{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:26:45Z","timestamp":1793903205318,"version":"4.8.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jhep.2023.03.016","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T13:04:50Z","timestamp":1680008690000},"page":"362-377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":397,"title":["ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis"],"prefix":"10.1016","volume":"79","author":[{"given":"Feng","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0469-7151","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-316X","authenticated-orcid":false,"given":"Randal J.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin C.","family":"Yaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-6473","authenticated-orcid":false,"given":"Michael","family":"Karin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2023.03.016_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jhep.2023.03.016_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2023.03.016_bib3","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3390\/cancers13051095","article-title":"From liver fat to cancer: perils of the Western diet","volume":"13","author":"Kim","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.jhep.2023.03.016_bib4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41571-018-0073-4","article-title":"Molecular therapies and precision medicine for hepatocellular carcinoma","volume":"15","author":"Llovet","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jhep.2023.03.016_bib5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ccell.2016.04.006","article-title":"p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells","volume":"29","author":"Umemura","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib6","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","article-title":"ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development","volume":"26","author":"Nakagawa","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cell.2005.04.014","article-title":"IKK\u03b2 couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis","volume":"121","author":"Maeda","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ccell.2016.11.009","article-title":"RIPK1 suppresses a TRAF2-dependent pathway to liver cancer","volume":"31","author":"Schneider","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib10","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: a matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2023.03.016_bib11","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2023.03.016_bib12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib13","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-\u03baB restricts inflammasome activation via elimination of damaged mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.03.016_bib15","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI124049","article-title":"Suppression of the SLC7A11\/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma","volume":"130","author":"Hu","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2023.03.016_bib16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/hep.29117","article-title":"Characterization of ferroptosis in murine models of hemochromatosis","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.016_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat Rev Mol Cel Biol"},{"key":"10.1016\/j.jhep.2023.03.016_bib18","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrc3800","article-title":"The impact of the endoplasmic reticulum protein-folding environment on cancer development","volume":"14","author":"Wang","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jhep.2023.03.016_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.29871","article-title":"Dual role for inositol-requiring enzyme 1\u0251 in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice","volume":"68","author":"Wu","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.016_bib20","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/emboj.2011.52","article-title":"The unfolded protein response transducer IRE1\u0251 prevents ER stress-induced hepatic steatosis","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2023.03.016_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao4617","article-title":"IRE1\u0251 prevents hepatic steatosis by processing and promoting the degradation of select microRNAs","volume":"11","author":"Wang","year":"2018","journal-title":"Sci Signal"},{"key":"10.1016\/j.jhep.2023.03.016_bib22","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1084\/jem.20122341","article-title":"ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells","volume":"210","author":"Niederreiter","year":"2013","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2023.03.016_bib23","doi-asserted-by":"crossref","first-page":"G965","DOI":"10.1152\/ajpgi.00132.2015","article-title":"Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat\/sugar diet","volume":"309","author":"Liu","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2023.03.016_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.febslet.2005.11.072","article-title":"Transformation-associated gene regulation by ATF6\u0251 during hepatocarcinogenesis","volume":"580","author":"Arai","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jhep.2023.03.016_bib25","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1172\/JCI62973","article-title":"ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth","volume":"122","author":"Hart","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2023.03.016_bib26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","article-title":"An integrated stress response regulates amino acid metabolism and resistance to oxidative stress","volume":"11","author":"Harding","year":"2003","journal-title":"Mol Cel"},{"key":"10.1016\/j.jhep.2023.03.016_bib27","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.2337\/db09-0335","article-title":"Atf4 regulates obesity, glucose homeostasis, and energy expenditure","volume":"58","author":"Seo","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2023.03.016_bib28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/cr.2010.4","article-title":"ATF4 regulates lipid metabolism and thermogenesis","volume":"20","author":"Wang","year":"2010","journal-title":"Cell Res"},{"key":"10.1016\/j.jhep.2023.03.016_bib29","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1091\/mbc.E16-01-0039","article-title":"Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver","volume":"27","author":"Fusakio","year":"2016","journal-title":"Mol Biol Cel"},{"key":"10.1016\/j.jhep.2023.03.016_bib30","doi-asserted-by":"crossref","first-page":"25350","DOI":"10.1074\/jbc.M113.470526","article-title":"ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice","volume":"288","author":"Xiao","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2023.03.016_bib31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/BJ20110263","article-title":"ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis","volume":"438","author":"Li","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.jhep.2023.03.016_bib32","doi-asserted-by":"crossref","first-page":"31259","DOI":"10.1073\/pnas.2017129117","article-title":"Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease","volume":"117","author":"Yueh","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2023.03.016_bib33","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2020.04.038","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Song","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.03.016_bib34","doi-asserted-by":"crossref","first-page":"18536","DOI":"10.1074\/jbc.M116.726836","article-title":"Liver-specific gene inactivation of the transcription factor ATF4 alleviates alcoholic liver steatosis in mice","volume":"291","author":"Li","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2023.03.016_bib35","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1136\/gutjnl-2020-321548","article-title":"ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1-TFAM