{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:02:52Z","timestamp":1784563372859,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jhep.2022.10.012","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T03:20:24Z","timestamp":1666927224000},"page":"364-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells"],"prefix":"10.1016","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-8056","authenticated-orcid":false,"given":"Lea","family":"Duwe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Munoz-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-992X","authenticated-orcid":false,"given":"Monika","family":"Lewinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lafuente-Barquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-0099","authenticated-orcid":false,"given":"Letizia","family":"Satriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"H\u00f8gdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-2185","authenticated-orcid":false,"given":"Andrzej","family":"Taranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boye S.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awaisa","family":"Ghazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2005-5266","authenticated-orcid":false,"given":"Matthias S.","family":"Matter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus M.","family":"Banales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca I.","family":"Aldana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8314-2682","authenticated-orcid":false,"given":"Jens U.","family":"Marquardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis R.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-8059","authenticated-orcid":false,"given":"Rui C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-6204","authenticated-orcid":false,"given":"Jill","family":"Koshiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colm J.","family":"O'Rourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-5244","authenticated-orcid":false,"given":"Jesper B.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jhep.2022.10.012_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.jhep.2022.10.012_bib2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jhep.2021.12.010","article-title":"Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry","volume":"76","author":"Izquierdo-Sanchez","year":"2022","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.10.012_bib3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.trecan.2018.01.007","article-title":"Desmoplastic tumor microenvironment and immunotherapy in cholangiocarcinoma","volume":"4","author":"Hogdall","year":"2018","journal-title":"Trends Cancer"},{"issue":"6561","key":"10.1016\/j.jhep.2022.10.012_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj0486","article-title":"Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis","volume":"373","author":"Del Poggetto","year":"2021","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jhep.2022.10.012_bib5","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/ng.3375","article-title":"Genomic spectra of biliary tract cancer","volume":"47","author":"Nakamura","year":"2015","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.jhep.2022.10.012_bib6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2018.01.009","article-title":"Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations","volume":"68","author":"Wardell","year":"2018","journal-title":"J\u00a0Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2022.10.012_bib7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/hep.29764","article-title":"Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma","volume":"68","author":"Nepal","year":"2018","journal-title":"Hepatology"},{"issue":"7793","key":"10.1016\/j.jhep.2022.10.012_bib8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","year":"2020","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jhep.2022.10.012_bib9","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1158\/2159-8290.CD-17-0368","article-title":"Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma","volume":"7","author":"Jusakul","year":"2017","journal-title":"Cancer Discov"},{"issue":"6","key":"10.1016\/j.jhep.2022.10.012_bib10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.trecan.2019.05.002","article-title":"Epigenome remodeling in cholangiocarcinoma","volume":"5","author":"O'Rourke","year":"2019","journal-title":"Trends Cancer"},{"issue":"5","key":"10.1016\/j.jhep.2022.10.012_bib11","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/hep.25890","article-title":"Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma","volume":"56","author":"Oishi","year":"2012","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2022.10.012_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-0038-1676097","article-title":"Noncoding RNA in cholangiocarcinoma","volume":"39","author":"Salati","year":"2019","journal-title":"Semin Liver Dis"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib13","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3892\/ijo.2017.3876","article-title":"miR-21 and KLF4 jointly augment epithelialmesenchymal transition via the Akt\/ERK1\/2 pathway","volume":"50","author":"Liu","year":"2017","journal-title":"Int J Oncol"},{"issue":"8","key":"10.1016\/j.jhep.2022.10.012_bib14","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.18632\/oncotarget.3465","article-title":"MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in\u00a0vitro and in\u00a0vivo by targeting PTPN14 and PTEN","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib15","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1053\/j.gastro.2017.10.043","article-title":"MIR21 drives resistance to heat shock protein 90 inhibition in cholangiocarcinoma","volume":"154","author":"Lampis","year":"2018","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib16","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1053\/j.gastro.2011.12.005","article-title":"Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors","volume":"142","author":"Andersen","year":"2012","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.jhep.2022.10.012_bib17","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/ijc.32026","article-title":"Application of patient-derived liver cancer cells for phenotypic characterization and therapeutic target identification","volume":"144","author":"Castven","year":"2019","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib18","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2015.05.023","article-title":"Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease","volume":"63","author":"Munoz-Garrido","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.10.012_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhep.2017.02.017","article-title":"SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma","volume":"67","author":"Merino-Azpitarte","year":"2017","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2022.10.012_bib20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/hep.30816","article-title":"Identification