{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:23:25Z","timestamp":1793899405390,"version":"4.8.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014923","name":"Cymabay Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jhep.2024.04.008","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T12:27:35Z","timestamp":1713961655000},"page":"726-742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Assessment of fatigue and its impact in chronic liver disease"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-948X","authenticated-orcid":false,"given":"Andreas E.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-4468","authenticated-orcid":false,"given":"Mark G.","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-6811","authenticated-orcid":false,"given":"Christopher","family":"Bowlus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-6425","authenticated-orcid":false,"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2024.04.008_bib1","unstructured":"World Health Organization (WHO). Health and Well Being Definition. Obtained from the world wide web at: https:\/\/www.who.int\/data\/gho\/data\/major-themes\/health-and-well-being#:\u223c:text=The%20WHO%20constitution%20states%3A%20%22Health,of%20mental%20disorders%20or%20disabilities. Last accessed on 12\/18\/23."},{"key":"10.1016\/j.jhep.2024.04.008_bib2","unstructured":"National Quality Forum. Patient Reported Outcome Definition. Obtained from the world wide web at: https:\/\/www.qualityforum.org\/Projects\/n-r\/Patient-Reported_Outcomes\/Patient-Reported_Outcomes.aspx. Last accessed on 12\/18\/23."},{"key":"10.1016\/j.jhep.2024.04.008_bib3","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s11136-015-1168-3","article-title":"Patient-reported outcomes: pathways to better health, better services, and better societies","volume":"25","author":"Black","year":"2016","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jhep.2024.04.008_bib4","unstructured":"WHO. Definition of Quality of Life. Obtained from the world wide web at: https:\/\/www.who.int\/tools\/whoqol. Last accessed on 12\/18\/2023."},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cld.2015.08.007","article-title":"Understanding and treating fatigue in primary biliary cirrhosis and primary sclerosing cholangitis","volume":"20","author":"Jopson","year":"2016","journal-title":"Clin Liver Dis"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/liv.13919","article-title":"Fatigue in chronic liver disease: new insights and therapeutic approaches","volume":"39","author":"Swain","year":"2019","journal-title":"Liver Int"},{"issue":"28","key":"10.1016\/j.jhep.2024.04.008_bib7","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.3748\/wjg.v25.i28.3669","article-title":"Importance of fatigue and its measurement in chronic liver disease","volume":"25","author":"Gerber","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhep.2024.04.008_bib8","doi-asserted-by":"crossref","first-page":"622","DOI":"10.7326\/0003-4819-118-8-199304150-00009","article-title":"Measuring health-related quality of life","volume":"118","author":"Guyatt","year":"1993","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11136-006-9131-y","article-title":"Generic and disease-specific health related quality of life of liver patients with various aetiologies: a survey","volume":"16","author":"van der Plas","year":"2007","journal-title":"Qual Life Res"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib10","first-page":"171","article-title":"Measuring change over time: assessing the usefulness of evaluative instruments","volume":"40","author":"Guyatt","year":"1987","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0197-2456(89)90005-6","article-title":"Measurement of health status","volume":"10","author":"Jaeschke","year":"1989","journal-title":"Control Clin Trials"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib12","doi-asserted-by":"crossref","first-page":"E82","DOI":"10.1179\/jmt.2008.16.4.82E","article-title":"The minimal clinically important change score (MCID): a necessary pretense","volume":"16","author":"Cook","year":"2008","journal-title":"J\u00a0Man Manip Ther"},{"key":"10.1016\/j.jhep.2024.04.008_bib13","unstructured":"US Food and Drug Administration. Incorporating clinical outcome assessments into endpoints for regulatory decision-making. Dec 6, 2019. Obtained from the world wide web at: https:\/\/www.fda.gov\/media\/132505\/download. Last accessed on 1\/9\/2024."},{"key":"10.1016\/j.jhep.2024.04.008_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"10.1016\/j.jhep.2024.04.008_bib15","unstructured":"EQ-5D. Obtained from the world wide web at: https:\/\/euroqol.org\/eq-5d-instruments\/. Last accessed on 2\/22\/23."