{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T06:43:14Z","timestamp":1794206594252,"version":"4.8.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2008928"],"award-info":[{"award-number":["GNT2008928"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015471","name":"Mater Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010230","name":"Queensland Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jhepr.2025.101657","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:58:19Z","timestamp":1762315099000},"page":"101657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4337-366X","authenticated-orcid":false,"given":"Hani","family":"Vu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-4261","authenticated-orcid":false,"given":"Yuliangzi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5038-5629","authenticated-orcid":false,"given":"Zherui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-7459","authenticated-orcid":false,"given":"Daniel","family":"Radford-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Causer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3178-8449","authenticated-orcid":false,"given":"Alex M.","family":"Dickens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuulia","family":"Hy\u00f6tyl\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9232-9418","authenticated-orcid":false,"given":"Ilia","family":"Evstafev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-9165","authenticated-orcid":false,"given":"Matej","family":"Oresic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nefzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-6595","authenticated-orcid":false,"given":"Eoin D.","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-6201","authenticated-orcid":false,"given":"Grant A.","family":"Ramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Clouston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-1605","authenticated-orcid":false,"given":"Katharine M.","family":"Irvine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan H.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2025.101657_bib1","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jhepr.2025.101657_bib2","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101657_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jhep.2025.02.033","article-title":"Integrative metabolism in MASLD and MASH: pathophysiology and emerging mechanisms","volume":"83","author":"Steinberg","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101657_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41572-025-00599-1","article-title":"Metabolic dysfunction-associated steatotic liver disease in adults","volume":"11","author":"Huang","year":"2025","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jhepr.2025.101657_bib5","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/d41591-025-00030-y","article-title":"The trials that could transform treatment for serious liver disease","volume":"31","author":"Healey","year":"2025","journal-title":"Nat Med"},{"key":"10.1016\/j.jhepr.2025.101657_bib6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jhep.2024.04.034","article-title":"FGF21 agonists: an emerging therapeutic for metabolic dysfunction-associated steatohepatitis and beyond","volume":"81","author":"Harrison","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101657_bib7","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jhep.2023.03.038","article-title":"An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH","volume":"79","author":"Tacke","year":"2023","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101657_bib8","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.redox.2017.01.012","article-title":"Metabolic zonation of the liver: the oxygen gradient revisited","volume":"11","author":"Kietzmann","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.jhepr.2025.101657_bib9","article-title":"A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver","volume":"5","author":"Perry","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jhepr.2025.101657_bib10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41467-024-55325-4","article-title":"Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution","volume":"16","author":"Watson","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2025.101657_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16125","article-title":"Spatial and single-cell transcriptomics reveals the regional division of the spatial structure of MASH fibrosis","volume":"45","author":"Li","year":"2025","journal-title":"Liver Int"},{"key":"10.1016\/j.jhepr.2025.101657_bib12","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/hep4.1208","article-title":"A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care","volume":"2","author":"Patel","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhepr.2025.101657_bib13","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.32475","article-title":"Reliability of histologic assessment for NAFLD and development of an expanded NAFLD activity score","volume":"76","author":"Pai","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101657_bib14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/path.6383","article-title":"Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues","volume":"265","author":"Vo","year":"2025","journal-title":"J Pathol"},{"key":"10.1016\/j.jhepr.2025.101657_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jhepr.2025.101657_bib16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.jhepr.2025.101657_bib17","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/hep.32324","article-title":"Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD","volume":"76","author":"Moore","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101657_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-pathmechdis-031521-024831","article-title":"Spatiotemporal metabolic liver zonation and consequences on pathophysiology","volume":"18","author":"Martini","year":"2023","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jhepr.2025.101657_bib19","article-title":"A spatial transcriptomics atlas of live donors reveals unique zonation patterns in the healthy human liver","volume":"2025","author":"Yakubovsky","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.jhepr.2025.101657_bib20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcmgh.2017.05.004","article-title":"Identification of the consistently altered metabolic targets in human hepatocellular carcinoma","volume":"4","author":"Nwosu","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2025.101657_bib21","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1016\/j.cell.2024.10.019","article-title":"Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging","volume":"187","author":"Ma","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jhepr.2025.101657_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180310","article-title":"The senescence-associated secretome of Hedgehog-deficient hepatocytes drives MASLD progression","volume":"134","author":"Jun","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhepr.2025.101657_bib23","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2025.101657_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cyto.2019.01.013","article-title":"The senescence-associated secretory phenotype and its