{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:28:51Z","timestamp":1792250931398,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2016\/001687"],"award-info":[{"award-number":["ECR\/2016\/001687"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jhep.2023.03.018","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T11:16:20Z","timestamp":1680002180000},"page":"167-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod"],"prefix":"10.1016","volume":"79","author":[{"given":"Sukriti","family":"Baweja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Negi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Mani","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash Kumar","family":"Mourya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-1874","authenticated-orcid":false,"given":"Aayushi","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Debishree","family":"Subudhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Thangariyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guresh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Srinivasa","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitranshu","family":"Vashistha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-1945","authenticated-orcid":false,"given":"Vivek","family":"Sarohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-5610","authenticated-orcid":false,"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2023.03.018_bib1","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1056\/NEJMra0707185","article-title":"Hepatopulmonary syndrome\u2014a liver-induced lung vascular disorder","volume":"358","author":"Rodr\u00edguez-Roisin","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2023.03.018_bib2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/jhep.2000.7519","article-title":"Pulmonary dysfunction in chronic liver disease","volume":"32","author":"Fallon","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.018_bib3","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.cgh.2020.09.050","article-title":"Diagnosis of hepatopulmonary syndrome in a large integrated health system","volume":"19","author":"Bommena","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2023.03.018_bib4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ccm.2005.06.010","article-title":"Hepatopulmonary syndrome and portopulmonary hypertension: implications for liver transplantation","volume":"26","author":"Krowka","year":"2005","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.jhep.2023.03.018_bib5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/jhep.2003.50023","article-title":"Prospective evaluation of outcomes and predictors of mortality in patients with hepatopulmonary syndrome undergoing liver transplantation","volume":"37","author":"Arguedas","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.018_bib6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0168-8278(98)80152-9","article-title":"Endothelin-1 in the rat bile duct ligation model of hepatopulmonary syndrome: correlation with pulmonary dysfunction","volume":"29","author":"Luo","year":"1998","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.03.018_bib7","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/hep.510260406","article-title":"Exhaled nitric oxide and oxygenation abnormalities in hepatic cirrhosis","volume":"26","author":"Rolla","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.018_bib8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/gast.1997.v113.pm9247483","article-title":"The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome","volume":"113","author":"Fallon","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2023.03.018_bib9","doi-asserted-by":"crossref","first-page":"G294","DOI":"10.1152\/ajpgi.00298.2003","article-title":"ET-1 and TNF-\u03b1 in HPS: analysis in prehepatic portal hypertension and biliary and nonbiliary cirrhosis in rats","volume":"286","author":"Luo","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2023.03.018_bib10","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1001\/archinte.168.16.1820","article-title":"Pentoxifylline therapy for hepatopulmonary syndrome: a pilot study","volume":"168","author":"Gupta","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jhep.2023.03.018_bib11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4240\/wjgs.v4.i6.146","article-title":"Pentoxifylline improves liver regeneration through down-regulation of TNF-\u03b1 synthesis and TGF-\u03b21 gene expression","volume":"4","author":"Martino","year":"2012","journal-title":"World J Gastrointest Surg"},{"key":"10.1016\/j.jhep.2023.03.018_bib12","doi-asserted-by":"crossref","first-page":"375A","DOI":"10.1002\/hep.27498","article-title":"Poster session 1: encephalopathy and other complications","volume":"60","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.03.018_bib13","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2147\/VHRM.S3608","article-title":"Current concepts in the management of hepatopulmonary syndrome","volume":"4","author":"Ho","year":"2008","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.jhep.2023.03.018_bib14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","year":"2018","journal-title":"J\u00a0Hepatol"},{"issue":"5","key":"10.1016\/j.jhep.2023.03.018_bib15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1183\/09031936.04.00010904","article-title":"ERS task force pulmonary-hepatic vascular disorders (PHD) scientific committee. Pulmonary-hepatic vascular disorders (PHD)","volume":"24","author":"Rodr\u00edguez-Roisin","year":"2004","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jhep.2023.03.018_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1665-2681(19)31816-2","article-title":"Successful treatment of severe hepatopulmonary syndrome with a sequential use of TIPS placement and liver transplantation","volume":"8","author":"Ben\u00edtez","year":"2009","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jhep.2023.03.018_bib17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/cvr\/cvp064","article-title":"Sphingosine-1-phosphate