{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:46:15Z","timestamp":1793915175247,"version":"4.8.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jhep.2026.04.016","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:50:38Z","timestamp":1781149838000},"page":"603-611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Updates in clinical science: Alcohol-related hepatitis"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5293-007X","authenticated-orcid":false,"given":"Alexandre","family":"Louvet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line Carolle","family":"Ntandja Wandji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2026.04.016_bib1","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMra2207599","article-title":"Alcohol-associated hepatitis","volume":"387","author":"Bataller","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2026.04.016_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib3","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2026.04.016_bib4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jhep.2021.05.029","article-title":"Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease","volume":"75","author":"Lackner","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib5","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/hep4.1669","article-title":"Clinical presentation and gene expression of acute alcohol-induced microvesicular steatosis mimicking alcoholic hepatitis","volume":"5","author":"Spahr","year":"2021","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2026.04.016_bib6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1365-2036.2007.03302.x","article-title":"Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features","volume":"25","author":"Mathurin","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2026.04.016_bib7","article-title":"Alcohol-associated hepatitis trends before and following the onset of the COVID-19 pandemic across two distinct cohorts in the United States and Hong Kong","volume":"7","author":"Yang","year":"2025","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2026.04.016_bib8","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/liv.15172","article-title":"Alcohol-related hepatitis admissions increased 50% in the first months of the COVID-19 pandemic in the USA","volume":"42","author":"Gonzalez","year":"2022","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2026.04.016_bib9","doi-asserted-by":"crossref","first-page":"e1170","DOI":"10.1016\/j.cgh.2021.10.030","article-title":"Impact of the COVID-19 pandemic on hospitalizations for alcoholic hepatitis or cirrhosis in Alberta, Canada","volume":"20","author":"Shaheen","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib10","article-title":"Incidence and mortality of alcohol-related hepatitis in Denmark - an update, 2016-2023","volume":"7","author":"Hazrat","year":"2025","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2026.04.016_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12876-015-0348-5","article-title":"Validation of coding algorithms for the identification of patients hospitalized for alcoholic hepatitis using administrative data","volume":"15","author":"Pang","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jhep.2026.04.016_bib12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jhep.2024.01.031","article-title":"Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis","volume":"80","author":"Gawrieh","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib13","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1001\/jama.2012.6147","article-title":"Prevalence of alcohol use disorders before and after bariatric surgery","volume":"307","author":"King","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2026.04.016_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/cob.70041","article-title":"Severe alcohol-related liver disease following bariatric surgery","volume":"15","author":"Ibrahim","year":"2025","journal-title":"Clin Obes"},{"key":"10.1016\/j.jhep.2026.04.016_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11695-022-06386-1","article-title":"Patients with a history of bariatric surgery are 8 Years younger at presentation with severe alcoholic hepatitis","volume":"33","author":"Van Melkebeke","year":"2023","journal-title":"Obes Surg"},{"key":"10.1016\/j.jhep.2026.04.016_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11920-019-1070-8","article-title":"Changes in alcohol use after metabolic and bariatric surgery: predictors and mechanisms","volume":"21","author":"Ivezaj","year":"2019","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.jhep.2026.04.016_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/hep.30866","article-title":"Diagnosis and treatment of alcohol-associated liver diseases: 2019 practice guidance from the American association for the study of liver diseases","volume":"71","author":"Crabb","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jhep.2018.03.018","article-title":"EASL clinical practice guidelines: management of alcohol-related liver disease","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cld.434","article-title":"Liver biopsy-transjugular","volume":"4","author":"Schwarzer","year":"2014","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"10.1016\/j.jhep.2026.04.016_bib20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1053\/j.gastro.2016.02.042","article-title":"Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: recommendation from the NIAAA alcoholic hepatitis consortia","volume":"150","author":"Crabb","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib21","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1016\/j.cgh.2023.03.023","article-title":"Adding inflammatory markers and refining national institute on alcohol abuse and alcoholism criteria improve diagnostic accuracy for alcohol-associated hepatitis","volume":"21","author":"Avitabile","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib22","article-title":"Validation of NIAAAm-CRP criteria to predict alcohol-associated steatohepatitis on liver histology","volume":"6","author":"Stauber","year":"2024","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2026.04.016_bib23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hep.29080","article-title":"A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis","volume":"66","author":"Bissonnette","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib24","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.14309\/ajg.0000000000000912","article-title":"In severe alcoholic hepatitis, serum keratin-18 fragments are diagnostic, prognostic, and theragnostic