{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:12:12Z","timestamp":1793664732950,"version":"4.5.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100013114","name":"Broad Institute","doi-asserted-by":"publisher","award":["U01HG04603"],"award-info":[{"award-number":["U01HG04603"]}],"id":[{"id":"10.13039\/100013114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013114","name":"Broad Institute","doi-asserted-by":"publisher","award":["U01HG004603"],"award-info":[{"award-number":["U01HG004603"]}],"id":[{"id":"10.13039\/100013114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013114","name":"Broad Institute","doi-asserted-by":"publisher","award":["U01HG004608"],"award-info":[{"award-number":["U01HG004608"]}],"id":[{"id":"10.13039\/100013114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","award":["U01-DK065193"],"award-info":[{"award-number":["U01-DK065193"]}],"id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","award":["U01-DK065184"],"award-info":[{"award-number":["U01-DK065184"]}],"id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-DK065201"],"award-info":[{"award-number":["U01-DK065201"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-DK065211"],"award-info":[{"award-number":["U01-DK065211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HG007417"],"award-info":[{"award-number":["U01HG007417"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-DK065176"],"award-info":[{"award-number":["U01-DK065176"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","award":["phs000360"],"award-info":[{"award-number":["phs000360"]}],"id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","award":["U01-DK100928"],"award-info":[{"award-number":["U01-DK100928"]}],"id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","award":["U01-DK082992"],"award-info":[{"award-number":["U01-DK082992"]}],"id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","award":["U01-DK083027"],"award-info":[{"award-number":["U01-DK083027"]}],"id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","award":["U01-DK083020"],"award-info":[{"award-number":["U01-DK083020"]}],"id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01HG004438"],"award-info":[{"award-number":["U01HG004438"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U01AG006781"],"award-info":[{"award-number":["U01AG006781"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["phs000303"],"award-info":[{"award-number":["phs000303"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003483","name":"Hebrew University of Jerusalem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006115","name":"Institute for Research in Fundamental Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["UOIHG004599"],"award-info":[{"award-number":["UOIHG004599"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["U01HG004424"],"award-info":[{"award-number":["U01HG004424"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007277","name":"Icahn School of Medicine at Mount Sinai","doi-asserted-by":"publisher","award":["U01HG007417"],"award-info":[{"award-number":["U01HG007417"]}],"id":[{"id":"10.13039\/100007277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["phs001271"],"award-info":[{"award-number":["phs001271"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007710","name":"University of Connecticut","doi-asserted-by":"publisher","award":["U01-DK065238"],"award-info":[{"award-number":["U01-DK065238"]}],"id":[{"id":"10.13039\/100007710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["phs000925"],"award-info":[{"award-number":["phs000925"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA155309"],"award-info":[{"award-number":["U01CA155309"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jhep.2022.09.010","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:11:56Z","timestamp":1663805516000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Clinical features, outcomes, and HLA risk factors associated with nitrofurantoin-induced liver injury"],"prefix":"10.1016","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-3178","authenticated-orcid":false,"given":"Naga","family":"Chalasani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-4834","authenticated-orcid":false,"given":"Yi-Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-4329","authenticated-orcid":false,"given":"Andrew","family":"Dellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Bonkovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiezhun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiman","family":"Barnhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-640X","authenticated-orcid":false,"given":"Craig","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-0095","authenticated-orcid":false,"given":"Tae-Hwi","family":"Schwantes-An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-4453","authenticated-orcid":false,"given":"David E.","family":"Kleiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay H.","family":"Hoofnagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2022.09.010_bib1","series-title":"LiverTox: clinical and research information on drug-induced liver injury","year":"2012"},{"key":"10.1016\/j.jhep.2022.09.010_bib2","unstructured":"Kane SP. Nitrofurantoin, ClinCalc DrugStats Database, Version 2021.10. ClinCalc: https:\/\/clincalc.com\/DrugStats\/Drugs\/Nitrofurantoin. Updated September 15, 2021. Accessed December 27,\u00a02021."},{"issue":"7","key":"10.1016\/j.jhep.2022.09.010_bib3","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1053\/j.gastro.2015.03.006","article-title":"Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study","volume":"148","author":"Chalasani","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.09.010_bib4","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/hep.23937","article-title":"Drug induced acute liver failure: results of a U.S. multicenter prospective study","volume":"52","author":"Reuben","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.010_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/lt.26246","article-title":"Trends in liver transplant waitlisting and outcomes for drug-induced liver injury in the United States","volume":"28","author":"Ghabril","year":"2022","journal-title":"Liver Transplant"},{"key":"10.1016\/j.jhep.2022.09.010_bib6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.1840080327","article-title":"Hepatic injury associated with use of nitrofurans: a clinicopathological study of 52 reported cases","volume":"8","author":"Stricker","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.010_bib7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0002-9343(80)90443-X","article-title":"Adverse