article-title":"Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function","volume":"4","author":"Sen","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib76","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1172\/JCI74382","article-title":"Splicing regulator SLU7 is essential for maintaining liver homeostasis","volume":"124","author":"Elizalde","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2022.09.001_bib77","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1093\/nar\/gkz014","article-title":"Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins","volume":"47","author":"Jim\u00e9nez","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2022.09.001_bib78","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MOG.0000000000000450","article-title":"Predictors of clinical outcomes in cirrhosis patients","volume":"34","author":"Haj","year":"2018","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.jhep.2022.09.001_bib79","doi-asserted-by":"crossref","DOI":"10.21037\/atm-20-4968","article-title":"Liver failure-future challenges and remaining questions","volume":"9","author":"Lemmer","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jhep.2022.09.001_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/biom12010066","article-title":"Liver progenitor cells in massive hepatic necrosis-how can a patient survive acute liver failure?","volume":"12","author":"Lin","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jhep.2022.09.001_bib81","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/febs.14389","article-title":"Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response","volume":"286","author":"Rutkowski","year":"2019","journal-title":"FEBS J"},{"key":"10.1016\/j.jhep.2022.09.001_bib82","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jhep.2020.04.033","article-title":"Danger signals in liver injury and restoration of homeostasis","volume":"73","author":"Han","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib83","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0168-8278(00)80122-1","article-title":"Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma","volume":"33","author":"Avila","year":"2000","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib84","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1152\/physrev.00047.2011","article-title":"S-adenosylmethionine in liver health, injury, and cancer","volume":"92","author":"Lu","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jhep.2022.09.001_bib85","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1096\/fasebj.14.1.95","article-title":"Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation","volume":"14","author":"Torres","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.jhep.2022.09.001_bib86","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1357-2725(01)00123-6","article-title":"Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I","volume":"34","author":"Mirpuri","year":"2002","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib87","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/hep.24815","article-title":"The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis","volume":"55","author":"Liu","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib88","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1172\/JCI73137","article-title":"Resetting the transcription factor network reverses terminal chronic hepatic failure","volume":"125","author":"Nishikawa","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2022.09.001_bib89","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/hep4.1172","article-title":"Liver-enriched transcription factor expression relates to chronic hepatic failure in humans","volume":"2","author":"Guzman-Lepe","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib90","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11004-3","article-title":"Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis","volume":"10","author":"Argemi","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib91","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.cmet.2021.06.005","article-title":"Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication","volume":"33","author":"Loft","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2022.09.001_bib92","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-021-01917-6","article-title":"Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases","volume":"19","author":"Guldiken","year":"2021","journal-title":"BMC Med"},{"key":"10.1016\/j.jhep.2022.09.001_bib93","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2021.05.041","article-title":"Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis","volume":"75","author":"Bou Saleh","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib94","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/jhep.2003.50269","article-title":"Expression of Wilms\u2019 tumor suppressor in the liver with cirrhosis: relation to hepatocyte nuclear factor 4 and hepatocellular function","volume":"38","author":"Berasain","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib95","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1136\/gutjnl-2018-317603","article-title":"Dysregulated activation of fetal liver programme in acute liver failure","volume":"68","author":"Hyun","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2022.09.001_bib96","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2019.04.004","article-title":"Single-cell analysis of the liver epithelium reveals dynamic heterogeneity and an essential role for YAP in homeostasis and regeneration","volume":"25","author":"Pepe-Mooney","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2022.09.001_bib97","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.stem.2022.04.008","article-title":"The spatiotemporal program of zonal liver regeneration following acute injury","volume":"29","author":"Ben-Moshe","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2022.09.001_bib98","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep.31759","article-title":"Gene deconvolution reveals aberrant liver regeneration and immune cell infiltration in alcohol-associated hepatitis","volume":"74","author":"Kim","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib99","article-title":"Cell differentiation trajectory in liver cirrhosis predicts hepatocellular carcinoma prognosis and reveals potential biomarkers for progression of liver cirrhosis to hepatocellular carcinoma","volume":"13","author":"He","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.jhep.2022.09.001_bib100","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1111\/liv.14223","article-title":"Biology and significance of alpha-fetoprotein in hepatocellular carcinoma","volume":"39","author":"Galle","year":"2019","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2022.09.001_bib101","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cgh.2020.04.084","article-title":"Serum levels of \u03b1-fetoprotein increased more than 10 Years before detection of hepatocellular carcinoma","volume":"19","author":"Hughes","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib102","article-title":"FOXA2 alleviates CCl 4-induced liver fibrosis by protecting hepatocytes in mice","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2022.09.001_bib103","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/hep.28831","article-title":"Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice","volume":"65","author":"McDaniel","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib104","article-title":"FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression","author":"Wang","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2022.09.001_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030014","article-title":"Foxa1 reduces lipid accumulation in human hepatocytes and is down-regulated in nonalcoholic fatty