{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:46:22Z","timestamp":1789739182046,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jhep-reports.eu","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JHEP Reports"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jhepr.2025.101666","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T21:25:35Z","timestamp":1762464335000},"page":"101666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Practice changing RCT design and rationale: Abbreviated MRI plus AFP vs. ultrasound plus AFP for HCC surveillance in cirrhosis (PREMIUM study)"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-8977","authenticated-orcid":false,"given":"George N.","family":"Ioannou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6500-1739","authenticated-orcid":false,"given":"Tamar H.","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-8335","authenticated-orcid":false,"given":"Beata M.","family":"Planeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-0002","authenticated-orcid":false,"given":"Grant D.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel S.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-0307","authenticated-orcid":false,"given":"Timothy R.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-7086","authenticated-orcid":false,"given":"Jason A.","family":"Dominitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan K.","family":"Abou-Alfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa R.","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Beheshti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit G.","family":"Singal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-7086","authenticated-orcid":false,"given":"Cynthia A.","family":"Moylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J.","family":"Boland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn F.","family":"Buchwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-5583","authenticated-orcid":false,"given":"Rajni L.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly S.","family":"Hoisington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhan V.","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari S.","family":"Rogal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-336X","authenticated-orcid":false,"given":"David E.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihane N.","family":"Benhammou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8701-774X","authenticated-orcid":false,"given":"Grace L.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genta","family":"Dani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-5676","authenticated-orcid":false,"given":"Dell P.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie T.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeyinwa Y.","family":"Onyiuke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashu","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tassos C.","family":"Kyriakides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy","family":"Baffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perica","family":"Davitkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Hernaez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Pisegna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramsey","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Patton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbey","family":"Barnard-Giustini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Jakab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Azar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupma","family":"Jati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preet","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzammil","family":"Hanif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Borghei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Walsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Swietlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Abedin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushin","family":"Vahdat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragati","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeyinwa","family":"Onyiuke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhepr.2025.101666_bib1","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1097\/HEP.0000000000000466","article-title":"AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma","volume":"78","author":"Singal","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jhep.2024.08.028","article-title":"EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma","volume":"82","year":"2025","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101666_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","article-title":"Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update","volume":"11","author":"Omata","year":"2017","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jhepr.2025.101666_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.7326\/M14-0558","article-title":"Screening for hepatocellular carcinoma in chronic liver disease: a systematic review","volume":"161","author":"Kansagara","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jhepr.2025.101666_bib5","series-title":"VA evidence-based synthesis Program reports. Screening for hepatocellular carcinoma in adults at increased risk","author":"Landsteiner","year":"2023"},{"key":"10.1016\/j.jhepr.2025.101666_bib6","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1053\/j.gastro.2018.06.079","article-title":"No association between screening for hepatocellular carcinoma and reduced cancer-related mortality in patients with cirrhosis","volume":"155","author":"Moon","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2025.101666_bib7","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1053\/j.gastro.2018.01.064","article-title":"Surveillance imaging and alpha fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis","volume":"154","author":"Tzartzeva","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2025.101666_bib8","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1001\/jamaoncol.2016.3147","article-title":"MRI with liver-specific contrast for surveillance of patients with cirrhosis at high risk of hepatocellular