biomarkers","volume":"115","author":"Atkinson","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.04.016_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hep.31256","article-title":"Circulating extracellular vesicles carrying sphingolipid cargo for the diagnosis and dynamic risk profiling of alcoholic hepatitis","volume":"73","author":"Sehrawat","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib26","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.ajpath.2022.08.009","article-title":"Integrated transcriptomic and proteomic analysis identifies plasma biomarkers of hepatocellular failure in alcohol-associated hepatitis","volume":"192","author":"Argemi","year":"2022","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2026.04.016_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cgh.2021.02.041","article-title":"Plasma-signature-model for end-stage liver disease score to predict survival in severe alcoholic hepatitis","volume":"20","author":"Fujiwara","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib28","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/apt.15335","article-title":"Baseline neutrophil-to-lymphocyte ratio predicts response to corticosteroids and is associated with infection and renal dysfunction in alcoholic hepatitis","volume":"50","author":"Forrest","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2026.04.016_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0016-5085(78)90401-8","article-title":"Corticosteroid therapy of alcoholic hepatitis","volume":"75","author":"Maddrey","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/gut.2010.224097","article-title":"Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data","volume":"60","author":"Mathurin","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2026.04.016_bib31","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1365-2036.2008.03685.x","article-title":"Systematic review: glucocorticosteroids for alcoholic hepatitis--a Cochrane Hepato-Biliary Group systematic review with meta-analyses and trial sequential analyses of randomized clinical trials","volume":"27","author":"Rambaldi","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2026.04.016_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/apt.15376","article-title":"Systematic review with meta-analysis: high mortality in patients with non-severe alcoholic hepatitis","volume":"50","author":"Bennett","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2026.04.016_bib33","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jhep.2019.12.023","article-title":"Long-term outcomes in patients with decompensated alcohol-related liver disease, steatohepatitis and Maddrey's discriminant function <32","volume":"72","author":"Degre","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib34","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000673","article-title":"Moderate alcohol-associated hepatitis: a real-world multicenter study","volume":"9","author":"Idalsoaga","year":"2025","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2026.04.016_bib35","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/hep.29240","article-title":"Main drivers of outcome differ between short term and long term in severe alcoholic hepatitis: a prospective study","volume":"66","author":"Louvet","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.14309\/ajg.0000000000001596","article-title":"The MELD score is superior to the Maddrey discriminant function score to predict short-term mortality in alcohol-associated hepatitis: a global study","volume":"117","author":"Morales-Arraez","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.04.016_bib37","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.jhep.2021.06.019","article-title":"Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: a worldwide study","volume":"75","author":"Arab","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib38","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1001\/jama.2023.4902","article-title":"Effect of prophylactic antibiotics on mortality in severe alcohol-related hepatitis: a randomized clinical trial","volume":"329","author":"Louvet","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2026.04.016_bib39","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/jama.2013.276300","article-title":"Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial","volume":"310","author":"Mathurin","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jhep.2026.04.016_bib40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jhep.2018.02.022","article-title":"The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis","volume":"69","author":"Serste","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib41","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1053\/j.gastro.2009.04.062","article-title":"Infection in patients with severe alcoholic hepatitis treated with steroids: early response to therapy is the key factor","volume":"137","author":"Louvet","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib42","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jhep.2017.06.013","article-title":"Sepsis in alcohol-related liver disease","volume":"67","author":"Gustot","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib43","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.14309\/ajg.0000000000001750","article-title":"Lung infection affects access to treatment and short-term outcome in patients with severe alcohol-related hepatitis treated with corticosteroids","volume":"117","author":"Ntandja Wandji","year":"2022","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.jhep.2026.04.016_bib44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/apt.70328","article-title":"Burden of invasive fungal diseases in patients with alcohol-related hepatitis and organ failure","volume":"63","author":"Mouliade","year":"2025","journal-title":"Aliment Pharmaocl Ther"},{"key":"10.1016\/j.jhep.2026.04.016_bib45","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1053\/j.gastro.2018.05.011","article-title":"Corticosteroids reduce risk of death within 28 Days for patients with severe alcoholic hepatitis, compared with pentoxifylline or placebo-a meta-analysis of individual data from controlled trials","volume":"155","author":"Louvet","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib46","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/hep.21607","article-title":"The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids","volume":"45","author":"Louvet","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib47","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/apt.70024","article-title":"Comparison between dynamic models for predicting response to