{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:33:06Z","timestamp":1792290786362,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jhep.2026.06.032","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:21:11Z","timestamp":1783603271000},"page":"959-972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validation of a pan-ELastography Machine-learning (ELM) score to predict clinically significant portal hypertension in compensated advanced chronic liver disease"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-3514","authenticated-orcid":false,"given":"Mauro","family":"Giuffr\u00e8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1700-7512","authenticated-orcid":false,"given":"Simone","family":"Kresevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-8585","authenticated-orcid":false,"given":"Federico","family":"Ravaioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romanas","family":"Zykus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-1859","authenticated-orcid":false,"given":"Pierre-Emmanuel","family":"Rautou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Elkrief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0217-8780","authenticated-orcid":false,"given":"Luigi","family":"Colecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6425-1624","authenticated-orcid":false,"given":"Sandro","family":"Kukic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mislav","family":"Barisic-Jaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-3483","authenticated-orcid":false,"given":"Ivica","family":"Grgurevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-5471","authenticated-orcid":false,"given":"Horia","family":"Stefanescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-5313","authenticated-orcid":false,"given":"Masashi","family":"Hirooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Fraquelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Rosselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pik Eu","family":"Jason Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lory","family":"Croc\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Ajcevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-1845","authenticated-orcid":false,"given":"Fabio","family":"Piscaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3583","authenticated-orcid":false,"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elba","family":"Llop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-6778","authenticated-orcid":false,"given":"Sebastian","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuly","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Puente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5255-9445","authenticated-orcid":false,"given":"Jos\u00e9 Ignacio","family":"Fortea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-459X","authenticated-orcid":false,"given":"Kisung","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-8545","authenticated-orcid":false,"given":"Francesco","family":"Azzaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-1842","authenticated-orcid":false,"given":"Dennis L.","family":"Shung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-1146","authenticated-orcid":false,"given":"Elton","family":"Dajti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Masutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Fusaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Vestito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Barbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin Chin","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina Vanessa","family":"Alemanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dante","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2026.06.032_bib1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/HEP.0000000000000647","article-title":"AASLD Practice Guidance on risk stratification and management of portal hypertension and varices in cirrhosis","volume":"79","author":"Kaplan","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.06.032_bib2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII \u2013 renewing consensus in portal hypertension","volume":"76","author":"de Franchis","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.06.032_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/hep.32737","article-title":"Nonselective beta blockers, hepatic decompensation, and mortality in cirrhosis: a national cohort study","volume":"77","author":"Serper","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.06.032_bib4","article-title":"Carvedilol versus traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices","volume":"2018","author":"Zacharias","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jhep.2026.06.032_bib5","doi-asserted-by":"crossref","DOI":"10.20524\/aog.2019.0368","article-title":"Carvedilol for prevention of variceal bleeding: a systematic review and meta analysis","author":"Malandris","year":"2019","journal-title":"Ann Gastroenterol"},{"key":"10.1016\/j.jhep.2026.06.032_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s13318-016-0353-2","article-title":"Optimizing the clinical use of carvedilol in liver cirrhosis using a physiologically based pharmacokinetic modeling approach","volume":"42","author":"Rasool","year":"2017","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.jhep.2026.06.032_bib7","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(18)31875-0","article-title":"\u03b2 blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial","volume":"393","author":"Villanueva","year":"2019","journal-title":"The Lancet"},{"key":"10.1016\/j.jhep.2026.06.032_bib8","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.cgh.2022.09.032","article-title":"The sequential application of Baveno VII criteria and VITRO score improves diagnosis of clinically significant portal hypertension","volume":"21","author":"Jachs","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.06.032_bib9","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.14309\/ajg.0000000000001887","article-title":"A combined Baveno VII and spleen stiffness algorithm to improve the noninvasive diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease","volume":"117","author":"Dajti","year":"2022","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.06.032_bib10","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S2468-1253(23)00150-4","article-title":"Accuracy of spleen stiffness measurement for the diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a systematic review and individual patient data meta-analysis","volume":"8","author":"Dajti","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.06.032_bib11","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1007\/s10620-021-07277-8","article-title":"Validation of the new diagnostic criteria for clinically significant portal hypertension by platelets and elastography","volume":"67","author":"Podrug","year":"2022","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhep.2026.06.032_bib12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.14309\/ajg.0000000000000994","article-title":"Noninvasive diagnosis of portal hypertension in patients with compensated advanced chronic liver