carcinoma","volume":"3","author":"Kim","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jhepr.2025.101666_bib9","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/hep.28895","article-title":"An assessment of benefits and harms of hepatocellular carcinoma surveillance in patients with cirrhosis","volume":"65","author":"Atiq","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib10","first-page":"626","article-title":"Evaluation of ultrasound-based surveillance for hepatocellular carcinoma in patients at risk: results from a German multicenter retrospective cohort study","volume":"11","author":"Gillessen","year":"2023","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.jhepr.2025.101666_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/hep.21966","article-title":"Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma","volume":"47","author":"Forner","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib12","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ajg.2009.663","article-title":"The radiological diagnosis of hepatocellular carcinoma","volume":"105","author":"Sherman","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhepr.2025.101666_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1572-0241.2006.00450.x","article-title":"The risk of hepatocellular carcinoma in cirrhotic patients with small liver nodules on MRI","volume":"101","author":"Shah","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhepr.2025.101666_bib15","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s00261-017-1339-5","article-title":"Evaluation of an abbreviated screening MRI protocol for patients at risk for hepatocellular carcinoma","volume":"43","author":"Lee","year":"2017","journal-title":"Abdom Radiol (NY)"},{"key":"10.1016\/j.jhepr.2025.101666_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2214\/AJR.14.12986","article-title":"Diagnostic per-patient accuracy of an abbreviated hepatobiliary phase gadoxetic acid-enhanced MRI for hepatocellular carcinoma surveillance","volume":"204","author":"Marks","year":"2015","journal-title":"AJR Am J roentgenology"},{"key":"10.1016\/j.jhepr.2025.101666_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.crad.2017.11.013","article-title":"Diagnostic per-lesion performance of a simulated gadoxetate disodium-enhanced abbreviated MRI protocol for hepatocellular carcinoma screening","volume":"73","author":"Tillman","year":"2018","journal-title":"Clin Radiol"},{"key":"10.1016\/j.jhepr.2025.101666_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00261-016-0841-5","article-title":"Hepatocellular carcinoma detection: diagnostic performance of a simulated abbreviated MRI protocol combining diffusion-weighted and T1-weighted imaging at the delayed phase post gadoxetic acid","volume":"42","author":"Besa","year":"2017","journal-title":"Abdom Radiol (NY)"},{"key":"10.1016\/j.jhepr.2025.101666_bib19","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1007\/s00330-023-09906-4","article-title":"The combination of non-contrast abbreviated MRI and alpha foetoprotein has high performance for hepatocellular carcinoma screening","volume":"33","author":"Girardet","year":"2023","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jhepr.2025.101666_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jhep.2024.03.048","article-title":"Comparison of non-contrast abbreviated MRI and ultrasound as surveillance modalities for HCC","volume":"81","author":"Kim","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101666_bib21","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1007\/s00330-020-07014-1","article-title":"Gadoxetate-enhanced abbreviated MRI is highly accurate for hepatocellular carcinoma screening","volume":"30","author":"Vietti Violi","year":"2020","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jhepr.2025.101666_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2017.26","article-title":"Cost-effectiveness of risk score-stratified hepatocellular carcinoma screening in patients with cirrhosis","volume":"8","author":"Goossens","year":"2017","journal-title":"Clin translational Gastroenterol"},{"key":"10.1016\/j.jhepr.2025.101666_bib23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cgh.2021.02.024","article-title":"Patient preferences for hepatocellular carcinoma surveillance parameters","volume":"20","author":"Woolen","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.jhepr.2025.101666_bib24","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.24581","article-title":"Feasibility of conducting a randomized control trial for liver cancer screening: is a randomized controlled trial for liver cancer screening feasible or still needed?","volume":"54","author":"Poustchi","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204412","article-title":"Differences in hepatocellular carcinoma risk, predictors and trends over time according to etiology of cirrhosis","volume":"13","author":"Ioannou","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jhepr.2025.101666_bib26","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1053\/j.gastro.2017.06.012","article-title":"Risk of hepatocellular cancer in HCV patients treated with direct-acting antiviral agents","volume":"153","author":"Kanwal","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2025.101666_bib27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jhep.2018.07.024","article-title":"Development of models estimating the risk of hepatocellular carcinoma after antiviral treatment for hepatitis C","volume":"69","author":"Ioannou","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101666_bib28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/hep.29408","article-title":"Impact of sustained virologic response with direct-acting antiviral treatment on mortality in patients with advanced liver disease","volume":"69","author":"Backus","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib29","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2019.07.033","article-title":"Increased risk for hepatocellular carcinoma persists up to 10 Years after HCV eradication in patients with baseline cirrhosis or high FIB-4 scores","volume":"157","author":"Ioannou","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhepr.2025.101666_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hep.30823","article-title":"Long-term risk of hepatocellular