corticosteroids in alcohol-associated hepatitis: a global cohort study","volume":"61","author":"Idalsoaga","year":"2025","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2026.04.016_bib48","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1056\/NEJMoa1101214","article-title":"Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis","volume":"365","author":"Nguyen-Khac","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2026.04.016_bib49","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1056\/NEJMoa1412278","article-title":"Prednisolone or pentoxifylline for alcoholic hepatitis","volume":"372","author":"Thursz","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2026.04.016_bib50","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/liv.15207","article-title":"Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: a pilot study (RIFA-AH)","volume":"42","author":"Jimenez","year":"2022","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2026.04.016_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264278","article-title":"The impact of rifaximin on inflammation and metabolism in alcoholic hepatitis: a randomized clinical trial","volume":"17","author":"Kimer","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jhep.2026.04.016_bib52","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1053\/j.gastro.2016.12.019","article-title":"Patients with severe alcoholic hepatitis, prednisolone increases susceptibility to infection and infection-related mortality, and is associated with high circulating levels of bacterial DNA","volume":"152","author":"Vergis","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib53","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/liv.12939","article-title":"Corticosteroids and occurrence of and mortality from infections in severe alcoholic hepatitis: a meta-analysis of randomized trials","volume":"36","author":"Hmoud","year":"2016","journal-title":"Liver Int"},{"issue":"12","key":"10.1016\/j.jhep.2026.04.016_bib54","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.14309\/ajg.0000000000003416","article-title":"Infections in standard or tapered dose of prednisolone for alcohol-associated hepatitis: a randomized trial (stash trial)","volume":"120","author":"Kulkarni","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.04.016_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/S0168-8278(25)00349-6","article-title":"Corticosteroids are ineffective in individuals with severe alcohol-associated hepatitis and early spontaneous improvement: a multicenter randomized controlled trial","volume":"82","author":"Moreno","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib56","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"Petrasek","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2026.04.016_bib57","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/hep.32478","article-title":"IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis","volume":"76","author":"Szabo","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib58","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cgh.2024.07.025","article-title":"IL-1 signal inhibition in alcohol-related hepatitis: a randomized, double-blind, placebo-controlled trial of canakinumab","volume":"23","author":"Vergis","year":"2025","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib59","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/hep.31046","article-title":"An open-label, dose-escalation study to assess the safety and efficacy of IL-22 agonist F-652 in patients with alcohol-associated hepatitis","volume":"72","author":"Arab","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib60","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2400243","article-title":"Larsucosterol for the treatment of alcohol-associated hepatitis","volume":"4","author":"Shiffman","year":"2025","journal-title":"NEJM Evid"},{"key":"10.1016\/j.jhep.2026.04.016_bib61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.14309\/ajg.0000000000002275","article-title":"Safety, pharmacokinetics, and efficacy signals of larsucosterol (DUR-928) in alcohol-associated hepatitis","volume":"119","author":"Hassanein","year":"2024","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.04.016_bib62","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.14309\/ajg.0000000000003038","article-title":"Granulocyte colony-stimulating factor improves prednisolone responsiveness and 90-day survival in steroid-eligible severe alcohol-associated hepatitis: the GPreAH study a randomized trial","volume":"120","author":"Mishra","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.04.016_bib63","article-title":"Granulocyte colony-stimulating factor for alcoholic hepatitis: a systematic review and meta-analysis of randomised controlled trials","volume":"2","author":"Marot","year":"2020","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2026.04.016_bib64","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.cgh.2016.10.029","article-title":"Healthy donor fecal microbiota transplantation in steroid-ineligible severe alcoholic hepatitis: a pilot study","volume":"15","author":"Philips","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib65","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12072-022-10438-0","article-title":"Fecal microbiota transplantation compared with prednisolone in severe alcoholic hepatitis patients: a randomized trial","volume":"17","author":"Pande","year":"2023","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhep.2026.04.016_bib66","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2015-310585","article-title":"Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease","volume":"65","author":"Llopis","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2026.04.016_bib67","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/hep4.1537","article-title":"Functional microbiomics reveals alterations of the gut microbiome and host Co-metabolism in patients with alcoholic hepatitis","volume":"4","author":"Gao","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2026.04.016_bib68","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/hep.30832","article-title":"Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis","volume":"71","author":"Lang","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib69","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jhep.2018.10.019","article-title":"Microbiome as a therapeutic target in alcohol-related liver