{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:52:08Z","timestamp":1793753528357,"version":"4.6.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202206080016"],"award-info":[{"award-number":["202206080016"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372914"],"award-info":[{"award-number":["82372914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173191"],"award-info":[{"award-number":["82173191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130083"],"award-info":[{"award-number":["82130083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["81825013"],"award-info":[{"award-number":["81825013"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1111020007"],"award-info":[{"award-number":["2023B1111020007"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010220"],"award-info":[{"award-number":["2020A1515010220"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jhep.2024.03.016","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T22:30:15Z","timestamp":1710801015000},"page":"265-277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma"],"prefix":"10.1016","volume":"81","author":[{"given":"Lixia","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3185-0422","authenticated-orcid":false,"given":"Xinlang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingle","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4011-9742","authenticated-orcid":false,"given":"Fei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaomin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongdao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-7505","authenticated-orcid":false,"given":"Xiaoxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianchen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-9101","authenticated-orcid":false,"given":"Xiaoxuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunli","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-5779","authenticated-orcid":false,"given":"Ming","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2024.03.016_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.03.016_bib2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1053\/j.gastro.2021.10.017","article-title":"Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2021","volume":"162","author":"Peery","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.03.016_bib3","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0140-6736(23)00727-4","article-title":"Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"401","author":"Kelley","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2024.03.016_bib4","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2200015","article-title":"Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer","volume":"1","author":"Oh","year":"2022","journal-title":"NEJM Evid"},{"key":"10.1016\/j.jhep.2024.03.016_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A\u00a0review of human carcinogens\u2013Part B: biological agents","volume":"10","author":"Bouvard","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jhep.2024.03.016_bib6","first-page":"121","volume":"61","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"key":"10.1016\/j.jhep.2024.03.016_bib7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2049-9957-1-4","article-title":"The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma","volume":"1","author":"Qian","year":"2012","journal-title":"Infect Dis Poverty"},{"key":"10.1016\/j.jhep.2024.03.016_bib8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0140-6736(15)60313-0","article-title":"Clonorchiasis","volume":"387","author":"Qian","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2024.03.016_bib9","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00436-012-3264-4","volume":"112","author":"Zheng","year":"2013","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jhep.2024.03.016_bib10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00436-008-1286-8","article-title":"Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products","volume":"104","author":"Pak","year":"2009","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jhep.2024.03.016_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molbiopara.2010.03.005","article-title":"Transcriptional induction of minichromosome maintenance protein 7 (Mcm7) in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products","volume":"173","author":"Kim","year":"2010","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.jhep.2024.03.016_bib12","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/hep.23134","article-title":"Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6","volume":"50","author":"Sripa","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.03.016_bib13","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1158\/2159-8290.CD-21-1077","article-title":"Mutant IDH inhibits IFNgamma-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma","volume":"12","author":"Wu","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jhep.2024.03.016_bib14","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1158\/0008-5472.CAN-14-2561","article-title":"Omega-3 polyunsaturated fatty acids upregulate 15-PGDH expression in cholangiocarcinoma cells by inhibiting miR-26a\/b expression","volume":"75","author":"Yao","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2024.03.016_bib15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jhep.2022.04.038","article-title":"Metabolic reprogramming in cholangiocarcinoma","volume":"77","author":"Raggi","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.03.016_bib16","article-title":"Clinical characteristics of Clonorchis sinensis-associated cholangiocarcinoma: a large-scale, single-center study","volume":"8","author":"Chang","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jhep.2024.03.016_bib17","first-page":"198","article-title":"Advances in the treatment of intrahepatic cholangiocarcinoma: an overview of the current and future therapeutic landscape for clinicians","volume":"73","author":"Moris","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jhep.2024.03.016_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1200\/GO.20.00030","article-title":"Lack of targetable FGFR2 fusions in endemic fluke-associated cholangiocarcinoma","volume":"6","author":"Kongpetch","year":"2020","journal-title":"JCO Glob Oncol"},{"key":"10.1016\/j.jhep.2024.03.016_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43803","article-title":"Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq","volume":"8","author":"Kotliar","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jhep.2024.03.016_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s42255-019-0038-7","article-title":"Molecular logic of mTORC1 signalling as a metabolic rheostat","volume":"1","author":"Valvezan","year":"2019","journal-title":"Nat Metab"},{"key":"10.1016\/j.jhep.2024.03.016_bib21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1158\/2159-8290.CD-21-0316","article-title":"Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level","volume":"12","author":"Wu","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jhep.2024.03.016_bib22","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1158\/2159-8290.CD-RW2021-051","article-title":"Breast cancer brain metastases rely on FASN-mediated lipid biosynthesis","volume":"11","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jhep.2024.03.016_bib23","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2019.10.003","article-title":"Landscape and dynamics of single immune cells in hepatocellular carcinoma","volume":"179","author":"Zhang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.03.016_bib24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ccell.2021.02.015","article-title":"Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma","volume":"39","author":"Bi","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2024.03.016_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113379","article-title":"Osteopontin: a key regulator of tumor progression and immunomodulation","volume":"12","author":"Moorman","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jhep.2024.03.016_bib26","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1016\/j.cell.2021.04.038","article-title":"Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages","volume":"184","author":"Obradovic","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.03.016_bib27","article-title":"Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy","volume":"11","author":"van Elsas","year":"2023","journal-title":"J\u00a0Immunother Cancer"},{"key":"10.1016\/j.jhep.2024.03.016_bib28","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2024.03.016_bib29","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.03.016_bib30","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41592-021-01274-5","article-title":"Systematic investigation of cytokine signaling activity at the tissue and single-cell levels","volume":"18","author":"Jiang","year":"2021","journal-title":"Nat Methods"},{"key":"10.1016\/j.jhep.2024.03.016_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3347\/kjp.2003.41.1.35","article-title":"Excretory-secretory antigen is better than crude antigen for the serodiagnosis of clonorchiasis by ELISA","volume":"41","author":"Choi","year":"2003","journal-title":"Korean J Parasitol"},{"key":"10.1016\/j.jhep.2024.03.016_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41571-019-0203-7","article-title":"Navigating metabolic pathways to enhance antitumour immunity and immunotherapy","volume":"16","author":"Li","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jhep.2024.03.016_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fmolb.2019.00106","article-title":"Fatty acid synthase contributes to restimulation-induced cell death of human CD4 T cells","volume":"6","author":"Voss","year":"2019","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jhep.2024.03.016_bib34","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic instruction of immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.03.016_bib35","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1158\/1078-0432.CCR-21-1157","article-title":"Multiomic analysis reveals comprehensive tumor heterogeneity and distinct immune subtypes in multifocal intrahepatic cholangiocarcinoma","volume":"28","author":"Chen","year":"2022","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jhep.2024.03.016_bib36","article-title":"Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application","volume":"4","author":"Ren","year":"2023","journal-title":"Cell Rep Med"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824001995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824001995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:10:29Z","timestamp":1778674229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824001995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0168827824001995"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2024.03.016","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2024.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}