{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:45:23Z","timestamp":1793389523611,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18K17918"],"award-info":[{"award-number":["18K17918"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20K11644"],"award-info":[{"award-number":["20K11644"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18H03172"],"award-info":[{"award-number":["18H03172"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20H04119"],"award-info":[{"award-number":["20H04119"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.jhepr.2021.100253","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T04:17:35Z","timestamp":1612930655000},"page":"100253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD"],"prefix":"10.1016","volume":"3","author":[{"given":"Sechang","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Tsujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bokun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Iizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeji","family":"Sakae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Shoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2021.100253_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2021.100253_bib2","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.3748\/wjg.v22.i43.9488","article-title":"Nonalcoholic fatty liver disease \u2013 a multisystem disease?","volume":"22","author":"Mikolasevic","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhepr.2021.100253_bib3","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00535-012-0533-z","article-title":"Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study","volume":"47","author":"Eguchi","year":"2012","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jhepr.2021.100253_bib4","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1136\/gut.2006.112094","article-title":"Benefits of lifestyle modification in NAFLD","volume":"56","author":"Harrison","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2021.100253_bib5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1053\/j.gastro.2015.04.005","article-title":"Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis","volume":"149","author":"Vilar-Gomez","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2021.100253_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111808","article-title":"Weight loss in nonalcoholic fatty liver disease patients in an ambulatory care setting is largely unsuccessful but correlates with frequency of clinic visits","volume":"9","author":"Dudekula","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2021.100253_bib7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhep.2017.05.016","article-title":"Treatment of NAFLD with diet, physical activity and exercise","volume":"67","author":"Romero-G\u00f3mez","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2021.100253_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3727\/105221617X15124844266408","article-title":"The effects\u00a0of\u00a0physical exercise on fatty liver disease","volume":"18","author":"van der Windt","year":"2018","journal-title":"Gene Expr"},{"key":"10.1016\/j.jhepr.2021.100253_bib9","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/hep.27544","article-title":"Moderate to vigorous physical activity volume is an important factor for managing nonalcoholic fatty liver disease: a retrospective study","volume":"61","author":"Oh","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2021.100253_bib10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1440-1746.2007.05001.x","article-title":"Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines","volume":"22","author":"Chitturi","year":"2007","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2021.100253_bib11","first-page":"794","article-title":"Evaluation committee on diagnostic criteria for metabolic syndrome","volume":"94","year":"2005","journal-title":"Intern Med"},{"key":"10.1016\/j.jhepr.2021.100253_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00535-017-1377-3","article-title":"Skeletal muscle mass to visceral fat area ratio is an important determinant affecting hepatic conditions of non-alcoholic fatty liver disease","volume":"53","author":"Shida","year":"2018","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jhepr.2021.100253_bib13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.jhepr.2021.100253_bib14","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep.21496","article-title":"The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD","volume":"45","author":"Angulo","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2021.100253_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/hep.21669","article-title":"FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest","volume":"46","author":"Vallet-Pichard","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2021.100253_bib16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S2468-1253(19)30383-8","article-title":"FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study","volume":"5","author":"Newsome","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2021.100253_bib17","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1249\/MSS.0b013e31829afc33","article-title":"Exercise reduces inflammation and oxidative stress in obesity-related liver diseases","volume":"45","author":"Oh","year":"2013","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jhepr.2021.100253_bib18","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jhep.2015.02.051","article-title":"Sarcopenia is associated with NAFLD independently of obesity and insulin resistance: nationwide surveys (KNHANES 2008-2011)","volume":"63","author":"Lee","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2021.100253_bib19","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.28055","article-title":"High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis","volume":"34","author":"Paradis","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2021.100253_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jhep.2015.02.031","article-title":"Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma","volume":"63","author":"Fujiwara","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2021.100253_bib21","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/j.2040-4603.2013.tb00522.x","article-title":"Muscle as a secretory organ","volume":"3","author":"Pedersen","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jhepr.2021.100253_bib22","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jcsm.12212","article-title":"Elevated serum myostatin level is associated with worse survival in patients with liver cirrhosis","volume":"8","author":"Nishikawa","year":"2017","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jhepr.2021.100253_bib23","doi-asserted-by":"crossref","first-page":"14938","DOI":"10.1073\/pnas.95.25.14938","article-title":"Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting","volume":"95","author":"Gonzalez-Cadavid","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jhepr.2021.100253_bib24","first-page":"343","article-title":"Serum myostatin-immunoreactive protein is increased in 60-92-year-old women and men with muscle wasting","volume":"6","author":"Yarasheski","year":"2002","journal-title":"J\u00a0Nutr Health Aging"},{"key":"10.1016\/j.jhepr.2021.100253_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210863","article-title":"Lifelong aerobic exercise protects against inflammaging and cancer","volume":"14","author":"Nilsson","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2021.100253_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4093\/dmj.2013.37.1.63","article-title":"Increased selenoprotein P levels in subjects with visceral obesity and nonalcoholic fatty liver disease","volume":"37","author":"Choi","year":"2013","journal-title":"Diab Metab J"},{"key":"10.1016\/j.jhepr.2021.100253_bib27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1258\/acb.2010.010169","article-title":"Serum fetuin A\/\u03b12HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis","volume":"47","author":"Yilmaz","year":"2010","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.jhepr.2021.100253_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2012.258","article-title":"The role of hepatokines in metabolism","volume":"9","author":"Stefan","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jhepr.2021.100253_bib29","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nm1214","article-title":"Angiopoietin-related growth factor antagonizes obesity and insulin resistance","volume":"11","author":"Oike","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jhepr.2021.100253_bib30","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1210\/jc.2015-3668","article-title":"Circulating follistatin is liver-derived and regulated by the glucagon-to-insulin ratio","volume":"101","author":"Hansen","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jhepr.2021.100253_bib31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.biochi.2015.10.024","article-title":"Adipocyte lipolysis and insulin resistance","volume":"125","author":"Morigny","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.jhepr.2021.100253_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1538\/expanim.17-0112","article-title":"Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis","volume":"67","author":"Akiyama","year":"2018","journal-title":"Exp Anim"},{"key":"10.1016\/j.jhepr.2021.100253_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00223-017-0345-5","article-title":"Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis","volume":"102","author":"Grosicki","year":"2017","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jhepr.2021.100253_bib34","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cmet.2012.05.012","article-title":"Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling","volume":"16","author":"Imajo","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2021.100253_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/ajpgi.00296.2009","article-title":"Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice","volume":"298","author":"Sugimoto","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhepr.2021.100253_bib36","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","article-title":"Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis","volume":"116","author":"Thimmulappa","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhepr.2021.100253_bib37","first-page":"419","article-title":"Effects of exercise on redox-sensitive transcription factor Nrf2-driven expression of HO-1 and NQO1 in human peripheral blood mononuclear cells","volume":"49","author":"Kim","year":"2010","journal-title":"KAPHED"},{"key":"10.1016\/j.jhepr.2021.100253_bib38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yjmcc.2014.09.022","article-title":"Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1\/AMPK pathway","volume":"77","author":"Zhang","year":"2014","journal-title":"J\u00a0Mol Cell Cardiol"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258955592100029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258955592100029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:06:23Z","timestamp":1778904383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258955592100029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S258955592100029X"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2021.100253","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2021.100253","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"100253"}}