{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:57:01Z","timestamp":1793973421004,"version":"4.8.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010035","name":"Outstanding Youth Foundation of Jiangsu Province of China","doi-asserted-by":"publisher","award":["BK20240039"],"award-info":[{"award-number":["BK20240039"]}],"id":[{"id":"10.13039\/501100010035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32322019"],"award-info":[{"award-number":["32322019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504352"],"award-info":[{"award-number":["82504352"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404206"],"award-info":[{"award-number":["82404206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12235004"],"award-info":[{"award-number":["12235004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373525"],"award-info":[{"award-number":["82373525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173465"],"award-info":[{"award-number":["82173465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M771452"],"award-info":[{"award-number":["2025M771452"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipality Science and Technology Commission","doi-asserted-by":"publisher","award":["24ZR1414300"],"award-info":[{"award-number":["24ZR1414300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230490"],"award-info":[{"award-number":["BK20230490"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jhep.2026.03.035","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:53:19Z","timestamp":1775145199000},"page":"212-226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-765X","authenticated-orcid":false,"given":"Zhisen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7159-2152","authenticated-orcid":false,"given":"Shuangshuang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-8493","authenticated-orcid":false,"given":"Yinyin","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1258-5693","authenticated-orcid":false,"given":"Shuhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2501-7835","authenticated-orcid":false,"given":"Yuhan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7433-6502","authenticated-orcid":false,"given":"Yiping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-8651","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0714-8132","authenticated-orcid":false,"given":"Xiaoni","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-5111","authenticated-orcid":false,"given":"Mintao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2668-4048","authenticated-orcid":false,"given":"Haisheng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7247-9125","authenticated-orcid":false,"given":"Yuanpei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0815-4774","authenticated-orcid":false,"given":"Shuang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8633-3349","authenticated-orcid":false,"given":"Wenle","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0076-942X","authenticated-orcid":false,"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2648-3146","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2288-1748","authenticated-orcid":false,"given":"Lei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2026.03.035_bib1","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2026.03.035_bib2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"Huch","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2026.03.035_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature14863","article-title":"Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver","volume":"524","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2026.03.035_bib4","doi-asserted-by":"crossref","first-page":"19530","DOI":"10.1073\/pnas.1908099116","article-title":"Lgr5(+) pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis","volume":"116","author":"Ang","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2026.03.035_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.stem.2019.10.011","article-title":"AXIN2(+) pericentral hepatocytes have limited contributions to liver homeostasis and regeneration","volume":"26","author":"Sun","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib6","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.stem.2021.05.013","article-title":"ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation","volume":"28","author":"Sun","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.nu.16.070196.001143","article-title":"Zonation of parenchymal and nonparenchymal metabolism in liver","volume":"16","author":"Jungermann","year":"1996","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.jhep.2026.03.035_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41575-019-0134-x","article-title":"Spatial heterogeneity in the mammalian liver","volume":"16","author":"Ben-Moshe","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.03.035_bib9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ncb3337","article-title":"The RSPO-LGR4\/5-ZNRF3\/RNF43 module controls liver zonation and size","volume":"18","author":"Planas-Paz","year":"2016","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhep.2026.03.035_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41586-025-09733-1","article-title":"Hepatic zonation determines tumorigenic potential of mutant beta-catenin","volume":"649","author":"Raven","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2026.03.035_bib11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2026.03.035_bib12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tem.2024.02.007","article-title":"Current status and future trends of the global burden of MASLD","volume":"35","author":"Miao","year":"2024","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhep.2026.03.035_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.03.035_bib14","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1158\/0008-5472.CAN-23-4034","article-title":"Ku70 binding to YAP alters PARP1 ubiquitination to regulate genome stability and tumorigenesis","volume":"84","author":"Shu","year":"2024","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2026.03.035_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500447","article-title":"Mammalian SWI\/SNF chromatin remodeling complexes and cancer: mechanistic insights gained from human genomics","volume":"1","author":"Kadoch","year":"2015","journal-title":"Sci