disease","volume":"116","author":"Pons","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2026.06.032_bib13","article-title":"Non-invasive assessment of portal hypertension: liver stiffness and beyond","volume":"7","author":"Mandorfer","year":"2025","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2026.06.032_bib14","article-title":"Advances in imaging \u2013 elastography","author":"Dajti","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2026.06.032_bib15","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S2468-1253(24)00234-6","article-title":"Spleen stiffness measurement by vibration-controlled transient elastography at 100 Hz for non-invasive predicted diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a modelling study","volume":"9","author":"Jachs","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhep.2026.06.032_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/liv.14228","article-title":"A novel spleen-dedicated stiffness measurement by FibroScan\u00ae improves the screening of high-risk oesophageal varices","volume":"40","author":"Stefanescu","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2026.06.032_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-63848-5","article-title":"Enhancing liver cirrhosis varices and CSPH risk prediction with spleen stiffness measurement using 100-Hz probe","volume":"14","author":"Yoo","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2026.06.032_bib18","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1111\/liv.15561","article-title":"High accuracy of spleen stiffness measurement in diagnosing clinically significant portal hypertension in metabolic-associated fatty liver disease","volume":"43","author":"Odriozola","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2026.06.032_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-078378","article-title":"TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods","author":"Collins","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.jhep.2026.06.032_bib20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/1094428114548590","article-title":"Missing data: five practical guidelines","volume":"17","author":"Newman","year":"2014","journal-title":"Organ Res Methods"},{"key":"10.1016\/j.jhep.2026.06.032_bib21","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.ultrasmedbio.2015.03.007","article-title":"WFUMB guidelines and recommendations for clinical use of ultrasound elastography: part 3: liver","volume":"41","author":"Ferraioli","year":"2015","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.jhep.2026.06.032_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scs.2024.105570","article-title":"Investigating the impact of data normalization methods on predicting electricity consumption in a building using different artificial neural network models","volume":"118","author":"Kim","year":"2025","journal-title":"Sustain Cities Soc"},{"key":"10.1016\/j.jhep.2026.06.032_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/mpr.329","article-title":"Multiple imputation by chained equations: what is it and how does it work?","volume":"20","author":"Azur","year":"2011","journal-title":"Int J Methods Psychiatr Res"},{"key":"10.1016\/j.jhep.2026.06.032_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12859-023-05156-9","article-title":"Evaluation of a decided sample size in machine learning applications","volume":"24","author":"Rajput","year":"2023","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jhep.2026.06.032_bib25","series-title":"ELM score GitHub repository by LIVER-MAINDS laboratory","author":"Giuffr\u00e8","year":"2025"},{"key":"10.1016\/j.jhep.2026.06.032_bib26","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jhep.2024.09.014","article-title":"Exploring algorithms to select candidates for non-selective beta-blockers in cirrhosis: a post hoc analysis of the PREDESCI trial","volume":"82","author":"Dajti","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.06.032_bib27","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jhep.2022.09.012","article-title":"Assessment of portal hypertension severity using machine learning models in patients with compensated cirrhosis","volume":"78","author":"Reini\u0161","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.06.032_bib28","doi-asserted-by":"crossref","DOI":"10.2196\/58080","article-title":"Exploring impediments imposed by the medical device regulation EU 2017\/745 on software as a medical device","volume":"12","author":"Svempe","year":"2024","journal-title":"JMIR Med Inform"},{"key":"10.1016\/j.jhep.2026.06.032_bib29","first-page":"1","article-title":"Regulation 2024\/1689 of the Eur. Parl. & Council of June 13, 2024 (Eu Artificial Intelligence Act)","author":"Smuha","year":"2025","journal-title":"Int Legal Mater"},{"key":"10.1016\/j.jhep.2026.06.032_bib30","article-title":"Blood-based vienna 3P\/5P risk models accurately predict first hepatic decompensation in compensated advanced chronic liver disease","author":"Kramer","year":"2025","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhep.2026.06.032_bib31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jhep.2024.08.016","article-title":"A machine learning model to predict liver-related outcomes after the functional cure of chronic hepatitis B","volume":"82","author":"Hur","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.06.032_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-09288-1","article-title":"Machine learning models using non-invasive tests & B-mode ultrasound to predict liver-related outcomes in metabolic dysfunction-associated steatotic liver disease","volume":"15","author":"Kosick","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhep.2026.06.032_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.15403\/jgld-5876","article-title":"Machine learning models predicting decompensation in CIRRHosis","volume":"34","author":"M\u00fcller","year":"2025","journal-title":"J Gastrointest Liver Dis"},{"key":"10.1016\/j.jhep.2026.06.032_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/jamiaopen\/ooaa010","article-title":"Rethinking domain adaptation for machine learning over clinical language","volume":"3","author":"Laparra","year":"2020","journal-title":"JAMIA Open"},{"key":"10.1016\/j.jhep.2026.06.032_bib35","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1109\/TBME.2021.3117407","article-title":"Domain adaptation for medical image analysis: a survey","volume":"69","author":"Guan","year":"2022","journal-title":"IEEE Trans Biomed Eng"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826026814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826026814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:59:11Z","timestamp":1792083551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827826026814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0168827826026814"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2026.06.032","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of a pan-ELastography Machine-learning (ELM) score to predict clinically significant portal hypertension in compensated advanced chronic liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2026.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.","name":"copyright","label":"Copyright"}]}}