{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:13:09Z","timestamp":1780395189215,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009253","name":"EASL International Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["MetaboHUB-ANR-11-INBS-0010"],"award-info":[{"award-number":["MetaboHUB-ANR-11-INBS-0010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-10-LABX-0046"],"award-info":[{"award-number":["ANR-10-LABX-0046"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010978","name":"Wallonie-Bruxelles International","doi-asserted-by":"publisher","award":["SUB\/2020\/479801"],"award-info":[{"award-number":["SUB\/2020\/479801"]}],"id":[{"id":"10.13039\/501100010978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101042759"],"award-info":[{"award-number":["101042759"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017228","name":"European Genomic Institute for Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017228","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","award":["EQU202203014645"],"award-info":[{"award-number":["EQU202203014645"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jhep.2025.02.004","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T16:52:55Z","timestamp":1739292775000},"page":"315-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-4810","authenticated-orcid":false,"given":"Alexandre","family":"Berthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Gheeraert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjula","family":"Vinod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-5949","authenticated-orcid":false,"given":"Manuel","family":"Johanns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-1092","authenticated-orcid":false,"given":"Lo\u00efc","family":"Guille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0028-5988","authenticated-orcid":false,"given":"Joel T.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-752X","authenticated-orcid":false,"given":"Julie","family":"Dubois-Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-9264","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Eeckhoute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Staels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-5129","authenticated-orcid":false,"given":"Philippe","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2025.02.004_bib1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cmet.2017.04.015","article-title":"Metabolic flexibility in health and disease","volume":"25","author":"Goodpaster","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41586-019-1797-8","article-title":"The integrative biology of type 2 diabetes","volume":"576","author":"Roden","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2025.02.004_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12902-019-0463-3","article-title":"Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: a narrative review with emphasis on data from Europe","volume":"20","author":"Kyrou","year":"2020","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.jhep.2025.02.004_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41574-018-0122-1","article-title":"Circadian clocks and insulin resistance","volume":"15","author":"Stenvers","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jhep.2025.02.004_bib5","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.aah4965","article-title":"Circadian time signatures of fitness and disease","volume":"354","author":"Bass","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jhep.2025.02.004_bib6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S2213-8587(20)30161-3","article-title":"Gestational diabetes: opportunities for improving maternal and child health","volume":"8","author":"Saravanan","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jhep.2025.02.004_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165923","article-title":"Stress induced hyperglycemia and the subsequent risk of type 2 diabetes in survivors of critical illness","volume":"11","author":"Plummer","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2025.02.004_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61241","article-title":"Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates","volume":"10","author":"Issah","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.jhep.2025.02.004_bib9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bbrc.2008.08.151","article-title":"A novel high-affinity peptide antagonist to the insulin receptor","volume":"376","author":"Schaffer","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2025.02.004_bib10","doi-asserted-by":"crossref","first-page":"19556","DOI":"10.1038\/s41598-019-55987-x","article-title":"Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL\/6 mice","volume":"9","author":"Lang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2025.02.004_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166097","article-title":"PPARs in liver physiology","author":"Berthier","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jhep.2025.02.004_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101165","article-title":"Nicotinamide N-methyltransferase: at the crossroads between cellular metabolism and epigenetic regulation","volume":"45","author":"Roberti","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110674","article-title":"The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression","volume":"39","author":"Fougeray","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2025.02.004_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12696","article-title":"Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock","volume":"7","author":"Dang","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2025.02.004_bib15","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/en.2005-1132","article-title":"Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression","volume":"147","author":"Patsouris","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhep.2025.02.004_bib16","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPARalpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2025.02.004_bib17","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.2337\/db16-1519","article-title":"Acyl-CoA thioesterase 1 (ACOT1) regulates PPARalpha to couple fatty acid flux with oxidative capacity during fasting","volume":"66","author":"Franklin","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2025.02.004_bib18","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.cell.2013.11.034","article-title":"Reprogramming of the circadian clock by nutritional challenge","volume":"155","author":"Eckel-Mahan","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2025.02.004_bib19","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","article-title":"High-fat diet disrupts behavioral and molecular circadian rhythms in mice","volume":"6","author":"Kohsaka","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutres.2020.10.003","article-title":"Does a high-fat diet affect the circadian clock, or is it the other way around? A systematic review","volume":"84","author":"Paula","year":"2020","journal-title":"Nutr