},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/gut.45.2.295","article-title":"Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease","volume":"45","author":"Younossi","year":"1999","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.jhep.2024.04.008_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jval.2016.02.005","article-title":"Performance and validation of chronic liver disease questionnaire-hepatitis C version (CLDQ-HCV) in clinical trials of patients with chronic hepatitis C","volume":"19","author":"Younossi","year":"2016","journal-title":"Value Health"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/jvh.13451","article-title":"Development and validation of a hepatitis B-specific health-related quality-of-life instrument: CLDQ-HBV","volume":"28","author":"Younossi","year":"2021","journal-title":"J\u00a0Viral Hepat"},{"issue":"8","key":"10.1016\/j.jhep.2024.04.008_bib19","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/liv.13391","article-title":"A\u00a0disease- specific quality of life instrument for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: CLDQ-NAFLD","volume":"37","author":"Younossi","year":"2017","journal-title":"Liver Int"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000049","article-title":"Development and validation of a primary sclerosing cholangitis-specific health-related quality of life instrument: CLDQ-PSC","volume":"7","author":"Younossi","year":"2023","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2024.04.008_bib21","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1136\/gut.2005.065862","article-title":"Development, validation and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis","volume":"54","author":"Jacoby","year":"2005","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.jhep.2024.04.008_bib22","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s11136-008-9395-5","article-title":"Deriving utility scores from the SF-36 health instrument using Rasch analysis","volume":"17","author":"Hawthorne","year":"2008","journal-title":"Qual Life Res"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib23","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-3999(94)00125-O","article-title":"The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue","volume":"39","author":"Smets","year":"1995","journal-title":"J\u00a0Psychosom Res"},{"key":"10.1016\/j.jhep.2024.04.008_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1523-5394.1998.006003143.x","article-title":"A\u00a0multidimensional measure of fatigue for use with cancer patients","volume":"6","author":"Stein","year":"1998","journal-title":"Cancer Pract"},{"key":"10.1016\/j.jhep.2024.04.008_bib25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1023\/A:1008960710415","article-title":"Psychometric evaluation of the fatigue severity scale for use in chronic hepatitis C","volume":"9","author":"Kleinman","year":"2000","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jhep.2024.04.008_bib26","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/clinids\/18.Supplement_1.S79","article-title":"Measuring the functional impact of fatigue: initial validation of the fatigue impact scale","volume":"18","author":"Fisk","year":"1994","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0885-3924(96)00274-6","article-title":"Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system","volume":"13","author":"Yellen","year":"1997","journal-title":"J\u00a0Pain Symptom Manage"},{"key":"10.1016\/j.jhep.2024.04.008_bib28","unstructured":"FACIT Tool. Obtained from the world wide web at: https:\/\/www.facit.org\/measures\/facit-fatigue. Last accessed on 12\/18\/2023."},{"key":"10.1016\/j.jhep.2024.04.008_bib29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0165-1781(91)90027-M","article-title":"Validity and reliability of a scale to assess fatigue","volume":"36","author":"Lee","year":"1991","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pain.2008.03.024","article-title":"The accuracy of pain and fatigue items across different reporting periods","volume":"139","author":"Broderick","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.jhep.2024.04.008_bib31","doi-asserted-by":"crossref","unstructured":"Schneider S, Junghaenel DU, Keefe FJ, et\u00a0al. Individual differences in the day-to-day variability of pain, fatigue, and well-being in patients with rheumatic disease: associations with psychological variables 2012. Pain, 153(4), 813\u2013822.","DOI":"10.1016\/j.pain.2012.01.001"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib32","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s11136-013-0553-z","article-title":"Measuring daily fatigue using a brief scale adapted from the Patient-Reported Outcomes Measurement Information System (PROMIS \u00ae)","volume":"23","author":"Christodoulou","year":"2014","journal-title":"Qual Life Res"},{"issue":"Suppl 1","key":"10.1016\/j.jhep.2024.04.008_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40273-017-0537-x","article-title":"Heath state utility values for cost-effectiveness models","volume":"35","author":"Karnon","year":"2017","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jhep.2024.04.008_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2165\/00019053-199304050-00006","article-title":"The validity and reproducibility of a work productivity and activity impairment instrument","volume":"4","author":"Reilly","year":"1993","journal-title":"Pharmaco Econ"},{"key":"10.1016\/j.jhep.2024.04.008_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0277-9536(99)00452-9","article-title":"Precision in measuring absence from