{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:49:06Z","timestamp":1786992546457,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","award":["R01 DK130317"],"award-info":[{"award-number":["R01 DK130317"]}],"id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007345","name":"University of Arizona Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA241618"],"award-info":[{"award-number":["R01CA241618"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jhepr.2023.100714","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T02:23:38Z","timestamp":1677119018000},"page":"100714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pathological bile acid concentrations in chronic cholestasis cause adipose mitochondrial defects"],"prefix":"10.1016","volume":"5","author":[{"given":"Weinan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"VanDuyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Riessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Barragan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair M.","family":"Rowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Teran-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Boppart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeepriyadarshini","family":"Anakk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2023.100714_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gut.12.2.145","article-title":"Serum bile acids in liver disease","volume":"12","author":"Neale","year":"1971","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2023.100714_bib2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/MPG.0000000000001493","article-title":"Clinical variability after partial external biliary diversion in familial intrahepatic cholestasis 1 deficiency","volume":"64","author":"Squires","year":"2017","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jhepr.2023.100714_bib3","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/gut.21.9.734","article-title":"Weight loss in primary biliary cirrhosis","volume":"21","author":"Beckett","year":"1980","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2023.100714_bib4","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1159\/000358150","article-title":"Primary sclerosing cholangitis","volume":"32","author":"Williamson","year":"2014","journal-title":"Dig Dis"},{"key":"10.1016\/j.jhepr.2023.100714_bib5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/0016-5085(87)90922-X","article-title":"Steatorrhea in patients with intrahepatic cholestasis of pregnancy","volume":"93","author":"Reyes","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2023.100714_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation","volume":"439","author":"Watanabe","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2023.100714_bib7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.cmet.2015.07.002","article-title":"The bile acid chenodeoxycholic acid increases human brown adipose tissue activity","volume":"22","author":"Broeders","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2023.100714_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/toxsci\/57.1.177","article-title":"Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy","volume":"57","author":"Rolo","year":"2000","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jhepr.2023.100714_bib9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1053\/jhep.2001.22702","article-title":"Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition","volume":"33","author":"Yerushalmi","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2023.100714_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1385\/CT:5:1:063","article-title":"Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?","volume":"5","author":"Ferreira","year":"2005","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.jhepr.2023.100714_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hep.28890","article-title":"Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart","volume":"65","author":"Desai","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2023.100714_bib12","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1091\/mbc.e15-10-0749","article-title":"Cell biology of fat storage","volume":"27","author":"Cohen","year":"2016","journal-title":"Mol Biol Cel"},{"key":"10.1016\/j.jhepr.2023.100714_bib13","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab063","article-title":"Deletion of intestinal SHP impairs short-term response to cholic acid challenge in male mice","volume":"162","author":"Nguyen","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhepr.2023.100714_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1172\/JCI42846","article-title":"Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis","volume":"121","author":"Anakk","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhepr.2023.100714_bib15","article-title":"Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis","volume":"2","author":"Mathur","year":"2020","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jhepr.2023.100714_bib16","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/hep.29305","article-title":"Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice","volume":"66","author":"Akinrotimi","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2023.100714_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-4939-9420-5_16","article-title":"3,5-Diethoxycarbonyl-1,4-dihydrocollidine diet: a rodent model in cholestasis research","volume":"1981","author":"Pose","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jhepr.2023.100714_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40608-019-0238-4","article-title":"Larger omental adipocytes correlate with greater Fetuin-A reduction following sleeve gastrectomy","volume":"6","author":"Robinson","year":"2019","journal-title":"BMC Obes"},{"key":"10.1016\/j.jhepr.2023.100714_bib19","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.15252\/embj.201694914","article-title":"Mfn2 is critical for brown adipose tissue thermogenic function","volume":"36","author":"Boutant","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.jhepr.2023.100714_bib20","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1038\/s41598-018-22020-6","article-title":"Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry","volume":"8","author":"Mei","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2023.100714_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tem.2010.09.002","article-title":"Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter","volume":"22","author":"Lodhi","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jhepr.2023.100714_bib22","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.2337\/db16-0136","article-title":"Adipose-specific deficiency of fumarate hydratase in mice protects against obesity, hepatic steatosis, and insulin resistance","volume":"65","author":"Yang","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jhepr.2023.100714_bib23","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1096\/fj.14-253971","article-title":"Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications","volume":"28","author":"Vernochet","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.jhepr.2023.100714_bib24","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF00340941","article-title":"Mitochondrial