{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T22:38:02Z","timestamp":1794436682358,"version":"4.9.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 GM103504"],"award-info":[{"award-number":["P41 GM103504"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013873","name":"Government of Ontario","doi-asserted-by":"publisher","award":["ERA19-15-210"],"award-info":[{"award-number":["ERA19-15-210"]}],"id":[{"id":"10.13039\/100013873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["HIT168002"],"award-info":[{"award-number":["HIT168002"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT162098"],"award-info":[{"award-number":["PJT162098"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT162298"],"award-info":[{"award-number":["PJT162298"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["NHC-42832"],"award-info":[{"award-number":["NHC-42832"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019210","name":"University Health Network Foundation","doi-asserted-by":"publisher","award":["CZF2019-002429"],"award-info":[{"award-number":["CZF2019-002429"]}],"id":[{"id":"10.13039\/100019210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008538","name":"PSC Partners Seeking a Cure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"The Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000923","name":"Silicon Valley Community Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jhep.2023.12.023","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T16:57:18Z","timestamp":1704733038000},"page":"730-743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":215,"title":["Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-2196","authenticated-orcid":false,"given":"Tallulah S.","family":"Andrews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4046-2109","authenticated-orcid":false,"given":"Diana","family":"Nakib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-1778","authenticated-orcid":false,"given":"Catia T.","family":"Perciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Zhong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damra","family":"Camat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2684-7122","authenticated-orcid":false,"given":"Sai W.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1155-9793","authenticated-orcid":false,"given":"Patricia","family":"Lumanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantel","family":"Mangroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal","family":"Arpinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Thoeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3224-8871","authenticated-orcid":false,"given":"Blayne","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-2211","authenticated-orcid":false,"given":"Jordan","family":"Feld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-5840","authenticated-orcid":false,"given":"Adam","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Gulamhusein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon M.","family":"Hirschfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Ricciuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-8861","authenticated-orcid":false,"given":"Gary D.","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"McGilvray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8036-1425","authenticated-orcid":false,"given":"Sonya","family":"MacParland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2023.12.023_bib1","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2023.12.023_bib2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/hep4.1854","article-title":"Single-cell, single-nucleus, and spatial RNA sequencing of the human liver identifies cholangiocyte and mesenchymal heterogeneity","volume":"6","author":"Andrews","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2023.12.023_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.12.023_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.12.023_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cell.2020.08.040","article-title":"Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in hepatocellular carcinoma","volume":"183","author":"Sharma","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.12.023_bib6","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/s41591-020-1102-2","article-title":"Acute liver failure is regulated by MYC- and microbiome-dependent programs","volume":"26","author":"Kolodziejczyk","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2023.12.023_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-0042-1755272","article-title":"Unraveling the complexity of liver disease one cell at a time","volume":"42","author":"Atif","year":"2022","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2023.12.023_bib8","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1042\/CS20190654","article-title":"The immune niche of the liver","volume":"135","author":"Cheng","year":"2021","journal-title":"Clin Sci"},{"key":"10.1016\/j.jhep.2023.12.023_bib9","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jhep.2017.07.022","article-title":"Primary sclerosing cholangitis - a comprehensive review","volume":"67","author":"Karlsen","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2023.12.023_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jhep.2021.03.016","article-title":"Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis","volume":"75","author":"Poch","year":"2021","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.jhep.2023.12.023_bib11","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jhep.2022.06.025","article-title":"Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis","volume":"77","author":"M\u00fcller","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2023.12.023_bib12","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000242","article-title":"Beyond genome-wide association studies: investigating the role of noncoding regulatory elements in primary sclerosing cholangitis","volume":"7","author":"Pratt","year":"2023","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2023.12.023_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb3107","article-title":"A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells","volume":"13","author":"Zimmer","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhep.2023.12.023_bib14","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/hep4.1200","article-title":"Gut and liver B cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease","volume":"2","author":"Chung","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2023.12.023_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jhep.2016.09.002","article-title":"Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease","volume":"66","author":"Henriksen","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2023.12.023_bib16","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jhep.2018.05.018","article-title":"Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice","volume":"69","author":"Guicciardi","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2023.12.023_bib17","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jhep.2021.03.029","article-title":"Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis","volume":"75","author":"Reich","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2023.12.023_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/path.5228","article-title":"High-throughput sequencing identifies aetiology-dependent differences in ductular reaction in human chronic liver disease","volume":"248","author":"Govaere","year":"2019","journal-title":"J Pathol"},{"key":"10.1016\/j.jhep.2023.12.023_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113512","article-title":"Aberrant peribiliary gland niche exacerbates fibrosis in primary sclerosing cholangitis and a potential therapeutic strategy","volume":"153","author":"Wu","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jhep.2023.12.023_bib20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jhepr.2019.10.003","article-title":"Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis","volume":"1","author":"Chen","year":"2019","journal-title":"JHEP Rep"},{"issue":"4","key":"10.1016\/j.jhep.2023.12.023_bib21","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/hep.31140","article-title":"Monocytes as potential mediators of pathogen-induced Th17 differentiation in patients with primary sclerosing cholangitis (PSC)","volume":"72","author":"Kunzmann","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.12.023_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162270","article-title":"CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis","volume":"8","author":"Greenman","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.jhep.2023.12.023_bib23","series-title":"Human liver caudate lobe dissociation for ScRNA-seq v2","author":"MacParland","year":"2018"},{"key":"10.1016\/j.jhep.2023.12.023_bib24","series-title":"Human liver tissue storage methods for multiomic applications v1","author":"Nakib","year":"2022"},{"key":"10.1016\/j.jhep.2023.12.023_bib25","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41591-020-0844-1","article-title":"A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors","volume":"26","author":"Slyper","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2023.12.023_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13059-019-1662-y","article-title":"EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data","volume":"20","author":"Lun","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.jhep.2023.12.023_bib27","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.12.023_bib28","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.jhep.2023.12.023_bib29","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1126\/science.1136800","article-title":"Clustering by passing messages between data points","volume":"315","author":"Frey","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jhep.2023.12.023_bib30","series-title":"Learning theory and kernel machines","first-page":"173","article-title":"Comparing clusterings by the variation of information","author":"Meil\u0103","year":"2003"},{"key":"10.1016\/j.jhep.2023.12.023_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.4644","article-title":"scmap: projection of single-cell RNA-seq data across data sets","volume":"15","author":"Kiselev","year":"2018","journal-title":"Nat Methods"},{"key":"10.1016\/j.jhep.2023.12.023_bib32","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","article-title":"CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes","volume":"15","author":"Efremova","year":"2020","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jhep.2023.12.023_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhep.2023.12.023_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.890410","article-title":"Challenges and opportunities for immunoprofiling using a spatial high-plex technology: the NanoString GeoMx\u00ae digital spatial profiler","volume":"12","author":"Hernandez","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.jhep.2023.12.023_bib35","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1021\/acsnano.6b06245","article-title":"Phenotype determines nanoparticle uptake by human macrophages from liver and blood","volume":"11","author":"MacParland","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jhep.2023.12.023_bib36","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/nmat4718","article-title":"Mechanism of hard-nanomaterial clearance by the liver","volume":"15","author":"Tsoi","year":"2016","journal-title":"Nat Mater"},{"key":"10.1016\/j.jhep.2023.12.023_bib37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1440-1827.2009.02500.x","article-title":"Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: interobserver agreement","volume":"60","author":"Nakanuma","year":"2010","journal-title":"Pathol Int"},{"key":"10.1016\/j.jhep.2023.12.023_bib38","doi-asserted-by":"crossref","first-page":"170","DOI":"10.32074\/1591-951X-245","article-title":"Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis","volume":"113","author":"Sarcognato","year":"2021","journal-title":"Pathologica"},{"key":"10.1016\/j.jhep.2023.12.023_bib39","series-title":"Qupath digital quantification of liver immune cells v1","author":"Wang","year":"2021"},{"key":"10.1016\/j.jhep.2023.12.023_bib40","series-title":"QuPath immunofluorescence cell detection and Co-localization protocol","author":"Lumanto","year":"2024"},{"key":"10.1016\/j.jhep.2023.12.023_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abf7777","article-title":"Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles","volume":"7","author":"Dick","year":"2022","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jhep.2023.12.023_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","article-title":"Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction","volume":"20","author":"Dick","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2023.12.023_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0964","article-title":"Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches","volume":"363","author":"Chakarov","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jhep.2023.12.023_bib44","first-page":"767","article-title":"LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation","volume":"126","author":"Schiller","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jhep.2023.12.023_bib45","article-title":"Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jhep.2023.12.023_bib46","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00011-017-1032-8","article-title":"The