work as a basis for calculating productivity costs in The Netherlands","volume":"51","author":"Severens","year":"2000","journal-title":"Social Sci Med"},{"issue":"5","key":"10.1016\/j.jhep.2024.04.008_bib36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MCG.0000000000001179","article-title":"A\u00a0comprehensive review of patient-reported outcomes in patients with chronic liver diseases","volume":"53","author":"Younossi","year":"2019","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jhep.2024.04.008_bib37","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1572-0241.2000.01857.x","article-title":"Impact of fatigue on the quality of life in patients with primary biliary cirrhosis","volume":"95","author":"Huet","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.jhep.2024.04.008_bib38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/apt.13090","article-title":"Systematic review: patient-reported outcomes in chronic hepatitis C--the impact of liver disease and new treatment regimens","volume":"41","author":"Younossi","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"issue":"9","key":"10.1016\/j.jhep.2024.04.008_bib39","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.cgh.2021.07.020","volume":"20","author":"Younossi","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"10.1016\/j.jhep.2024.04.008_bib40","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.cgh.2021.11.004","article-title":"Clinical and patient-reported outcomes from patients with nonalcoholic fatty liver disease across the world: data from the global non-alcoholic steatohepatitis (NASH)\/non-alcoholic fatty liver disease (NAFLD) registry","volume":"20","author":"Younossi","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.jhep.2024.04.008_bib41","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1016\/j.cgh.2019.02.024","article-title":"Reduced patient-reported outcome scores associate with level of fibrosis in patients with nonalcoholic steatohepatitis","volume":"17","author":"Younossi","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib42","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/jvh.13800","article-title":"Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry","volume":"30","author":"Younossi","year":"2023","journal-title":"J\u00a0Viral Hepat"},{"issue":"11","key":"10.1016\/j.jhep.2024.04.008_bib43","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/jvh.13741","article-title":"Severe impairment of patient-reported outcomes in patients with chronic hepatitis C virus infection seen in real-world practices across the world: data from the global liver registry","volume":"29","author":"Younossi","year":"2022","journal-title":"J\u00a0Viral Hepat"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib44","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cgh.2016.10.037","article-title":"Sofosbuvir and velpatasvir combination improves patient-reported outcomes for patients with HCV infection, without or with compensated or decompensated cirrhosis","volume":"15","author":"Younossi","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.jhep.2024.04.008_bib45","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1053\/j.gastro.2020.12.003","article-title":"The association of histologic and noninvasive tests with adverse clinical and patient-reported outcomes in patients with advanced fibrosis due to nonalcoholic steatohepatitis","volume":"160","author":"Younossi","year":"2021","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib46","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000057","article-title":"Impact of setanaxib on quality of life outcomes in primary biliary cholangitis in a phase 2 randomized controlled trial","volume":"7","author":"Jones","year":"2023","journal-title":"Hepatol Commun"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib47","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/liv.15039","article-title":"Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis","volume":"42","author":"Kremer","year":"2022","journal-title":"Liver Int"},{"issue":"9","key":"10.1016\/j.jhep.2024.04.008_bib48","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1056\/NEJMoa2312100","article-title":"A\u00a0phase 3 trial of seladelpar in primary biliary cholangitis","volume":"390","author":"Hirschfield","year":"2024","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pneurobio.2012.07.004","article-title":"Neurobiological studies of fatigue","volume":"99","author":"Harrington","year":"2012","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jhep.2024.04.008_bib50","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/gerona\/glu146","article-title":"Walking energetics, fatigability, and fatigue in older adults: the study of energy and aging pilot","volume":"70","author":"Richardson","year":"2015","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"10.1016\/j.jhep.2024.04.008_bib51","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/jgs.14138","article-title":"Fatigued, but not frail: perceived fatigability as a marker of impending decline in mobility-intact older