{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:40:44Z","timestamp":1788792044521,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Danish Agency for Higher Education and Science","doi-asserted-by":"publisher","award":["5229-00012B"],"award-info":[{"award-number":["5229-00012B"]}],"id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","award":["NNF21SA0072746"],"award-info":[{"award-number":["NNF21SA0072746"]}],"id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["1052-00003B"],"award-info":[{"award-number":["1052-00003B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001537","name":"The University of Auckland","doi-asserted-by":"publisher","award":["3706927"],"award-info":[{"award-number":["3706927"]}],"id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["2100-00047B"],"award-info":[{"award-number":["2100-00047B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF23SA0084103"],"award-info":[{"award-number":["NNF23SA0084103"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF21OC0067271"],"award-info":[{"award-number":["NNF21OC0067271"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF19OC0055001"],"award-info":[{"award-number":["NNF19OC0055001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF22OC0079577"],"award-info":[{"award-number":["NNF22OC0079577"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF24OC0088402"],"award-info":[{"award-number":["NNF24OC0088402"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002808","name":"Carlsbergfondet","doi-asserted-by":"publisher","award":["CF21-0505"],"award-info":[{"award-number":["CF21-0505"]}],"id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jhep.2026.04.033","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:29:35Z","timestamp":1778340575000},"page":"479-492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arachidonoyl-taurine is elevated in human MASLD and protects against hepatic steatosis and inflammation in preclinical models"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-5466","authenticated-orcid":false,"given":"Katharina B.","family":"Kuentzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-4094","authenticated-orcid":false,"given":"Samuel A.J.","family":"Trammell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-8784","authenticated-orcid":false,"given":"Anna S.","family":"Hassing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bradi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6774-6631","authenticated-orcid":false,"given":"Michelle","family":"Damgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma B.","family":"Fals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-8417","authenticated-orcid":false,"given":"Katja T.","family":"Michler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-556X","authenticated-orcid":false,"given":"Jens C.B.","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte P.","family":"Suppli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel P.","family":"Werge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3843-6806","authenticated-orcid":false,"given":"Cameron J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4230-5753","authenticated-orcid":false,"given":"Nicolai J.","family":"Wewer Albrechtsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-4468","authenticated-orcid":false,"given":"Lise L.","family":"Glud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-5034","authenticated-orcid":false,"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-1464","authenticated-orcid":false,"given":"James F.","family":"Markworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Gillum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-7012","authenticated-orcid":false,"given":"Jonas T.","family":"Treebak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-3640","authenticated-orcid":false,"given":"Jesmund","family":"Dalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-3950","authenticated-orcid":false,"given":"Trisha J.","family":"Grevengoed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2026.04.033_bib1","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2026.04.033_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhep.2026.04.033_bib3","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.033_bib4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3350\/cmh.2022.0239","article-title":"Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach","volume":"28","author":"Le","year":"2022","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.033_bib5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatol Baltim Md"},{"key":"10.1016\/j.jhep.2026.04.033_bib6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2026.04.033_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.033_bib8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cmet.2022.05.003","article-title":"Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer","volume":"34","author":"Huang","year":"2022","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2026.04.033_bib9","volume":"43","year":"2025","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jhep.2026.04.033_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s40265-024-02045-0","article-title":"Resmetirom: first approval","volume":"84","author":"Keam","year":"2024","journal-title":"Drugs"},{"key":"10.1016\/j.jhep.2026.04.033_bib11","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/s41591-023-02603-1","article-title":"Resmetirom for nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled phase 3 trial","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2026.04.033_bib12","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/S0140-6736(19)32517-6","article-title":"Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"394","author":"Harrison","year":"2019","journal-title":"The Lancet"},{"key":"10.1016\/j.jhep.2026.04.033_bib13","doi-asserted-by":"crossref","first-page":"24770","DOI":"10.1073\/pnas.1916288116","article-title":"N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis","volume":"116","author":"Grevengoed","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2026.04.033_bib14","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143861","article-title":"An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides","volume":"131","author":"Grevengoed","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2026.04.033_bib15","doi-asserted-by":"crossref","first-page":"E4397","DOI":"10.1073\/pnas.1605578113","article-title":"Endogenous N-acyl taurines regulate skin wound