{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:33:52Z","timestamp":1793644432938,"version":"4.5.1"},"reference-count":214,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004807","name":"California Department of Fish and Game","doi-asserted-by":"publisher","award":["Ta434\/8-1"],"award-info":[{"award-number":["Ta434\/8-1"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"California Department of Fish and Game","doi-asserted-by":"publisher","award":["SFB\/TRR 296"],"award-info":[{"award-number":["SFB\/TRR 296"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"California Department of Fish and Game","doi-asserted-by":"publisher","award":["403224013"],"award-info":[{"award-number":["403224013"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"California Department of Fish and Game","doi-asserted-by":"publisher","award":["SFB1382"],"award-info":[{"award-number":["SFB1382"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYYC23026"],"award-info":[{"award-number":["ZYYC23026"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYGD18004"],"award-info":[{"award-number":["ZYGD18004"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170623"],"award-info":[{"award-number":["82170623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241054"],"award-info":[{"award-number":["82241054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170625"],"award-info":[{"award-number":["82170625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322011"],"award-info":[{"award-number":["82322011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 DK136511"],"award-info":[{"award-number":["R01 DK136511"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jhep.2024.05.014","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T07:05:37Z","timestamp":1715929537000},"page":"543-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Angiocrine signaling in sinusoidal homeostasis and liver diseases"],"prefix":"10.1016","volume":"81","author":[{"given":"Jinhang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enis","family":"Kostallari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangkun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enjiang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6002-9986","authenticated-orcid":false,"given":"Adrien","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0226","authenticated-orcid":false,"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-573X","authenticated-orcid":false,"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2024.05.014_bib1","doi-asserted-by":"crossref","first-page":"G246","DOI":"10.1152\/ajpgi.00118.2016","article-title":"Angiocrine signaling in the hepatic sinusoids in health and disease","volume":"311","author":"Kostallari","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2024.05.014_bib2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A\u00a0human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.05.014_bib3","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jcmgh.2020.12.007","article-title":"Single-cell transcriptomics reveals zone-specific alterations of liver sinusoidal endothelial cells in cirrhosis","volume":"11","author":"Su","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/srep44356","article-title":"Immunofluorescence identifies distinct subsets of endothelial cells in the human liver","volume":"7","author":"Strauss","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2024.05.014_bib5","doi-asserted-by":"crossref","first-page":"G1204","DOI":"10.1152\/ajpgi.00302.2010","article-title":"Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity","volume":"299","author":"Xie","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2024.05.014_bib6","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.stem.2022.04.008","article-title":"The spatiotemporal program of zonal liver regeneration following acute injury","volume":"29","author":"Ben-Moshe","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2024.05.014_bib7","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2024.05.014_bib8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nbt.4231","article-title":"Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells","volume":"36","author":"Halpern","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jhep.2024.05.014_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-020-00411-3","article-title":"Role of liver sinusoidal endothelial cells in liver diseases","volume":"18","author":"Gracia-Sancho","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2024.05.014_bib10","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/cphy.c140078","article-title":"Liver sinusoidal endothelial cells","volume":"5","author":"Sorensen","year":"2015","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jhep.2024.05.014_bib11","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000207","article-title":"The evolving role of liver sinusoidal endothelial cells in liver health and disease","author":"McConnell","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib12","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jhep.2016.04.018","article-title":"Sinusoidal communication in liver fibrosis and regeneration","volume":"65","author":"Marrone","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41575-018-0020-y","article-title":"Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity","volume":"15","author":"Shetty","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib14","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1002\/hep.27376","article-title":"Liver sinusoidal endothelial cells in hepatic fibrosis","volume":"61","author":"DeLeve","year":"2015","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib15","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2014.05.047","article-title":"Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions","volume":"61","author":"Iwakiri","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib16","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0002-9440(10)63487-6","article-title":"Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis","volume":"163","author":"Xu","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2024.05.014_bib17","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.jhep.2019.02.012","article-title":"Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease","volume":"70","author":"Hammoutene","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41575-018-0097-3","article-title":"Hepatic microcirculation and mechanisms of portal hypertension","volume":"16","author":"Gracia-Sancho","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-5926-1-1","article-title":"Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review","volume":"1","author":"Braet","year":"2002","journal-title":"Comp Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib20","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jhep.2020.06.004","article-title":"Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology","volume":"73","author":"Saviano","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/a-2128-5907","article-title":"Angiocrine