{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:00:04Z","timestamp":1789502404077,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009187","name":"Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"ANRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jhepr.2022.100480","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T19:50:49Z","timestamp":1648929049000},"page":"100480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-055X","authenticated-orcid":false,"given":"Tobias","family":"Boettler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upkar S.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Allweiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Pollicino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8711-4240","authenticated-orcid":false,"given":"John E.","family":"Tavis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Zoulim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2022.100480_bib1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S2468-1253(19)30119-0","article-title":"A\u00a0global scientific strategy to cure hepatitis B","volume":"4","author":"Revill","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1053\/j.gastro.2018.08.061","article-title":"Insights from antiviral therapy into immune responses to hepatitis B and C virus infection","volume":"156","author":"Rehermann","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2022.100480_bib3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/j.gastro.2020.04.019","article-title":"Effects of hepatitis B surface antigen on virus-specific and global T cells in patients with chronic hepatitis B virus infection","volume":"159","author":"Le Bert","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2022.100480_bib4","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41573-019-0037-0","article-title":"Therapeutic strategies for hepatitis B virus infection: towards a cure","volume":"18","author":"Fanning","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhepr.2022.100480_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jhep.2021.05.025","article-title":"EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis \u2013 2021 update","volume":"75","author":"Berzigotti","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21037\/atm.2017.01.28","article-title":"Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection","volume":"5","author":"Parikh","year":"2017","journal-title":"Ann Translational Med"},{"key":"10.1016\/j.jhepr.2022.100480_bib7","first-page":"Fc08","article-title":"A\u00a0comparative evaluation of scoring systems for assessing necro-inflammatory activity and fibrosis in liver biopsies of patients with chronic viral hepatitis","volume":"8","author":"Mannan","year":"2014","journal-title":"J\u00a0Clin Diagn Res: JCDR"},{"key":"10.1016\/j.jhepr.2022.100480_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jhep.2018.11.030","article-title":"Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients","volume":"70","author":"Testoni","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jhep.2016.09.028","article-title":"Serum HBV pgRNA as a clinical marker for cccDNA activity","volume":"66","author":"Giersch","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib10","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1053\/j.gastro.2016.07.012","article-title":"HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant","volume":"151","author":"Mason","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2022.100480_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/v9040075","article-title":"HBV DNA integration: molecular mechanisms and clinical implications","volume":"9","author":"Tu","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.jhepr.2022.100480_bib12","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1084\/jem.20162115","article-title":"IL-2(high) tissue-resident T cells in the human liver: sentinels for hepatotropic infection","volume":"214","author":"Pallett","year":"2017","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jhepr.2022.100480_bib13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.immuni.2016.07.007","article-title":"A\u00a0high-dimensional atlas of human T cell diversity reveals tissue-specific trafficking and cytokine signatures","volume":"45","author":"Wong","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jhepr.2022.100480_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2893.2005.00626.x","article-title":"Flow cytometry of fine-needle-aspiration biopsies: a new method to monitor the intrahepatic immunological environment in chronic viral hepatitis","volume":"12","author":"Sprengers","year":"2005","journal-title":"J\u00a0viral Hepat"},{"key":"10.1016\/j.jhepr.2022.100480_bib15","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1136\/gutjnl-2018-317071","article-title":"Fine needle aspirates comprehensively sample intrahepatic immunity","volume":"68","author":"Gill","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100480_bib16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/gutjnl-2013-304472","article-title":"The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon \u03b1 treatment","volume":"63","author":"Pembroke","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100480_bib17","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.celrep.2016.06.078","article-title":"Distinct metabolic requirements of exhausted and functional virus-specific CD8 T cells in the same host","volume":"16","author":"Schurich","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhepr.2022.100480_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01457-18","article-title":"Spatiotemporal differences in presentation of CD8 T cell epitopes during hepatitis B virus infection","volume":"93","author":"Khakpoor","year":"2019","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100480_bib19","article-title":"Quantification of viral RNA in multiple pieces of explant liver tissue shows distinct focal differences of hepatitis B infection","author":"Rydell","year":"2021","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jhepr.2022.100480_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/hep.31240","article-title":"Rapid turnover of hepatitis B virus covalently closed circular DNA indicated by monitoring emergence and reversion of signature-mutation in treated chronic hepatitis B patients","volume":"73","author":"Huang","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2022.100480_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140584","article-title":"Single hepatocytes show persistence and transcriptional inactivity of hepatitis B","volume":"5","author":"Balagopal","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jhepr.2022.100480_bib22","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/infdis\/jiz607","article-title":"Single hepatocyte hepatitis B virus transcriptional landscape in HIV coinfection","volume":"221","author":"Balagopal","year":"2020","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.jhepr.2022.100480_bib23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jhep.2012.12.008","article-title":"The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus","volume":"58","author":"Volz","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/v13020210","article-title":"Hepatitis B virus DNA integration and clonal expansion of hepatocytes in the chronically infected liver","volume":"13","author":"Mason","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jhepr.2022.100480_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/v13030368","article-title":"HBV-integration studies in the clinic: role in the natural history of infection","volume":"13","author":"Pollicino","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jhepr.2022.100480_bib26","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jhep.2021.04.051","article-title":"Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load","volume":"75","author":"Meier","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220376","article-title":"Genomic modeling of hepatitis B virus integration frequency in the human genome","volume":"14","author":"Podlaha","year":"2019","journal-title":"PloS