and modulation of vascular tone","volume":"82","author":"Igarashi","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jhep.2023.03.018_bib18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/HYPERTENSIONAHA.117.09088","article-title":"S1PR1 (sphingosine-1-phosphate receptor 1) signaling regulates blood flow and pressure","volume":"70","author":"Cantalupo","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.jhep.2023.03.018_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrneurol.2010.76","article-title":"Fingolimod is a potential novel therapy for multiple sclerosis","volume":"6","author":"Aktas","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jhep.2023.03.018_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/WNF.0b013e3181cbf825","article-title":"Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis","volume":"33","author":"Chun","year":"2010","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.jhep.2023.03.018_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1056\/NEJMoa0909494","article-title":"A\u00a0placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis","volume":"362","author":"Kappos","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2023.03.018_bib22","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.3390\/ijms21186548","article-title":"Fingolimod (FTY720) preserves high energy phosphates and improves cardiac function in heterotopic heart transplantation model","volume":"21","author":"Ahmed","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2023.03.018_bib23","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jhep.2014.08.010","article-title":"Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance","volume":"61","author":"Albillos","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.03.018_bib24","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1002\/hep4.1561","article-title":"Serum sphingosine-1-phosphate is decreased in patients with acute-on-chronic liver failure and predicts early mortality","volume":"4","author":"M\u00fccke","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2023.03.018_bib25","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1194\/jlr.R059543","article-title":"Sources, metabolism, and regulation of circulating sphingosine-1-phosphate","volume":"56","author":"Ksi\u0105\u017cek","year":"2015","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jhep.2023.03.018_bib26","doi-asserted-by":"crossref","first-page":"E1636","DOI":"10.3390\/ijms18081636","article-title":"A\u00a0novel perspective on the ApoM\u2013S1P axis, highlighting the metabolism of ApoM and its role in liver fibrosis and neuroinflammation","volume":"18","author":"Hajny","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2023.03.018_bib27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1086\/677356","article-title":"Mechanisms regulating endothelial permeability","volume":"4","author":"Sukriti","year":"2014","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jhep.2023.03.018_bib28","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.012941","article-title":"Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b","volume":"296","author":"Nguyen","year":"2021","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2023.03.018_bib29","doi-asserted-by":"crossref","first-page":"ftw063","DOI":"10.1093\/femspd\/ftw063","article-title":"Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection","volume":"74","author":"Tiper","year":"2016","journal-title":"Pathog Dis"},{"key":"10.1016\/j.jhep.2023.03.018_bib30","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1164\/rccm.200906-0826OC","article-title":"Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema","volume":"181","author":"Diab","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jhep.2023.03.018_bib31","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.3390\/ijms21207537","article-title":"Sphingosine-1-phosphate receptor modulators and oligodendroglial cells: beyond immunomodulation","volume":"21","author":"Roggeri","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2023.03.018_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ana.22186","article-title":"Fingolimod provides long-term protection in rodent models of cerebral ischemia","volume":"69","author":"Wei","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jhep.2023.03.018_bib33","doi-asserted-by":"crossref","first-page":"G300","DOI":"10.1152\/ajpgi.00222.2016","article-title":"Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis","volume":"312","author":"Mauer","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2023.03.018_bib34","doi-asserted-by":"crossref","first-page":"10707","DOI":"10.1007\/s13277-014-2386-y","article-title":"FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K\/AKT\/mTOR\/p70S6K signaling pathway","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1016\/j.jhep.2023.03.018_bib35","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1177\/1352458518799598","article-title":"Liver injury with drugs used for multiple sclerosis: a contemporary analysis of the FDA Adverse Event Reporting System","volume":"25","author":"Antonazzo","year":"2019","journal-title":"Mult Scler"},{"issue":"3","key":"10.1016\/j.jhep.2023.03.018_bib36","first-page":"88","article-title":"Effects of fingolimod treatments on alanine transaminase and aspartate transaminase levels in patients with multiple sclerosis","volume":"12","author":"Joni","year":"2020","journal-title":"Int J Physiol Pathophysiol Pharmacol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827823001927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827823001927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:50:57Z","timestamp":1759175457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827823001927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0168827823001927"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2023.03.018","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2023.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}