{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:01:49Z","timestamp":1793318509039,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jhep.2024.08.024","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T22:42:25Z","timestamp":1725057745000},"page":"427-437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Frailty and risk of metabolic dysfunction-associated steatotic liver disease and other chronic liver diseases"],"prefix":"10.1016","volume":"82","author":[{"given":"Qi","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Dian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Fei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Yue","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1176-7200","authenticated-orcid":false,"given":"Shi-Ao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-9599","authenticated-orcid":false,"given":"Xian-Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2024.08.024_bib1","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.cgh.2023.04.015","article-title":"The global burden of liver disease","volume":"21","author":"Younossi","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.08.024_bib2","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A\u00a0multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.08.024_bib3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.08.024_bib4","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2024.08.024_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41575-021-00523-4","article-title":"Advancing the global public health agenda for NAFLD: a consensus statement","volume":"19","author":"Lazarus","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.08.024_bib6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41591-023-02242-6","article-title":"Challenges and opportunities in NASH drug development","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2024.08.024_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11912-021-01097-9","article-title":"Determination of biological age: geriatric assessment vs biological biomarkers","volume":"23","author":"Diebel","year":"2021","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.jhep.2024.08.024_bib8","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2024.08.024_bib9","first-page":"234","article-title":"Frailty in metabolic syndrome, focusing on nonalcoholic fatty liver disease","volume":"35","author":"Karakousis","year":"2022","journal-title":"Ann Gastroenterol"},{"key":"10.1016\/j.jhep.2024.08.024_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/lt.25346","article-title":"Differing impact of sarcopenia and frailty in nonalcoholic steatohepatitis and alcoholic liver disease","volume":"25","author":"Bhanji","year":"2019","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jhep.2024.08.024_bib11","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/apt.17324","article-title":"Systematic review: the role of frailty in advanced chronic liver disease","volume":"57","author":"Bowers","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2024.08.024_bib12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/hep.32157","article-title":"Frailty is associated with increased risk of cirrhosis disease progression and death","volume":"75","author":"Wang","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.08.024_bib13","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/SLA.0000000000003207","article-title":"Multicenter study of age, frailty, and waitlist mortality among liver transplant candidates","volume":"271","author":"Haugen","year":"2020","journal-title":"Ann Surg"},{"key":"10.1016\/j.jhep.2024.08.024_bib14","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1111\/ajt.12762","article-title":"Frailty predicts waitlist mortality in liver transplant candidates","volume":"14","author":"Lai","year":"2014","journal-title":"Am J Transpl"},{"key":"10.1016\/j.jhep.2024.08.024_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1245\/s10434-020-08742-w","article-title":"Significance of frailty in prognosis after hepatectomy for elderly patients with hepatocellular carcinoma","volume":"28","author":"Yamada","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jhep.2024.08.024_bib16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1148\/radiol.2021204288","article-title":"Quantification of liver fat content with CT and MRI: state of the art","volume":"301","author":"Starekova","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.jhep.2024.08.024_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"Plos Med"},{"key":"10.1016\/j.jhep.2024.08.024_bib18","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1038\/s41467-020-15948-9","article-title":"The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions","volume":"11","author":"Littlejohns","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2024.08.024_bib19","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.31726","article-title":"Administrative coding in electronic health care record-based research of NAFLD: an Expert Panel consensus statement","volume":"74","author":"Hagstr\u00f6m","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.08.024_bib20","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41574-022-00711-5","article-title":"Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation","volume":"18","author":"Lonardo","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jhep.2024.08.024_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/ageing\/aft160","article-title":"The frailty phenotype and the frailty index: different instruments for different purposes","volume":"43","author":"Cesari","year":"2014","journal-title":"Age Ageing"},{"key":"10.1016\/j.jhep.2024.08.024_bib22","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jhep.2024.08.024_bib23","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jhep.2024.08.024_bib24","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/gerona\/gly094","article-title":"A\u00a0frailty index for UK biobank participants","volume":"74","author":"Williams","year":"2019","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jhep.2024.08.024_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-002111","article-title":"Frailty in rheumatoidrmdopen-2021-002111 arthritis and its relationship with disease activity, hospitalisation and mortality: a longitudinal analysis of the Scottish Early Rheumatoid Arthritis cohort and UK Biobank","volume":"8","author":"Hanlon","year":"2022","journal-title":"RMD Open"},{"key":"10.1016\/j.jhep.2024.08.024_bib26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/ageing\/afw039","article-title":"Development and validation of an electronic frailty index using routine primary care electronic health record data","volume":"45","author":"Clegg","year":"2016","journal-title":"Age Ageing"},{"key":"10.1016\/j.jhep.2024.08.024_bib27","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41588-022-01199-5","article-title":"Multiomics study of nonalcoholic fatty liver disease","volume":"54","author":"Sveinbjornsson","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2024.08.024_bib28","article-title":"Adverse muscle composition is a significant risk factor for all-cause