one"},{"key":"10.1016\/j.jhepr.2022.100480_bib28","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jhep.2020.11.003","article-title":"Transition to HBeAg-negative chronic hepatitis B virus infection is associated with reduced cccDNA transcriptional activity","volume":"74","author":"Suslov","year":"2021","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan0241","article-title":"RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg","volume":"9","author":"Wooddell","year":"2017","journal-title":"Sci translational Med"},{"key":"10.1016\/j.jhepr.2022.100480_bib30","article-title":"Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment","author":"Yuen","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100480_bib31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.omtn.2020.03.005","article-title":"Permanent inactivation of HBV genomes by CRISPR\/Cas9-Mediated non-cleavage base editing","volume":"20","author":"Yang","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jhepr.2022.100480_bib32","first-page":"71","article-title":"Long term nucleos(t)ide analogue therapy reduced the extent of HBV DNA integration in chronic Hepatitis B patients","author":"Chow","year":"2020","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.jhepr.2022.100480_bib33","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1053\/j.gastro.2021.12.286","article-title":"Inhibition of viral replication reduces transcriptionally active distinct hepatitis B virus integrations with implications on host gene dysregulation","volume":"162","author":"Hsu","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2022.100480_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02007-17","article-title":"Hepatitis B virus DNA integration occurs early in the viral life cycle in an in\u00a0vitro infection model via sodium taurocholate cotransporting polypeptide-dependent uptake of enveloped virus particles","volume":"92","author":"Tu","year":"2018","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100480_bib35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/apt.15311","article-title":"High risk of clinical events in untreated HBeAg-negative chronic hepatitis B patients with high viral load and no significant ALT elevation","volume":"50","author":"Choi","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhepr.2022.100480_bib36","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/gutjnl-2017-314904","article-title":"High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B","volume":"67","author":"Kim","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100480_bib37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/v13020180","article-title":"Hepatitis B virus DNA integration: in\u00a0vitro models for investigating viral pathogenesis and persistence","volume":"13","author":"Tu","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jhepr.2022.100480_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/v9050096","article-title":"Immune tolerant chronic hepatitis B: the unrecognized risks","volume":"9","author":"Kennedy","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.jhepr.2022.100480_bib39","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1136\/gutjnl-2011-301073","article-title":"Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection","volume":"61","author":"Bertoletti","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100480_bib40","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1136\/gutjnl-2020-323300","article-title":"Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B","volume":"70","author":"Svicher","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100480_bib41","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/gutjnl-2020-323153","article-title":"Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma","volume":"71","author":"P\u00e9neau","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100480_bib42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00281-020-00780-6","article-title":"Epigenetic modulation in chronic hepatitis B virus infection","volume":"42","author":"Dandri","year":"2020","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jhepr.2022.100480_bib43","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/COH.0000000000000616","article-title":"In-vitro and in-vivo models for hepatitis B cure research","volume":"15","author":"Allweiss","year":"2020","journal-title":"Curr Opin HIV AIDS"},{"key":"10.1016\/j.jhepr.2022.100480_bib44","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3390\/genes9100469","article-title":"Viral biomarkers in chronic HBeAg negative HBV infection","volume":"9","author":"Hadziyannis","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.jhepr.2022.100480_bib45","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02036-18","article-title":"Mapping the heterogeneity of histone modifications on hepatitis B virus DNA using liver needle biopsies obtained from chronically infected patients","volume":"93","author":"Flecken","year":"2019","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100480_bib46","doi-asserted-by":"crossref","first-page":"21097","DOI":"10.1038\/s41598-020-78001-1","article-title":"Quantification and epigenetic evaluation of the residual pool of hepatitis B covalently closed circular DNA in long-term nucleoside analogue-treated patients","volume":"10","author":"Leboss\u00e9","year":"2020","journal-title":"Scientific Rep"},{"key":"10.1016\/j.jhepr.2022.100480_bib47","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1053\/j.gastro.2007.06.057","article-title":"Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients","volume":"133","author":"Volz","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2022.100480_bib48","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/nm1096-1104","article-title":"The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response","volume":"2","author":"Rehermann","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.jhepr.2022.100480_bib49","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1053\/j.gastro.2017.02.009","article-title":"Hepatitis B reactivation associated with immune\u00a0suppressive and biological modifier therapies: current concepts, management strategies, and future directions","volume":"152","author":"Loomba","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2022.100480_bib50","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41575-019-0196-9","article-title":"Restoring, releasing or replacing adaptive immunity in chronic hepatitis B","volume":"16","author":"Maini","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2022.100480_bib51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41590-020-00817-w","article-title":"Memory-like HCV-specific CD8(+) T cells retain a molecular scar after cure of chronic HCV infection","volume":"22","author":"Hensel","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhepr.2022.100480_bib52","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1038\/s41467-021-22967-7","article-title":"Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint","volume":"12","author":"Schmidt","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2022.100480_bib53","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41590-021-00979-1","article-title":"Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans","volume":"22","author":"Yates","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jhepr.2022.100480_bib54","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.1243462","article-title":"Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA","volume":"343","author":"Lucifora","year":"2014","journal-title":"Science (New York, NY)"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555922000520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555922000520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:27:39Z","timestamp":1762900059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555922000520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2589555922000520"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2022.100480","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2022.100480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"100480"}}