adults","volume":"64","author":"Simonsick","year":"2016","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"5","key":"10.1016\/j.jhep.2024.04.008_bib52","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/gerona\/glv150","article-title":"Fatigue may contribute to reduced physical activity among older people: an observational study","volume":"71","author":"Egerton","year":"2016","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib53","first-page":"21","article-title":"Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management","volume":"17","author":"Ko\u015bnik","year":"2022","journal-title":"Prz Gastroenterol"},{"key":"10.1016\/j.jhep.2024.04.008_bib54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2013.10.009","article-title":"Liver-brain interactions in inflammatory liver diseases: implications for fatigue and mood disorders","volume":"35","author":"D'Mello","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jhep.2024.04.008_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fimmu.2017.00021","article-title":"Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms","volume":"8","author":"Karshikoff","year":"2017","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib56","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/liv.13919","article-title":"Fatigue in chronic liver disease: new insights and therapeutic approaches","volume":"39","author":"Swain","year":"2019","journal-title":"Liver Int"},{"issue":"8","key":"10.1016\/j.jhep.2024.04.008_bib57","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2174\/1389200220666190725115503","article-title":"The relationship between the serotonin metabolism, gut-microbiota and the gut-brain Axis","volume":"20","author":"Stasi","year":"2019","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.jhep.2024.04.008_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1171253","article-title":"Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms","volume":"17","author":"Nguyen","year":"2023","journal-title":"Front Neurosci"},{"issue":"30","key":"10.1016\/j.jhep.2024.04.008_bib59","doi-asserted-by":"crossref","first-page":"10821","DOI":"10.1523\/JNEUROSCI.0575-15.2015","article-title":"Probiotics improve inflammation-associated sickness behavior by altering communication between the peripheral immune system and the brain","volume":"35","author":"D'Mello","year":"2015","journal-title":"J\u00a0Neurosci"},{"issue":"5","key":"10.1016\/j.jhep.2024.04.008_bib60","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1053\/j.gastro.2017.08.011","article-title":"Interactions between platelets and inflammatory monocytes affect sickness behavior in mice with liver inflammation","volume":"153","author":"D'Mello","year":"2017","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib61","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1038\/ctg.2017.34","article-title":"Primary biliary cholangitis alters functional connections of the brain's deep gray matter","volume":"8","author":"Mosher","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"issue":"18","key":"10.1016\/j.jhep.2024.04.008_bib62","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1113\/jphysiol.2013.251629","article-title":"Muscle glycogen stores and fatigue","volume":"591","author":"\u00d8rtenblad","year":"2013","journal-title":"J\u00a0Physiol"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib63","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jceh.2021.08.028","article-title":"Fatigue in cirrhosis","volume":"12","author":"Bhandari","year":"2022","journal-title":"J\u00a0Clin Exp Hepatol"},{"key":"10.1016\/j.jhep.2024.04.008_bib64","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbacli.2014.04.001","article-title":"Association of mitochondrial dysfunction and fatigue: a review of the literature","volume":"1","author":"Filler","year":"2014","journal-title":"BBA Clin"},{"issue":"7998","key":"10.1016\/j.jhep.2024.04.008_bib65","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41586-023-06866-z","article-title":"A\u00a0break in mitochondrial endosymbiosis as a basis for inflammatory diseases","volume":"626","author":"Murphy","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Writing group for the European working group on sarcopenia in older people 2 (EWGSOP2), and the extended group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"6","key":"10.1016\/j.jhep.2024.04.008_bib67","article-title":"Contribution of sarcopenia and physical inactivity to mortality in people with non-alcoholic fatty liver disease","volume":"2","author":"Golabi","year":"2020","journal-title":"JHEP Rep"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib68","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jpainsymman.2007.08.019","article-title":"The measurement of fatigue in chronic illness: a systematic review of unidimensional and multidimensional fatigue measures","volume":"37","author":"Whitehead","year":"2009","journal-title":"J\u00a0Pain Symptom Manage"},{"key":"10.1016\/j.jhep.2024.04.008_bib69","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1152\/japplphysiol.01139.2007","article-title":"Resolving fatigue mechanisms determining exercise performance: integrative physiology at its