signaling in sinusoidal health and disease","volume":"43","author":"Cooper","year":"2023","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2024.05.014_bib22","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrc2791","article-title":"Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors","volume":"10","author":"Butler","year":"2010","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"10.1016\/j.jhep.2024.05.014_bib23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41575-019-0134-x","article-title":"Spatial heterogeneity in the mammalian liver","volume":"16","author":"Ben-Moshe","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib24","article-title":"Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration","author":"Bibo","year":"2023","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.jhep.2024.05.014_bib25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.29613","article-title":"Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice","volume":"68","author":"Leibing","year":"2018","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib26","article-title":"ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver","author":"Schmid","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib27","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.celrep.2015.10.049","article-title":"The angiocrine factor Rspondin3 is a key determinant of liver zonation","volume":"13","author":"Rocha","year":"2015","journal-title":"Cel Rep"},{"issue":"4","key":"10.1016\/j.jhep.2024.05.014_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1182\/blood-2016-07-729822","article-title":"Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis","volume":"129","author":"Koch","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2024.05.014_bib29","article-title":"Liver sinusoidal endothelial cells induce BMP6 expression in response to non-transferrin bound iron","author":"Charlebois","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jhep.2024.05.014_bib30","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1002\/hep.31900","article-title":"Liver sinusoidal endothelial cells suppress bone morphogenetic protein 2 production in response to TGF\u03b2 pathway activation","volume":"74","author":"Colucci","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.stem.2022.03.002","article-title":"Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction","volume":"29","author":"G\u00f3mez-Salinero","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2024.05.014_bib32","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1016\/j.cell.2023.07.017","article-title":"Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions","volume":"186","author":"Kaffe","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.05.014_bib33","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/eji.201445346","article-title":"Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway","volume":"45","author":"Neumann","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.866040","article-title":"Role of immune cells in biliary repair","volume":"13","author":"Lan","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120091","article-title":"Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids","volume":"251","author":"Yap","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jhep.2024.05.014_bib36","article-title":"Understanding the cellular interactome of non-alcoholic fatty liver disease","volume":"4","author":"Wallace","year":"2022","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2024.05.014_bib37","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2011.12.017","article-title":"Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats","volume":"142","author":"Xie","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib38","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/hep.22351","article-title":"Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence","volume":"48","author":"DeLeve","year":"2008","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2012.08.026","article-title":"The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins","volume":"58","author":"Marrone","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib40","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/hep.30655","article-title":"Bone morphogenetic protein 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting against hepatic fibrosis","volume":"70","author":"Desroches-Castan","year":"2019","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib41","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.celrep.2019.10.024","article-title":"Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis","volume":"29","author":"Dobie","year":"2019","journal-title":"Cel Rep"},{"key":"10.1016\/j.jhep.2024.05.014_bib42","doi-asserted-by":"crossref","first-page":"G234","DOI":"10.1152\/ajpgi.00254.2021","article-title":"Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis","volume":"322","author":"Kostallari","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2024.05.014_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050503","article-title":"Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis","volume":"8","author":"Krenkel","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2024.05.014_bib44","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.05.014_bib45","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/hep.31743","article-title":"Heterogeneity of HSCs in a mouse model of NASH","volume":"74","author":"Rosenthal","year":"2021","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib46","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/hep.32456","article-title":"Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis","volume":"76","author":"Lei","year":"2022","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib47","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1097\/TP.0000000000002690","article-title":"Immune cell trafficking to the liver","volume":"103","author":"Chaudhry","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2024.05.014_bib48","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1172\/JCI119468","article-title":"A\u00a0minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature","volume":"99","author":"Wong","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.05.014_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399402004155","article-title":"The liver: a model of organ-specific lymphocyte recruitment","volume":"4","author":"Lalor","year":"2002","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib50","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.24085","article-title":"Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity","volume":"53","author":"Liaskou","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib51","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/hep.21497","article-title":"Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion","volume":"45","author":"Lalor","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib52","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1189\/jlb.0107052","article-title":"Stabilin-2 