healing","volume":"113","author":"Sasso","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhep.2026.04.033_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100361","article-title":"Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids","volume":"64","author":"Trammell","year":"2023","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jhep.2026.04.033_bib17","article-title":"The bile acid-CoA ligase, FATP5, is necessary for synthesis of N-acyl taurines in the liver","volume":"0","author":"Kuentzel","year":"2026","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jhep.2026.04.033_bib18","doi-asserted-by":"crossref","first-page":"14332","DOI":"10.1021\/bi0480335","article-title":"Assignment of endogenous substrates to enzymes by global metabolite profiling","volume":"43","author":"Saghatelian","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.jhep.2026.04.033_bib19","doi-asserted-by":"crossref","first-page":"9007","DOI":"10.1021\/bi0608008","article-title":"A FAAH-regulated class of N-acyl taurines that activates TRP ion channels","volume":"45","author":"Saghatelian","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.jhep.2026.04.033_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1194\/jlr.M012153","article-title":"An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase","volume":"52","author":"Long","year":"2011","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jhep.2026.04.033_bib21","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1073\/pnas.161191698","article-title":"Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase","volume":"98","author":"Cravatt","year":"2001","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jhep.2026.04.033_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","article-title":"Omega-6 fatty acids and inflammation","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.jhep.2026.04.033_bib23","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S2213-8587(20)30148-0","article-title":"Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases","volume":"8","author":"Schulze","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jhep.2026.04.033_bib24","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.3390\/ijms19113285","article-title":"Arachidonic acid metabolites in cardiovascular and metabolic diseases","volume":"19","author":"Sonnweber","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jhep.2026.04.033_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/ars.2017.7332","article-title":"The eicosanoids, redox-regulated lipid mediators in immunometabolic disorders","volume":"29","author":"Ara\u00fajo","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jhep.2026.04.033_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.prostaglandins.2016.11.001","article-title":"Eicosanoids: Emerging contributors in stem cell-mediated wound healing","volume":"132","author":"Berry","year":"2017","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jhep.2026.04.033_bib27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid storm in infection and inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jhep.2026.04.033_bib28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/hep.23463","article-title":"5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice","volume":"51","author":"Mart\u00ednez-Clemente","year":"2010","journal-title":"Hepatol Baltim Md"},{"key":"10.1016\/j.jhep.2026.04.033_bib29","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/hep.23928","article-title":"Disruption of the 12\/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease","volume":"52","author":"Mart\u00ednez-Clemente","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.033_bib30","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1194\/jlr.M022723","article-title":"Macrophage 12\/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis","volume":"53","author":"Rong","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jhep.2026.04.033_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cmet.2015.05.003","article-title":"Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease","volume":"22","author":"B\u00f6rgeson","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhep.2026.04.033_bib32","first-page":"4287","article-title":"Lipoxin A4 attenuates adipose inflammation","volume":"26","author":"B\u00f6rgeson","year":"2012","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/j.jhep.2026.04.033_bib33","doi-asserted-by":"crossref","first-page":"G558","DOI":"10.1152\/ajpgi.00147.2024","article-title":"Hepatic steatosis and not type 2 diabetes, body mass index, or hepatic fibrosis associates with hyperglucagonemia in individuals with steatotic liver disease","volume":"327","author":"Kjeldsen","year":"2024","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhep.2026.04.033_bib34","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.033_bib35","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1210\/clinem\/dgad666","article-title":"Signs of glucagon resistance after a 2-week hypercaloric diet intervention","volume":"109","author":"Suppli","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jhep.2026.04.033_bib36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.plefa.2017.12.003","article-title":"Arachidonic acid supplementation modulates blood and skeletal muscle lipid profile with no effect on basal inflammation in resistance exercise trained men","volume":"128","author":"Markworth","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.jhep.2026.04.033_bib37","doi-asserted-by":"crossref","unstructured":"Gabery S, Salinas CG, Paulsen SJ, et al. Semaglutide lowers body weight in rodents via distributed neural pathways. JCI Insight n.d.;5:e133429.","DOI":"10.1172\/jci.insight.133429"},{"key":"10.1016\/j.jhep.2026.04.033_bib38","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/s42255-022-00700-y","article-title":"A researcher\u2019s guide to preclinical mouse NASH models","volume":"4","author":"Gallage","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.jhep.2026.04.033_bib39","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","article-title":"Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity","volume":"115","author":"Osei-Hyiaman","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2026.04.033_bib40","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S0954422420000062","article-title":"Biomarkers of appetite: is there a potential role for metabolomics?","volume":"33","author":"Horner","year":"2020","journal-title":"Nutr