{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:20:59Z","timestamp":1793402459913,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005624","name":"Medizinischen Hochschule Hannover","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 3696\/3-1"],"award-info":[{"award-number":["ME 3696\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jhep.2024.03.005","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T12:23:03Z","timestamp":1710159783000},"page":"248-257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Validation of Baveno VII criteria and other non-invasive diagnostic algorithms for clinically significant portal hypertension in hepatitis delta"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-4147","authenticated-orcid":false,"given":"Mathias","family":"Jachs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4425-2640","authenticated-orcid":false,"given":"Lisa","family":"Sandmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-6120","authenticated-orcid":false,"given":"Lukas","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammo","family":"Tergast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2587-1385","authenticated-orcid":false,"given":"Michael","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-8518","authenticated-orcid":false,"given":"David Josef Maria","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-3061","authenticated-orcid":false,"given":"Lorenz","family":"Balcar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Ehrenbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-3372","authenticated-orcid":false,"given":"Benedikt Silvester","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Lenzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Deterding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-6425","authenticated-orcid":false,"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3583","authenticated-orcid":false,"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-3177","authenticated-orcid":false,"given":"Benjamin","family":"Maasoumy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2024.03.005_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jhep.2017.10.020","article-title":"Clinical states of cirrhosis and competing risks","volume":"68","author":"D'Amico","year":"2018","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII - renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib3","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(18)31875-0","article-title":"\u03b2 blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial","volume":"393","author":"Villanueva","year":"2019","journal-title":"The Lancet"},{"key":"10.1016\/j.jhep.2024.03.005_bib4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1055\/s-0040-1708806","article-title":"Noninvasive diagnostics for portal hypertension: a comprehensive review","volume":"40","author":"Mandorfer","year":"2020","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2024.03.005_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00508-023-02229-w","article-title":"Austrian consensus on the diagnosis and management of portal hypertension in advanced chronic liver disease (Billroth IV)","volume":"135","author":"Mandorfer","year":"2023","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jhep.2024.03.005_bib6","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/hep.28824","article-title":"Noninvasive tools and risk of\u00a0clinically significant portal hypertension and varices in compensated\u00a0cirrhosis: the \"Anticipate\" study","volume":"64","author":"Abraldes","year":"2016","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.03.005_bib7","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.cgh.2022.09.032","article-title":"The sequential application of Baveno VII criteria and VITRO score improves diagnosis of clinically significant portal hypertension","volume":"21","author":"Jachs","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib8","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.14309\/ajg.0000000000001887","article-title":"A\u00a0combined Baveno VII and spleen stiffness algorithm to improve the noninvasive diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease","volume":"117","author":"Dajti","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2024.03.005_bib9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S2468-1253(23)00150-4","article-title":"Accuracy of spleen stiffness measurement for the diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a systematic review and individual patient data meta-analysis","volume":"8","author":"Dajti","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jhep.2022.09.012","article-title":"Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis","volume":"78","author":"Reini\u0161","year":"2023","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jhep.2020.04.008","article-title":"The global prevalence of hepatitis D virus infection: systematic review and meta-analysis","volume":"73","author":"Stockdale","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/ueg2.12163","article-title":"Hepatitis D virus (HDV) prevalence in Austria is low but causes considerable morbidity due to fast progression to cirrhosis","volume":"9","author":"Jachs","year":"2021","journal-title":"United Eur Gastroenterol J"},{"key":"10.1016\/j.jhep.2024.03.005_bib13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/jvh.13235","article-title":"Vibration-controlled transient elastography for the detection of cirrhosis in chronic hepatitis D infection","volume":"27","author":"Da","year":"2020","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1016\/j.jhep.2024.03.005_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/apt.13834","article-title":"Noninvasive markers for staging\u00a0fibrosis in chronic delta hepatitis","volume":"45","author":"Takyar","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2024.03.005_bib15","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/j.jhep.2023.01.004","article-title":"3P and 5P models of limited value for the detection of clinically significant portal hypertension in patients with hepatitis delta","volume":"79","author":"Sandmann","year":"2023","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jhep.2023.05.001","article-title":"EASL Clinical Practice Guidelines on hepatitis delta virus","volume":"79","author":"European Association