is involved in lymphocyte adhesion to the hepatic sinusoidal endothelium via the interaction with alphaMbeta2 integrin","volume":"82","author":"Jung","year":"2007","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jhep.2024.05.014_bib53","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13182","article-title":"A\u00a0promoter-level mammalian expression atlas","volume":"507","author":"Forrest","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.05.014_bib54","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1038\/s41467-021-24843-w","article-title":"Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2024.05.014_bib55","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1084\/jem.20041035","article-title":"Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis","volume":"200","author":"Eksteen","year":"2004","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib56","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41575-021-00444-2","article-title":"Regulation and functional roles of chemokines in liver diseases","volume":"18","author":"Cao","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib57","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1002\/hep.23591","article-title":"CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium","volume":"51","author":"Aspinall","year":"2010","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib58","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/hep.31617","article-title":"Endothelial p300 promotes portal hypertension and hepatic fibrosis through C-C motif chemokine ligand 2-mediated angiocrine signaling","volume":"73","author":"Gao","year":"2021","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"1","key":"10.1016\/j.jhep.2024.05.014_bib59","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12443","article-title":"Transendothelial migration: unifying principles from the endothelial perspective","volume":"273","author":"Muller","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jhep.2024.05.014_bib60","doi-asserted-by":"crossref","DOI":"10.1038\/s41574-022-00675-6","article-title":"Macrophage functional diversity in NAFLD - more than inflammation","author":"Barreby","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jhep.2024.05.014_bib61","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.jhep.2024.05.014_bib62","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver--from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib63","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000270","article-title":"Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression","author":"Guillot","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1129831","article-title":"The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer-Challenges and opportunities","volume":"10","author":"Kohlhepp","year":"2023","journal-title":"Front Mol biosciences"},{"key":"10.1016\/j.jhep.2024.05.014_bib65","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib66","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2023-000003","article-title":"Spatial dimension of macrophage heterogeneity in liver diseases","volume":"1","author":"Guillot","year":"2023","journal-title":"eGastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib67","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/hep4.1356","article-title":"Liver macrophages: old dogmas and new insights","volume":"3","author":"Guillot","year":"2019","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2024.05.014_bib68","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.immuni.2019.09.002","article-title":"Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain kupffer cell identity","volume":"51","author":"Sakai","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2024.05.014_bib69","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.immuni.2019.08.017","article-title":"Stellate cells, hepatocytes, and endothelial cells imprint the kupffer cell identity on monocytes colonizing the liver macrophage niche","volume":"51","author":"Bonnardel","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jhep.2024.05.014_bib70","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-020-2977-2","article-title":"Commensal-driven immune zonation of the liver promotes host defence","volume":"589","author":"Gola","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.05.014_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107966","article-title":"The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration","volume":"26","author":"Wilkinson","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.jhep.2024.05.014_bib72","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.05.014_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13112688","article-title":"Transcriptomic profiling of the liver sinusoidal endothelium during cirrhosis reveals stage-specific secretory signature","volume":"13","author":"Manicardi","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.jhep.2024.05.014_bib74","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hep.28285","article-title":"Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver","volume":"63","author":"Zimmermann","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib75","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib76","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/ATVBAHA.110.218255","article-title":"Primary monocytes regulate endothelial cell survival through secretion of angiopoietin-1 and activation of endothelial Tie2","volume":"31","author":"Schubert","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jhep.2024.05.014_bib77","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.jhep.2015.05.011","article-title":"Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse","volume":"63","author":"Melgar-Lesmes","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib78","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"Calvente","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.05.014_bib79","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.jhep.2024.05.014_bib80","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1053\/j.gastro.2019.03.013","article-title":"Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal hypertension","volume":"157","author":"Hilscher","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2022.03.029","article-title":"Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in\u00a0vitro and in\u00a0vivo","author":"Greuter","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib82","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jcmgh.2018.01.003","article-title":"Neutrophil-hepatic stellate cell interactions promote fibrosis in experimental