{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:21:31Z","timestamp":1791836491512,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TI 323\/4\\u20131"],"award-info":[{"award-number":["TI 323\/4\\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 179"],"award-info":[{"award-number":["TRR 179"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["272983813"],"award-info":[{"award-number":["272983813"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010127","name":"J\u00fcrgen Manchot Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jhep.2024.10.047","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T15:15:39Z","timestamp":1731424539000},"page":"805-815","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["HBV shows different levels of adaptation to HLA class I-associated\u00a0selection pressure correlating with markers of replication"],"prefix":"10.1016","volume":"82","author":[{"given":"Tatjana","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-5649","authenticated-orcid":false,"given":"Johannes","family":"Ptok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-7719","authenticated-orcid":false,"given":"Maximilian","family":"Damagnez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-8766","authenticated-orcid":false,"given":"Christopher","family":"Menne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe Salimi","family":"Alizei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0374-1093","authenticated-orcid":false,"given":"Julia","family":"Lang-Meli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Maas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Habermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2973-7869","authenticated-orcid":false,"given":"Daniel","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Schulze zur Wiesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-4271","authenticated-orcid":false,"given":"Georg M.","family":"Lauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-4506","authenticated-orcid":false,"given":"Helenie","family":"Kefalakes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-8001","authenticated-orcid":false,"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9666-0753","authenticated-orcid":false,"given":"Anke R.M.","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaranda","family":"Gliga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-7464","authenticated-orcid":false,"given":"Hans H.","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala K.","family":"Maini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Nattermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-1154","authenticated-orcid":false,"given":"Falko M.","family":"Heinemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Luedde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-1387","authenticated-orcid":false,"given":"Christoph","family":"Neumann-Haefelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-0863","authenticated-orcid":false,"given":"Andreas","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Timm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2024.10.047_bib2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection","volume":"67","author":"European Association for the Study of the Liver","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.10.047_bib3","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1080\/21645515.2019.1607132","article-title":"Is the function of the HBeAg really unknown?","volume":"15","author":"Milich","year":"2019","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.jhep.2024.10.047_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1172\/JCI115590","article-title":"Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion","volume":"89","author":"Tsai","year":"1992","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.10.047_bib5","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41575-019-0196-9","article-title":"Restoring, releasing or replacing adaptive immunity in chronic hepatitis B","volume":"16","author":"Maini","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.10.047_bib6","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.jhep.2016.01.026","article-title":"Adaptive immunity in HBV infection","volume":"64","author":"Bertoletti","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhep.2024.10.047_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.coviro.2021.10.002","article-title":"Immunotherapy and therapeutic vaccines for chronic HBV infection","volume":"51","author":"Lang-Meli","year":"2021","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.jhep.2024.10.047_bib8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S2468-1253(18)30007-4","article-title":"Defective T-cell immunity in hepatitis B virus infection: why therapeutic vaccination needs a helping hand","volume":"3","author":"Maini","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2024.10.047_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.coviro.2021.08.002","article-title":"Mutational escape from cellular immunity in viral hepatitis: variations on a theme","volume":"50","author":"Salimi Alizei","year":"2021","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.jhep.2024.10.047_bib10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1084\/jem.180.3.933","article-title":"Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope","volume":"180","author":"Bertoletti","year":"1994","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2024.10.047_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/369407a0","article-title":"Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells","volume":"369","author":"Bertoletti","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.10.047_bib12","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.4049\/jimmunol.145.10.3442","article-title":"Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection","volume":"145","author":"Ferrari","year":"1990","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jhep.2024.10.047_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/hep.27771","article-title":"Adaptation of the hepatitis B virus core protein to CD8 T-cell selection pressure","volume":"62","author":"Kefalakes","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.10.047_bib14","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.181.3.1047","article-title":"The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis","volume":"181","author":"Rehermann","year":"1995","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2024.10.047_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/gut.47.1.137","article-title":"Cytotoxic T lymphocyte responses and CTL epitope escape mutation in HBsAg, anti-HBe positive individuals","volume":"47","author":"Khakoo","year":"2000","journal-title":"Gut"},{"issue":"Suppl 1","key":"10.1016\/j.jhep.2024.10.047_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1399-0039.2006.758_5.x","article-title":"Typing of potential and selected donors for transplant: methodology and resolution","volume":"69","author":"Oudshoorn","year":"2007","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.jhep.2024.10.047_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1045498","article-title":"Immune escape pathways from the HBV core(18-27) CD8 T cell response are driven by individual HLA class I alleles","volume":"13","author":"Walker","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2024.10.047_bib18","article-title":"Sequence diversity of hepatitis D virus in Mongolia","volume":"10","author":"Magvan","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jhep.2024.10.047_bib19","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jhep.2024.10.047_bib20","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/bioinformatics\/17.8.754","article-title":"MRBAYES: Bayesian inference of phylogenetic trees","volume":"17","author":"Huelsenbeck","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhep.2024.10.047_bib21","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gkw290","article-title":"Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees","volume":"44","author":"Letunic","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2024.10.047_bib22","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1093\/bioinformatics\/btac134","article-title":"HAMdetector: a Bayesian regression model that integrates information to detect HLA-associated mutations","volume":"38","author":"Habermann","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhep.2024.10.047_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/hep.21702","article-title":"Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution","volume":"46","author":"Timm","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.10.047_bib24","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1128\/JVI.01700-07","article-title":"Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level","volume":"82","author":"Neumann-Haefelin","year":"2008","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2024.10.047_bib25","doi-asserted-by":"crossref","first-page":"E5393","DOI":"10.1073\/pnas.1413339111","article-title":"Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence","volume":"111","author":"Payne","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2024.10.047_bib26","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1084\/jem.20041455","article-title":"Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA","volume":"201","author":"Leslie","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhep.2024.10.047_bib27","doi-asserted-by":"crossref","first-page":"13202","DOI":"10.1128\/JVI.01998-12","article-title":"Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1","volume":"86","author":"Carlson","year":"2012","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2024.10.047_bib28","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nature07746","article-title":"Adaptation of HIV-1 to human leukocyte antigen class I","volume":"458","author":"Kawashima","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2024.10.047_bib29","first-page":"665","article-title":"Role of HLA adaptation in HIV evolution","volume":"6","author":"Kloverpris","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jhep.2024.10.047_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00430-014-0372-z","article-title":"Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections","volume":"204","author":"Timm","year":"2015","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.jhep.2024.10.047_bib31","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.510260435","article-title":"Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: interaction with HLA and T-cell receptor","volume":"26","author":"Bertoletti","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2024.10.047_bib32","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1053\/j.gastro.2011.02.060","article-title":"CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins","volume":"140","author":"Ruhl","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.10.047_bib33","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1069660","article-title":"Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level","volume":"296","author":"Moore","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jhep.2024.10.047_bib34","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1053\/j.gastro.2019.02.003","article-title":"Mutations in hepatitis D virus allow it to escape detection by CD8(+) T cells and evolve at the population level","volume":"156","author":"Karimzadeh","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.10.047_bib35","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1128\/JVI.01108-08","article-title":"Transmission and long-term stability of compensated CD8 escape mutations","volume":"83","author":"Schneidewind","year":"2009","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhep.2024.10.047_bib36","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nm.4100","article-title":"Impact of pre-adapted HIV transmission","volume":"22","author":"Carlson","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2024.10.047_bib37","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tim.2008.09.001","article-title":"Rates of HIV immune escape and reversion: implications for vaccination","volume":"16","author":"Davenport","year":"2008","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jhep.2024.10.047_bib38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/jvh.13011","article-title":"Differential escape of HCV from CD8(+) T cell selection pressure between China and Germany depends on the presenting HLA class I molecule","volume":"26","author":"Xia","year":"2019","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1016\/j.jhep.2024.10.047_bib39","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1136\/gutjnl-2021-324646","article-title":"Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection","volume":"71","author":"Aliabadi","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.10.047_bib40","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/j.gastro.2020.04.019","article-title":"Effects of hepatitis B surface antigen on virus-specific and global T cells in patients with chronic hepatitis B virus infection","volume":"159","author":"Le Bert","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.10.047_bib41","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1053\/j.gastro.2015.11.050","article-title":"Hepatitis B virus--specific and global T-cell dysfunction in chronic hepatitis B","volume":"150","author":"Park","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.10.047_bib42","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/gutjnl-2018-316641","article-title":"Phenotypic and functional differences\u00a0of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load","volume":"68","author":"Schuch","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.10.047_bib43","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1136\/gutjnl-2018-316644","article-title":"Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection","volume":"68","author":"Hoogeveen","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2024.10.047_bib44","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1053\/j.gastro.2007.06.011","article-title":"Viral quasi-species evolution during hepatitis Be antigen seroconversion","volume":"133","author":"Lim","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.10.047_bib45","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.3389\/fmicb.2018.02521","article-title":"Immunomodulatory function of HBeAg related to short-sighted evolution, transmissibility, and clinical manifestation of hepatitis B virus","volume":"9","author":"Kramvis","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jhep.2024.10.047_bib46","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1172\/JCI118191","article-title":"Hepatitis B virus (HBV)\u00a0sequence variation of cytotoxic T lymphocyte epitopes is not common\u00a0in patients with chronic HBV infection","volume":"96","author":"Rehermann","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhep.2024.10.047_bib47","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1053\/j.gastro.2007.06.057","article-title":"Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients","volume":"133","author":"Volz","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2024.10.047_bib48","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.jhep.2016.02.008","article-title":"Intracellular transport and egress of hepatitis B virus","volume":"64","author":"Blondot","year":"2016","journal-title":"J\u00a0Hepatol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824027053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827824027053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:10:30Z","timestamp":1778674230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827824027053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0168827824027053"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2024.10.047","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HBV shows different levels of adaptation to HLA class I-associated\u00a0selection pressure correlating with markers of replication","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2024.10.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}