{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:58:21Z","timestamp":1775509101980,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016148","name":"Korean Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016147","name":"Korean Association for the Study of the Liver","doi-asserted-by":"publisher","award":["KASLKLF2022-05"],"award-info":[{"award-number":["KASLKLF2022-05"]}],"id":[{"id":"10.13039\/501100016147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jhepr.2024.101251","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:15:29Z","timestamp":1730938529000},"page":"101251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk of hepatocellular carcinoma in Asian patients with primary biliary cholangitis: A nationwide and hospital cohort study"],"prefix":"10.1016","volume":"7","author":[{"given":"Jihye","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye-Jee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1815-6957","authenticated-orcid":false,"given":"Sehee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-5850","authenticated-orcid":false,"given":"Jonggi","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2024.101251_bib1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3350\/cmh.2022.0387","article-title":"Epidemiology and updated management for autoimmune liver disease","volume":"29","author":"Heo","year":"2023","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.jhepr.2024.101251_bib2","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/jgh.15329","article-title":"Regional variation and temporal trend of primary biliary cholangitis epidemiology: a systematic review and meta-analysis","volume":"36","author":"Lv","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2024.101251_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"EASL clinical practice guidelines: the diagnosis and management of patients with primary biliary cholangitis","volume":"67","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2024.101251_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary biliary cholangitis: 2018 practice guidance from the American association for the study of liver diseases","volume":"69","author":"Lindor","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib5","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2024.101251_bib6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/jvh.13663","article-title":"Global incidence and mortality of hepatitis B and hepatitis C acute infections, cirrhosis and hepatocellular carcinoma from 2010 to 2019","volume":"29","author":"Veracruz","year":"2022","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1016\/j.jhepr.2024.101251_bib7","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s10620-020-06498-7","article-title":"Incidence of hepatocellular carcinoma in primary biliary cholangitis: a systematic review and meta-analysis","volume":"66","author":"Natarajan","year":"2021","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jhepr.2024.101251_bib8","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1111\/j.1572-0241.2005.50007.x","article-title":"A\u00a0retrospective study on clinical features and prognostic factors of biopsy-proven primary biliary cirrhosis in Chinese patients","volume":"100","author":"Wong","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhepr.2024.101251_bib9","first-page":"101","article-title":"Cancer risk in primary biliary cirrhosis:\u00a0a\u00a0population-based study from Sweden","volume":"20","author":"L\u00f6\u00f6f","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.12997\/jla.2022.11.2.103","article-title":"Understanding and utilizing claim data from the Korean national health insurance Service (NHIS) and health insurance review & assessment (HIRA) database for research","volume":"11","author":"Kyoung","year":"2022","journal-title":"J\u00a0Lipid Atheroscler"},{"key":"10.1016\/j.jhepr.2024.101251_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13023-019-1032-6","article-title":"The cumulative incidence and trends of rare diseases in South Korea: a nationwide study of the administrative data from the National Health Insurance Service database from 2011-2015","volume":"14","author":"Lim","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jhepr.2024.101251_bib12","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/jgh.14855","article-title":"Nationwide validation study of diagnostic\u00a0algorithms for inflammatory bowel disease in Korean National Health Insurance Service database","volume":"35","author":"Lee","year":"2020","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2024.101251_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016640","article-title":"Cohort profile: the national health insurance service-national health screening cohort (NHIS-HEALS) in Korea","volume":"7","author":"Seong","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.jhepr.2024.101251_bib14","series-title":"Status of general health examination targets and number of examinees","year":"2022"},{"key":"10.1016\/j.jhepr.2024.101251_bib16","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22428","article-title":"Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis","volume":"48","author":"Corpechot","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib17","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jhep.2011.02.031","article-title":"Early primary biliary cirrhosis: biochemical response to treatment and prediction of long-term outcome","volume":"55","author":"Corpechot","year":"2011","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jhepr.2024.101251_bib18","first-page":"1495","article-title":"Relatively high risk for hepatocellular\u00a0carcinoma in patients with primary biliary cirrhosis not responding to ursodeoxycholic acid","volume":"22","author":"Kuiper","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2024.101251_bib19","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1038\/ajg.2010.216","article-title":"Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis","volume":"105","author":"Kumagi","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhepr.2024.101251_bib20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid","volume":"130","author":"Pares","year":"2006","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.jhepr.2024.101251_bib31","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1053\/j.gastro.2015.07.061","article-title":"Development and validation of a scoring system to predict outcomes of patients with primary biliary cirrhosis receiving ursodeoxycholic acid therapy","volume":"149","author":"Lammers","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2024.101251_bib21","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","article-title":"A\u00a0simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C","volume":"38","author":"Wai","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/hep.21669","article-title":"FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest","volume":"46","author":"Vallet-Pichard","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib23","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/hep.23095","article-title":"Incidence, risk factors, and survival of hepatocellular carcinoma in primary biliary cirrhosis: comparative analysis from two centers","volume":"50","author":"Cavazza","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/gutjnl-2014-308351","article-title":"Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study","volume":"65","author":"Trivedi","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jhepr.2024.101251_bib25","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.14309\/ajg.0000000000001280","article-title":"Ursodeoxycholic acid response is associated with reduced mortality in primary biliary cholangitis with compensated cirrhosis","volume":"116","author":"John","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhepr.2024.101251_bib26","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/hep.32434","article-title":"Risk factors for HCC in contemporary cohorts of patients with cirrhosis","volume":"77","author":"Kanwal","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib27","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep.29913","article-title":"Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases","volume":"68","author":"Marrero","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2024.101251_bib28","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1053\/j.gastro.2014.08.029","article-title":"Levels of alkaline\u00a0phosphatase and bilirubin are surrogate end points of\u00a0outcomes\u00a0of\u00a0patients with primary biliary cirrhosis: an international\u00a0follow-up\u00a0study","volume":"147","author":"Lammers","year":"2014","journal-title":"Gastroenterology"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555924002556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555924002556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:35:16Z","timestamp":1738802116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555924002556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2589555924002556"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2024.101251","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of hepatocellular carcinoma in Asian patients with primary biliary cholangitis: A nationwide and hospital cohort study","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2024.101251","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101251"}}