{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:18:53Z","timestamp":1790270333291,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101095679"],"award-info":[{"award-number":["101095679"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SGR-2021-00491"],"award-info":[{"award-number":["SGR-2021-00491"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Junta de Andalucia Consejeria de Salud","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI21\/01248"],"award-info":[{"award-number":["PI21\/01248"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI19-00883"],"award-info":[{"award-number":["PI19-00883"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI-0310-2018"],"award-info":[{"award-number":["PI-0310-2018"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PEMP-0127-2020"],"award-info":[{"award-number":["PEMP-0127-2020"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PT23\/00137"],"award-info":[{"award-number":["PT23\/00137"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["IFI21\/0034"],"award-info":[{"award-number":["IFI21\/0034"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007761","name":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["FPU22\/03868"],"award-info":[{"award-number":["FPU22\/03868"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d&apos;Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Gobierno de Espa\u00f1a Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018689","name":"SCReN","doi-asserted-by":"publisher","award":["PT23\/00137"],"award-info":[{"award-number":["PT23\/00137"]}],"id":[{"id":"10.13039\/501100018689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","award":["101095679"],"award-info":[{"award-number":["101095679"]}],"id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","award":["HORIZON-HLTH-2022-STAYHLTH-02"],"award-info":[{"award-number":["HORIZON-HLTH-2022-STAYHLTH-02"]}],"id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2021.04902"],"award-info":[{"award-number":["2021.04902"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["PID2022-1429560B-I00"],"award-info":[{"award-number":["PID2022-1429560B-I00"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["PID2019-111669RB-100"],"award-info":[{"award-number":["PID2019-111669RB-100"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["PID2023AEP068"],"award-info":[{"award-number":["PID2023AEP068"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jhep.2024.04.026","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T22:14:26Z","timestamp":1714688066000},"page":"630-640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network"],"prefix":"10.1016","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3421-1792","authenticated-orcid":false,"given":"Antonio","family":"Segovia-Zafra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4728-201X","authenticated-orcid":false,"given":"Marina","family":"Villanueva-Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-9511","authenticated-orcid":false,"given":"Ana Sofia","family":"Serras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-6708","authenticated-orcid":false,"given":"Gonzalo","family":"Matilla-Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-5202","authenticated-orcid":false,"given":"Ana","family":"Bodoque-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-0518","authenticated-orcid":false,"given":"Daniel E.","family":"Di Zeo-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-0604","authenticated-orcid":false,"given":"Ismael","family":"\u00c1lvarez-\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-4224","authenticated-orcid":false,"given":"Laura","family":"Sanz-Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4173-6765","authenticated-orcid":false,"given":"Sergej","family":"Godec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-7238","authenticated-orcid":false,"given":"Irina","family":"Milisav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-9630","authenticated-orcid":false,"given":"Pierre","family":"Bagnaninchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-0757","authenticated-orcid":false,"given":"Ra\u00fal J.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-4896","authenticated-orcid":false,"given":"M Isabel","family":"Lucena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-7724","authenticated-orcid":false,"given":"Jos\u00e9 C.","family":"Fern\u00e1ndez-Checa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-650X","authenticated-orcid":false,"given":"Francisco Javier","family":"Cubero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Paiva","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4197-4843","authenticated-orcid":false,"given":"Leonard J.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2024.04.026_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41572-019-0105-0","article-title":"Drug-induced liver injury","volume":"5","author":"Andrade","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jhep.2024.04.026_bib2","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00204-020-02763-w","article-title":"The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development","volume":"94","author":"Walker","year":"2020","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib3","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL clinical practice guidelines: drug-induced liver injury","volume":"70","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.04.026_bib4","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jhep.2021.06.021","article-title":"Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]","volume":"75","author":"Fernandez-Checa","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.04.026_bib5","article-title":"A\u00a0critical perspective on 3D liver models for drug metabolism and toxicology studies","volume":"9","author":"Serras","year":"2021","journal-title":"Front Cel Dev Biol"},{"key":"10.1016\/j.jhep.2024.04.026_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41573-019-0048-x","article-title":"Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models","volume":"19","author":"Weaver","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhep.2024.04.026_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/rtph.2000.1399","article-title":"Concordance of the toxicity of pharmaceuticals in humans and in