Adv"},{"key":"10.1016\/j.jhep.2026.03.035_bib16","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/hep.30487","article-title":"Arid1a loss drives nonalcoholic steatohepatitis in mice through epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation","volume":"69","author":"Moore","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.03.035_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ebiom.2019.03.021","article-title":"Arid1a regulates insulin sensitivity and lipid metabolism","volume":"42","author":"Qu","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jhep.2026.03.035_bib18","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ccell.2017.10.007","article-title":"Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer","volume":"32","author":"Sun","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-018-0658-1","article-title":"The SWI\/SNF complex is a mechanoregulated inhibitor of YAP and TAZ","volume":"563","author":"Chang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jhep.2026.03.035_bib20","article-title":"The origin of hepatocellular carcinoma depends on metabolic zonation","author":"Guo","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.jhep.2026.03.035_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2019.06.008","article-title":"A homeostatic arid1a-dependent permissive chromatin state licenses hepatocyte responsiveness to liver-injury-associated YAP signaling","volume":"25","author":"Li","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.stem.2016.03.001","article-title":"Suppression of the SWI\/SNF component Arid1a promotes mammalian regeneration","volume":"18","author":"Sun","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.stem.2018.12.001","article-title":"The BAF and PRC2 complex subunits Dpf2 and eed antagonistically converge on Tbx3 to control ESC differentiation","volume":"24","author":"Zhang","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib24","doi-asserted-by":"crossref","first-page":"21951","DOI":"10.1074\/jbc.M109.087783","article-title":"Requiem protein links RelB\/p52 and the Brm-type SWI\/SNF complex in a noncanonical NF-kappaB pathway","volume":"285","author":"Tando","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2026.03.035_bib25","doi-asserted-by":"crossref","first-page":"11924","DOI":"10.1074\/jbc.M111.322792","article-title":"Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI\/SNF complex-dependent activation of NF-kappaB RelA\/p50 heterodimer","volume":"287","author":"Ishizaka","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2026.03.035_bib26","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2518762122","article-title":"The SWI\/SNF chromatin-remodeling subunit DPF2 regulates macrophage inflammation in intestinal injury via the CACNA1D-mediated MAPK pathway","volume":"122","author":"Ji","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2026.03.035_bib27","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158419","article-title":"The SWI\/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression","volume":"133","author":"Mas","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2026.03.035_bib28","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-1741","article-title":"Inflammatory arthritis as a possible feature of coffin-siris syndrome","volume":"144","author":"Melo Gomes","year":"2019","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhep.2026.03.035_bib29","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ajhg.2018.01.014","article-title":"Mutations in the BAF-complex subunit DPF2 are associated with coffin-siris syndrome","volume":"102","author":"Vasileiou","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jhep.2026.03.035_bib30","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/hep.25798","article-title":"Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice","volume":"56","author":"Tsuchiya","year":"2012","journal-title":"HEPATOLOGY"},{"key":"10.1016\/j.jhep.2026.03.035_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib32","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1016\/j.cell.2024.10.019","article-title":"Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging","volume":"187","author":"Ma","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jhep.2026.03.035_bib33","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41575-024-00915-2","article-title":"Spatial genomics: mapping human steatotic liver disease","volume":"21","author":"Matchett","year":"2024","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.03.035_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwac224","article-title":"Correction to: identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis","volume":"10","author":"Jin","year":"2023","journal-title":"Natl Sci Rev"},{"key":"10.1016\/j.jhep.2026.03.035_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41408-021-00514-3","article-title":"Acute promyelocytic leukemia current treatment algorithms","volume":"11","author":"Yilmaz","year":"2021","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.jhep.2026.03.035_bib36","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jhep.2012.11.042","article-title":"Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease","volume":"58","author":"Derdak","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.03.035_bib37","doi-asserted-by":"crossref","first-page":"47898","DOI":"10.1074\/jbc.M408149200","article-title":"AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells","volume":"279","author":"Zang","year":"2004","journal-title":"J Biol Chem"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782600190X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016882782600190X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:43:10Z","timestamp":1784133790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016882782600190X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S016882782600190X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2026.03.035","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromatin remodeling in pericentral hepatocytes modulates MASH through CYP450 activity","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2026.03.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Association for the Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}