liver","volume":"7","author":"Moya","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2022.09.001_bib106","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.99","article-title":"Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia","volume":"8","author":"Dong","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib107","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI132691","article-title":"Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis","volume":"130","author":"Hyun","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2022.09.001_bib108","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/hep.20155","article-title":"Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors","volume":"39","author":"Lazarevich","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib109","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/gut.2007.129544","article-title":"The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma","volume":"57","author":"Hellerbrand","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2022.09.001_bib110","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/hep.24647","article-title":"Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice","volume":"54","author":"Zeng","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib111","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13215357","article-title":"Disruption of tumor suppressors HNF4\u03b1\/HNF1\u03b1 causes tumorigenesis in liver","volume":"13","author":"Teeli","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jhep.2022.09.001_bib112","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1158\/0008-5472.CAN-08-2545","article-title":"Wilms\u2019 tumor 1 gene expression in hepatocellular carcinoma promotes cell dedifferentiation and resistance to chemotherapy","volume":"69","author":"Perugorria","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2022.09.001_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8466","article-title":"A\u00a0metabolic stress-inducible miR-34a-HNF4\u03b1 pathway regulates lipid and lipoprotein metabolism","volume":"6","author":"Xu","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib114","article-title":"Carboxylesterase 1 is regulated by hepatocyte nuclear factor 4\u03b1 and protects against alcohol- and MCD diet-induced liver injury","volume":"6","author":"Xu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2022.09.001_bib115","article-title":"Emergent properties of the HNF4\u03b1-PPAR\u03b3 network may drive consequent phenotypic plasticity in NAFLD","volume":"9","author":"Sahoo","year":"2020","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.jhep.2022.09.001_bib116","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.32119","article-title":"Follistatin-controlled activin-HNF4\u03b1-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure","volume":"75","author":"Lin","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib117","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1002\/hep.32029","article-title":"Splicing factor SLU7 prevents oxidative stress-mediated hepatocyte nuclear factor 4\u03b1 degradation, preserving hepatic differentiation and protecting from liver damage","volume":"74","author":"G\u00e1rate-Rasc\u00f3n","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib118","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.3748\/wjg.v25.i30.4074","article-title":"Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases","volume":"25","author":"Yeh","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2022.09.001_bib119","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/path.1928","article-title":"Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer","volume":"208","author":"Tanaka","year":"2006","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jhep.2022.09.001_bib120","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/nar\/26.2.497","article-title":"An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types","volume":"26","author":"Nakhei","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2022.09.001_bib121","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0925-4773(01)00521-4","article-title":"Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3\u2019 end splicing","volume":"109","author":"Torres-Padilla","year":"2001","journal-title":"Mech Dev"},{"key":"10.1016\/j.jhep.2022.09.001_bib122","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/sj.emboj.7601021","article-title":"In\u00a0vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping","volume":"25","author":"Brian\u00e7on","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2022.09.001_bib123","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.1128\/MCB.00297-06","article-title":"Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression","volume":"26","author":"Hatzis","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib124","article-title":"HNF4\u03b1 regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer","volume":"11","author":"Xu","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib125","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/hep4.1505","article-title":"Cellular location of HNF4\u03b1 is linked with terminal liver failure in humans","volume":"4","author":"Florentino","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib126","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1002\/jcp.26270","article-title":"High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4\u03b1 and leads to hepatic steatosis in mice","volume":"233","author":"Yu","year":"2018","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jhep.2022.09.001_bib127","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-2000-8","article-title":"YAP integrates the regulatory Snail\/HNF4\u03b1 circuitry controlling epithelial\/hepatocyte differentiation","volume":"10","author":"Noce","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib128","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.28450","article-title":"Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha","volume":"64","author":"Desai","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib129","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1055\/s-0039-1685539","article-title":"Contributions of fibroblasts, extracellular matrix, stiffness, and mechanosensing to hepatocarcinogenesis","volume":"39","author":"Filliol","year":"2019","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib130","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13225719","article-title":"The hepatic sinusoid in chronic liver disease: the optimal milieu for cancer","volume":"13","author":"Gibert-ramos","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jhep.2022.09.001_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","author":"Peiseler","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib132","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.bbadis.2017.07.024","article-title":"Role of inflammation and proinflammatory cytokines in cholangiocyte pathophysiology","volume":"1864","author":"Pinto","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib133","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0041-1742277","article-title":"Role of YAP1 signaling in biliary development, repair, and disease","volume":"42","author":"Molina","year":"2022","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib134","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jcmgh.2019.09.006","article-title":"The dynamic chromatin architecture of the regenerating liver","volume":"9","author":"Wang","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.semcdb.2019.03.004","article-title":"Chromatin dynamics during liver regeneration","volume":"97","author":"Arechederra","year":"2020","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib136","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1039\/D1MO00382H","article-title":"Systems-level analysis of transcriptome reorganization during liver regeneration","volume":"18","author":"Porukala","year":"2022","journal-title":"Mol Omi"},{"key":"10.1016\/j.jhep.2022.09.001_bib137","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41594-018-0129-2","article-title":"Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration","volume":"25","author":"Bangru","year":"2018","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jhep.2022.09.001_bib138","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.480","article-title":"Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice","volume":"8","author":"Alvarez-Sola","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2022.09.001_bib139","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1053\/j.gastro.2016.12.040","article-title":"X-Box