Res"},{"key":"10.1016\/j.jhep.2025.02.004_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.molcel.2019.10.007","article-title":"Cistromic reprogramming of the diurnal glucocorticoid hormone response by high-fat diet","volume":"76","author":"Quagliarini","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.jhep.2025.02.004_bib22","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI6223","article-title":"Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting","volume":"103","author":"Kersten","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2025.02.004_bib23","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1073\/pnas.94.9.4312","article-title":"Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator- activated receptors alpha and delta","volume":"94","author":"Forman","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2025.02.004_bib24","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jhep.2014.04.013","article-title":"PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism","volume":"61","author":"van Diepen","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2025.02.004_bib25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature13961","article-title":"Nutrient-sensing nuclear receptors coordinate autophagy","volume":"516","author":"Lee","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2025.02.004_bib26","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1074\/jbc.271.3.1764","article-title":"Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm","volume":"271","author":"Lemberger","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2025.02.004_bib27","doi-asserted-by":"crossref","DOI":"10.1530\/JME-23-0017","article-title":"A time- and space-resolved nuclear receptor atlas in mouse liver","volume":"71","author":"Zummo","year":"2023","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.jhep.2025.02.004_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000442","article-title":"Harmonics of circadian gene transcription in mammals","volume":"5","author":"Hughes","year":"2009","journal-title":"Plos Genet"},{"key":"10.1016\/j.jhep.2025.02.004_bib29","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1073\/pnas.0909591106","article-title":"Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression","volume":"106","author":"Vollmers","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2025.02.004_bib30","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1038\/s41467-021-23857-8","article-title":"Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling","volume":"12","author":"de la Calle Arregui","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2025.02.004_bib31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2006.06.050","article-title":"Nuclear receptor expression links the circadian clock to metabolism","volume":"126","author":"Yang","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2025.02.004_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5551\/jat.12.169","article-title":"CLOCK\/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element","volume":"12","author":"Inoue","year":"2005","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jhep.2025.02.004_bib33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1101\/gad.564110","article-title":"The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors","volume":"24","author":"Schmutz","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhep.2025.02.004_bib34","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/hep.27297","article-title":"The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice","volume":"60","author":"Pawlak","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2025.02.004_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11048","article-title":"Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta","volume":"485","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2025.02.004_bib36","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1101\/gad.281972.116","article-title":"HNF6 and Rev-erbalpha integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms","volume":"30","author":"Zhang","year":"2016","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhep.2025.02.004_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810569","article-title":"Death of a protein: the role of E3 ubiquitin ligases in circadian rhythms of mice and flies","volume":"23","author":"Abdalla","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2025.02.004_bib38","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205755119","article-title":"Circadian clock controls rhythms in ketogenesis by interfering with PPARalpha transcriptional network","volume":"119","author":"Mezhnina","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2025.02.004_bib39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cmet.2017.06.002","article-title":"CRY1\/2 selectively repress PPARdelta and limit exercise capacity","volume":"26","author":"Jordan","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib40","doi-asserted-by":"crossref","first-page":"8776","DOI":"10.1073\/pnas.1704955114","article-title":"Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity","volume":"114","author":"Kriebs","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2025.02.004_bib41","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0092-8674(01)00401-9","article-title":"Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock","volume":"105","author":"McNamara","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2025.02.004_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101162","article-title":"Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD","volume":"45","author":"Ribas-Aulinas","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib43","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/MOP.0000000000001202","article-title":"Long-term outcomes of acute kidney injury in children","volume":"35","author":"Schuermans","year":"2023","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jhep.2025.02.004_bib44","first-page":"389","article-title":"Update on glucose control during and after critical illness","volume":"28","author":"Deane","year":"2022","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.jhep.2025.02.004_bib45","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s42255-021-00439-y","article-title":"Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity","volume":"3","author":"Hild","year":"2021","journal-title":"Nat Metab"},{"issue":"10415","key":"10.1016\/j.jhep.2025.02.004_bib46","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0140-6736(23)01517-9","article-title":"Gestational weight change in a diverse pregnancy cohort and mortality over 50 years: a prospective observational cohort study","volume":"402","author":"Hinkle","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2025.02.004_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4900209","article-title":"Long-term metabolic outcomes after gestational diabetes mellitus (GDM): results from the odense GDM follow-up study (OGFUS)","volume":"2022","author":"Jacobsen","year":"2022","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jhep.2025.02.004_bib48","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1073\/pnas.1621069114","article-title":"Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice","volume":"114","author":"Okamoto","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2025.02.004_bib49","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbrc.2010.06.070","article-title":"S961, an insulin receptor antagonist causes hyperinsulinemia, insulin-resistance and depletion of energy stores in rats","volume":"398","author":"Vikram","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2025.02.004_bib50","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1152\/physiolgenomics.00117.2020","article-title":"Probing metabolic memory in the hepatic response to fasting","volume":"52","author":"Defour","year":"2020","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jhep.2025.02.004_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.01.019","article-title":"Metabolic transcriptional memory","volume":"38","author":"Bheda","year":"2020","journal-title":"Mol Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib52","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.celrep.2014.06.015","article-title":"The role of the endocrine system in feeding-induced tissue-specific circadian entrainment","volume":"8","author":"Sato","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2025.02.004_bib53","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/srep00439","article-title":"Real-time monitoring in three-dimensional hepatocytes reveals that insulin acts as a synchronizer for liver clock","volume":"2","author":"Yamajuku","year":"2012","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2025.02.004_bib54","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.bbrc.2009.08.045","article-title":"Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells","volume":"388","author":"Ramakrishnan","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2025.02.004_bib55","doi-asserted-by":"crossref","first-page":"E11033","DOI":"10.1073\/pnas.1805397115","article-title":"Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT\/REV-ERBalpha complex","volume":"115","author":"Berthier","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2025.02.004_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000181","article-title":"REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis","volume":"7","author":"Le Martelot","year":"2009","journal-title":"Plos Biol"},{"key":"10.1016\/j.jhep.2025.02.004_bib57","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.febslet.2012.11.021","article-title":"Role of Rev-erbalpha domains for transactivation of the connexin43 promoter with Sp1","volume":"587","author":"Negoro","year":"2013","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jhep.2025.02.004_bib58","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnins.2017.00046","article-title":"Postnatal light effects on pup stress Axis development are independent of maternal behavior","volume":"11","author":"Coleman","year":"2017","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jhep.2025.02.004_bib59","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1038\/s41598-017-03406-4","article-title":"Maternal and early-life circadian disruption have long-lasting negative consequences on offspring development and adult behavior in mice","volume":"7","author":"Smarr","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2025.02.004_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12335","article-title":"Oestradiol exposure early in life programs daily and circadian activity rhythms in adult mice","volume":"28","author":"Royston","year":"2016","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"10.1016\/j.jhep.2025.02.004_bib61","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162775","article-title":"ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients","volume":"133","author":"Cunningham","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2025.02.004_bib62","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1038\/s41598-020-63579-3","article-title":"Hepatocyte-specific deletion of Pparalpha promotes NAFLD in the context of obesity","volume":"10","author":"Regnier","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2025.02.004_bib63","doi-asserted-by":"crossref","first-page":"R733","DOI":"10.1152\/ajpregu.00153.2019","article-title":"Loss of hepatic PPARalpha promotes inflammation and serum hyperlipidemia in diet-induced obesity","volume":"317","author":"Stec","year":"2019","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jhep.2025.02.004_bib64","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.2337\/diabetes.50.12.2809","article-title":"PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance","volume":"50","author":"Guerre-Millo","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2025.02.004_bib65","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cmet.2005.01.006","article-title":"A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes","volume":"1","author":"Finck","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib66","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1039\/D3FO01636F","article-title":"PPAR\u03b1 is involved in high-fat diet-induced risk avoidance impairment via the regulation of hippocampal BDNF","volume":"14","author":"Zhu","year":"2023","journal-title":"Food Funct"},{"key":"10.1016\/j.jhep.2025.02.004_bib67","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.2337\/db13-1435","article-title":"Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting","volume":"63","author":"Jiao","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jhep.2025.02.004_bib68","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cmet.2018.06.020","article-title":"Lipolysis triggers a systemic insulin response essential for efficient energy replenishment of activated Brown adipose tissue in mice","volume":"28","author":"Heine","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111436","article-title":"E2F1 transcription factor mediates a link between fat and islets to promote beta cell proliferation in response to acute insulin resistance","volume":"41","author":"Shirakawa","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhep.2025.02.004_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101438","article-title":"Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction","volume":"57","author":"Gueddouri","year":"2022","journal-title":"Mol Metab"},{"key":"10.1016\/j.jhep.2025.02.004_bib71","doi-asserted-by":"crossref","first-page":"i8","DOI":"10.1093\/bioinformatics\/btw243","article-title":"What time is it? Deep learning approaches for circadian rhythms","volume":"32","author":"Agostinelli","year":"2016","journal-title":"Bioinformatics"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827825000807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827825000807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:09:25Z","timestamp":1773349765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827825000807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0168827825000807"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2025.02.004","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2025.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}