steatohepatitis","volume":"5","author":"Zhou","year":"2018","journal-title":"Cel Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib83","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.20071765","article-title":"Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids","volume":"205","author":"McDonald","year":"2008","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib84","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.4049\/jimmunol.0901786","article-title":"Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10","volume":"183","author":"Menezes","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib85","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.4049\/jimmunol.163.11.6236","article-title":"Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver","volume":"163","author":"Shields","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib86","article-title":"Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury","volume":"42","author":"Papaioannou","year":"2023","journal-title":"Cel Rep"},{"key":"10.1016\/j.jhep.2024.05.014_bib87","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/hep.22443","article-title":"Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines","volume":"48","author":"Schrage","year":"2008","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib88","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.4049\/jimmunol.1002961","article-title":"Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium","volume":"186","author":"Shetty","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib89","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jhep.2015.02.046","article-title":"CMV infection of human sinusoidal endothelium regulates hepatic T cell recruitment and activation","volume":"63","author":"Bruns","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib90","doi-asserted-by":"crossref","first-page":"G138","DOI":"10.1152\/ajpgi.00411.2016","article-title":"CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma","volume":"313","author":"Wadkin","year":"2017","journal-title":"Am J Physiology-Gastrointestinal Liver Physiol"},{"key":"10.1016\/j.jhep.2024.05.014_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123867","article-title":"Chemokine transfer by liver sinusoidal endothelial cells contributes to the recruitment of CD4+ T cells into the murine liver","volume":"10","author":"Neumann","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2024.05.014_bib92","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.cell.2015.03.005","article-title":"Immunosurveillance of the liver by intravascular effector CD8(+) T cells","volume":"161","author":"Guidotti","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.05.014_bib93","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune responses in the liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib94","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1002\/eji.200526034","article-title":"Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance","volume":"35","author":"Limmer","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib95","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.21965","article-title":"Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance","volume":"47","author":"Diehl","year":"2008","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib96","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/gut.2006.093906","article-title":"Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction","volume":"56","author":"Karrar","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.05.014_bib97","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jhep.2014.04.027","article-title":"TGF-\u03b2-dependent induction of CD4\u207aCD25\u207aFoxp3\u207a Tregs by liver sinusoidal endothelial cells","volume":"61","author":"Carambia","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib98","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jhep.2012.09.008","article-title":"Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells","volume":"58","author":"Carambia","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib99","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.4049\/jimmunol.1301262","article-title":"TLR1\/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in\u00a0vitro","volume":"191","author":"Liu","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib100","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jhep.2016.12.015","article-title":"Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2","volume":"66","author":"Wittlich","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib101","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1053\/j.gastro.2009.07.051","article-title":"Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response","volume":"137","author":"Tang","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib102","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/stcltm\/szac070","article-title":"Comprehensive review of the vascular niche in regulating organ regeneration and fibrosis","volume":"11","author":"Chen","year":"2022","journal-title":"Stem Cell translational Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib103","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/hep4.1196","article-title":"Endothelial Wnts regulate beta-catenin signaling in murine liver zonation and regeneration: a sequel to the Wnt-Wnt situation","volume":"2","author":"Preziosi","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2024.05.014_bib104","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","article-title":"Liver regeneration: biological and pathological mechanisms and implications","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-pathol-020117-044010","article-title":"Wnt\/beta-Catenin signaling in liver development, homeostasis, and pathobiology","volume":"13","author":"Russell","year":"2018","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jhep.2024.05.014_bib106","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.jcmgh.2022.01.019","article-title":"Notch-regulated c-kit-positive liver sinusoidal endothelial cells contribute to liver zonation and regeneration","volume":"13","author":"Duan","year":"2022","journal-title":"Cel Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib107","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.1244880","article-title":"Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat","volume":"343","author":"Hu","year":"2014","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.jhep.2024.05.014_bib108","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1079562","article-title":"Angiogenesis-independent endothelial protection of liver: role of VEGFR-1","volume":"299","author":"LeCouter","year":"2003","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.jhep.2024.05.014_bib109","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature09493","article-title":"Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration","volume":"468","author":"Ding","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.05.014_bib110","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040929","article-title":"The endothelium as a driver of liver fibrosis and regeneration","volume":"9","author":"Lafoz","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2024.05.014_bib111","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00109-019-01811-y","article-title":"Relevance