finest","volume":"104","author":"McKenna","year":"2008","journal-title":"J\u00a0Appl Physiol"},{"key":"10.1016\/j.jhep.2024.04.008_bib70","first-page":"549e572","article-title":"Impairment of neuromuscular propagation during human fatiguing contractions at submaximal forces","volume":"460","author":"Fuglevand","year":"1993","journal-title":"JPhysiol"},{"key":"10.1016\/j.jhep.2024.04.008_bib71","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1001\/jama.285.17.2196","article-title":"Grip strength and subjective fatigue in patients with primary biliary cirrhosis","volume":"285","author":"Goldblatt","year":"2001","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.jhep.2024.04.008_bib72","first-page":"1376","article-title":"Aerobic capacity and exercise performance in nonalcoholic fatty liver disease","volume":"59","author":"Austin","year":"2019","journal-title":"J\u00a0Sports Med Phys Fitness"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib73","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pmrj.2015.06.001","article-title":"Perception of effort during activity in patients with chronic hepatitis C and nonalcoholic fatty liver disease","volume":"8","author":"Weinstein","year":"2016","journal-title":"PM R"},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib74","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1007\/s11136-017-1516-6","article-title":"Demonstration of two types of fatigue in subjects with chronic liver disease using factor analysis","volume":"26","author":"Weinstein","year":"2017","journal-title":"Qual Life Res"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41395-018-0390-3","article-title":"Diagnosis and management of primary biliary cholangitis","volume":"114","author":"Younossi","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2024.04.008_bib76","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0140-6736(15)00154-3","article-title":"Primary biliary cirrhosis","volume":"386","author":"Carey","year":"2015","journal-title":"Lancet."},{"key":"10.1016\/j.jhep.2024.04.008_bib77","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jhep.2015.06.031","article-title":"Changing nomenclature for PBC: from \u2018cirrhosis\u2019 to \u2018cholangitis\u2019","volume":"63","author":"Beuers","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"12","key":"10.1016\/j.jhep.2024.04.008_bib78","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrgastro.2015.187","article-title":"Primary biliary cirrhosis: renaming primary biliary cirrhosis-clarity or confusion?","volume":"12","author":"Trivedi","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.jhep.2024.04.008_bib79","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000179","article-title":"Primary biliary cholangitis: epidemiology, prognosis, and treatment","volume":"7","author":"Trivella","year":"2023","journal-title":"Hepatol Commun"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib80","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1053\/j.gastro.2012.12.005","article-title":"Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid","volume":"144","author":"Carbone","year":"2013","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.jhep.2024.04.008_bib81","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1159\/000360515","article-title":"Pathogenesis of primary biliary cirrhosis and its fatigue","volume":"32","author":"Griffiths","year":"2014","journal-title":"Dig Dis"},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib82","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1007\/s10620-020-06502-0","article-title":"Understanding fatigue in primary biliary cholangitis","volume":"66","author":"Phaw","year":"2021","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2024.04.008_bib83","series-title":"Development of A primary biliary cholangitis (PBC)-Specific version of chronic liver disease questionnaire: CLDQ-PBC","author":"Younossi","year":"2023"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211906","article-title":"Primary biliary cholangitis patients exhibit MRI changes in structure and function of interoceptive brain regions","volume":"14","author":"Mosher","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib85","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.neuroimage.2009.11.020","article-title":"Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect","volume":"49","author":"Lim","year":"2010","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib86","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1152\/japplphysiol.91324.2008","article-title":"Mental fatigue impairs physical performance in humans","volume":"106","author":"Marcora","year":"2009","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"21","key":"10.1016\/j.jhep.2024.04.008_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222112064","article-title":"Early deconditioning of human skeletal muscles and the effects of a thigh cuff countermeasure","volume":"22","author":"Fovet","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib88","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0002-8703(96)90537-2","article-title":"Physical deconditioning may be a mechanism for the