{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:25:01Z","timestamp":1789021501964,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["101016726"],"award-info":[{"award-number":["101016726"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2016-02364358"],"award-info":[{"award-number":["RF-2016-02364358"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 di Catania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009702","name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universita e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jhep.2023.09.020","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T08:48:40Z","timestamp":1698223720000},"page":"10-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-2935","authenticated-orcid":false,"given":"Federico","family":"Salomone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria Maria","family":"Pipitone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-5883","authenticated-orcid":false,"given":"Miriam","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-3492","authenticated-orcid":false,"given":"Francesco","family":"Malvestiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Maria","family":"Amorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfio","family":"Distefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5938-0149","authenticated-orcid":false,"given":"Elia","family":"Casirati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Ciociola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-9329","authenticated-orcid":false,"given":"Nunzio","family":"Iraci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-7644","authenticated-orcid":false,"given":"Loredana","family":"Leggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Zito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-3962","authenticated-orcid":false,"given":"Nunzio","family":"Vicario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Saoca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Pennisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cabibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-7279","authenticated-orcid":false,"given":"Giuseppe","family":"Lazzarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-0171","authenticated-orcid":false,"given":"Anna Ludovica","family":"Fracanzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-7213","authenticated-orcid":false,"given":"Paola","family":"Dongiovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-0345","authenticated-orcid":false,"given":"Luca","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Petta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Li","family":"Volti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Grimaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jhep.2023.09.020_bib1","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.jhep.2023.09.020_bib2","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1053\/j.gastro.2020.01.043","article-title":"Association between fibrosis stage and outcomes of patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"158","author":"Taylor","year":"2020","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jhep.2023.09.020_bib3","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jhep.2020.02.020","article-title":"Update on NAFLD genetics: from new variants to the clinic","volume":"72","author":"Trepo","year":"2020","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.jhep.2023.09.020_bib4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cmet.2018.01.016","article-title":"The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications","volume":"27","author":"Carrico","year":"2018","journal-title":"Cell Metab"},{"issue":"9","key":"10.1016\/j.jhep.2023.09.020_bib5","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1074\/mcp.R114.046664","article-title":"Metabolic regulation by lysine malonylation, succinylation, and glutarylation","volume":"14","author":"Hirschey","year":"2015","journal-title":"Mol Cell Proteomics"},{"issue":"8","key":"10.1016\/j.jhep.2023.09.020_bib6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1089\/ars.2017.7270","article-title":"Extranuclear sirtuins and metabolic stress","volume":"28","author":"Elkhwanky","year":"2018","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"10.1016\/j.jhep.2023.09.020_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/10409238.2018.1458071","article-title":"Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology","volume":"53","author":"Kumar","year":"2018","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"11","key":"10.1016\/j.jhep.2023.09.020_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027157","article-title":"Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque","volume":"6","author":"Dong","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jhep.2023.09.020_bib9","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1136\/gutjnl-2019-319226","article-title":"Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker","volume":"69","author":"Baselli","year":"2020","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.jhep.2023.09.020_bib10","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"15","key":"10.1016\/j.jhep.2023.09.020_bib11","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.jhep.2023.09.020_bib12","doi-asserted-by":"crossref","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jhep.2023.09.020_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhep.2023.09.020_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"12","key":"10.1016\/j.jhep.2023.09.020_bib15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"43","key":"10.1016\/j.jhep.2023.09.020_bib16","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.jhep.2023.09.020_bib17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.jhep.2023.09.020_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-0716-1433-4_12","article-title":"Protocols for mitochondria as the target of pharmacological therapy in the context of nonalcoholic fatty liver disease (NAFLD)","volume":"2310","author":"Grattagliano","year":"2021","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10.1016\/j.jhep.2023.09.020_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42255-019-0161-5","article-title":"NAD(+) homeostasis in health and disease","volume":"2","author":"Katsyuba","year":"2020","journal-title":"Nat Metab"},{"issue":"4","key":"10.1016\/j.jhep.2023.09.020_bib25","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/hep.28245","article-title":"Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice","volume":"63","author":"Gariani","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2023.09.020_bib26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2013.10.033","article-title":"SIRT5 desuccinylates and activates SOD1 to eliminate ROS","volume":"441","author":"Lin","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.jhep.2023.09.020_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051126","article-title":"SIRT5 inhibition induces Brown fat-like phenotype in 3T3-L1 preadipocytes","volume":"10","author":"Molinari","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.jhep.2023.09.020_bib27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbrc.2018.06.073","article-title":"Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms","volume":"503","author":"Du","year":"2018","journal-title":"Biochem Biophys Res Commun"}],"updated-by":[{"DOI":"10.1016\/j.jhep.2023.12.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000}},{"DOI":"10.1016\/j.jhep.2026.05.005","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000}},{"DOI":"10.1016\/j.jhep.2026.05.005","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000}}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827823051474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827823051474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:15:52Z","timestamp":1774314952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827823051474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0168827823051474"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2023.09.020","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2023.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}