of VEGFA in rat livers subjected to partial hepatectomy under ischemia-reperfusion","volume":"97","author":"Bujaldon","year":"2019","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.jhep.2024.05.014_bib112","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1053\/j.gastro.2012.08.008","article-title":"Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells","volume":"143","author":"Wang","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib113","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12681","article-title":"Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis","volume":"505","author":"Ding","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.05.014_bib114","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/hep.27116","article-title":"Sinusoidal endothelial cells direct traffic at the intersection of regeneration and fibrosis","volume":"60","author":"Huebert","year":"2014","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib115","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jhep.2015.07.002","article-title":"A\u00a0focus on the role of platelets in liver regeneration: do platelet-endothelial cell interactions initiate the regenerative process?","volume":"63","author":"Meyer","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib116","article-title":"Platelets prime hematopoietic and vascular niche to drive angiocrine-mediated liver regeneration","volume":"2","author":"Shido","year":"2017","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"10.1016\/j.jhep.2024.05.014_bib117","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/hep.32209","article-title":"Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21\/P16 axis","volume":"75","author":"Duan","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/s43587-022-00348-z","article-title":"Age-related liver endothelial zonation triggers steatohepatitis by inactivating pericentral endothelium-derived C-kit","author":"Duan","year":"2022","journal-title":"Nat Aging"},{"key":"10.1016\/j.jhep.2024.05.014_bib119","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.29834","article-title":"Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice","volume":"68","author":"Duan","year":"2018","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib120","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cmet.2020.11.019","article-title":"Aging reprograms the hematopoietic-vascular niche to impede regeneration and promote fibrosis","volume":"33","author":"Chen","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2024.05.014_bib121","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/01.SLA.0000059986.96051.EA","article-title":"Endothelial-directed hepatic regeneration after partial hepatectomy","volume":"237","author":"Greene","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2024.05.014_bib122","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1073\/pnas.0909374107","article-title":"Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration","volume":"107","author":"Hoehme","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2024.05.014_bib123","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1007\/s11538-017-0375-1","article-title":"Model prediction and validation of an order mechanism controlling the spatiotemporal phenotype of early hepatocellular carcinoma","volume":"80","author":"Hoehme","year":"2018","journal-title":"Bull Math Biol"},{"key":"10.1016\/j.jhep.2024.05.014_bib124","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/acer.14331","article-title":"Persistent hyperactivation of endothelial cells in patients with alcoholic hepatitis","volume":"44","author":"Xia","year":"2020","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2024.05.014_bib125","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s12072-021-10165-y","article-title":"Endothelial dysfunction markers predict short-term mortality in patients with severe alcoholic hepatitis","volume":"15","author":"Blaya","year":"2021","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2024.05.014_bib126","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jhep.2021.02.028","article-title":"Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease","volume":"75","author":"Yang","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib127","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hep.32140","article-title":"Ductular reaction promotes intrahepatic angiogenesis through Slit2-Roundabout 1 signaling","volume":"75","author":"Coll","year":"2022","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib128","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gutjnl-2011-301146","article-title":"Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis","volume":"62","author":"Aff\u00f2","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.05.014_bib129","doi-asserted-by":"crossref","first-page":"G838","DOI":"10.1152\/ajpgi.00151.2013","article-title":"HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol-induced parenchymal cell injury","volume":"305","author":"Seo","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2024.05.014_bib130","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1530-0277.2009.01141.x","article-title":"Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury","volume":"34","author":"Miller","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2024.05.014_bib131","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.alcohol.2004.07.006","article-title":"Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure","volume":"34","author":"Gao","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.jhep.2024.05.014_bib132","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","volume":"77","author":"Peiseler","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib133","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A\u00a0multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib134","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.molcel.2019.07.028","article-title":"Landscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis","volume":"75","author":"Xiong","year":"2019","journal-title":"Mol Cel"},{"key":"10.1016\/j.jhep.2024.05.014_bib135","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.freeradbiomed.2017.12.019","article-title":"The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease","volume":"115","author":"Matsumoto","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib136","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1530\/JME-14-0049","article-title":"oxLDL induces injury and defenestration of human liver sinusoidal endothelial cells via LOX1","volume":"53","author":"Zhang","year":"2014","journal-title":"J\u00a0Mol Endocrinol"},{"key":"10.1016\/j.jhep.2024.05.014_bib137","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115005","article-title":"Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage","volume":"9","author":"Herrnberger","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2024.05.014_bib138","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/db11-0255","article-title":"Endothelial