skeletal muscle energy phosphate metabolism abnormalities in chronic heart failure","volume":"131","author":"Chati","year":"1996","journal-title":"Am Heart J"},{"key":"10.1016\/j.jhep.2024.04.008_bib89","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/hep.29717","article-title":"Milder disease stage in patients with primary biliary cholangitis over a 44-year period: a changing natural history","volume":"67","author":"Murillo Perez","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.jhep.2024.04.008_bib90","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s12576-015-0399-y","article-title":"Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder","volume":"65","author":"Tanaka","year":"2015","journal-title":"J\u00a0Physiol Sci"},{"issue":"8","key":"10.1016\/j.jhep.2024.04.008_bib91","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1111\/j.1572-0241.2007.01235.x","article-title":"Ursodeoxycholic acid for patients with primary biliary cirrhosis: an updated systematic review and meta-analysis of randomized clinical trials using Bayesian approach as sensitivity analyses","volume":"102","author":"Gong","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2024.04.008_bib92","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/j.gastro.2014.12.005","article-title":"Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid","volume":"148","author":"Hirschfield","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.04.008_bib93","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0168-8278(99)80136-6","article-title":"Comparison of three doses of ursodeoxycholic acid in the treatment of primary biliary cirrhosis: a randomized trial","volume":"30","author":"Angulo","year":"1999","journal-title":"J\u00a0Hepatol"},{"issue":"6","key":"10.1016\/j.jhep.2024.04.008_bib94","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.4254\/wjh.v14.i6.1111","article-title":"Understanding fatigue in primary biliary cholangitis: from pathophysiology to treatment perspectives","volume":"14","author":"Lynch","year":"2022","journal-title":"World J Hepatol"},{"issue":"10","key":"10.1016\/j.jhep.2024.04.008_bib95","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1007\/s10620-019-06009-3","article-title":"Symptom burden and treatment response in patients with primary biliary cholangitis (PBC)","volume":"65","author":"Kaps","year":"2020","journal-title":"Dig Dis Sci"},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib96","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMoa1509840","article-title":"A\u00a0placebo-controlled trial of obeticholic acid in primary biliary cholangitis","volume":"375","author":"Nevens","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib97","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jhep.2013.04.017","article-title":"The effect of liver transplantation on fatigue in patients with primary biliary cirrhosis: a prospective study","volume":"59","author":"Carbone","year":"2013","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib98","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jhep.2013.02.019","article-title":"The impact of liver transplantation on the phenotype of primary biliary cirrhosis patients in the UK-PBC cohort","volume":"59","author":"Pells","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2024.04.008_bib99","article-title":"Efficacy and safety of elafibranor in primary biliary cholangitis","author":"Kowdley","year":"2023","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib100","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.cgh.2022.10.032","article-title":"GLIMMER: a randomized phase 2b dose-ranging trial of linerixibat in primary biliary cholangitis patients with pruritus","volume":"21","author":"Levy","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.04.008_bib101","unstructured":"Volixibat. Obtained from the world wide web at: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT02787304. Last accessed on 1\/10\/24."},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib102","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1053\/j.gastro.2016.02.039","article-title":"Extrahepatic manifestations of hepatitis C: a meta-analysis of prevalence, quality of life, and economic burden","volume":"150","author":"Younossi","year":"2016","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib103","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cld.2017.03.008","article-title":"Neurologic manifestations of hepatitis C virus infection","volume":"21","author":"Iriana","year":"2017","journal-title":"Clin Liver Dis"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib104","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s10620-016-4067-8","article-title":"Tired of hepatitis B?","volume":"61","author":"Patidar","year":"2016","journal-title":"Dig Dis Sci"},{"issue":"8","key":"10.1016\/j.jhep.2024.04.008_bib105","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3748\/wjg.v21.i8.2269","article-title":"Chronic hepatitis C virus infection and neurological and psychiatric disorders: an overview","volume":"21","author":"Adinolfi","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib106","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jvh.12674","article-title":"Persistent