reactions to nitrofurantoin. Analysis of 921 reports","volume":"69","author":"Holmberg","year":"1980","journal-title":"Am J Med"},{"key":"10.1016\/j.jhep.2022.09.010_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2796.1992.tb00562.x","article-title":"Drug-induced hepatic injury: an analysis of 1100 cases reported to the Danish Committee on Adverse Drug Reactions between 1978 and 1987","volume":"232","author":"Friis","year":"1992","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.jhep.2022.09.010_bib9","first-page":"315","article-title":"Drug associated hepatic reactions in New Zealand: 21 years\u2019 experience","volume":"109","author":"Pillans","year":"1996","journal-title":"N\u00a0Z Med J"},{"key":"10.1016\/j.jhep.2022.09.010_bib10","first-page":"6650","article-title":"Hepatic toxicity of nitrofurantoin. Cases reported to the center for monitoring adverse drug reactions 1968-1998. Danish","volume":"161","author":"Dam-Larsen","year":"1999","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.jhep.2022.09.010_bib11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ng.379","article-title":"HLA-B-\u22175701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin","volume":"41","author":"Daly","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2022.09.010_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1053\/j.gastro.2011.04.001","article-title":"Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles","volume":"141","author":"Lucena","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2022.09.010_bib13","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jhep.2018.08.004","article-title":"The role of HLA-A\u221733:01 in patients with cholestatic hepatitis attributed to terbinafine","volume":"69","author":"Fontana","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2022.09.010_bib14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/hep.31258","article-title":"Human leukocyte antigen B\u221714:01 and B\u221735:01 are associated with trimethoprim-sulfamethoxazole induced liver injury","volume":"73","author":"Li","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.010_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0002-9343(79)90086-X","article-title":"Nitrofurantoin: another cause of drug-induced chronic active hepatitis? A report of a patient with HLA-B8 antigen","volume":"67","author":"Hatoff","year":"1979","journal-title":"Am J Med"},{"key":"10.1016\/j.jhep.2022.09.010_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cgh.2016.05.043","article-title":"Features of autoimmune hepatitis in patients with drug-induced liver injury","volume":"15","author":"De Boer","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2022.09.010_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2165\/00002018-200932010-00005","article-title":"Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct","volume":"32","author":"Fontana","year":"2009","journal-title":"Drug Saf"},{"key":"10.1016\/j.jhep.2022.09.010_bib18","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2008.09.011","article-title":"Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States","volume":"135","author":"Chalasani","year":"2008","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jhep.2022.09.010_bib19","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1053\/j.gastro.2019.01.034","article-title":"A\u00a0missense variant in PTPN22 is a risk factor for drug-induced liver injury","volume":"156","author":"Cirulli","year":"2019","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jhep.2022.09.010_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/tpj.2013.18","article-title":"HIBAG--HLA genotype imputation with attribute bagging","volume":"14","author":"Zheng","year":"2014","journal-title":"Pharmacogenomics J"},{"issue":"8","key":"10.1016\/j.jhep.2022.09.010_bib21","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2022.09.010_bib22","first-page":"137A","article-title":"Discovery of ERAP2 gene expression as a risk factor for drug-induced liver injury due to amoxicillin-clavulanic acid","volume":"70","author":"Nicoletti","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.010_bib23","series-title":"qvalue: Q-value estimation for false discovery rate control","author":"Storey","year":"2022"},{"key":"10.1016\/j.jhep.2022.09.010_bib24","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/hep.29283","article-title":"Death and liver transplantation within two years of onset of drug-induced liver injury","volume":"66","author":"Hayashi","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.010_bib25","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/hep.31538","article-title":"HLA-B\u221735:01 and green tea induced liver injury","volume":"73","author":"Hoofnagle","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.09.010_bib26","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/020064s019lbl.pdf (Accessed on May\/8\/2022)."},{"key":"10.1016\/j.jhep.2022.09.010_bib27","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/016620s068lbl.pdf (Accessed on May\/8\/2022)."},{"key":"10.1016\/j.jhep.2022.09.010_bib28","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/009175s037lbl.pdf (Accessed on May\/8\/2022)."},{"key":"10.1016\/j.jhep.2022.09.010_bib29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1017\/ice.2016.315","article-title":"Preferential use of nitrofurantoin over fluoroquinolones for acute uncomplicated cystitis and outpatient Escherichia coli resistance in an integrated health care system","volume":"38","author":"Pedala","year":"2017","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jhep.2022.09.010_bib30","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/hep4.1959","article-title":"Setting up criteria for drug-induced autoimmune-like hepatitis through a systematic analysis of published reports","volume":"6 (8)","author":"Bjornsson","year":"2022","journal-title":"Hepatol Commun"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822031178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827822031178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:56:35Z","timestamp":1777510595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827822031178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0168827822031178"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2022.09.010","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical features, outcomes, and HLA risk factors associated with nitrofurantoin-induced liver injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2022.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}