NO\/cGMP\/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding","volume":"60","author":"Tateya","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2024.05.014_bib139","article-title":"Free fatty acids differentially downregulate chemokines in liver sinusoidal endothelial cells: insights into non-alcoholic fatty liver disease","volume":"11","author":"McMahan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2024.05.014_bib140","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.celrep.2017.02.039","article-title":"Roles for cell-cell adhesion and contact in obesity-induced hepatic myeloid cell accumulation and glucose intolerance","volume":"18","author":"Miyachi","year":"2017","journal-title":"Cel Rep"},{"key":"10.1016\/j.jhep.2024.05.014_bib141","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143690","article-title":"Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis","volume":"131","author":"Furuta","year":"2021","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.05.014_bib142","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2021.09.032","article-title":"Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis","volume":"76","author":"Qing","year":"2022","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib143","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jhep.2019.07.019","article-title":"Integrin \u03b2(1)-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH","volume":"71","author":"Guo","year":"2019","journal-title":"J\u00a0Hepatol"},{"issue":"614","key":"10.1016\/j.jhep.2024.05.014_bib144","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd1206","article-title":"Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis","volume":"13","author":"Zhang","year":"2021","journal-title":"Sci translational Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib145","article-title":"Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase","author":"Fang","year":"2022","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib146","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/hep.30294","article-title":"Angiopoietin-2 promotes pathological angiogenesis and is a therapeutic target in murine nonalcoholic fatty liver disease","volume":"69","author":"Lefere","year":"2019","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib147","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jhep.2019.10.028","article-title":"A\u00a0defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis","volume":"72","author":"Hammoutene","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106572","article-title":"Expansion of macrophage and liver sinusoidal endothelial cell subpopulations during non-alcoholic steatohepatitis progression","volume":"26","author":"Shen","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.jhep.2024.05.014_bib149","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.autrev.2018.06.008","article-title":"IL-17 and IL-17-producing cells and liver diseases, with focus on autoimmune liver diseases","volume":"17","author":"Beringer","year":"2018","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jhep.2024.05.014_bib150","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/hep.23191","article-title":"Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3- regulatory T cells suppressing autoimmune hepatitis","volume":"50","author":"Kruse","year":"2009","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib151","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/imm.13298","article-title":"Nanoparticle-mediated targeting of autoantigen peptide to cross-presenting liver sinusoidal endothelial cells protects from CD8 T-cell-driven autoimmune cholangitis","volume":"162","author":"Carambia","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.jhep.2024.05.014_bib152","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/j.ymthe.2018.08.016","article-title":"Targeting endothelial Erk1\/2-Akt Axis as a regeneration strategy to bypass fibrosis during chronic liver injury in mice","volume":"26","author":"Lao","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.jhep.2024.05.014_bib153","article-title":"Adipocyte fatty acid binding protein promotes the onset and progression of liver fibrosis via mediating the crosstalk between liver sinusoidal endothelial cells and hepatic stellate cells","volume":"8","author":"Wu","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jhep.2024.05.014_bib154","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.983255","article-title":"Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis","volume":"13","author":"Guo","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib155","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/hep.32256","article-title":"Sphingosine-1-phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy","volume":"76","author":"Kawai","year":"2022","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib156","doi-asserted-by":"crossref","first-page":"30684","DOI":"10.1074\/jbc.M115.671735","article-title":"Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-Phosphate-dependent migration","volume":"290","author":"Wang","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhep.2024.05.014_bib157","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1083\/jcb.127.6.2037","article-title":"Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis","volume":"127","author":"Jarnagin","year":"1994","journal-title":"J\u00a0Cel Biol"},{"key":"10.1016\/j.jhep.2024.05.014_bib158","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-030-11093-2_9","article-title":"Pericytes in the liver","volume":"1122","author":"Kostallari","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jhep.2024.05.014_bib159","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.048884","article-title":"Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH","volume":"14","author":"Bravo","year":"2021","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.jhep.2024.05.014_bib160","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.cell.2019.07.021","article-title":"LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis","volume":"178","author":"Xu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2024.05.014_bib161","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/gut.2010.220913","article-title":"Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver","volume":"60","author":"Gracia-Sancho","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.05.014_bib162","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1136\/gutjnl-2014-308338","article-title":"KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins","volume":"64","author":"Marrone","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.05.014_bib163","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1172\/JCI90086","article-title":"GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis","volume":"127","author":"G\u00e9raud","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.05.014_bib164","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jhep.2020.08.033","article-title":"Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling","volume":"74","author":"Winkler","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib165","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.7150\/thno.83714","article-title":"Endothelial