neuropsychiatric impairment in HCV patients despite clearance of the virus?","volume":"24","author":"Dirks","year":"2017","journal-title":"J\u00a0Viral Hepat"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib107","first-page":"93","article-title":"Psychosocial issues in patients with chronic hepatitis B and C","volume":"40","author":"Enescu","year":"2014","journal-title":"Curr Health Sci J"},{"issue":"10","key":"10.1016\/j.jhep.2024.04.008_bib108","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1007\/s10620-006-9708-x","article-title":"Fatigue and health-related quality of life (HRQL) in chronic hepatitis C virus infection","volume":"52","author":"Kallman","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2024.04.008_bib109","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1001\/archinte.1993.00410240067007","article-title":"Prevalence of fatigue and chronic fatigue syndrome in a primary care practice","volume":"153","author":"Bates","year":"1993","journal-title":"Arch Intern Med"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib110","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/039463201102400313","article-title":"An Italian study on health-related quality of life and fatigue in patients with chronic fatigue syndrome and patients with chronic HCV virus infection: similarities and differences","volume":"24","author":"Racciatti","year":"2011","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib111","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2893.2002.00364.x","article-title":"Fatigue in patients with chronic hepatitis C","volume":"9","author":"Poynard","year":"2002","journal-title":"J\u00a0Viral Hepat"},{"issue":"5","key":"10.1016\/j.jhep.2024.04.008_bib112","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/hep.510300504","article-title":"The impact of diagnosis of hepatitis C virus on quality of life","volume":"30","author":"Rodger","year":"1999","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib113","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cld.2017.03.011","article-title":"Patient-reported outcomes and fatigue in patients with chronic hepatitis C infection","volume":"21","author":"Golabi","year":"2017","journal-title":"Clin Liver Dis"},{"issue":"11","key":"10.1016\/j.jhep.2024.04.008_bib114","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/jvh.13741","article-title":"Severe impairment of patient-reported outcomes in patients with chronic hepatitis C virus infection seen in real-world practices across the world: data from the global liver registry","volume":"29","author":"Younossi","year":"2022","journal-title":"J\u00a0Viral Hepat"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib115","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12072-018-9879-5","article-title":"Depression, fatigue and neurocognitive deficits in chronic hepatitis C","volume":"12","author":"Yeoh","year":"2018","journal-title":"Hepatol Int"},{"issue":"9413","key":"10.1016\/j.jhep.2024.04.008_bib116","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0140-6736(04)15794-2","article-title":"Fatigue in neurological disorders","volume":"363","author":"Chaudhuri","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2024.04.008_bib117","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/236148","article-title":"HCV related nervous system disorders","volume":"2012","author":"Monaco","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"3","key":"10.1016\/j.jhep.2024.04.008_bib118","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yfrne.2012.09.003","article-title":"Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise","volume":"33","author":"Felger","year":"2012","journal-title":"Front Neuroendocrinol"},{"issue":"10","key":"10.1016\/j.jhep.2024.04.008_bib119","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2165\/00007256-200636100-00006","article-title":"Central fatigue: the serotonin hypothesis and beyond","volume":"36","author":"Meeusen","year":"2006","journal-title":"Sports Med"},{"issue":"11","key":"10.1016\/j.jhep.2024.04.008_bib120","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1136\/gut.2005.080267","article-title":"Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment","volume":"55","author":"Weissenborn","year":"2006","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib121","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cgh.2021.01.026","article-title":"Long-term patient-centered outcomes in cirrhotic patients with chronic hepatitis C after achieving sustained virologic response","volume":"20","author":"Younossi","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib122","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cgh.2015.07.035","article-title":"Effects of viral eradication with ledipasvir and sofosbuvir, with or without ribavirin, on measures of fatigue in patients with chronic hepatitis C virus