animals","volume":"32","author":"Olson","year":"2000","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.jhep.2024.04.026_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01093","article-title":"Comprehensive evaluation of organotypic and microphysiological liver models for prediction of drug-induced liver injury","volume":"10","author":"Zhou","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jhep.2024.04.026_bib9","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1021\/acs.chemrestox.1c00227","article-title":"Evaluation of a three-dimensional primary human hepatocyte spheroid model: adoption and industrialization for the enhanced detection of drug-induced liver injury","volume":"34","author":"Schofield","year":"2021","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib10","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1007\/s00204-018-2297-6","article-title":"Characterization of hepatocyte-based in\u00a0vitro systems for reliable toxicity testing","volume":"92","author":"Vinken","year":"2018","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib11","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jhep.2024.04.026_bib12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"10.1016\/j.jhep.2024.04.026_bib13","first-page":"138","article-title":"ToxRTool","volume":"189","author":"Schneider","year":"2009","journal-title":"A\u00a0New Tool Assess Reliability Toxicological Data Toxicol Lett"},{"key":"10.1016\/j.jhep.2024.04.026_bib14","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.yrtph.2015.03.005","article-title":"Evaluation of the ToxRTool\u2019s ability to rate the reliability of toxicological data for human health hazard assessments","volume":"72","author":"Segal","year":"2015","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.jhep.2024.04.026_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/rtph.1996.1076","article-title":"A\u00a0systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data","volume":"25","author":"Klimisch","year":"1997","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.jhep.2024.04.026_bib16","series-title":"Guidelines for ATC classification and DDD assignment","year":"2010"},{"key":"10.1016\/j.jhep.2024.04.026_bib17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jhep.2021.01.029","article-title":"Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry","volume":"75","author":"Stephens","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.04.026_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/liv.15378","article-title":"A\u00a0new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry","volume":"43","author":"Bj\u00f6rnsson","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2024.04.026_bib19","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1053\/j.gastro.2015.03.006","article-title":"Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study","volume":"148","author":"Chalasani","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.04.026_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/ijms17030313","article-title":"The Latin American DILI Registry experience: a successful ongoing collaborative strategic initiative","volume":"17","author":"Bessone","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib21","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource for in silico drug discovery and exploration","volume":"34","author":"Wishart","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2024.04.026_bib22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.drudis.2011.05.007","article-title":"FDA-approved drug labeling for the study of drug-induced liver injury","volume":"16","author":"Chen","year":"2011","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.jhep.2024.04.026_bib23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.drudis.2016.02.015","article-title":"DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans","volume":"21","author":"Chen","year":"2016","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.jhep.2024.04.026_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.drudis.2019.09.022","article-title":"Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity","volume":"25","author":"Thakkar","year":"2020","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.jhep.2024.04.026_bib25","unstructured":"LiverTox. Clinical and research information on drug-induced liver injury [cited 27 April 2023]; Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547852\/."},{"key":"10.1016\/j.jhep.2024.04.026_bib26","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00204-019-02492-9","article-title":"Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations","volume":"93","author":"Albrecht","year":"2019","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib27","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/acs.chemrestox.7b00048","article-title":"Evaluating the role of multidrug resistance protein 3 (MDR3) inhibition in predicting drug-induced liver injury using 125 pharmaceuticals","volume":"30","author":"Aleo","year":"2017","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.taap.2013.11.022","article-title":"Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans","volume":"275","author":"Atienzar","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jhep.2024.04.026_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115279","article-title":"HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI)","volume":"408","author":"Basharat","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jhep.2024.04.026_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/toxsci\/kfx289","article-title":"Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study","volume":"2","author":"Bell","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib31","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/s41467-020-15058-6","article-title":"Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines","volume":"11","author":"Boon","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2024.04.026_bib32","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3109\/00498254.2012.675093","article-title":"Generation of proliferating human hepatocytes using Upcyte\u00ae technology: characterisation and applications in induction and cytotoxicity assays","volume":"42","author":"Burkard","year":"2012","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jhep.2024.04.026_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112828","article-title":"Evaluation