binding protein 1 regulates unfolded protein, acute-phase, and DNA damage responses during regeneration of mouse liver","volume":"152","author":"Argem\u00ed","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.09.001_bib140","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00474-5","article-title":"Liver disease severity predicts carcinogenesis of dysplastic liver nodules in cirrhosis","volume":"11","author":"Gazelakis","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2022.09.001_bib141","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12072-017-9841-y","article-title":"Pathogenesis of non-alcoholic fatty liver disease mediated by YAP","volume":"12","author":"Chen","year":"2018","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2022.09.001_bib142","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/hep.30928","article-title":"Hepatocyte stress increases expression of yes-associated protein and transcriptional coactivator with PDZ-binding motif in hepatocytes to promote parenchymal inflammation and fibrosis","volume":"71","author":"Mooring","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib143","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cmet.2016.09.016","article-title":"Hepatocyte TAZ\/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis","volume":"24","author":"Wang","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2022.09.001_bib144","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jhep.2021.11.031","article-title":"TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis","volume":"76","author":"Wang","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib145","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jhep.2021.04.033","article-title":"Dysregulation of the ESRP2-NF2-YAP\/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease","volume":"75","author":"Hyun","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib146","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jhep.2014.06.033","article-title":"YAP activation is an early event and a potential therapeutic target in liver cancer development","volume":"61","author":"Perra","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib147","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.celrep.2015.02.027","article-title":"YAP inhibition restores hepatocyte differentiation in advanced HCC, leading to tumor regression","volume":"10","author":"Fitamant","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2022.09.001_bib148","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jhep.2021.11.010","article-title":"Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis","volume":"76","author":"Liu","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib149","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/hep.28911","article-title":"Yes-associated protein\/TEA domain family member and hepatocyte nuclear factor 4-alpha (HNF4\u03b1) repress reciprocally to regulate hepatocarcinogenesis in rats and mice","volume":"65","author":"Cai","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib150","doi-asserted-by":"crossref","DOI":"10.1038\/s41588-022-01119-7","article-title":"YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis","author":"Wu","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2022.09.001_bib151","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jhep.2021.08.011","article-title":"Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model","volume":"75","author":"Yang","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib152","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1101\/gr.267013.120","article-title":"Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver","volume":"31","author":"Chembazhi","year":"2021","journal-title":"Genome Res"},{"key":"10.1016\/j.jhep.2022.09.001_bib153","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1158\/1541-7786.MCR-18-0968","article-title":"Opposing roles of the forkhead box factors FoxM1 and FoxA2 in liver cancer","volume":"17","author":"Chand","year":"2019","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jhep.2022.09.001_bib154","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/gut.2008.174904","article-title":"Hepatocyte nuclear factor 4alpha attenuates hepatic fibrosis in rats","volume":"59","author":"Yue","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2022.09.001_bib155","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jhep.2021.12.015","article-title":"Modern therapeutic approaches to liver-related disorders","volume":"76","author":"Gardin","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib156","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.ymthe.2020.10.018","article-title":"Liver injury increases the incidence of HCC following AAV gene therapy in mice","volume":"29","author":"Dalwadi","year":"2021","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhep.2022.09.001_bib157","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/hep.26669","article-title":"Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in\u00a0vivo","volume":"59","author":"Reebye","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.001_bib158","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.omtn.2019.10.044","article-title":"Liver activation of hepatocellular nuclear factor-4\u03b1 by small activating RNA rescues dyslipidemia and improves metabolic profile","volume":"19","author":"Huang","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jhep.2022.09.001_bib159","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/gutjnl-2019-318269","article-title":"Messenger RNA therapy for rare genetic metabolic diseases","volume":"68","author":"Berraondo","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2022.09.001_bib160","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/s41591-018-0199-z","article-title":"Systemic messenger RNA as an etiological treatment for acute intermittent porphyria","volume":"24","author":"Jiang","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2022.09.001_bib161","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.omtn.2021.05.010","article-title":"mRNA-based therapy in a rabbit model of variegate porphyria offers new insights into the pathogenesis of acute attacks","volume":"25","author":"Jeric\u00f3","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jhep.2022.09.001_bib162","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/hep4.1763","article-title":"Hepatocyte nuclear factor 4 alpha 2 messenger RNA reprograms liver-enriched transcription factors and functional proteins in end-stage cirrhotic human hepatocytes","volume":"5","author":"Tafaleng","year":"2021","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2022.09.001_bib163","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.stem.2020.08.016","article-title":"Epithelial plasticity during liver injury and regeneration","volume":"27","author":"Gadd","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2022.09.001_bib164","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.001_bib165","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.jhep.2021.11.013","article-title":"The importance of liver functional reserve in the non-surgical treatment of hepatocellular carcinoma","volume":"76","author":"D\u2019Avola","year":"2022","journal-title":"J\u00a0Hepatol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822030732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822030732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:48:11Z","timestamp":1759175291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827822030732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":165,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0168827822030732"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2022.09.001","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of liver function in chronic liver disease: An\u00a0identity crisis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2022.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}