{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:20:32Z","timestamp":1793251232515,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974485"],"award-info":[{"award-number":["81974485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jhepr.2024.101060","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T04:01:03Z","timestamp":1709956863000},"page":"101060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Xanthine oxidase promotes hepatic lipid accumulation through high fat absorption by the small intestine"],"prefix":"10.1016","volume":"6","author":[{"given":"Lin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxue","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingnan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2024.101060_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101238","article-title":"Metabolic-associated fatty liver disease and lipoprotein metabolism","volume":"50","author":"Heeren","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.jhepr.2024.101060_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.metabol.2018.11.005","article-title":"Obesity and dyslipidemia","volume":"92","author":"Vekic","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.jhepr.2024.101060_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41575-022-00717-4","article-title":"NAFLD, MAFLD and obesity: brothers in arms?","volume":"20","author":"Machado","year":"2022","journal-title":"Nature Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2024.101060_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3559","article-title":"Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight\/obesity","volume":"38","author":"Di Bonito","year":"2022","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.jhepr.2024.101060_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13098-023-00997-z","article-title":"Association between serum uric acid levels and long-term mortality of metabolic dysfunction-associated fatty liver disease: a nationwide cohort study","volume":"15","author":"Liu","year":"2023","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.jhepr.2024.101060_bib6","article-title":"Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies","volume":"357","author":"Li","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.jhepr.2024.101060_bib7","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2337\/dc17-1434","article-title":"Elevated serum xanthine oxidase activity is associated with the development of type 2 diabetes: a prospective cohort study","volume":"41","author":"Li","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jhepr.2024.101060_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000441091","article-title":"Plasma xanthine oxidase activity is predictive of cardiovascular disease in patients with chronic kidney disease, independently of uric acid levels","volume":"131","author":"Gondouin","year":"2015","journal-title":"Nephron"},{"key":"10.1016\/j.jhepr.2024.101060_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0003-9861(76)90088-6","article-title":"The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O)","volume":"172","author":"Waud","year":"1976","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jhepr.2024.101060_bib10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1081\/DMR-120037569","article-title":"Physiological roles of xanthine oxidoreductase","volume":"36","author":"Harrison","year":"2004","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jhepr.2024.101060_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/152308602753625933","article-title":"Serum xanthine oxidase: origin, regulation, and contribution to control of trypanosome parasitemia","volume":"4","author":"Wang","year":"2002","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jhepr.2024.101060_bib12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jnutbio.2019.05.015","article-title":"Apigenin ameliorates HFD-induced NAFLD through regulation of the XO\/NLRP3 pathways","volume":"71","author":"Lv","year":"2019","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.jhepr.2024.101060_bib13","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.jhep.2015.01.019","article-title":"Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: one stone hits two birds","volume":"62","author":"Xu","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2024.101060_bib14","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00125-018-4674-3","article-title":"Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China","volume":"61","author":"Du","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.jhepr.2024.101060_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jhepr.2024.101060_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","article-title":"Mitochondrial dysfunction and oxidative stress in heart disease","volume":"51","author":"Peoples","year":"2019","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jhepr.2024.101060_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbalip.2005.08.018","article-title":"Long-chain fatty acid uptake and FAT\/CD36 translocation in heart and skeletal muscle","volume":"1736","author":"Koonen","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jhepr.2024.101060_bib18","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/ncomms2581","article-title":"Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes","volume":"4","author":"Sun","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2024.101060_bib19","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/MPA.0000000000001587","article-title":"Measures of dietary fat and energy absorption in healthy adults","volume":"49","author":"Bashaw","year":"2020","journal-title":"Pancreas"},{"key":"10.1016\/j.jhepr.2024.101060_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12876-020-01189-z","article-title":"Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p\/FGF21 axis","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jhepr.2024.101060_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5455\/msm.2013.25.167-169","article-title":"Allopurinol effect on values of lipid profile fractions in hyperuricemic patients diagnosed with metabolic syndrome","volume":"25","author":"Ziga","year":"2013","journal-title":"Mater Sociomed"},{"key":"10.1016\/j.jhepr.2024.101060_bib22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bpg.2016.02.007","article-title":"Physiology of intestinal absorption and secretion","volume":"30","author":"Kiela","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.jhepr.2024.101060_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1542\/peds.98.1.103","article-title":"Role of xanthine oxidase and its inhibitor in hypoxia: reoxygenation injury","volume":"98","author":"Saugstad","year":"1996","journal-title":"Pediatrics"},{"key":"10.1016\/j.jhepr.2024.101060_bib24","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/s41598-020-80835-8","article-title":"Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease","volume":"11","author":"Saito","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2024.101060_bib25","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/HYPERTENSIONAHA.112.196980","article-title":"Uric acid reduction rectifies prehypertension in obese adolescents","volume":"60","author":"Soletsky","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jhepr.2024.101060_bib26","first-page":"1600","article-title":"Digestion and absorption of bovine milk xanthine oxidase and its role as an aldehyde oxidase","volume":"106","author":"Ho","year":"1976","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.jhepr.2024.101060_bib27","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1101\/gad.1032702","article-title":"The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland","volume":"16","author":"Vorbach","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.jhepr.2024.101060_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00441-019-03152-1","article-title":"Formation and degradation of lipid droplets in human adipocytes and the expression of aldehyde oxidase (AOX)","volume":"379","author":"Heid","year":"2020","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jhepr.2024.101060_bib29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ijbiomac.2021.08.231","article-title":"Investigation of the interaction between Chrysoeriol and xanthine oxidase using computational and in\u00a0vitro approaches","volume":"190","author":"Liu","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jhepr.2024.101060_bib30","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1055\/s-0029-1185521","article-title":"Hydrophilic ester-bearing chlorogenic acid binds to a novel domain to inhibit xanthine oxidase","volume":"75","author":"Wang","year":"2009","journal-title":"Planta Med"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555924000612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555924000612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T19:37:15Z","timestamp":1722973035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555924000612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2589555924000612"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2024.101060","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xanthine oxidase promotes hepatic lipid accumulation through high fat absorption by the small intestine","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2024.101060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101060"}}