of the utility of the beta human liver emulation system (BHLES) for CFSAN's regulatory toxicology program","volume":"161","author":"Eckstrum","year":"2022","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tiv.2013.10.015","article-title":"Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes","volume":"28","author":"Garside","year":"2014","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.jhep.2024.04.026_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10565-011-9208-4","article-title":"Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins","volume":"28","author":"Gerets","year":"2012","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105159","article-title":"Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential","volume":"74","author":"Harada","year":"2021","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.jhep.2024.04.026_bib37","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jat.3435","article-title":"Prediction of drug-induced liver injury using keratinocytes","volume":"37","author":"Hirashima","year":"2017","journal-title":"J\u00a0Appl Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib38","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s00204-020-02778-3","article-title":"Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling","volume":"94","author":"Hussain","year":"2020","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114958","article-title":"Mechanism-based integrated assay systems for the prediction of drug-induced liver injury","volume":"394","author":"Kawaguchi","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jhep.2024.04.026_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/toxsci\/kfs326","article-title":"Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans","volume":"132","author":"Khetani","year":"2013","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/toxsci\/kfz229","article-title":"High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice","volume":"173","author":"Kohara","year":"2020","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib42","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.xphs.2020.02.021","article-title":"Three-Dimensional spheroids with primary human liver cells and differential roles of kupffer cells in drug-induced liver injury","volume":"109","author":"Li","year":"2020","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/toxsci\/kfr339","article-title":"Evaluation of drugs with specific organ toxicities in organ-specific cell lines","volume":"126","author":"Lin","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib44","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/toxsci\/kfs208","article-title":"Palmitate increases the susceptibility of cells to drug-induced toxicity: an in\u00a0Vitro method to identify drugs with potential contraindications in patients with metabolic disease","volume":"129","author":"Luo","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib45","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1124\/jpet.117.242354","article-title":"Synergistic cytotoxicity from drugs and cytokines in\u00a0vitro as an approach to classify drugs according to their potential to cause idiosyncratic hepatotoxicity: a proof-of-concept study","volume":"362","author":"Maiuri","year":"2017","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jhep.2024.04.026_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122786","article-title":"Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in\u00a0vitro?","volume":"10","author":"Mennecozzi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2024.04.026_bib47","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1007\/s00204-020-02804-4","article-title":"In\u00a0vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk","volume":"94","author":"Norona","year":"2020","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2017.09.013","article-title":"Long-enduring primary hepatocyte-based co-cultures improve prediction of hepatotoxicity","author":"Novik","year":"2017","journal-title":"Toxicol Appl Pharmacol United States"},{"key":"10.1016\/j.jhep.2024.04.026_bib49","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00204-006-0091-3","article-title":"High concordance of drug-induced human hepatotoxicity with in\u00a0vitro cytotoxicity measured in a novel cell-based model using high content screening","volume":"80","author":"O'Brien","year":"2006","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxlet.2015.10.029","article-title":"A\u00a0novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury","volume":"241","author":"Oda","year":"2016","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jhep.2024.04.026_bib51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00204-020-02882-4","article-title":"An in\u00a0vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury","volume":"95","author":"Oda","year":"2021","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib52","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/2472555217701058","article-title":"An automated multiplexed hepatotoxicity and CYP induction assay using HepaRG cells in 2D and 3D","volume":"22","author":"Ott","year":"2017","journal-title":"SLAS Discov"},{"key":"10.1016\/j.jhep.2024.04.026_bib53","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.vascn.2013.08.001","article-title":"A\u00a0high content screening assay to predict human drug-induced liver injury during drug discovery","volume":"68","author":"Persson","year":"2013","journal-title":"J\u00a0Pharmacol Toxicol Methods"},{"key":"10.1016\/j.jhep.2024.04.026_bib54","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1007\/s00204-017-2002-1","article-title":"Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury","volume":"91","author":"Proctor","year":"2017","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib55","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/acs.chemrestox.8b00246","article-title":"Evaluation of in\u00a0vitro mitochondrial toxicity assays and physicochemical properties for prediction of organ toxicity using 228 pharmaceutical drugs","volume":"32","author":"Rana","year":"2019","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00204-021-03178-x","article-title":"DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies","volume":"96","author":"Rose","year":"2022","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib57","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.tiv.2015.09.019","article-title":"Minimizing