{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:15:59Z","timestamp":1793103359183,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972266"],"award-info":[{"award-number":["81972266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002622"],"award-info":[{"award-number":["82002622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170548"],"award-info":[{"award-number":["82170548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173100"],"award-info":[{"award-number":["82173100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300600"],"award-info":[{"award-number":["82300600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jhep.2023.12.024","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T03:34:57Z","timestamp":1704339297000},"page":"764-777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Ileitis promotes MASLD progression via bile acid modulation and enhanced TGR5 signaling in ileal CD8+ T cells"],"prefix":"10.1016","volume":"80","author":[{"given":"Chang","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6995-9557","authenticated-orcid":false,"given":"Runqiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2023.12.024_bib1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A\u00a0multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.12.024_bib2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","article-title":"A\u00a0new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement","volume":"73","author":"Eslam","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.12.024_bib3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/ije\/dyaa196","article-title":"Global trend of aetiology-based primary liver cancer incidence from 1990 to 2030: a modelling study","volume":"50","author":"Liu","year":"2021","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jhep.2023.12.024_bib4","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2023.12.024_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41423-020-00579-3","article-title":"Immunological mechanisms and therapeutic targets of fatty liver diseases","volume":"18","author":"Wang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jhep.2023.12.024_bib6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1053\/j.gastro.2019.06.028","article-title":"Microbiome signatures\u00a0associated with steatohepatitis and moderate to severe fibrosis in\u00a0children with nonalcoholic fatty liver disease","volume":"157","author":"Schwimmer","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2023.12.024_bib7","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jhep.2019.08.005","article-title":"Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development","volume":"71","author":"Mouries","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.12.024_bib8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/ibd\/izaa189","article-title":"Prevalence of nonalcoholic fatty liver disease in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"27","author":"Lin","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jhep.2023.12.024_bib9","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/ibd\/izy051","article-title":"Nonalcoholic fatty liver disease in inflammatory bowel disease: prevalence and risk factors","volume":"24","author":"Principi","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jhep.2023.12.024_bib10","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.cgh.2019.02.045","article-title":"Crohn's disease is associated with an increased prevalence of nonalcoholic fatty liver disease: a cross-sectional study using magnetic resonance proton density fat fraction mapping","volume":"17","author":"McHenry","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2023.12.024_bib11","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn's disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2023.12.024_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2023.12.024_bib13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.crohns.2013.11.021","article-title":"Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe--an ECCO-EpiCom study","volume":"8","author":"Burisch","year":"2014","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.jhep.2023.12.024_bib14","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1194\/jlr.R054114","article-title":"Intestinal transport and metabolism of bile acids","volume":"56","author":"Dawson","year":"2015","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jhep.2023.12.024_bib15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jhep.2010.12.004","article-title":"The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation","volume":"54","author":"Pols","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.12.024_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12915-017-0462-7","article-title":"Bile acid is a significant host factor shaping\u00a0the gut microbiome of diet-induced obese mice","volume":"15","author":"Zheng","year":"2017","journal-title":"BMC Biol"},{"key":"10.1016\/j.jhep.2023.12.024_bib17","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/apt.13333","article-title":"Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?","volume":"42","author":"Pavlidis","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2023.12.024_bib18","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1074\/jbc.M506710200","article-title":"Deoxycholic acid induces intracellular signaling through membrane perturbations","volume":"281","author":"Jean-Louis","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2023.12.024_bib19","doi-asserted-by":"crossref","first-page":"H216","DOI":"10.1111\/1750-3841.13166","article-title":"High-fat diet-induced intestinal hyperpermeability is associated with increased bile acids in the large intestine of mice","volume":"81","author":"Murakami","year":"2016","journal-title":"J\u00a0Food Sci"},{"key":"10.1016\/j.jhep.2023.12.024_bib20","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1111\/liv.15003","article-title":"Anti-TNF\u03b1 treatment in Crohn's disease: impact on hepatic steatosis, gut-derived hormones and metabolic status","volume":"41","author":"Manka","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2023.12.024_bib21","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41385-019-0162-4","article-title":"Emerging roles of bile acids in mucosal immunity and inflammation","volume":"12","author":"Chen","year":"2019","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jhep.2023.12.024_bib22","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1007\/s00259-013-2466-z","article-title":"Recycling rate of bile acids in the enterohepatic recirculation as a major determinant of whole body 75SeHCAT retention","volume":"40","author":"Peters","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jhep.2023.12.024_bib23","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/S0016-5085(99)70507-X","article-title":"Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn's disease","volume":"116","author":"Brink","year":"1999","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.jhep.2023.12.024_bib24","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jhep.2023.12.024_bib25","first-page":"10","article-title":"High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review","author":"Malesza","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2023.12.024_bib26","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jhep.2023.12.024_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2023.12.024_bib28","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1161\/01.ATV.0000178994.21828.a7","article-title":"The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism","volume":"25","author":"Claudel","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jhep.2023.12.024_bib29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2023.12.024_bib30","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/gutjnl-2017-314307","article-title":"Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD","volume":"67","author":"Jiao","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2023.12.024_bib31","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","article-title":"Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2023.12.024_bib32","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1038\/s41586-020-2030-5","article-title":"Author Correction: bile acid metabolites control T(H)17 and T(reg) cell differentiation","volume":"579","author":"Hang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.12.024_bib33","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-019-1865-0","article-title":"Microbial bile acid metabolites modulate gut ROR\u03b3(+) regulatory T cell homeostasis","volume":"577","author":"Song","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.12.024_bib34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-020-2193-0","article-title":"Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells","volume":"581","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.12.024_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061281","article-title":"Bile acids activated receptors in inflammatory bowel disease","volume":"10","author":"Biagioli","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2023.12.024_bib36","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-020-2569-1","article-title":"Structural basis of GPBAR activation and bile acid recognition","volume":"587","author":"Yang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2023.12.024_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109726","article-title":"Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling","volume":"36","author":"Hu","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2023.12.024_bib38","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1172\/JCI76289","article-title":"TGR5 reduces macrophage migration through mTOR-induced C\/EBP\u03b2 differential translation","volume":"124","author":"Perino","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2023.12.024_bib39","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ni.1603","article-title":"Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking","volume":"9","author":"Sinclair","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2023.12.024_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nri2888","article-title":"Metabolism, migration and memory in cytotoxic T cells","volume":"11","author":"Finlay","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2023.12.024_bib41","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ni.3314","article-title":"The cytotoxic T cell proteome\u00a0and its shaping by the kinase mTOR","volume":"17","author":"Hukelmann","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhep.2023.12.024_bib42","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41467-017-00612-6","article-title":"NFATc1 controls the cytotoxicity of CD8(+) T cells","volume":"8","author":"Klein-Hessling","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2023.12.024_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe9977","article-title":"Mitochondrial translation is required for sustained killing by cytotoxic T cells","volume":"374","author":"Lisci","year":"2021","journal-title":"Science"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824000047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824000047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T23:22:24Z","timestamp":1713309744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824000047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S0168827824000047"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2023.12.024","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ileitis promotes MASLD progression via bile acid modulation and enhanced TGR5 signaling in ileal CD8+ T cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2023.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}