{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:18:43Z","timestamp":1788477523155,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["272983813 \\u2013 SFB\/TRR 179"],"award-info":[{"award-number":["272983813 \\u2013 SFB\/TRR 179"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007131","name":"Texas Tech University","doi-asserted-by":"publisher","award":["05.704"],"award-info":[{"award-number":["05.704"]}],"id":[{"id":"10.13039\/100007131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007131","name":"Texas Tech University","doi-asserted-by":"publisher","award":["05.806"],"award-info":[{"award-number":["05.806"]}],"id":[{"id":"10.13039\/100007131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum fur Infektionsforschung eV","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jhepr.2022.100551","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T10:04:26Z","timestamp":1659866666000},"page":"100551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-2929","authenticated-orcid":false,"given":"Bingqian","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firat","family":"Nebioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-2360","authenticated-orcid":false,"given":"Mila M.","family":"Leuthold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1197-4161","authenticated-orcid":false,"given":"Yi","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-2095","authenticated-orcid":false,"given":"Pascal","family":"Mutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Beneke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Erfle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian W.R.","family":"Vondran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5601-9307","authenticated-orcid":false,"given":"Ralf","family":"Bartenschlager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2022.100551_bib1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1021\/acsinfecdis.8b00081","article-title":"Virological basis for the cure of chronic hepatitis B","volume":"5","author":"Hu","year":"2019","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.jhepr.2022.100551_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41573-019-0037-0","article-title":"Therapeutic strategies for hepatitis B virus infection: towards a cure","volume":"18","author":"Fanning","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jhepr.2022.100551_bib3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01703079","article-title":"Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell","volume":"8","author":"Bock","year":"1994","journal-title":"Virus Genes"},{"key":"10.1016\/j.jhepr.2022.100551_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/jmbi.2000.4481","article-title":"Structural organization of the hepatitis B virus minichromosome","volume":"307","author":"Bock","year":"2001","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.jhepr.2022.100551_bib5","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1002\/hep.25928","article-title":"Hepatitis B virus X protein stimulates gene expression selectively from extrachromosomal DNA templates","volume":"56","author":"van Breugel","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2022.100551_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040834","article-title":"Hepatitis B virus HBx protein mediates the degradation of host restriction factors through the cullin 4 DDB1 E3 ubiquitin ligase complex","volume":"9","author":"Minor","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jhepr.2022.100551_bib7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nature17170","article-title":"Hepatitis B virus X protein identifies the Smc5\/6 complex as a host restriction factor","volume":"531","author":"Decorsiere","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2022.100551_bib8","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1016\/j.celrep.2016.08.026","article-title":"Hepatitis B virus X protein promotes degradation of SMC5\/6 to enhance HBV replication","volume":"16","author":"Murphy","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jhepr.2022.100551_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.coviro.2018.01.007","article-title":"Role of HBx in hepatitis B virus persistence and its therapeutic implications","volume":"30","author":"Slagle","year":"2018","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.cell.2008.07.022","article-title":"Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation","volume":"134","author":"Duda","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2022.100551_bib11","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jmb.2011.03.023","article-title":"Neddylation-induced conformational control regulates cullin RING ligase activity in\u00a0vivo","volume":"409","author":"Boh","year":"2011","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.jhepr.2022.100551_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00281-020-00780-6","article-title":"Epigenetic modulation in chronic hepatitis B virus infection","volume":"42","author":"Dandri","year":"2020","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jhepr.2022.100551_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrm3919","article-title":"Protein neddylation: beyond cullin-RING ligases","volume":"16","author":"Enchev","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jhepr.2022.100551_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040854","article-title":"Direct conjugation of NEDD8 to the N-terminus of a model protein can induce degradation","volume":"10","author":"Vijayasimha","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jhepr.2022.100551_bib15","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1002\/hep.30491","article-title":"Pevonedistat, a neuronal precursor cell-expressed developmentally down-regulated protein 8-activating enzyme inhibitor, is a potent inhibitor of hepatitis B virus","volume":"69","author":"Sekiba","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2022.100551_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jcmgh.2018.10.010","article-title":"Inhibition of HBV transcription from cccDNA with nitazoxanide by targeting the HBx-DDB1 interaction","volume":"7","author":"Sekiba","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2022.100551_bib17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.antiviral.2007.08.005","article-title":"Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication","volume":"77","author":"Korba","year":"2008","journal-title":"Antivir Res"},{"key":"10.1016\/j.jhepr.2022.100551_bib18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1128\/jvi.52.2.396-402.1984","article-title":"Large surface proteins of hepatitis B virus containing the pre-s sequence","volume":"52","author":"Heermann","year":"1984","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib19","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1128\/JVI.02741-06","article-title":"Hepatitis B virus subviral envelope particle morphogenesis and intracellular trafficking","volume":"81","author":"Patient","year":"2007","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib20","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1128\/JVI.03109-15","article-title":"Subviral hepatitis B virus filaments, like infectious viral particles, are released via multivesicular bodies","volume":"90","author":"Jiang","year":"2015","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib21","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1053\/j.gastro.2016.07.012","article-title":"HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant","volume":"151","author":"Mason","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2022.100551_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/v9040075","article-title":"HBV DNA integration: molecular mechanisms and clinical implications","volume":"9","author":"Tu","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.jhepr.2022.100551_bib23","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1172\/JCI121960","article-title":"Circulating and intrahepatic antiviral B cells are defective in hepatitis