Res Rev"},{"key":"10.1016\/j.jhep.2026.04.033_bib41","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1021\/bi702530z","article-title":"Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine","volume":"47","author":"Turman","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.jhep.2026.04.033_bib42","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1021\/jm00038a020","article-title":"(R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability","volume":"37","author":"Abadji","year":"1994","journal-title":"J Med Chem"},{"key":"10.1016\/j.jhep.2026.04.033_bib43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/metabo14010012","article-title":"Lipid metabolism in metabolic-associated steatotic liver disease (MASLD)","volume":"14","author":"Syed-Abdul","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jhep.2026.04.033_bib44","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jhep.2017.11.012","article-title":"Determinants of fibrosis progression and regression in NASH","volume":"68","author":"Schuppan","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.04.033_bib45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0038-1677517","article-title":"NASH in lean individuals","volume":"39","author":"Younes","year":"2019","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jhep.2026.04.033_bib46","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/HEP.0000000000000329","article-title":"Lean individuals with NAFLD have more severe liver disease and poorer clinical outcomes (NASH-CO Study)","volume":"78","author":"Nabi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.04.033_bib47","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3350\/cmh.2024.0631","article-title":"Long-term outcomes and risk modifiers of metabolic dysfunction-associated steatotic liver disease between lean and non-lean populations","volume":"31","author":"Danpanichkul","year":"2024","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.jhep.2026.04.033_bib48","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06328","article-title":"Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport","volume":"4","author":"Hashidate-Yoshida","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.jhep.2026.04.033_bib49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06557","article-title":"Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion","volume":"4","author":"Rong","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.jhep.2026.04.033_bib50","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/hep.20590","article-title":"Interplay among cardiotrophin-1, prostaglandins, and vascular endothelial growth factor in rat liver regeneration","volume":"41","author":"Beraza","year":"2005","journal-title":"Hepatol Baltim Md"},{"key":"10.1016\/j.jhep.2026.04.033_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54652-7","article-title":"Participation of 5-lipoxygenase and LTB4 in liver regeneration after partial hepatectomy","volume":"9","author":"Lorenzetti","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2026.04.033_bib52","first-page":"3132","article-title":"Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia\/reperfusion injury through the enhancement of macrophage recruitment","volume":"27","author":"Ohkubo","year":"2013","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"10.1016\/j.jhep.2026.04.033_bib53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nm.4451","article-title":"An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jhep.2026.04.033_bib54","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1136\/gut.2008.157420","article-title":"Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats","volume":"58","author":"Paik","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.jhep.2026.04.033_bib55","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbadis.2017.11.001","article-title":"PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p","volume":"1864","author":"Brea","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jhep.2026.04.033_bib56","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-13-0201","article-title":"Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance","volume":"218","author":"Asrih","year":"2013","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jhep.2026.04.033_bib57","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, stress, and diabetes","volume":"115","author":"Wellen","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2026.04.033_bib58","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/oxfordjournals.jbchem.a003101","article-title":"Phospholipase A2","volume":"131","author":"Murakami","year":"2002","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.jhep.2026.04.033_bib59","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1002\/hep4.2041","article-title":"Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice","volume":"6","author":"Alrehaili","year":"2022","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhep.2026.04.033_bib60","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2013.02.004","article-title":"Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency","volume":"144","author":"Setchell","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2026.04.033_bib61","doi-asserted-by":"crossref","first-page":"14966","DOI":"10.1073\/pnas.1212887109","article-title":"Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism","volume":"109","author":"Brown","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jhep.2026.04.033_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033717","article-title":"Peripheral effects of FAAH deficiency on fuel and energy homeostasis: role of dysregulated lysine acetylation","volume":"7","author":"Vaitheesvaran","year":"2012","journal-title":"PLOS ONE"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826002710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826002710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:41:15Z","timestamp":1787380875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827826002710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0168827826002710"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2026.04.033","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arachidonoyl-taurine is elevated in human MASLD and protects against hepatic steatosis and inflammation in preclinical models","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2026.04.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}