{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:45:04Z","timestamp":1792086304886,"version":"4.4.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004756","name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF22OC0074397"],"award-info":[{"award-number":["NNF22OC0074397"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010113","name":"Wilhelm and Else Stockmanns Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010113","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010116","name":"Medical Association of Life and Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["350545"],"award-info":[{"award-number":["350545"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal-of-hepatology.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jhep.2026.08.003","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:35:00Z","timestamp":1787657700000},"page":"1046-1048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial NAD+ determines the metabolic capacity for liver regeneration"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-679X","authenticated-orcid":false,"given":"Panu K.","family":"Luukkonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2026.08.003_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration - mechanisms and models to clinical application","volume":"13","author":"Forbes","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"26","key":"10.1016\/j.jhep.2026.08.003_bib2","first-page":"2701","article-title":"Pushing the boundaries of liver resection for liver cancer","volume":"S0168\u20138278","author":"Sapisochin","year":"2026","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.jhep.2026.08.003_bib3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jhep.2016.06.006","article-title":"Liver resection for cancer: new developments in prediction, prevention and management of postresectional liver failure","volume":"65","author":"van Mierlo","year":"2016","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2026.08.003_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2018.09.020","article-title":"Metabolic remodeling during liver regeneration","volume":"47","author":"Caldez","year":"2018","journal-title":"Dev Cell"},{"issue":"4","key":"10.1016\/j.jhep.2026.08.003_bib5","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1042\/bj1210655","article-title":"Nicotinamide nucleotide synthesis in regenerating rat liver","volume":"121","author":"Ferris","year":"1971","journal-title":"Biochem J"},{"issue":"20","key":"10.1016\/j.jhep.2026.08.003_bib6","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1074\/jbc.TM117.000239","article-title":"The redox requirements of proliferating mammalian cells","volume":"293","author":"Hosios","year":"2018","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.jhep.2026.08.003_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42255-019-0161-5","article-title":"NAD(+) homeostasis in health and disease","volume":"2","author":"Katsyuba","year":"2020","journal-title":"Nat Metab"},{"issue":"2","key":"10.1016\/j.jhep.2026.08.003_bib8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/hep.28912","article-title":"Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration","volume":"65","author":"Mukherjee","year":"2017","journal-title":"Hepatology"},{"issue":"7836","key":"10.1016\/j.jhep.2026.08.003_bib9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-020-2741-7","article-title":"SLC25A51 is a mammalian mitochondrial NAD(+) transporter","volume":"588","author":"Luongo","year":"2020","journal-title":"Nature"},{"issue":"43","key":"10.1016\/j.jhep.2026.08.003_bib10","doi-asserted-by":"crossref","first-page":"eabe5310","DOI":"10.1126\/sciadv.abe5310","article-title":"MCART1\/SLC25A51 is required for mitochondrial NAD transport","volume":"6","author":"Kory","year":"2020","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.jhep.2026.08.003_bib11","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1038\/s41467-020-19871-x","article-title":"Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import","volume":"11","author":"Girardi","year":"2020","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.jhep.2026.08.003_bib12","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1038\/s42255-025-01408-5","article-title":"Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration","volume":"7","author":"Mukherjee","year":"2025","journal-title":"Nat Metab"},{"issue":"12","key":"10.1016\/j.jhep.2026.08.003_bib13","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s42255-024-01174-w","article-title":"Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD","volume":"6","author":"H\u00f8yland","year":"2024","journal-title":"Nat Metab"},{"issue":"2","key":"10.1016\/j.jhep.2026.08.003_bib14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial alterations in fatty liver diseases","volume":"78","author":"Fromenty","year":"2023","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.jhep.2026.08.003_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.tips.2024.02.003","article-title":"Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease","volume":"45","author":"Jokinen","year":"2024","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jhep.2026.08.003_bib16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jhep.2024.08.009","article-title":"ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD\/MASH","volume":"82","author":"Liu","year":"2025","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.jhep.2026.08.003_bib17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2016.08.024","article-title":"Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease","volume":"66","author":"Gariani","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2026.08.003_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155275","article-title":"The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions","volume":"135","author":"Fu","year":"2022","journal-title":"Metabolism"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826028436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827826028436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:58:52Z","timestamp":1792083532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827826028436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0168827826028436"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2026.08.003","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial NAD+ determines the metabolic capacity for liver regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhep.2026.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Association for the Study of the Liver. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}