for the Study of the Liver","year":"2023","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa2213429","article-title":"A\u00a0phase 3, randomized trial of bulevirtide in chronic hepatitis D","volume":"389","author":"Wedemeyer","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jhep.2024.03.005_bib18","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.jhep.2022.07.016","article-title":"Bulevirtide monotherapy for 48 weeks in patients with HDV-related compensated cirrhosis and clinically significant portal hypertension","volume":"77","author":"Degasperi","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/apt.16945","article-title":"Response-guided long-term treatment of chronic hepatitis D patients with bulevirtide-results of a \"real world\" study","volume":"56","author":"Jachs","year":"2022","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.jhep.2024.03.005_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/apt.12788","article-title":"Long-term therapy of chronic delta hepatitis with peginterferon alfa","volume":"40","author":"Heller","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2024.03.005_bib21","article-title":"Measurement of the hepatic venous pressure gradient and transjugular liver biopsy","author":"Reiberger","year":"2020","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.jhep.2024.03.005_bib22","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1128\/JCM.43.5.2363-2369.2005","article-title":"Quantification of hepatitis delta virus RNA in serum by consensus real-time PCR indicates different patterns of virological response to interferon therapy in chronically infected patients","volume":"43","author":"Le Gal","year":"2005","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jhep.2024.03.005_bib23","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.cgh.2021.07.012","article-title":"Decreasing von Willebrand factor levels upon nonselective beta blocker therapy indicate a decreased risk of further decompensation, acute-on-chronic liver failure, and death","volume":"20","author":"Jachs","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib24","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jhep.2021.05.025","article-title":"EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver\u00a0disease severity and prognosis - 2021 update","volume":"75","author":"European Association for the Study of the Liver","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.005_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/liv.13205","article-title":"Non-invasive fibrosis score for hepatitis delta","volume":"37","author":"Lutterkort","year":"2017","journal-title":"Liver Int"},{"issue":"10","key":"10.1016\/j.jhep.2024.03.005_bib26","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/infdis\/jiz633","article-title":"Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection","volume":"221","author":"Miao","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jhep.2024.03.005_bib27","article-title":"Liver stiffness measurement as a noninvasive method for the diagnosis of liver cirrhosis in patients with chronic hepatitis D virus infection","author":"Sandmann","year":"2024","journal-title":"Aliment Pharmacol Ther"},{"issue":"S1","key":"10.1016\/j.jhep.2024.03.005_bib28","first-page":"S64","article-title":"Liver stiffness measurement to detect severe fibrosis and cirrhosis in patients with chronic hepatitis D infection","volume":"78","author":"Roulot","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.03.005_bib29","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jhep.2023.12.028","article-title":"Prognostic performance of non-invasive tests for portal hypertension is comparable to that of hepatic venous pressure gradient","volume":"80","author":"Jachs","year":"2024","journal-title":"J\u00a0Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.jhep.2024.03.005_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/liv.15410","article-title":"Interferon-based treatment of chronic hepatitis D","volume":"43","author":"Sandmann","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2024.03.005_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223531","article-title":"Treatment of chronic hepatitis D with bulevirtide-A fight against two foes-an update","volume":"11","author":"Ferenci","year":"2022","journal-title":"Cells"},{"issue":"S1","key":"10.1016\/j.jhep.2024.03.005_bib32","first-page":"26","article-title":"Bulevirtide, with or without Peg- interferon, in HDV infected patients in a real-life setting. Two-year results from the French multicenter early access program","volume":"76","author":"De L\u00e9dinghen","year":"2022","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.jhep.2024.03.005_bib33","article-title":"Long-term follow-up of patients discontinuing bulevirtide treatment upon long-term HDV-RNA suppression","volume":"5","author":"Jachs","year":"2023","journal-title":"JHEP Rep"},{"issue":"12","key":"10.1016\/j.jhep.2024.03.005_bib34","doi-asserted-by":"crossref","first-page":"e715","DOI":"10.1055\/a-2181-3345","article-title":"Antiviral Therapy of Chronic Hepatitis D Virus infection - Addendum to the S3 Guideline \u201dProphylaxis, Diagnosis and Therapy of Hepatitis B Virus Infection\" of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS)","volume":"61","author":"Sandmann","year":"2023","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.jhep.2024.03.005_bib35","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jhep.2022.08.025","article-title":"Non-invasive tests for clinically significant portal hypertension after HCV cure","volume":"77","author":"Semmler","year":"2022","journal-title":"J\u00a0Hepatol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824001569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824001569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:59:39Z","timestamp":1773457179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824001569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0168827824001569"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2024.03.005","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of Baveno VII criteria and other non-invasive diagnostic algorithms for clinically significant portal hypertension in hepatitis delta","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2024.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}