carcinoma in HCV patients treated with direct acting antiviral agents","volume":"71","author":"Kanwal","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jhep.2019.05.008","article-title":"Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification","volume":"71","author":"Ioannou","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101666_bib32","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/HEP.0000000000000647","article-title":"AASLD Practice Guidance on risk stratification and management of portal hypertension and varices in cirrhosis","volume":"79","author":"Kaplan","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/HEP.0000000000001183","article-title":"Validation and expansion of Baveno VII criteria for cACLD and CSPH based on liver stiffness and platelet count: correlation with risk of hepatic decompensation and death","volume":"82","author":"Vutien","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib34","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/HEP.0000000000000339","article-title":"Screening of liver cancer with abbreviated MRI","volume":"78","author":"Ronot","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jmri.26835","article-title":"Abbreviated-protocol screening MRI vs. complete-protocol diagnostic MRI for detection of hepatocellular carcinoma in patients with cirrhosis: an equivalence study using LI-RADS v2018","volume":"51","author":"Khatri","year":"2020","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jhepr.2025.101666_bib36","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.rcl.2017.06.012","article-title":"Screening and surveillance of hepatocellular carcinoma: an introduction to ultrasound liver imaging reporting and data system","volume":"55","author":"Fetzer","year":"2017","journal-title":"Radiol Clin North Am"},{"issue":"Supple 1","key":"10.1016\/j.jhepr.2025.101666_bib37","article-title":"Hepatocellular carcinoma screening in patients with chronic hepatitis B infection is associated with A lower risk of cancer-related mortality","volume":"70","author":"Su","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib38","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/jnci\/93.14.1054","article-title":"Phases of biomarker development for early detection of cancer","volume":"93","author":"Pepe","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jhepr.2025.101666_bib39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0197-2456(86)90047-4","article-title":"Sample size determination in clinical trials with time-dependent rates of losses and noncompliance","volume":"7","author":"Lakatos","year":"1986","journal-title":"Controlled Clin trials"},{"key":"10.1016\/j.jhepr.2025.101666_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2307\/2531910","article-title":"Sample sizes based on the log-rank statistic in complex clinical trials","volume":"44","author":"Lakatos","year":"1988","journal-title":"Biometrics"},{"key":"10.1016\/j.jhepr.2025.101666_bib41","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-083701","article-title":"Study protocol for FASTRAK: a randomised controlled trial evaluating the cost impact and effectiveness of FAST-MRI for HCC suRveillance in pAtients with high risK of liver cancer","volume":"14","author":"Nahon","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.jhepr.2025.101666_bib42","unstructured":"Abbreviated MRI for Liver Cancer Screening in Cirrhotic Patients, the FAST-MRI Study. Natl Cancer Inst. Available at: https:\/\/www.cancer.gov\/research\/participate\/clinical-trials-search\/v?id=NCI-2021-00372 (accessed: May 19, 2025)."},{"key":"10.1016\/j.jhepr.2025.101666_bib44","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000565","article-title":"National liver cancer screening trial (TRACER) study protocol","volume":"8","author":"Singal","year":"2024","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jhepr.2025.101666_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/S0168-8278(24)00441-0","article-title":"LBO-006 A prospective, blinded multicenter US evaluation of a multi-analysis blood-based test for the detection of hepatocellular carcinoma (HCC) in patients with cirrhosisEASL Congress2024, June 5-8","volume":"80","author":"Taggart","year":"2024","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhepr.2025.101666_bib48","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/HEP.0000000000001203","article-title":"Value of HCC surveillance in a landscape of emerging surveillance options: perspectives of a multi-stakeholder modified Delphi panel","volume":"82","author":"Singal","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib49","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/hep.21176","article-title":"The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients","volume":"43","author":"Sangiovanni","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib50","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/hep.32434","article-title":"Risk factors for HCC in contemporary cohorts of patients with cirrhosis","volume":"77","author":"Kanwal","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jhepr.2025.101666_bib51","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1148\/rg.2019180123","article-title":"Abbreviated MRI protocols for the abdomen","volume":"39","author":"Canellas","year":"2019","journal-title":"Radiographics"}],"container-title":["JHEP Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555925003490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589555925003490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:23:25Z","timestamp":1777634605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589555925003490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2589555925003490"],"URL":"https:\/\/doi.org\/10.1016\/j.jhepr.2025.101666","relation":{},"ISSN":["2589-5559"],"issn-type":[{"value":"2589-5559","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Practice changing RCT design and rationale: Abbreviated MRI plus AFP vs. ultrasound plus AFP for HCC surveillance in cirrhosis (PREMIUM study)","name":"articletitle","label":"Article Title"},{"value":"JHEP Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhepr.2025.101666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).","name":"copyright","label":"Copyright"}],"article-number":"101666"}}