mortality in NAFLD","volume":"5","author":"Linge","year":"2023","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2024.08.024_bib29","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/oby.22210","article-title":"Body composition profiling in the UK biobank imaging study","volume":"26","author":"Linge","year":"2018","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jhep.2024.08.024_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163332","article-title":"Feasibility of MR-based body composition analysis in large scale population studies","volume":"11","author":"West","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2024.08.024_bib31","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/hep.29639","article-title":"Optimal threshold of controlled attenuation parameter with MRI-PDFF as the gold standard for the detection of hepatic steatosis","volume":"67","author":"Caussy","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.08.024_bib32","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.mayocp.2021.01.036","article-title":"Nonlinear associations between cumulative dietary risk factors and cardiovascular diseases, cancer, and all-cause mortality: a prospective cohort study from UK biobank","volume":"96","author":"Petermann-Rocha","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jhep.2024.08.024_bib33","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jhep.2024.08.024_bib34","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/jcsm.12971","article-title":"Association of shorter leucocyte telomere length with risk of frailty","volume":"13","author":"Bountziouka","year":"2022","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jhep.2024.08.024_bib35","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/liv.13886","article-title":"Leucocyte telomere shortening is associated with nonalcoholic fatty liver disease-related advanced fibrosis","volume":"38","author":"Kim","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2024.08.024_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112296","article-title":"Association of energy-adjusted dietary inflammatory index and frailty in older adults with nonalcoholic fatty liver disease","volume":"182","author":"Shi","year":"2023","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jhep.2024.08.024_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/liv.15725","article-title":"Metabolic dysfunction-associated steatotic liver disease in older adults is associated with frailty and social disadvantage","volume":"44","author":"Clayton-Chubb","year":"2024","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2024.08.024_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/nu12103005","article-title":"Vitamin D insufficiency reduces grip strength, grip endurance and increases frailty in aged C57Bl\/6J mice","volume":"12","author":"Seldeen","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jhep.2024.08.024_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113302","article-title":"Vitamin D and metabolic dysfunction-associated fatty liver disease (MAFLD): an update","volume":"12","author":"Barchetta","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jhep.2024.08.024_bib40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12072-019-09964-1","article-title":"Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"14","author":"Cai","year":"2020","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2024.08.024_bib41","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S2213-8587(18)30110-4","article-title":"Frailty and the endocrine system","volume":"6","author":"Clegg","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jhep.2024.08.024_bib42","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1002\/cphy.c210034","article-title":"Physiological systems in promoting frailty","volume":"12","author":"Perazza","year":"2022","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jhep.2024.08.024_bib43","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/hep.30429","article-title":"Modulation of insulin resistance in nonalcoholic fatty liver disease","volume":"70","author":"Khan","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.08.024_bib44","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s42255-021-00501-9","article-title":"Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity","volume":"3","author":"Tilg","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.jhep.2024.08.024_bib45","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1093\/gerona\/glad125","article-title":"Frailty, an independent risk factor in progression trajectory of cardiometabolic multimorbidity: a prospective study of UK biobank","volume":"78","author":"Ma","year":"2023","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jhep.2024.08.024_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002543","article-title":"Comparative analysis of the association between 35 frailty scores and cardiovascular events, cancer, and total mortality in an elderly general population in England: an observational study","volume":"15","author":"Aguayo","year":"2018","journal-title":"Plos Med"},{"key":"10.1016\/j.jhep.2024.08.024_bib47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ageing\/afaa219","article-title":"Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies","volume":"50","author":"O'Caoimh","year":"2021","journal-title":"Age Ageing"},{"key":"10.1016\/j.jhep.2024.08.024_bib48","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3350\/cmh.2023.0035","article-title":"Association of visceral fat obesity, sarcopenia, and myosteatosis with non-alcoholic fatty liver disease without obesity","volume":"29","author":"Kim","year":"2023","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.jhep.2024.08.024_bib49","article-title":"Lean nonalcoholic fatty liver disease and sarcopenia","volume":"14","author":"Chen","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jhep.2024.08.024_bib50","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hep.29219","article-title":"Development of a novel frailty index to predict mortality in patients with end-stage liver disease","volume":"66","author":"Lai","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.08.024_bib51","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/jgs.17002","article-title":"Changes in a frailty index and association with mortality","volume":"69","author":"Shi","year":"2021","journal-title":"J\u00a0Am Geriatr Soc"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824025029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824025029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T16:37:14Z","timestamp":1739551034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824025029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0168827824025029"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2024.08.024","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frailty and risk of metabolic dysfunction-associated steatotic liver disease and other chronic liver diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2024.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Association for the Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}