myelin-like figures: a non-specific reactive process of mitochondrial phospholipid membranes to several stimuli","volume":"99","author":"Le Beux","year":"1969","journal-title":"Z\u00a0Zellforsch Mikrosk Anat"},{"key":"10.1016\/j.jhepr.2023.100714_bib25","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.2353\/ajpath.2010.091037","article-title":"Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease","volume":"177","author":"Siskov\u00e1","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhepr.2023.100714_bib26","doi-asserted-by":"crossref","first-page":"36759","DOI":"10.1074\/jbc.M110.166231","article-title":"The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-\u03b3 and interfering with the Wnt\/\u03b2-catenin pathways","volume":"285","author":"Abdelkarim","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhepr.2023.100714_bib27","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1194\/jlr.M094508","article-title":"FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements","volume":"60","author":"van Zutphen","year":"2019","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jhepr.2023.100714_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2022.111616","article-title":"Enterohepatic and non-canonical roles of farnesoid X receptor in controlling lipid and glucose metabolism","volume":"549","author":"Zhou","year":"2022","journal-title":"Mol Cel Endocrinol"},{"key":"10.1016\/j.jhepr.2023.100714_bib29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/jcp.28.6.506","article-title":"Diagnositic value of serum bile acid estimations in liver disease","volume":"28","author":"Barnes","year":"1975","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jhepr.2023.100714_bib30","doi-asserted-by":"crossref","first-page":"11039","DOI":"10.1074\/jbc.M510258200","article-title":"The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice","volume":"281","author":"Cariou","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhepr.2023.100714_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41467-017-02068-0","article-title":"TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue","volume":"9","author":"Velazquez-Villegas","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2023.100714_bib32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.isci.2019.09.011","article-title":"CIDEA transcriptionally regulates UCP1 for britening and thermogenesis in human fat cells","volume":"20","author":"Jash","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.jhepr.2023.100714_bib33","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bbabio.2014.02.008","article-title":"Brite\/beige fat and UCP1 \u2013 is it thermogenesis?","volume":"1837","author":"Keipert","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhepr.2023.100714_bib34","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1210\/me.2011-1157","article-title":"Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob\/ob mice","volume":"26","author":"Zhang","year":"2012","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jhepr.2023.100714_bib35","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1194\/jlr.M016048","article-title":"Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner","volume":"52","author":"Park","year":"2011","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.jhepr.2023.100714_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-444-63912-7.00010-2","article-title":"Shivering and nonshivering thermogenesis in skeletal muscles","volume":"156","author":"Blondin","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.jhepr.2023.100714_bib37","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.jcmgh.2022.02.003","article-title":"Melanchol\u00e9: the dark side of bile acids and its cellular consequences","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2023.100714_bib38","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1172\/JCI200315737","article-title":"Paradoxical resistance to diet-induced obesity in UCP1-deficient mice","volume":"111","author":"Liu","year":"2003","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jhepr.2023.100714_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/387090a0","article-title":"Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese","volume":"387","author":"Enerb\u00e4ck","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2023.100714_bib40","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1073\/pnas.1705406114","article-title":"UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction","volume":"114","author":"Kazak","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhepr.2023.100714_bib41","doi-asserted-by":"crossref","first-page":"16616","DOI":"10.1074\/jbc.M117.790451","article-title":"Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice","volume":"292","author":"Bal","year":"2017","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhepr.2023.100714_bib42","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.bbabio.2010.02.033","article-title":"Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects","volume":"1797","author":"Shabalina","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhepr.2023.100714_bib43","doi-asserted-by":"crossref","first-page":"12282","DOI":"10.1074\/jbc.M115.637603","article-title":"Uncoupling protein 1 and sarcolipin are required to maintain optimal thermogenesis, and loss of both systems compromises survival of mice under cold stress","volume":"290","author":"Rowland","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jhepr.2023.100714_bib44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2008.12.014","article-title":"UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality","volume":"9","author":"Feldmann","year":"2009","journal-title":"Cel Metab"},{"key":"10.1016\/j.jhepr.2023.100714_bib45","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1001\/archinte.1980.00330160140050","article-title":"Causes of hypothermia","volume":"140","author":"Gordon","year":"1980","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jhepr.2023.100714_bib46","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0002-9343(87)90928-4","article-title":"Hypothermia associated with terminal liver failure","volume":"83","author":"Gayed","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.jhepr.2023.100714_bib47","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.4081\/cp.2011.e18","article-title":"Recurrent hypothermia and hypoglycemia as the initial presentation of hepatitis C","volume":"1","author":"Senadhi","year":"2011","journal-title":"Clin Pract"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555923000459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555923000459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:30:27Z","timestamp":1762900227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555923000459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2589555923000459"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2023.100714","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathological bile acid concentrations in chronic cholestasis cause adipose mitochondrial defects","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2023.100714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"100714"}}