of a pan-gamma-secretase inhibitor response signature for notch-driven cholangiocarcinoma","volume":"71","author":"O'Rourke","year":"2020","journal-title":"Hepatology"},{"issue":"13","key":"10.1016\/j.jhep.2022.10.012_bib21","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.celrep.2017.06.008","article-title":"Integrative genomic analysis of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles","volume":"19","author":"Farshidfar","year":"2017","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.jhep.2022.10.012_bib22","doi-asserted-by":"crossref","first-page":"9170","DOI":"10.1038\/s41598-021-88480-5","article-title":"miRNA activity inferred from single cell mRNA expression","volume":"11","author":"Nielsen","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2022.10.012_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.lfs.2017.11.030","article-title":"The regulation of FOXO1 and its role in disease progression","volume":"193","author":"Xing","year":"2018","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.jhep.2022.10.012_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/path.5514","article-title":"miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR-451a\/ATF2 axis","volume":"252","author":"Loeffler","year":"2020","journal-title":"J\u00a0Pathol"},{"issue":"1","key":"10.1016\/j.jhep.2022.10.012_bib25","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1038\/s41467-018-07657-1","article-title":"Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors","volume":"9","author":"Dhawan","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jhep.2022.10.012_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res"},{"issue":"2","key":"10.1016\/j.jhep.2022.10.012_bib27","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.celrep.2015.12.031","article-title":"Elucidating MicroRNA regulatory networks using transcriptional, post-transcriptional, and histone modification measurements","volume":"14","author":"Gosline","year":"2016","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.jhep.2022.10.012_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/gutjnl-2020-322983","article-title":"Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis","volume":"71","author":"Goeppert","year":"2022","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jhep.2014.10.033","article-title":"Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6\/STAT3 signalling","volume":"62","author":"Xiao","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"6","key":"10.1016\/j.jhep.2022.10.012_bib30","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/hep.20966","article-title":"Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells","volume":"42","author":"Isomoto","year":"2005","journal-title":"Hepatology"},{"issue":"21","key":"10.1016\/j.jhep.2022.10.012_bib31","doi-asserted-by":"crossref","first-page":"10517","DOI":"10.1158\/0008-5472.CAN-06-2130","article-title":"Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression","volume":"66","author":"Wehbe","year":"2006","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib32","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.29533","article-title":"MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation","volume":"67","author":"Erice","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.jhep.2022.10.012_bib33","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.jhep.2017.02.002","article-title":"miR-425 regulates inflammatory cytokine production in CD4(+) T cells via N-Ras upregulation in primary biliary cholangitis","volume":"66","author":"Nakagawa","year":"2017","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.jhep.2022.10.012_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jhep.2020.03.008","article-title":"Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma","volume":"73","author":"Montal","year":"2020","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib35","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1053\/j.gastro.2013.01.001","article-title":"Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes","volume":"144","author":"Sia","year":"2013","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(04)00452-0","article-title":"FoxOs at the crossroads of cellular metabolism, differentiation, and transformation","volume":"117","author":"Accili","year":"2004","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jhep.2022.10.012_bib37","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/hep.28496","article-title":"FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1-Nrf2 signaling","volume":"63","author":"Guan","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2022.10.012_bib38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1186\/1471-2407-14-909","article-title":"MicroRNA-1269 promotes proliferation in human hepatocellular carcinoma via downregulation of FOXO1","volume":"14","author":"Yang","year":"2014","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.jhep.2022.10.012_bib39","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3892\/or.2017.5873","article-title":"Downregulation of microRNA-196a inhibits human liver cancer cell proliferation and invasion by targeting FOXO1","volume":"38","author":"Yang","year":"2017","journal-title":"Oncol Rep"},{"issue":"7585","key":"10.1016\/j.jhep.2022.10.012_bib40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature16498","article-title":"FOXO1 couples metabolic activity and growth state in the vascular endothelium","volume":"529","author":"Wilhelm","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jhep.2022.10.012_bib41","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41419-020-02982-0","article-title":"Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming","volume":"11","author":"Yan","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2022.10.012_bib42","first-page":"127","article-title":"Therapeutic advances of miRNAs: a preclinical and clinical update","volume":"28","author":"Chakraborty","year":"2021","journal-title":"J\u00a0Adv Res"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782203149X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782203149X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:47:47Z","timestamp":1759175267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882782203149X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S016882782203149X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2022.10.012","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2022.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}