infection","volume":"14","author":"Gerber","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.04.008_bib123","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/gut.2007.139303","article-title":"Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance","volume":"57","author":"Newton","year":"2008","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.jhep.2024.04.008_bib124","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/hep4.1581","article-title":"Fatigue and pruritus in patients with advanced fibrosis due to nonalcoholic steatohepatitis: the impact on patient-reported outcomes","volume":"4","author":"Younossi","year":"2020","journal-title":"Hepatol Commun"},{"issue":"7","key":"10.1016\/j.jhep.2024.04.008_bib125","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/hep4.1710","article-title":"Improvements of fibrosis and disease activity are associated with improvement of patient-reported outcomes in patients with advanced fibrosis due to nonalcoholic steatohepatitis","volume":"5","author":"Younossi","year":"2021","journal-title":"Hepatol Commun"},{"issue":"10","key":"10.1016\/j.jhep.2024.04.008_bib126","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.cgh.2021.11.004","article-title":"Clinical and patient-reported outcomes from patients with nonalcoholic fatty liver disease across the world: data from the global non-alcoholic steatohepatitis (NASH)\/non-alcoholic fatty liver disease (NAFLD) registry","volume":"20","author":"Younossi","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"10.1016\/j.jhep.2024.04.008_bib127","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.14309\/ajg.0000000000000375","article-title":"Patients with nonalcoholic steatohepatitis experience severe impairment of health-related quality of life","volume":"114","author":"Younossi","year":"2019","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.1016\/j.jhep.2024.04.008_bib128","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.cgh.2022.04.023","article-title":"The potential role of fatigue in identifying patients with NASH and advanced fibrosis who experience disease progression","volume":"21","author":"Younossi","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.jhep.2024.04.008_bib129","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1111\/liv.15437","article-title":"The impact of fatigue on mortality of patients with non-alcoholic fatty liver disease: data from National Health and nutrition examination survey 2005-2010 and 2017-2018","volume":"42","author":"Younossi","year":"2022","journal-title":"Liver Int"},{"issue":"11","key":"10.1016\/j.jhep.2024.04.008_bib130","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41575-023-00800-4","article-title":"Lifestyle interventions in nonalcoholic fatty liver disease","volume":"20","author":"Younossi","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib131","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jhep.2009.10.010","article-title":"Potential strategies to improve uptake of exercise interventions in non-alcoholic fatty liver disease","volume":"52","author":"Frith","year":"2010","journal-title":"J\u00a0Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2024.04.008_bib132","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S2213-8587(22)00317-5","article-title":"Treating chronic diseases without tackling excess adiposity promotes multimorbidity","volume":"11","author":"Sattar","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"10.1016\/j.jhep.2024.04.008_bib133","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/apt.15580","article-title":"The impact of modifiable risk factors on the long-term outcomes of non-alcoholic fatty liver disease","volume":"51","author":"Paik","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"issue":"24","key":"10.1016\/j.jhep.2024.04.008_bib134","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.3390\/nu14245344","article-title":"Ideal cardiovascular health metrics are associated with reduced severity of hepatic steatosis and liver fibrosis detected by transient elastography","volume":"14","author":"Fan","year":"2022","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.jhep.2024.04.008_bib135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10286-009-0031-4","article-title":"Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease","volume":"19","author":"Newton","year":"2009","journal-title":"Clin Auton Res"},{"issue":"10","key":"10.1016\/j.jhep.2024.04.008_bib136","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/liv.13706","article-title":"Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib","volume":"38","author":"Younossi","year":"2018","journal-title":"Liver Int"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824002769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824002769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:37:59Z","timestamp":1773967079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824002769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":136,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0168827824002769"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2024.04.008","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of fatigue and its impact in chronic liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2024.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}