B","volume":"128","author":"Burton","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhepr.2022.100551_bib24","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1172\/JCI121957","article-title":"PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection","volume":"128","author":"Salimzadeh","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhepr.2022.100551_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan0241","article-title":"RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg","volume":"9","author":"Wooddell","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhepr.2022.100551_bib26","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1038\/s41598-020-58870-2","article-title":"Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients","volume":"10","author":"Kim","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2022.100551_bib27","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1128\/JVI.00430-14","article-title":"Envelope proteins derived from naturally integrated hepatitis B virus DNA support assembly and release of infectious hepatitis delta virus particles","volume":"88","author":"Freitas","year":"2014","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib28","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1128\/JVI.00346-14","article-title":"Support of the infectivity of hepatitis delta virus particles by the envelope proteins of different genotypes of hepatitis B virus","volume":"88","author":"Freitas","year":"2014","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01117-18","article-title":"T5 exonuclease hydrolysis of hepatitis B virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR","volume":"92","author":"Qu","year":"2018","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4939-6700-1_2","article-title":"Hepatitis B virus infection of HepaRG cells, HepaRG-hNTCP cells, and primary human hepatocytes","volume":"1540","author":"Ni","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jhepr.2022.100551_bib31","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1128\/AAC.41.8.1715","article-title":"Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication","volume":"41","author":"Ladner","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jhepr.2022.100551_bib32","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1101\/gr.215103.116","article-title":"Solid-phase reverse transfection for intracellular delivery of functionally active proteins","volume":"27","author":"Bulkescher","year":"2017","journal-title":"Genome Res"},{"key":"10.1016\/j.jhepr.2022.100551_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15338-0","article-title":"Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP","volume":"7","author":"Donkers","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2022.100551_bib34","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ncb2510","article-title":"Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway","volume":"14","author":"Simpson","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhepr.2022.100551_bib35","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1038\/s41467-019-10211-2","article-title":"Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation","volume":"10","author":"Lempp","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2022.100551_bib36","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nature07884","article-title":"An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer","volume":"458","author":"Soucy","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2022.100551_bib37","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jhep.2011.02.015","article-title":"Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection","volume":"55","author":"Lucifora","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2022.100551_bib38","series-title":"International meeting on the molecular biology of hepatitis B viruses. Taipeh","article-title":"HBx expression regulates HBV gene transcription from cccDNA in authentic infection systems","author":"Sonnabend","year":"2010"},{"key":"10.1016\/j.jhepr.2022.100551_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/104303404772680001","article-title":"Hepatitis B virus-based vectors allow the elimination of viral gene expression and the insertion of foreign promoters","volume":"15","author":"Untergasser","year":"2004","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.jhepr.2022.100551_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nsmb.1719","article-title":"A\u00a0promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery","volume":"17","author":"Li","year":"2010","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jhepr.2022.100551_bib41","article-title":"Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5\/6 complex and silencing of the viral genome in\u00a0vivo","author":"Allweiss","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2022.100551_bib42","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.antiviral.2006.05.006","article-title":"Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays","volume":"72","author":"Zhou","year":"2006","journal-title":"Antivir Res"},{"key":"10.1016\/j.jhepr.2022.100551_bib43","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/jcmm.16137","article-title":"Neddylation inhibitor MLN4924 has anti-HBV activity via modulating the ERK-HNF1alpha-C\/EBPalpha-HNF4alpha axis","volume":"25","author":"Xie","year":"2021","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.jhepr.2022.100551_bib44","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/hep.27722","article-title":"Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma","volume":"61","author":"Yan","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2022.100551_bib45","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ng.2295","article-title":"Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma","volume":"44","author":"Sung","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhepr.2022.100551_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02007-17","article-title":"Hepatitis B virus DNA integration occurs early in the viral life cycle in an in\u00a0vitro infection model via sodium taurocholate cotransporting polypeptide-dependent uptake of enveloped virus particles","volume":"92","author":"Tu","year":"2018","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jhepr.2022.100551_bib47","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.3748\/wjg.v26.i38.5759","article-title":"Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma","volume":"26","author":"D'Souza","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jhepr.2022.100551_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/v13020180","article-title":"Hepatitis B virus DNA integration: in\u00a0vitro models for investigating viral pathogenesis and persistence","volume":"13","author":"Tu","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jhepr.2022.100551_bib49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000024969","article-title":"Hepatitis B virus X protein: structure, function and biology","volume":"42","author":"Murakami","year":"1999","journal-title":"Intervirology"},{"key":"10.1016\/j.jhepr.2022.100551_bib50","series-title":"Untersuchungen zur Proteom-basierten Aufkl\u00e4rung einer durch Adenovirus 5 E4orf6 Protein vermittelten Interferenz mit der Hepadnavirus Replikation","author":"Miller","year":"2020"},{"key":"10.1016\/j.jhepr.2022.100551_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00340-17","article-title":"HDM2 promotes NEDDylation of hepatitis B virus HBx to enhance its stability and function","volume":"91","author":"Liu","year":"2017","journal-title":"J\u00a0Virol"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555922001239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555922001239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:44:37Z","timestamp":1779122677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555922001239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S2589555922001239"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2022.100551","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2022.100551","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"100551"}}