signalling in alcoholic steatohepatitis","volume":"70","author":"Hao","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2023.03.016_bib36","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/emboj.2010.81","article-title":"The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation","volume":"29","author":"Ye","year":"2010","journal-title":"EMBO J"},{"key":"10.1016\/j.jhep.2023.03.016_bib37","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s41556-019-0347-9","article-title":"ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression","volume":"21","author":"Tameire","year":"2019","journal-title":"Nat Cel Biol"},{"key":"10.1016\/j.jhep.2023.03.016_bib38","doi-asserted-by":"crossref","first-page":"27290","DOI":"10.1074\/jbc.M112.374777","article-title":"Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy","volume":"287","author":"Ebert","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2023.03.016_bib39","doi-asserted-by":"crossref","first-page":"13943","DOI":"10.1073\/pnas.93.24.13943","article-title":"NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development","volume":"93","author":"Chan","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2023.03.016_bib40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(91)90615-6","article-title":"Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene","volume":"66","author":"Sandgren","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib41","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.jhep.2020.01.023","article-title":"NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly","volume":"72","author":"He","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.03.016_bib42","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib43","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/ars.2014.5851","article-title":"Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease","volume":"21","author":"Cao","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jhep.2023.03.016_bib44","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine\u2013glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jhep.2023.03.016_bib45","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2018.10.426","article-title":"Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer","volume":"129","author":"Shin","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2023.03.016_bib46","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jhep.2023.03.016_bib47","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0022-2836(02)00234-6","article-title":"Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response","volume":"318","author":"Ma","year":"2002","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.jhep.2023.03.016_bib48","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbamcr.2012.06.001","article-title":"Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells","volume":"1823","author":"Zong","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhep.2023.03.016_bib49","doi-asserted-by":"crossref","first-page":"20858","DOI":"10.1074\/jbc.M101198200","article-title":"Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation","volume":"276","author":"He","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2023.03.016_bib50","doi-asserted-by":"crossref","first-page":"44765","DOI":"10.1074\/jbc.M208704200","article-title":"Electrophile response element-mediated induction of the cystine\/glutamate exchange transporter gene expression","volume":"277","author":"Sasaki","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2023.03.016_bib51","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1128\/MCB.00221-14","article-title":"Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition","volume":"34","author":"Ye","year":"2014","journal-title":"Mol Cel Biol"},{"key":"10.1016\/j.jhep.2023.03.016_bib52","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A\u00a0diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.03.016_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12072-014-9582-0","article-title":"Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy","volume":"9","author":"Vandewynckel","year":"2015","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2023.03.016_bib54","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature21065","article-title":"Single-cell spatial reconstruction reveals global division of labour in the mammalian liver","volume":"542","author":"Halpern","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.03.016_bib55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.03.016_bib56","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0168-8278(88)80004-7","article-title":"Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver","volume":"7","author":"Benedetti","year":"1988","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.03.016_bib57","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S1470-2045(11)70077-8","article-title":"Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score","volume":"12","author":"Yang","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jhep.2023.03.016_bib58","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/jnci\/djs372","article-title":"Hepatocellular\u00a0carcinoma risk prediction model for the general population:\u00a0the predictive power of transaminases","volume":"104","author":"Wen","year":"2012","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.jhep.2023.03.016_bib59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41586-018-0519-y","article-title":"Necroptosis microenvironment directs lineage commitment in liver cancer","volume":"562","author":"Seehawer","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.03.016_bib60","first-page":"325","article-title":"Apoptosis and necrosis: two types of cell death in alcoholic liver disease","volume":"21","author":"Nanji","year":"1997","journal-title":"Alcohol Health Res World"},{"key":"10.1016\/j.jhep.2023.03.016_bib61","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/hep.23479","article-title":"Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice","volume":"51","author":"Weber","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.016_bib62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jhep.2012.01.027","article-title":"Bak deficiency inhibits liver carcinogenesis: a causal link between apoptosis and carcinogenesis","volume":"57","author":"Hikita","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.03.016_bib63","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41419-019-1678-y","article-title":"Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis","volume":"10","author":"Tsurusaki","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2023.03.016_bib64","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jhep.2023.03.016_bib65","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114351","article-title":"YAP\/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis","volume":"13","author":"Gao","year":"2021","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jhep.2023.03.016_bib66","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.016_bib67","doi-asserted-by":"crossref","first-page":"eaat5314","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: from mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jhep.2023.03.016_bib68","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ncb2738","article-title":"ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death","volume":"15","author":"Han","year":"2013","journal-title":"Nat Cel Biol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827823001939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827823001939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:51:19Z","timestamp":1759175479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827823001939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0168827823001939"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2023.03.016","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2023.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}