TAZ inhibits capillarization of liver sinusoidal endothelium and damage-induced liver fibrosis via nitric oxide production","volume":"13","author":"Hwang","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jhep.2024.05.014_bib166","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.molimm.2016.05.018","article-title":"MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt\/\u03b2-catenin pathway","volume":"75","author":"Zhou","year":"2016","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib167","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/cvr\/cvab148","article-title":"Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis","volume":"118","author":"de Haan","year":"2022","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jhep.2024.05.014_bib168","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/liv.15187","article-title":"JAM-A is a multifaceted regulator in hepatic fibrogenesis, supporting LSEC integrity and stellate cell quiescence","volume":"42","author":"Brozat","year":"2022","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2024.05.014_bib169","article-title":"The liver matrisome - looking beyond collagens","volume":"2","author":"Arteel","year":"2020","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2024.05.014_bib170","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.1840150603","article-title":"Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver","volume":"15","author":"McGuire","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib171","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/gutjnl-2018-317593","article-title":"Advances in non-invasive assessment of hepatic fibrosis","volume":"69","author":"Loomba","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.05.014_bib172","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.actbio.2015.06.028","article-title":"Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function","volume":"24","author":"Ford","year":"2015","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jhep.2024.05.014_bib173","article-title":"Capillarized liver sinusoidal endothelial cells undergo partial endothelial-mesenchymal transition to actively deposit sinusoidal ECM in liver fibrosis","volume":"9","author":"Ruan","year":"2021","journal-title":"Front Cel Dev Biol"},{"key":"10.1016\/j.jhep.2024.05.014_bib174","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0168-8278(99)80350-X","article-title":"Transforming growth factor-beta1 stimulates the synthesis of basement membrane proteins laminin, collagen type IV and entactin in rat liver sinusoidal endothelial cells","volume":"31","author":"Neubauer","year":"1999","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib175","doi-asserted-by":"crossref","first-page":"G492","DOI":"10.1152\/ajpgi.00428.2016","article-title":"A\u00a0small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury","volume":"313","author":"Ribera","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2024.05.014_bib176","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.4049\/jimmunol.1000332","article-title":"In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity","volume":"185","author":"Connolly","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2024.05.014_bib177","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1002\/hep.31215","article-title":"Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury","volume":"72","author":"Terkelsen","year":"2020","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib178","article-title":"Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension","volume":"5","author":"Ortega-Ribera","year":"2023","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2024.05.014_bib179","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1152\/physrev.1995.75.3.519","article-title":"Flow-mediated endothelial mechanotransduction","volume":"75","author":"Davies","year":"1995","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jhep.2024.05.014_bib180","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1172\/JCI119842","article-title":"Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids","volume":"100","author":"Shah","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.05.014_bib181","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/hep.27343","article-title":"Molecular pathophysiology of portal hypertension","volume":"61","author":"Fernandez","year":"2015","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib182","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.jhep.2015.01.003","article-title":"Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments","volume":"62","author":"Bosch","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib183","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jhep.2010.07.004","article-title":"Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension?","volume":"53","author":"Thabut","year":"2010","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib184","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201745","article-title":"GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension","volume":"218","author":"Drzewiecki","year":"2021","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib185","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/gast.2002.31040","article-title":"5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes","volume":"122","author":"Graupera","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib186","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hep.510240137","article-title":"Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance","volume":"24","author":"Rockey","year":"1996","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib187","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0016-5085(98)70487-1","article-title":"Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension","volume":"114","author":"Rockey","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib188","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0016-5085(99)70408-7","article-title":"Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat","volume":"117","author":"Shah","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib189","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jhep.2010.07.034","article-title":"Tempol administration, a superoxide dismutase mimetic, reduces hepatic vascular resistance and portal pressure in cirrhotic rats","volume":"54","author":"Garcia-Caldero","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib190","doi-asserted-by":"crossref","first-page":"10389","DOI":"10.1111\/jcmm.16968","article-title":"Celecoxib reduces hepatic vascular resistance in portal hypertension by amelioration of endothelial oxidative stress","volume":"25","author":"Tai","year":"2021","journal-title":"J\u00a0Cel Mol