DILI risk in drug discovery - a screening tool for drug candidates","volume":"30","author":"Schadt","year":"2015","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.jhep.2024.04.026_bib58","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/toxsci\/kfv152","article-title":"Setting clinical exposure levels of concern for drug-induced liver injury (DILI) using mechanistic in\u00a0vitro assays","volume":"147","author":"Shah","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2131\/jts.46.167","article-title":"Association of CYP1A1 and CYP1B1 inhibition in in\u00a0vitro assays with drug-induced liver injury","volume":"46","author":"Shimizu","year":"2021","journal-title":"J\u00a0Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib60","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1053\/j.gastro.2020.10.002","article-title":"High-fidelity drug-induced liver injury screen using human pluripotent stem cell-derived organoids","volume":"160","author":"Shinozawa","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.04.026_bib61","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1021\/tx300091x","article-title":"In\u00a0vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs","volume":"25","author":"Thompson","year":"2012","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/toxsci\/kfs083","article-title":"Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs","volume":"127","author":"Tolosa","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib63","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.toxlet.2015.04.014","article-title":"Multiparametric assay using HepaRG cells for predicting drug-induced liver injury","volume":"236","author":"Tomida","year":"2015","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jhep.2024.04.026_bib64","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/jat.3371","article-title":"A\u00a0modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk","volume":"37","author":"Tomida","year":"2017","journal-title":"J\u00a0Appl Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib65","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/toxsci\/kfy058","article-title":"Prediction of drug-induced hepatotoxicity using long-term stable primary hepatic 3D spheroid cultures in chemically defined conditions","volume":"163","author":"Vorrink","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib66","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/toxsci\/kfv048","article-title":"Prediction of drug-induced liver injury in micropatterned co-cultures containing iPSC-derived human hepatocytes","volume":"145","author":"Ware","year":"2015","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib67","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3727\/105221619X15638857793317","article-title":"Long-Term engineered cultures of primary mouse hepatocytes for strain and species comparison studies during drug development","volume":"19","author":"Ware","year":"2019","journal-title":"Gene Expr"},{"key":"10.1016\/j.jhep.2024.04.026_bib68","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/toxsci\/kfab018","article-title":"Micropatterned coculture with 3T3-J2 fibroblasts enhances hepatic functions and drug screening utility of HepaRG cells","volume":"181","author":"Ware","year":"2021","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1021\/acs.chemrestox.9b00264","article-title":"Predicting drug-induced liver injury with bayesian machine learning","volume":"33","author":"Williams","year":"2020","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib70","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tiv.2018.01.019","article-title":"Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury","volume":"48","author":"Xu","year":"2018","journal-title":"Toxicol Vitro"},{"key":"10.1016\/j.jhep.2024.04.026_bib71","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/toxsci\/kfn109","article-title":"Cellular imaging predictions of clinical drug-induced liver injury","volume":"105","author":"Xu","year":"2008","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib72","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1021\/acs.chemrestox.9b00033","article-title":"Can galactose Be converted to glucose in HepG2 cells? Improving the in\u00a0vitro mitochondrial toxicity assay for the assessment of drug induced liver injury","volume":"32","author":"Xu","year":"2019","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib73","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.vascn.2015.08.157","article-title":"Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites","volume":"76","author":"Yamaoka","year":"2015","journal-title":"J\u00a0Pharmacol Toxicol Methods"},{"key":"10.1016\/j.jhep.2024.04.026_bib74","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00204-017-2126-3","article-title":"Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays","volume":"92","author":"Yu","year":"2018","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jhep.2024.04.026_bib75","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/toxsci\/kfx060","article-title":"In\u00a0vitro drug-induced liver injury prediction: criteria optimization of efflux transporter IC50 and physicochemical properties","volume":"157","author":"Yucha","year":"2017","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.04.026_bib76","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cbi.2015.11.008","article-title":"Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: results from 152 marketed drugs with known liver injury profiles","volume":"255","author":"Zhang","year":"2016","journal-title":"Chem-Biol Interact"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824003258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824003258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:46:34Z","timestamp":1778730394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824003258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0168827824003258"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2024.04.026","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3578817\/v1","asserted-by":"object"}]},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2024.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}