immunological function of CD52 and its targeting in organ transplantation","volume":"66","author":"Zhao","year":"2017","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jhep.2023.12.023_bib47","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-associated macrophages control metabolic homeostasis in a trem2-dependent manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.12.023_bib48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jhep.2023.12.023_bib49","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.immuni.2019.08.017","article-title":"Stellate cells, hepatocytes, and endothelial cells imprint the kupffer cell identity on monocytes colonizing the liver macrophage niche","volume":"51","author":"Bonnardel","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2023.12.023_bib50","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1084\/jem.187.12.1965","article-title":"Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34","volume":"187","author":"Sassetti","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2023.12.023_bib51","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1084\/jem.188.11.2181","article-title":"The functional paradox of CD43 in leukocyte recruitment: a study using CD43-deficient mice","volume":"188","author":"Woodman","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2023.12.023_bib52","first-page":"56","article-title":"Important role of P-selectin for leukocyte recruitment, hepatocellular injury, and apoptosis in endotoxemic mice","volume":"11","author":"Klintman","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.jhep.2023.12.023_bib53","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1002\/hep4.2001","article-title":"Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis","volume":"6","author":"Chung","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2023.12.023_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.649311","article-title":"Insights into human intrahepatic NK cell function from single cell RNA sequencing datasets","volume":"12","author":"Jameson","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2023.12.023_bib55","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1038\/s41467-019-11947-7","article-title":"Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome","volume":"10","author":"Yang","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2023.12.023_bib56","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nature04651","article-title":"Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction","volume":"440","author":"Castellino","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.12.023_bib57","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1073\/pnas.0508235103","article-title":"Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes","volume":"103","author":"Das","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2023.12.023_bib58","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1038\/s41598-017-01828-8","article-title":"IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis","volume":"7","author":"Peshkova","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2023.12.023_bib59","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.imbio.2006.05.008","article-title":"Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1","volume":"211","author":"R\u00fcckerl","year":"2006","journal-title":"Immunobiology"},{"key":"10.1016\/j.jhep.2023.12.023_bib60","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2016.07.019","article-title":"The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity","volume":"166","author":"Damgaard","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.12.023_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109897","article-title":"Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease","volume":"37","author":"Tiwari-Heckler","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2023.12.023_bib62","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.immunol.16.1.137","article-title":"Regulation of immune responses by TGF-beta","volume":"16","author":"Letterio","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2023.12.023_bib63","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/hep.31488","article-title":"A fibrosis-independent hepatic transcriptomic signature identifies drivers of disease progression in primary sclerosing cholangitis","volume":"73","author":"Gindin","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jhep.2023.12.023_bib64","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/HEP.0000000000000270","article-title":"Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression","volume":"78","author":"Guillot","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.12.023_bib65","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41586-018-0075-5","article-title":"De novo formation of the biliary system by TGF\u03b2-mediated hepatocyte transdifferentiation","volume":"557","author":"Schaub","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.12.023_bib66","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.ajpath.2014.01.005","article-title":"Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver","volume":"184","author":"Sekiya","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2023.12.023_bib67","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1016\/j.cell.2022.06.048","article-title":"Epigenetic reader SP140 loss of function drives Crohn\u2019s disease due to uncontrolled macrophage topoisomerases","volume":"185","author":"Amatullah","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2023.12.023_bib68","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.chom.2022.08.018","article-title":"Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease","volume":"30","author":"Fraschilla","year":"2022","journal-title":"Cell Host Microbe"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824000035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824000035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:10:45Z","timestamp":1778674245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824000035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0168827824000035"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2023.12.023","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2023.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}