Med"},{"key":"10.1016\/j.jhep.2024.05.014_bib191","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jhep.2007.03.014","article-title":"Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers","volume":"47","author":"Gracia-Sancho","year":"2007","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib192","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1002\/hep.29084","article-title":"The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells","volume":"65","author":"Vilaseca","year":"2017","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib193","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jhep.2021.05.014","article-title":"Co-expression gene network analysis reveals novel regulatory pathways involved in porto-sinusoidal vascular disease","volume":"75","author":"Hern\u00e1ndez-Gea","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib194","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41575-021-00566-7","article-title":"Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology","volume":"19","author":"Fuchs","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib195","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jhep.2016.12.005","article-title":"The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction","volume":"66","author":"Schwabl","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102712","article-title":"Vascular endothelial cells: heterogeneity and targeting approaches","volume":"10","author":"Hennigs","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jhep.2024.05.014_bib197","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hep.21228","article-title":"The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis","volume":"44","author":"Matei","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib198","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s12072-019-09951-6","article-title":"Nonselective beta-blockers and development of portal vein thrombosis in liver cirrhosis: a systematic review and meta-analysis","volume":"13","author":"Xu","year":"2019","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2024.05.014_bib199","first-page":"1238","article-title":"Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension","volume":"21","author":"Wanless","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.05.014_bib200","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00535-016-1190-4","article-title":"Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights","volume":"51","author":"Greuter","year":"2016","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jhep.2024.05.014_bib201","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1172\/JCI18114","article-title":"The Fgl2\/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis","volume":"112","author":"Marsden","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.05.014_bib202","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jhep.2015.08.017","article-title":"Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury","volume":"64","author":"Rautou","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib203","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2010.01.042","article-title":"Hemostasis and thrombosis in patients with liver disease: the ups and downs","volume":"53","author":"Lisman","year":"2010","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib204","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/hep.22758","article-title":"Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats","volume":"49","author":"Mejias","year":"2009","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib205","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/hep.25545","article-title":"Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice","volume":"55","author":"Sahin","year":"2012","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib206","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41419-020-02749-7","article-title":"Anlotinib suppresses tumor progression via blocking the VEGFR2\/PI3K\/AKT cascade in intrahepatic cholangiocarcinoma","volume":"11","author":"Song","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jhep.2024.05.014_bib207","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","article-title":"Vascular endothelial growth factor promotes fibrosis resolution and repair in mice","volume":"146","author":"Yang","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.05.014_bib208","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.32299","article-title":"A\u00a0strategy of vascular-targeted therapy for liver fibrosis","volume":"76","author":"Lin","year":"2022","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib209","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1478-3231.2008.01664.x","article-title":"Treatment of bile duct-ligated rats with the nitric oxide synthase transcription enhancer AVE 9488 ameliorates portal hypertension","volume":"28","author":"Biecker","year":"2008","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2024.05.014_bib210","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/toxsci\/kfh291","article-title":"Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice","volume":"83","author":"Ito","year":"2005","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhep.2024.05.014_bib211","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/hep.30169","article-title":"Liver-Selective MMP-9 inhibition in the rat eliminates ischemia-reperfusion injury and accelerates liver regeneration","volume":"69","author":"Wang","year":"2019","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jhep.2024.05.014_bib212","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2019.11.013","article-title":"Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice","volume":"72","author":"Xiang","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.05.014_bib213","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10456-016-9522-9","article-title":"Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats","volume":"19","author":"Gao","year":"2016","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jhep.2024.05.014_bib214","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.nano.2017.06.019","article-title":"Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid","volume":"13","author":"Lin","year":"2017","journal-title":"Nanomedicine"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824003490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824003490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:03:45Z","timestamp":1724393025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824003490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":214,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0168827824003490"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2024.05.014","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiocrine signaling in sinusoidal homeostasis and liver diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2024.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Association for the Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}