{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:33:52Z","timestamp":1791588832651,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jhepr.2020.100140","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T12:06:44Z","timestamp":1593691604000},"page":"100140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis"],"prefix":"10.1016","volume":"2","author":[{"given":"Bhoomika","family":"Mathur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqar","family":"Arif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Patton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahiman","family":"Faiyaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Harpavat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Schoonjans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auinash","family":"Kalsotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony M.","family":"Wheatley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeepriyadarshini","family":"Anakk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2020.100140_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2007.11.010","article-title":"Mechanisms of cholestasis","volume":"12","author":"Zollner","year":"2008","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.jhepr.2020.100140_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jceh.2013.10.005","article-title":"Progressive familial intrahepatic cholestasis","volume":"4","author":"Srivastava","year":"2014","journal-title":"J\u00a0Clin Exp Hepatol"},{"key":"10.1016\/j.jhepr.2020.100140_bib3","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/hep.22789","article-title":"Bile acids: trying to understand their chemistry and biology with the hope of helping patients","volume":"49","author":"Hofmann","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2020.100140_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0168-8278(90)90269-W","article-title":"Drug metabolism in end-stage liver disease. In\u00a0vitro activities of some phase I and phase II enzymes","volume":"11","author":"Iqbal","year":"1990","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2020.100140_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/1389200043489054","article-title":"The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes","volume":"5","author":"Elbekai","year":"2004","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.jhepr.2020.100140_bib6","doi-asserted-by":"crossref","first-page":"e0120055","DOI":"10.1371\/journal.pone.0120055","article-title":"Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction","volume":"10","author":"Chai","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2020.100140_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/03602532.2012.740048","article-title":"Nuclear receptors in bile acid metabolism","volume":"45","author":"Li","year":"2013","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jhepr.2020.100140_bib8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2362.1971.tb00552.x","article-title":"Alcohol-drugs interaction in man: alcohol and tolbutamide","volume":"1","author":"Carulli","year":"1971","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jhepr.2020.100140_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.me.33.020182.000553","article-title":"Major drug interactions: effect of liver disease, alcohol, and malnutrition","volume":"33","author":"Hoyumpa","year":"1982","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jhepr.2020.100140_bib10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrd753","article-title":"PXR, CAR and drug metabolism","volume":"1","author":"Willson","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhepr.2020.100140_bib11","doi-asserted-by":"crossref","first-page":"e01500","DOI":"10.1128\/mBio.01500-15","article-title":"Transcriptomic analysis of chronic hepatitis B and C and liver cancer reveals microRNA-mediated control of cholesterol synthesis programs","volume":"6","author":"Selitsky","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.jhepr.2020.100140_bib12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/gutjnl-2011-301146","article-title":"Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis","volume":"62","author":"Aff\u00f2","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2020.100140_bib13","doi-asserted-by":"crossref","first-page":"G462","DOI":"10.1152\/ajpgi.00358.2018","article-title":"Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals","volume":"316","author":"Suppli","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhepr.2020.100140_bib14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/hep.27045","article-title":"Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease","volume":"60","author":"Bessho","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2020.100140_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1172\/JCI42846","article-title":"Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis","volume":"121","author":"Anakk","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhepr.2020.100140_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhepr.2020.100140_bib17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn\u2014a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams","volume":"9","author":"Hulsen","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jhepr.2020.100140_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jhepr.2020.100140_bib19","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1210\/en.2018-00110","article-title":"Xenobiotic nuclear receptor signaling determines molecular pathogenesis of progressive familial intrahepatic cholestasis","volume":"159","author":"Kim","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhepr.2020.100140_bib20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/toxsci\/kfr177","article-title":"Dose-response of five bile acids on serum and liver bile acid concentrations and hepatotoxicity in mice","volume":"123","author":"Song","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhepr.2020.100140_bib21","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1101\/gad.846800","article-title":"Reciprocal activation of xenobiotic response genes by nuclear receptors SXR\/PXR and CAR","volume":"14","author":"Xie","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhepr.2020.100140_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/sj.tpj.6500087","article-title":"Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response","volume":"2","author":"Wei","year":"2002","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.jhepr.2020.100140_bib23","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bbagrm.2016.04.010","article-title":"RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome","volume":"1859","author":"Cui","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhepr.2020.100140_bib24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF02353474","article-title":"The human drug metabolizing cytochromes P450","volume":"24","author":"Wrighton","year":"1996","journal-title":"J\u00a0Pharmacokinet Pharmacodyn"},{"key":"10.1016\/j.jhepr.2020.100140_bib25","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1053\/j.gastro.2019.06.017","article-title":"Gene expression signatures associated with survival times of pediatric patients with biliary atresia identify potential therapeutic agents","volume":"157","author":"Luo","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2020.100140_bib26","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1146\/annurev.bi.56.070187.004501","article-title":"P450 genes: structure, evolution, and regulation","volume":"56","author":"Nebert","year":"1987","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jhepr.2020.100140_bib27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/toxsci\/kfw127","article-title":"Neonatal activation of the xenobiotic-sensors PXR and CAR results in acute and persistent down-regulation of PPAR\u03b1-signaling in mouse liver","volume":"153","author":"Li","year":"2016","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhepr.2020.100140_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.taap.2008.11.008","article-title":"Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells","volume":"234","author":"Lambert","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jhepr.2020.100140_bib29","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1093\/nar\/gkr458","article-title":"Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure","volume":"39","author":"Kodama","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jhepr.2020.100140_bib30","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1124\/dmd.117.075135","article-title":"RNA sequencing reveals age and species differences of constitutive androstane receptor-targeted drug-processing genes in the livers","volume":"45","author":"Cheng","year":"2017","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.jhepr.2020.100140_bib31","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.coph.2010.08.010","article-title":"HNF4\u03b1-role in drug metabolism and potential drug target?","volume":"10","author":"Hwang-Verslues","year":"2010","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jhepr.2020.100140_bib32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1126\/science.1073502","article-title":"Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR","volume":"298","author":"Zhang","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jhepr.2020.100140_bib33","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.ajpath.2013.07.012","article-title":"Role of bile acids in liver injury and regeneration following acetaminophen overdose","volume":"183","author":"Bhushan","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhepr.2020.100140_bib34","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1006\/bbrc.1994.2215","article-title":"Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity","volume":"203","author":"Snawder","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhepr.2020.100140_bib35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-3-642-00663-0_12","article-title":"Mechanisms of acetaminophen-induced liver necrosis","volume":"196","author":"Hinson","year":"2010","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jhepr.2020.100140_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0891-5849(95)00023-Q","article-title":"Oxidative stress by acute acetaminophen administration in mouse liver","volume":"19","author":"Arnaiz","year":"1995","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhepr.2020.100140_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/35019116","article-title":"Humanized xenobiotic response in mice expressing nuclear receptor SXR","volume":"406","author":"Xie","year":"2000","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jhepr.2020.100140_bib38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1479-7364-1-4-300","article-title":"Cytochrome P450 humanised mice","volume":"1","author":"Gonzalez","year":"2004","journal-title":"Hum Genomics"},{"key":"10.1016\/j.jhepr.2020.100140_bib39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2362.1975.tb02309.x","article-title":"Alteration of drug metabolism during cholestasis in man","volume":"5","author":"Carulli","year":"1975","journal-title":"Eur J Clin Invest"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555920300744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555920300744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:24:26Z","timestamp":1762899866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555920300744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S2589555920300744"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2020.100140","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/520692","asserted-by":"object"}]},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2020.100140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"100140"}}