regulation","volume":"117","author":"Lopes-Paciencia","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.jhepr.2025.101657_bib25","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1038\/s41467-023-43120-6","article-title":"Robust mapping of spatiotemporal trajectories and cell-cell interactions in healthy and diseased tissues","volume":"14","author":"Pham","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2025.101657_bib26","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1038\/s41467-020-18873-z","article-title":"Predicting cell-to-cell communication networks using NATMI","volume":"11","author":"Hou","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2025.101657_bib27","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1038\/sj.emboj.7601281","article-title":"Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein","volume":"25","author":"Jung","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.jhepr.2025.101657_bib28","doi-asserted-by":"crossref","first-page":"11069","DOI":"10.1074\/jbc.M111490200","article-title":"Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis","volume":"277","author":"Murphy","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhepr.2025.101657_bib29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/s12964-024-01921-2","article-title":"IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways","volume":"22","author":"Siraj","year":"2024","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jhepr.2025.101657_bib30","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.26937","article-title":"The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease","volume":"59","author":"Gadd","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101657_bib31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/HEP.0000000000000270","article-title":"Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression","volume":"78","author":"Guillot","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101657_bib32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2024.07.044","article-title":"Portal fibrosis and the ductular reaction: pathophysiological role in the progression of liver disease and translational opportunities","volume":"168","author":"Gupta","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2025.101657_bib33","doi-asserted-by":"crossref","first-page":"G881","DOI":"10.1152\/ajpgi.00289.2013","article-title":"Evidence for and against epithelial-to-mesenchymal transition in the liver","volume":"305","author":"Xie","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhepr.2025.101657_bib34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1053\/j.gastro.2023.03.228","article-title":"Macrophage-derived osteopontin (SPP1) protects from nonalcoholic steatohepatitis","volume":"165","author":"Han","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2025.101657_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101184","article-title":"Characterization of the roles of vimentin in regulating the proliferation and migration of HSCs during hepatic fibrogenesis","volume":"8","author":"Wang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jhepr.2025.101657_bib36","doi-asserted-by":"crossref","first-page":"G203","DOI":"10.1152\/ajpgi.00193.2016","article-title":"Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases","volume":"311","author":"Liepelt","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jhepr.2025.101657_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add3949","article-title":"An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis","volume":"15","author":"Wang","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhepr.2025.101657_bib38","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s43587-022-00348-z","article-title":"Age-related liver endothelial zonation triggers steatohepatitis by inactivating pericentral endothelium-derived C-kit","volume":"3","author":"Duan","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.jhepr.2025.101657_bib39","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1042\/BCJ20170867","article-title":"Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4","volume":"475","author":"Fujita","year":"2018","journal-title":"Biochem J"},{"key":"10.1016\/j.jhepr.2025.101657_bib40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cmet.2024.01.015","article-title":"IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline","volume":"36","author":"Yu","year":"2024","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2025.101657_bib41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cmet.2024.11.001","article-title":"FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology","volume":"37","author":"Yu","year":"2024","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2025.101657_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adm6783","article-title":"Spatial genomics: mapping the landscape of fibrosis","volume":"17","author":"Velu","year":"2025","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jhepr.2025.101657_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhepr.2025.101657_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-67697-0","article-title":"MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice","volume":"14","author":"Hense","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jhepr.2025.101657_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13767","article-title":"Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age","volume":"22","author":"Islam","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.jhepr.2025.101657_bib46","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41556-020-0511-2","article-title":"FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome","volume":"22","author":"Li","year":"2020","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jhepr.2025.101657_bib47","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cmet.2016.05.010","article-title":"From ancient pathways to aging cells-connecting metabolism and cellular senescence","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2025.101657_bib48","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.cmet.2024.05.003","article-title":"Metabolic reprogramming in liver fibrosis","volume":"36","author":"Horn","year":"2024","journal-title":"Cell Metab"},{"key":"10.1016\/j.jhepr.2025.101657_bib49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1042\/CS20220661","article-title":"Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization","volume":"137","author":"Xu","year":"2023","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jhepr.2025.101657_bib50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41586-024-08317-9","article-title":"FBP1 controls liver cancer evolution from senescent MASH hepatocytes","volume":"637","author":"Gu","year":"2025","journal-title":"Nature"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555925003398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555925003398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:23:17Z","timestamp":1777634597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555925003398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2589555925003398"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2025.101657","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2025.101657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101657"}}