disease","volume":"70","author":"Sarin","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib70","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jhep.2023.04.013","article-title":"Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming","volume":"79","author":"Aguilar-Bravo","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib71","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1136\/gutjnl-2014-308410","article-title":"Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis","volume":"64","author":"Dubuquoy","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2026.04.016_bib72","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2021.05.041","article-title":"Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis","volume":"75","author":"Bou Saleh","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib73","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1038\/s41467-019-11004-3","article-title":"Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis","volume":"10","author":"Argemi","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhep.2026.04.016_bib74","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13613-020-00795-0","article-title":"Uncertainty in the impact of liver support systems in acute-on-chronic liver failure: a systematic review and network meta-analysis","volume":"11","author":"Ocskay","year":"2021","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jhep.2026.04.016_bib75","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jceh.2021.07.010","article-title":"Low volume plasma exchange and low dose steroid improve survival in patients with alcohol-related acute on chronic liver failure and severe alcoholic hepatitis - preliminary experience","volume":"12","author":"Kumar","year":"2022","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib76","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0168-8278(01)00289-6","article-title":"Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH","volume":"36","author":"Mathurin","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib77","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1056\/NEJMoa1105703","article-title":"Early liver transplantation for severe alcoholic hepatitis","volume":"365","author":"Mathurin","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2026.04.016_bib78","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1053\/j.gastro.2018.04.009","article-title":"Outcomes of early liver transplantation for patients with severe alcoholic hepatitis","volume":"155","author":"Lee","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib79","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S2468-1253(21)00430-1","article-title":"Early liver transplantation for severe alcohol-related hepatitis not responding to medical treatment: a prospective controlled study","volume":"7","author":"Louvet","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib80","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0005-7967(79)90025-1","article-title":"Reliability of alcohol abusers' self-reports of drinking behavior","volume":"17","author":"Sobell","year":"1979","journal-title":"Behav Res Ther"},{"key":"10.1016\/j.jhep.2026.04.016_bib81","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1053\/j.gastro.2019.04.012","article-title":"Model to calculate harms and benefits of early vs delayed liver transplantation for patients with alcohol-associated hepatitis","volume":"157","author":"Lee","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib82","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1097\/HEP.0000000000000267","article-title":"Multicentered study of patient outcomes after declined for early liver transplantation in severe alcohol-associated hepatitis","volume":"77","author":"Hsu","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.016_bib83","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1053\/j.gastro.2021.08.004","article-title":"Results of early transplantation for alcohol-related cirrhosis: integrated addiction treatment with low rate of relapse","volume":"161","author":"Carrique","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.016_bib84","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1001\/jamasurg.2021.3748","article-title":"Evaluation of early vs standard liver transplant for alcohol-associated liver disease","volume":"156","author":"Herrick-Reynolds","year":"2021","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jhep.2026.04.016_bib85","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.14309\/ajg.0000000000001901","article-title":"Early liver transplantation for severe alcohol-associated hepatitis and a history of prior liver decompensation","volume":"117","author":"Weinberg","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.04.016_bib86","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/acer.13276","article-title":"Follow-up of alcohol consumption after liver transplantation: interest of an addiction team?","volume":"41","author":"Donnadieu-Rigole","year":"2017","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2026.04.016_bib87","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/acer.12117","article-title":"Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center","volume":"37","author":"Addolorato","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jhep.2026.04.016_bib88","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.cgh.2023.04.005","article-title":"Liver transplantation 2023: status report, current and future challenges","volume":"21","author":"Terrault","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.016_bib89","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.alcohol.2018.07.009","article-title":"Good outcome of living donor liver transplantation for severe alcoholic hepatitis not responding to medical management: a single center experience of 39 patients","volume":"77","author":"Choudhary","year":"2019","journal-title":"Alcohol"},{"key":"10.1016\/j.jhep.2026.04.016_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2023.101098","article-title":"Early living donor liver transplantation for alcohol-associated hepatitis","volume":"28","author":"Kulkarni","year":"2023","journal-title":"Ann Hepatol"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826002199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826002199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:40:40Z","timestamp":1787380840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827826002199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":90,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0168827826002199"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2026.04.016","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Updates in clinical science: Alcohol-related hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2026.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}